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Items: 34


Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo.

Schofield DJ, Irving L, Calo L, Bogstedt A, Rees G, Nuccitelli A, Narwal R, Petrone M, Roberts J, Brown L, Cusdin F, Dosanjh B, Lloyd C, Dobson C, Gurrell I, Fraser G, McFarlane M, Rockenstein E, Spencer B, Masliah E, Spillantini MG, Tan K, Billinton A, Vaughan T, Chessell I, Perkinton MS.

Neurobiol Dis. 2019 Aug 21;132:104582. doi: 10.1016/j.nbd.2019.104582. [Epub ahead of print]


Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo.

Ondrejcak T, Hu NW, Qi Y, Klyubin I, Corbett GT, Fraser G, Perkinton MS, Walsh DM, Billinton A, Rowan MJ.

Neurobiol Dis. 2019 Jul;127:582-590. doi: 10.1016/j.nbd.2019.03.022. Epub 2019 Mar 22.


Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.

Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, Schott JM, Walsh DM.

Alzheimers Dement. 2019 Mar;15(3):487-496. doi: 10.1016/j.jalz.2018.09.010. Epub 2018 Nov 9.


Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo.

Ondrejcak T, Klyubin I, Corbett GT, Fraser G, Hong W, Mably AJ, Gardener M, Hammersley J, Perkinton MS, Billinton A, Walsh DM, Rowan MJ.

J Neurosci. 2018 Dec 12;38(50):10595-10606. doi: 10.1523/JNEUROSCI.1700-18.2018. Epub 2018 Oct 24.


Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy.

Lionnet A, Wade MA, Corbillé AG, Prigent A, Paillusson S, Tasselli M, Gonzales J, Durieu E, Rolli-Derkinderen M, Coron E, Duchalais E, Neunlist M, Perkinton MS, Hanger DP, Noble W, Derkinderen P.

Acta Neuropathol Commun. 2018 Jul 23;6(1):65. doi: 10.1186/s40478-018-0568-3.


Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways.

Evans LD, Wassmer T, Fraser G, Smith J, Perkinton M, Billinton A, Livesey FJ.

Cell Rep. 2018 Mar 27;22(13):3612-3624. doi: 10.1016/j.celrep.2018.03.021.


Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures.

Croft CL, Wade MA, Kurbatskaya K, Mastrandreas P, Hughes MM, Phillips EC, Pooler AM, Perkinton MS, Hanger DP, Noble W.

Cell Death Dis. 2017 Mar 16;8(3):e2671. doi: 10.1038/cddis.2017.97.


Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.

Cox CJ, Choudhry F, Peacey E, Perkinton MS, Richardson JC, Howlett DR, Lichtenthaler SF, Francis PT, Williams RJ.

Neurobiol Aging. 2015 Jan;36(1):178-87. doi: 10.1016/j.neurobiolaging.2014.07.032. Epub 2014 Jul 30.


AMPA receptor activation promotes non-amyloidogenic amyloid precursor protein processing and suppresses neuronal amyloid-β production.

Hoey SE, Buonocore F, Cox CJ, Hammond VJ, Perkinton MS, Williams RJ.

PLoS One. 2013 Oct 24;8(10):e78155. doi: 10.1371/journal.pone.0078155. eCollection 2013.


Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production.

Vagnoni A, Glennon EB, Perkinton MS, Gray EH, Noble W, Miller CC.

Hum Mol Genet. 2013 Nov 15;22(22):4646-52. doi: 10.1093/hmg/ddt313. Epub 2013 Jul 3.


Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production.

Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC.

Hum Mol Genet. 2012 Jul 1;21(13):2845-54. doi: 10.1093/hmg/dds109. Epub 2012 Mar 20.


GULP1 is a novel APP-interacting protein that alters APP processing.

Hao Y, Perkinton MS, Chan WW, Chan HY, Miller CC, Lau KF.

Biochem J. 2011 Jun 15;436(3):631-9. doi: 10.1042/BJ20110145. Erratum in: Biochem J. 2011 Aug 1;437(3):576. Hao, Candy Yan [corrected to Hao, Yan].


Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production.

Gray EH, De Vos KJ, Dingwall C, Perkinton MS, Miller CC.

J Alzheimers Dis. 2010;21(4):1101-5. doi: 10.3233/JAD-2010-100717.


An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.

Lau KF, Perkinton MS, Rodriguez L, McLoughlin DM, Miller CC.

Neuroreport. 2010 Aug 4;21(11):761-6. doi: 10.1097/WNR.0b013e32833bfca0.


Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease.

Mitchell JC, Perkinton MS, Yates DM, Lau KF, Rogelj B, Miller CC, McLoughlin DM.

J Alzheimers Dis. 2010;20(1):31-6. doi: 10.3233/JAD-2009-1341.


Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.

Tudor EL, Galtrey CM, Perkinton MS, Lau KF, De Vos KJ, Mitchell JC, Ackerley S, Hortobágyi T, Vámos E, Leigh PN, Klasen C, McLoughlin DM, Shaw CE, Miller CC.

Neuroscience. 2010 May 19;167(3):774-85. doi: 10.1016/j.neuroscience.2010.02.035. Epub 2010 Feb 24.


Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery.

Cousins SL, Hoey SE, Anne Stephenson F, Perkinton MS.

J Neurochem. 2009 Dec;111(6):1501-13. doi: 10.1111/j.1471-4159.2009.06424.x. Epub 2009 Oct 7.


X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.

Mitchell JC, Ariff BB, Yates DM, Lau KF, Perkinton MS, Rogelj B, Stephenson JD, Miller CC, McLoughlin DM.

Hum Mol Genet. 2009 Dec 1;18(23):4492-500. doi: 10.1093/hmg/ddp408. Epub 2009 Sep 10.


Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.

Hoey SE, Williams RJ, Perkinton MS.

J Neurosci. 2009 Apr 8;29(14):4442-60. doi: 10.1523/JNEUROSCI.6017-08.2009.


Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.

Lau KF, Chan WM, Perkinton MS, Tudor EL, Chang RC, Chan HY, McLoughlin DM, Miller CC.

J Biol Chem. 2008 Dec 12;283(50):34728-37. doi: 10.1074/jbc.M801874200. Epub 2008 Oct 15.


ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.

Tudor EL, Perkinton MS, Schmidt A, Ackerley S, Brownlees J, Jacobsen NJ, Byers HL, Ward M, Hall A, Leigh PN, Shaw CE, McLoughlin DM, Miller CC.

J Biol Chem. 2005 Oct 14;280(41):34735-40. Epub 2005 Jul 26.


The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice.

Lee JH, Lau KF, Perkinton MS, Standen CL, Rogelj B, Falinska A, McLoughlin DM, Miller CC.

J Biol Chem. 2004 Nov 19;279(47):49099-104. Epub 2004 Sep 3.


p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

Ackerley S, Grierson AJ, Banner S, Perkinton MS, Brownlees J, Byers HL, Ward M, Thornhill P, Hussain K, Waby JS, Anderton BH, Cooper JD, Dingwall C, Leigh PN, Shaw CE, Miller CC.

Mol Cell Neurosci. 2004 Jun;26(2):354-64.


The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.

Perkinton MS, Standen CL, Lau KF, Kesavapany S, Byers HL, Ward M, McLoughlin DM, Miller CC.

J Biol Chem. 2004 May 21;279(21):22084-91. Epub 2004 Mar 18.


The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).

Standen CL, Perkinton MS, Byers HL, Kesavapany S, Lau KF, Ward M, McLoughlin D, Miller CC.

Mol Cell Neurosci. 2003 Dec;24(4):851-7.


The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.

Lee JH, Lau KF, Perkinton MS, Standen CL, Shemilt SJ, Mercken L, Cooper JD, McLoughlin DM, Miller CC.

J Biol Chem. 2003 Nov 21;278(47):47025-9. Epub 2003 Sep 11.


The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings.

Suchak SK, Baloyianni NV, Perkinton MS, Williams RJ, Meldrum BS, Rattray M.

J Neurochem. 2003 Feb;84(3):522-32.


Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn.

Pezet S, Malcangio M, Lever IJ, Perkinton MS, Thompson SW, Williams RJ, McMahon SB.

Mol Cell Neurosci. 2002 Dec;21(4):684-95.


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