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Items: 1 to 50 of 209

1.

The solution structure of the human IgG2 subclass is distinct from those for human IgG1 and IgG4 providing an explanation for their discrete functions.

Hui GK, Gardener AD, Begum H, Gor J, Perkins SJ.

J Biol Chem. 2019 May 14. pii: jbc.RA118.007134. doi: 10.1074/jbc.RA118.007134. [Epub ahead of print]

2.

An Expanded Conformation of an Antibody Fab Region by X-Ray Scattering, Molecular Dynamics, and smFRET Identifies an Aggregation Mechanism.

Codina N, Hilton D, Zhang C, Chakroun N, Ahmad SS, Perkins SJ, Dalby PA.

J Mol Biol. 2019 Mar 29;431(7):1409-1425. doi: 10.1016/j.jmb.2019.02.009. Epub 2019 Feb 16.

3.

Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces.

Osborne AJ, Nan R, Miller A, Bhatt JS, Gor J, Perkins SJ.

J Biol Chem. 2018 Nov 2;293(44):17166-17187. doi: 10.1074/jbc.RA118.004767. Epub 2018 Sep 14.

4.

Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.

Osborne AJ, Breno M, Borsa NG, Bu F, Frémeaux-Bacchi V, Gale DP, van den Heuvel LP, Kavanagh D, Noris M, Pinto S, Rallapalli PM, Remuzzi G, Rodríguez de Cordoba S, Ruiz A, Smith RJH, Vieira-Martins P, Volokhina E, Wilson V, Goodship THJ, Perkins SJ.

J Immunol. 2018 Apr 1;200(7):2464-2478. doi: 10.4049/jimmunol.1701695. Epub 2018 Mar 2.

5.

Non-linearity of the collagen triple helix in solution and implications for collagen function.

Walker KT, Nan R, Wright DW, Gor J, Bishop AC, Makhatadze GI, Brodsky B, Perkins SJ.

Biochem J. 2017 Jun 16;474(13):2203-2217. doi: 10.1042/BCJ20170217.

6.

Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.

Nan R, Furze CM, Wright DW, Gor J, Wallis R, Perkins SJ.

Structure. 2017 Feb 7;25(2):364-375. doi: 10.1016/j.str.2016.12.014. Epub 2017 Jan 19.

7.

Atomistic modelling of scattering data in the Collaborative Computational Project for Small Angle Scattering (CCP-SAS).

Perkins SJ, Wright DW, Zhang H, Brookes EH, Chen J, Irving TC, Krueger S, Barlow DJ, Edler KJ, Scott DJ, Terrill NJ, King SM, Butler PD, Curtis JE.

J Appl Crystallogr. 2016 Oct 14;49(Pt 6):1861-1875. eCollection 2016 Dec 1.

8.

Matchout deuterium labelling of proteins for small-angle neutron scattering studies using prokaryotic and eukaryotic expression systems and high cell-density cultures.

Dunne O, Weidenhaupt M, Callow P, Martel A, Moulin M, Perkins SJ, Haertlein M, Forsyth VT.

Eur Biophys J. 2017 Jul;46(5):425-432. doi: 10.1007/s00249-016-1186-2. Epub 2016 Nov 14.

9.

Domain structure of human complement C4b extends with increasing NaCl concentration: implications for its regulatory mechanism.

Fung KW, Wright DW, Gor J, Swann MJ, Perkins SJ.

Biochem J. 2016 Dec 1;473(23):4473-4491. Epub 2016 Oct 13.

PMID:
27738201
10.

A simple microfluidic device to study cell-scale endothelial mechanotransduction.

Lafaurie-Janvore J, Antoine EE, Perkins SJ, Babataheri A, Barakat AI.

Biomed Microdevices. 2016 Aug;18(4):63. doi: 10.1007/s10544-016-0090-y.

PMID:
27402497
11.

Zinc-induced oligomerization of zinc α2 glycoprotein reveals multiple fatty acid-binding sites.

Zahid H, Miah L, Lau AM, Brochard L, Hati D, Bui TT, Drake AF, Gor J, Perkins SJ, McDermott LC.

Biochem J. 2016 Jan 1;473(1):43-54. doi: 10.1042/BJ20150836. Epub 2015 Oct 20.

PMID:
26487699
12.

Extension of resolution and oligomerization-state studies of 2,4'-dihydroxyacetophenone dioxygenase from Alcaligenes sp. 4HAP.

Guo J, Erskine P, Coker AR, Gor J, Perkins SJ, Wood SP, Cooper JB.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1258-63. doi: 10.1107/S2053230X15015873. Epub 2015 Sep 23.

13.

The solution structures of native and patient monomeric human IgA1 reveal asymmetric extended structures: implications for function and IgAN disease.

Hui GK, Wright DW, Vennard OL, Rayner LE, Pang M, Yeo SC, Gor J, Molyneux K, Barratt J, Perkins SJ.

Biochem J. 2015 Oct 15;471(2):167-85. doi: 10.1042/BJ20150612. Epub 2015 Aug 12.

14.

SCT: a suite of programs for comparing atomistic models with small-angle scattering data.

Wright DW, Perkins SJ.

J Appl Crystallogr. 2015 May 9;48(Pt 3):953-961. eCollection 2015 Jun 1.

15.

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

Zhao H, Ghirlando R, Alfonso C, Arisaka F, Attali I, Bain DL, Bakhtina MM, Becker DF, Bedwell GJ, Bekdemir A, Besong TM, Birck C, Brautigam CA, Brennerman W, Byron O, Bzowska A, Chaires JB, Chaton CT, Cölfen H, Connaghan KD, Crowley KA, Curth U, Daviter T, Dean WL, Díez AI, Ebel C, Eckert DM, Eisele LE, Eisenstein E, England P, Escalante C, Fagan JA, Fairman R, Finn RM, Fischle W, de la Torre JG, Gor J, Gustafsson H, Hall D, Harding SE, Cifre JG, Herr AB, Howell EE, Isaac RS, Jao SC, Jose D, Kim SJ, Kokona B, Kornblatt JA, Kosek D, Krayukhina E, Krzizike D, Kusznir EA, Kwon H, Larson A, Laue TM, Le Roy A, Leech AP, Lilie H, Luger K, Luque-Ortega JR, Ma J, May CA, Maynard EL, Modrak-Wojcik A, Mok YF, Mücke N, Nagel-Steger L, Narlikar GJ, Noda M, Nourse A, Obsil T, Park CK, Park JK, Pawelek PD, Perdue EE, Perkins SJ, Perugini MA, Peterson CL, Peverelli MG, Piszczek G, Prag G, Prevelige PE, Raynal BD, Rezabkova L, Richter K, Ringel AE, Rosenberg R, Rowe AJ, Rufer AC, Scott DJ, Seravalli JG, Solovyova AS, Song R, Staunton D, Stoddard C, Stott K, Strauss HM, Streicher WW, Sumida JP, Swygert SG, Szczepanowski RH, Tessmer I, Toth RT 4th, Tripathy A, Uchiyama S, Uebel SF, Unzai S, Gruber AV, von Hippel PH, Wandrey C, Wang SH, Weitzel SE, Wielgus-Kutrowska B, Wolberger C, Wolff M, Wright E, Wu YS, Wubben JM, Schuck P.

PLoS One. 2015 May 21;10(5):e0126420. doi: 10.1371/journal.pone.0126420. eCollection 2015.

16.

The solution structures of two human IgG1 antibodies show conformational stability and accommodate their C1q and FcγR ligands.

Rayner LE, Hui GK, Gor J, Heenan RK, Dalby PA, Perkins SJ.

J Biol Chem. 2015 Mar 27;290(13):8420-38. doi: 10.1074/jbc.M114.631002. Epub 2015 Feb 6.

17.

A revised mechanism for the activation of complement C3 to C3b: a molecular explanation of a disease-associated polymorphism.

Rodriguez E, Nan R, Li K, Gor J, Perkins SJ.

J Biol Chem. 2015 Jan 23;290(4):2334-50. doi: 10.1074/jbc.M114.605691. Epub 2014 Dec 8.

18.

New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3.

Rodriguez E, Rallapalli PM, Osborne AJ, Perkins SJ.

Biosci Rep. 2014 Oct 22;34(5). pii: e00146. doi: 10.1042/BSR20140117.

19.

Positive selection during the evolution of the blood coagulation factors in the context of their disease-causing mutations.

Rallapalli PM, Orengo CA, Studer RA, Perkins SJ.

Mol Biol Evol. 2014 Nov;31(11):3040-56. doi: 10.1093/molbev/msu248. Epub 2014 Aug 25.

20.

The Fab conformations in the solution structure of human immunoglobulin G4 (IgG4) restrict access to its Fc region: implications for functional activity.

Rayner LE, Hui GK, Gor J, Heenan RK, Dalby PA, Perkins SJ.

J Biol Chem. 2014 Jul 25;289(30):20740-56. doi: 10.1074/jbc.M114.572404. Epub 2014 May 29.

21.

Molecular Interactions between Complement Factor H and Its Heparin and Heparan Sulfate Ligands.

Perkins SJ, Fung KW, Khan S.

Front Immunol. 2014 Mar 31;5:126. doi: 10.3389/fimmu.2014.00126. eCollection 2014. Review.

22.

Developing and mature human granulocytes express ELP 6 in the cytoplasm.

Wagner LA, Wang S, Wayner EA, Christensen C, Perkins SJ, Ward GW, Weiss RB, Dunn DM, Redd MJ, Spangrude GJ, Gleich GJ.

Hum Antibodies. 2013;22(1-2):21-9. doi: 10.3233/HAB-130268.

23.

The concave face of decorin mediates reversible dimerization and collagen binding.

Islam M, Gor J, Perkins SJ, Ishikawa Y, Bächinger HP, Hohenester E.

J Biol Chem. 2013 Dec 6;288(49):35526-33. doi: 10.1074/jbc.M113.504530. Epub 2013 Oct 29.

24.

The solution structure of heparan sulfate differs from that of heparin: implications for function.

Khan S, Fung KW, Rodriguez E, Patel R, Gor J, Mulloy B, Perkins SJ.

J Biol Chem. 2013 Sep 27;288(39):27737-51. doi: 10.1074/jbc.M113.492223. Epub 2013 Aug 6.

25.

Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration.

Nan R, Tetchner S, Rodriguez E, Pao PJ, Gor J, Lengyel I, Perkins SJ.

J Biol Chem. 2013 Jun 28;288(26):19197-210. doi: 10.1074/jbc.M113.476143. Epub 2013 May 9.

26.

An interactive mutation database for human coagulation factor IX provides novel insights into the phenotypes and genetics of hemophilia B.

Rallapalli PM, Kemball-Cook G, Tuddenham EG, Gomez K, Perkins SJ.

J Thromb Haemost. 2013 Jul;11(7):1329-40. doi: 10.1111/jth.12276.

27.

The solution structure of rabbit IgG accounts for its interactions with the Fc receptor and complement C1q and its conformational stability.

Rayner LE, Kadkhodayi-Kholghi N, Heenan RK, Gor J, Dalby PA, Perkins SJ.

J Mol Biol. 2013 Feb 8;425(3):506-23. doi: 10.1016/j.jmb.2012.11.019. Epub 2012 Nov 20.

28.

Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin.

Khan S, Nan R, Gor J, Mulloy B, Perkins SJ.

Biochem J. 2012 Jun 15;444(3):417-28. doi: 10.1042/BJ20120183.

PMID:
22471560
29.

Solution structure of TT30, a novel complement therapeutic agent, provides insight into its joint binding to complement C3b and C3d.

Li K, Gor J, Holers VM, Storek MJ, Perkins SJ.

J Mol Biol. 2012 May 4;418(3-4):248-63. doi: 10.1016/j.jmb.2012.02.038. Epub 2012 Mar 1.

PMID:
22387467
30.

Near-planar solution structures of mannose-binding lectin oligomers provide insight on activation of lectin pathway of complement.

Miller A, Phillips A, Gor J, Wallis R, Perkins SJ.

J Biol Chem. 2012 Feb 3;287(6):3930-45. doi: 10.1074/jbc.M111.320341. Epub 2011 Dec 13.

31.

Complement factor H-ligand interactions: self-association, multivalency and dissociation constants.

Perkins SJ, Nan R, Li K, Khan S, Miller A.

Immunobiology. 2012 Feb;217(2):281-97. doi: 10.1016/j.imbio.2011.10.003. Epub 2011 Oct 28. Review.

32.

The solution structure of heparan sulfate differs from that of heparin: implications for function.

Khan S, Rodriguez E, Patel R, Gor J, Mulloy B, Perkins SJ.

J Biol Chem. 2011 Jul 15;286(28):24842-54. doi: 10.1074/jbc.M111.226027. Epub 2011 May 16. Retraction in: J Biol Chem. 2013 Jul 19;288(29):21209.

33.

Zinc binding to the Tyr402 and His402 allotypes of complement factor H: possible implications for age-related macular degeneration.

Nan R, Farabella I, Schumacher FF, Miller A, Gor J, Martin AC, Jones DT, Lengyel I, Perkins SJ.

J Mol Biol. 2011 May 13;408(4):714-35. doi: 10.1016/j.jmb.2011.03.006. Epub 2011 Mar 17.

34.

Analytical ultracentrifugation combined with X-ray and neutron scattering: Experiment and modelling.

Perkins SJ, Nan R, Li K, Khan S, Abe Y.

Methods. 2011 May;54(1):181-99. doi: 10.1016/j.ymeth.2011.01.004. Epub 2011 Jan 20. Review.

PMID:
21256219
35.

Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy.

Abe Y, Gor J, Bracewell DG, Perkins SJ, Dalby PA.

Biochem J. 2010 Nov 15;432(1):101-11. doi: 10.1042/BJ20100641.

PMID:
20722630
36.

Multiple interactions of complement Factor H with its ligands in solution: a progress report.

Perkins SJ, Nan R, Okemefuna AI, Li K, Khan S, Miller A.

Adv Exp Med Biol. 2010;703:25-47. doi: 10.1007/978-1-4419-5635-4_3. Review.

PMID:
20711705
37.

Self-association and domain rearrangements between complement C3 and C3u provide insight into the activation mechanism of C3.

Li K, Gor J, Perkins SJ.

Biochem J. 2010 Oct 1;431(1):63-72. doi: 10.1042/BJ20100759.

PMID:
20666732
38.

An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation.

Tchepeleva SN, Thurman JM, Ruff K, Perkins SJ, Morel L, Boackle SA.

J Immunol. 2010 Aug 15;185(4):2331-9. doi: 10.4049/jimmunol.1000783. Epub 2010 Jul 21.

39.

Unravelling protein-protein interactions between complement factor H and C-reactive protein using a multidisciplinary strategy.

Perkins SJ, Okemefuna AI, Nan R.

Biochem Soc Trans. 2010 Aug;38(4):894-900. doi: 10.1042/BST0380894. Review.

PMID:
20658973
40.

Oligomeric assembly and interactions within the human RuvB-like RuvBL1 and RuvBL2 complexes.

Niewiarowski A, Bradley AS, Gor J, McKay AR, Perkins SJ, Tsaneva IR.

Biochem J. 2010 Jul 1;429(1):113-25. doi: 10.1042/BJ20100489.

PMID:
20412048
41.

The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein.

Leonard PG, Parkinson GN, Gor J, Perkins SJ, Ladbury JE.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Apr 1;66(Pt 4):421-5. doi: 10.1107/S1744309110004574. Epub 2010 Mar 31.

42.

Impact of compound heterozygous complement factor H mutations on development of atypical hemolytic uremic syndrome-A pedigree revisited.

Johnson SA, Williams JM, Hakobyan S, Richards A, Perkins SJ, Marchbank KJ, Goodship TH, Morgan BP, Taylor CM, Savage CO.

Mol Immunol. 2010 Apr;47(7-8):1585-91. doi: 10.1016/j.molimm.2009.12.001. Epub 2010 Mar 20.

PMID:
20304497
43.

Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4.

Hebecker M, Okemefuna AI, Perkins SJ, Mihlan M, Huber-Lang M, Józsi M.

Mol Immunol. 2010 Mar;47(6):1347-55. doi: 10.1016/j.molimm.2009.12.005. Epub 2009 Dec 29.

PMID:
20042240
44.

C-reactive protein exists in an NaCl concentration-dependent pentamer-decamer equilibrium in physiological buffer.

Okemefuna AI, Stach L, Rana S, Buetas AJ, Gor J, Perkins SJ.

J Biol Chem. 2010 Jan 8;285(2):1041-52. doi: 10.1074/jbc.M109.044495. Epub 2009 Nov 10.

45.

Semi-rigid solution structures of heparin by constrained X-ray scattering modelling: new insight into heparin-protein complexes.

Khan S, Gor J, Mulloy B, Perkins SJ.

J Mol Biol. 2010 Jan 22;395(3):504-21. doi: 10.1016/j.jmb.2009.10.064. Epub 2009 Nov 3. Erratum in: J Mol Biol. 2013 May 27;425(10):1847.

PMID:
19895822
46.

Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations.

Okemefuna AI, Nan R, Miller A, Gor J, Perkins SJ.

J Biol Chem. 2010 Jan 8;285(2):1053-65. doi: 10.1074/jbc.M109.044529. Epub 2009 Oct 22.

47.

Structural analysis of eight novel and 112 previously reported missense mutations in the interactive FXI mutation database reveals new insight on FXI deficiency.

Saunders RE, Shiltagh N, Gomez K, Mellars G, Cooper C, Perry DJ, Tuddenham EG, Perkins SJ.

Thromb Haemost. 2009 Aug;102(2):287-301. doi: 10.1160/TH09-01-0044.

PMID:
19652879
48.

Constrained solution scattering modelling of human antibodies and complement proteins reveals novel biological insights.

Perkins SJ, Okemefuna AI, Nan R, Li K, Bonner A.

J R Soc Interface. 2009 Oct 6;6 Suppl 5:S679-96. doi: 10.1098/rsif.2009.0164.focus. Epub 2009 Jul 15.

49.

Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria.

Leonard PG, Ono S, Gor J, Perkins SJ, Ladbury JE.

Mol Microbiol. 2009 Jul;73(2):165-79. doi: 10.1111/j.1365-2958.2009.06754.x. Epub 2009 Jun 8.

50.

Electrostatic interactions contribute to the folded-back conformation of wild type human factor H.

Okemefuna AI, Nan R, Gor J, Perkins SJ.

J Mol Biol. 2009 Aug 7;391(1):98-118. doi: 10.1016/j.jmb.2009.06.010. Epub 2009 Jun 6.

PMID:
19505476

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