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Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IkBa.

Ivanova IG, Perkins ND.

Biosci Rep. 2019 Sep 4. pii: BSR20192101. doi: 10.1042/BSR20192101. [Epub ahead of print]


Induction of the immunoprotective coat of Yersinia pestis at body temperature is mediated by the Caf1R transcription factor.

Al-Jawdah AD, Ivanova IG, Waller H, Perkins ND, Lakey JH, Peters DT.

BMC Microbiol. 2019 Mar 29;19(1):68. doi: 10.1186/s12866-019-1444-4.


More than just an IκB kinase: the IKK complex coordinates mRNA stability and transcription.

Perkins ND.

EMBO J. 2018 Dec 14;37(24). pii: e101084. doi: 10.15252/embj.2018101084. Epub 2018 Dec 3. No abstract available.


RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation.

Szołtysek K, Janus P, Zając G, Stokowy T, Walaszczyk A, Widłak W, Wojtaś B, Gielniewski B, Cockell S, Perkins ND, Kimmel M, Widlak P.

BMC Genomics. 2018 Nov 12;19(1):813. doi: 10.1186/s12864-018-5211-y.


Pro-inflammatory cytokine and high doses of ionizing radiation have similar effects on the expression of NF-kappaB-dependent genes.

Janus P, Szołtysek K, Zając G, Stokowy T, Walaszczyk A, Widłak W, Wojtaś B, Gielniewski B, Iwanaszko M, Braun R, Cockell S, Perkins ND, Kimmel M, Widlak P.

Cell Signal. 2018 Jun;46:23-31. doi: 10.1016/j.cellsig.2018.02.011. Epub 2018 Feb 21.


A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer.

Moles A, Butterworth JA, Sanchez A, Hunter JE, Leslie J, Sellier H, Tiniakos D, Cockell SJ, Mann DA, Oakley F, Perkins ND.

Oncogene. 2016 Sep 1;35(35):4623-32. doi: 10.1038/onc.2015.526. Epub 2016 Feb 8.


c-Rel and its many roles in cancer: an old story with new twists.

Hunter JE, Leslie J, Perkins ND.

Br J Cancer. 2016 Jan 12;114(1):1-6. doi: 10.1038/bjc.2015.410. Review.


NFKB1: a suppressor of inflammation, ageing and cancer.

Cartwright T, Perkins ND, L Wilson C.

FEBS J. 2016 May;283(10):1812-22. doi: 10.1111/febs.13627. Epub 2016 Jan 13. Review.


The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma.

Hunter JE, Butterworth JA, Zhao B, Sellier H, Campbell KJ, Thomas HD, Bacon CM, Cockell SJ, Gewurz BE, Perkins ND.

Oncogene. 2016 Jun 30;35(26):3476-84. doi: 10.1038/onc.2015.399. Epub 2015 Nov 2.


The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma.

Walton MI, Eve PD, Hayes A, Henley AT, Valenti MR, De Haven Brandon AK, Box G, Boxall KJ, Tall M, Swales K, Matthews TP, McHardy T, Lainchbury M, Osborne J, Hunter JE, Perkins ND, Aherne GW, Reader JC, Raynaud FI, Eccles SA, Collins I, Garrett MD.

Oncotarget. 2016 Jan 19;7(3):2329-42. doi: 10.18632/oncotarget.4919.


The importance of the p50 NF-κB subunit.

Perkins ND.

Cell Cycle. 2015;14(18):2877-8. doi: 10.1080/15384101.2015.1010952. Epub 2015 Aug 20. No abstract available.


Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.

Iannetti A, Ledoux AC, Tudhope SJ, Sellier H, Zhao B, Mowla S, Moore A, Hummerich H, Gewurz BE, Cockell SJ, Jat PS, Willmore E, Perkins ND.

PLoS Genet. 2014 Sep 25;10(9):e1004642. doi: 10.1371/journal.pgen.1004642. eCollection 2014 Sep.


Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins.

Bonacci T, Audebert S, Camoin L, Baudelet E, Bidaut G, Garcia M, Witzel II, Perkins ND, Borg JP, Iovanna JL, Soubeyran P.

J Proteome Res. 2014 May 2;13(5):2478-94. doi: 10.1021/pr401258d. Epub 2014 Apr 2.


NF-κB and the cell cycle.

Ledoux AC, Perkins ND.

Biochem Soc Trans. 2014 Feb;42(1):76-81. doi: 10.1042/BST20130156. Review.


Using body temperature, food and water consumption as biomarkers of disease progression in mice with Eμ-myc lymphoma.

Hunter JE, Butterworth J, Perkins ND, Bateson M, Richardson CA.

Br J Cancer. 2014 Feb 18;110(4):928-34. doi: 10.1038/bjc.2013.818. Epub 2014 Jan 9.


Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence.

Mowla SN, Perkins ND, Jat PS.

Onco Targets Ther. 2013 Sep 4;6:1221-9. doi: 10.2147/OTT.S36160. Review.


NFκB regulates expression of Polo-like kinase 4.

Ledoux AC, Sellier H, Gillies K, Iannetti A, James J, Perkins ND.

Cell Cycle. 2013 Sep 15;12(18):3052-62. doi: 10.4161/cc.26086. Epub 2013 Aug 21.


Emerging from NF-κB's shadow, SUMOylated IκBα represses transcription.

Perkins ND.

Cancer Cell. 2013 Aug 12;24(2):139-40. doi: 10.1016/j.ccr.2013.07.011.


NF-κB is a critical mediator of BRCA1-induced chemoresistance.

Harte MT, Gorski JJ, Savage KI, Purcell JW, Barros EM, Burn PM, McFarlane C, Mullan PB, Kennedy RD, Perkins ND, Harkin DP.

Oncogene. 2014 Feb 6;33(6):713-723. doi: 10.1038/onc.2013.10. Epub 2013 Feb 25.


Identification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21.

Yamada K, Ono M, Perkins ND, Rocha S, Lamond AI.

Mol Cell. 2013 Mar 7;49(5):922-33. doi: 10.1016/j.molcel.2012.12.023. Epub 2013 Jan 31.


Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response.

Moles A, Sanchez AM, Banks PS, Murphy LB, Luli S, Borthwick L, Fisher A, O'Reilly S, van Laar JM, White SA, Perkins ND, Burt AD, Mann DA, Oakley F.

Hepatology. 2013 Feb;57(2):817-28. doi: 10.1002/hep.26068. Epub 2013 Jan 8.


Nuclear factor-κB, p53, and mitochondria: regulation of cellular metabolism and the Warburg effect.

Johnson RF, Perkins ND.

Trends Biochem Sci. 2012 Aug;37(8):317-24. doi: 10.1016/j.tibs.2012.04.002. Epub 2012 May 23. Review.


The diverse and complex roles of NF-κB subunits in cancer.

Perkins ND.

Nat Rev Cancer. 2012 Jan 19;12(2):121-32. doi: 10.1038/nrc3204. Review.


Cysteine 38 holds the key to NF-κB activation.

Perkins ND.

Mol Cell. 2012 Jan 13;45(1):1-3. doi: 10.1016/j.molcel.2011.12.023.


BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis.

Southern SL, Collard TJ, Urban BC, Skeen VR, Smartt HJ, Hague A, Oakley F, Townsend PA, Perkins ND, Paraskeva C, Williams AC.

Oncogene. 2012 May 31;31(22):2761-72. doi: 10.1038/onc.2011.452. Epub 2011 Oct 3.


p53-dependent regulation of mitochondrial energy production by the RelA subunit of NF-κB.

Johnson RF, Witzel II, Perkins ND.

Cancer Res. 2011 Aug 15;71(16):5588-97. doi: 10.1158/0008-5472.CAN-10-4252. Epub 2011 Jul 8.


The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration.

Msaki A, Sánchez AM, Koh LF, Barré B, Rocha S, Perkins ND, Johnson RF.

Mol Biol Cell. 2011 Sep;22(17):3032-40. doi: 10.1091/mbc.E11-04-0280. Epub 2011 Jul 7.


Phosphorylation of the p52 NF-κB subunit.

Barré B, Perkins ND.

Cell Cycle. 2010 Dec 15;9(24):4774-5. Epub 2010 Dec 15. No abstract available. Retraction in: Cell Cycle. 2015;14(5):784.


Regulation of activity and function of the p52 NF-κB subunit following DNA damage.

Barré B, Coqueret O, Perkins ND.

Cell Cycle. 2010 Dec 15;9(24):4795-804. Epub 2010 Dec 15. Retraction in: Cell Cycle. 2014;13(14):2312.


Regulation of cyclin D1 gene expression.

Witzel II, Koh LF, Perkins ND.

Biochem Soc Trans. 2010 Feb;38(Pt 1):217-22. doi: 10.1042/BST0380217. Review.


Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation.

O'Shea JM, Perkins ND.

Biochem J. 2010 Feb 24;426(3):345-54. doi: 10.1042/BJ20091630.


Getting away from it all in Capri: the 2008 EMBO workshop on NF-kappaB.

Gilmore TD, Perkins ND, Franzoso G.

Cell Death Differ. 2009 Apr;16(4):651-4. doi: 10.1038/cdd.2009.3. No abstract available.


Regulation of cyclin D1 RNA stability by SNIP1.

Bracken CP, Wall SJ, Barré B, Panov KI, Ajuh PM, Perkins ND.

Cancer Res. 2008 Sep 15;68(18):7621-8. doi: 10.1158/0008-5472.CAN-08-1217.


Regulation of the RelA (p65) transactivation domain.

O'Shea JM, Perkins ND.

Biochem Soc Trans. 2008 Aug;36(Pt 4):603-8. doi: 10.1042/BST0360603. Review.


IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis.

Arlt A, Rosenstiel P, Kruse ML, Grohmann F, Minkenberg J, Perkins ND, Fölsch UR, Schreiber S, Schäfer H.

Biochim Biophys Acta. 2008 May;1783(5):941-52. doi: 10.1016/j.bbamcr.2007.12.010. Epub 2007 Dec 23.


A cell cycle regulatory network controlling NF-kappaB subunit activity and function.

Barré B, Perkins ND.

EMBO J. 2007 Nov 28;26(23):4841-55. Epub 2007 Oct 25. Retraction in: EMBO J. 2014 Sep 1;33(17):1978.


Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-kappaB- and p53-regulated gene targets.

McTavish N, Copeland LA, Saville MK, Perkins ND, Spruce BA.

Cell Death Differ. 2007 Sep;14(9):1700-10. Epub 2007 Jun 29.


p53 and NF-kappaB crosstalk: IKKalpha tips the balance.

Tergaonkar V, Perkins ND.

Mol Cell. 2007 Apr 27;26(2):158-9. Review.


Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1.

Roche KC, Rocha S, Bracken CP, Perkins ND.

Oncogene. 2007 Jul 5;26(31):4523-30. Epub 2007 Jan 29.


Transcriptional profiling of the LPS induced NF-kappaB response in macrophages.

Sharif O, Bolshakov VN, Raines S, Newham P, Perkins ND.

BMC Immunol. 2007 Jan 12;8:1.


Integrating cell-signalling pathways with NF-kappaB and IKK function.

Perkins ND.

Nat Rev Mol Cell Biol. 2007 Jan;8(1):49-62. Review.


SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes.

Fujii M, Lyakh LA, Bracken CP, Fukuoka J, Hayakawa M, Tsukiyama T, Soll SJ, Harris M, Rocha S, Roche KC, Tominaga SI, Jen J, Perkins ND, Lechleider RJ, Roberts AB.

Mol Cell. 2006 Dec 8;24(5):771-783. doi: 10.1016/j.molcel.2006.11.006.


Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit.

Schumm K, Rocha S, Caamano J, Perkins ND.

EMBO J. 2006 Oct 18;25(20):4820-32. Epub 2006 Sep 21.


Regulation of NF-kappaB function.

Campbell KJ, Perkins ND.

Biochem Soc Symp. 2006;(73):165-80. Review.


Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation.

Campbell KJ, Witty JM, Rocha S, Perkins ND.

Cancer Res. 2006 Jan 15;66(2):929-35.

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