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U.K. Intensivists' Preferences for Patient Admission to ICU: Evidence From a Choice Experiment.

Bassford CR, Krucien N, Ryan M, Griffiths FE, Svantesson M, Fritz Z, Perkins GD, Quinton S, Slowther AM.

Crit Care Med. 2019 Aug 9. doi: 10.1097/CCM.0000000000003903. [Epub ahead of print]


IgM ANCA in healthy individuals and in patients with ANCA-associated vasculitis.

Jeffs LS, Peh CA, Nelson A, Tan PG, Davey E, Chappell K, Perkins GB, Hurtado PR.

Immunol Res. 2019 Aug 1. doi: 10.1007/s12026-019-09091-x. [Epub ahead of print]


Ampullary carcinoma prognostic markers.

Perkins G, Laurent-Puig P, Taieb J.

Oncotarget. 2019 Jul 16;10(44):4509-4510. doi: 10.18632/oncotarget.27067. eCollection 2019 Jul 16. No abstract available.


Patient experience and reflective learning (PEARL): a mixed methods protocol for staff insight development in acute and intensive care medicine in the UK.

Brookes O, Brown C, Tarrant C, Archer J, Buckley D, Buckley LM, Clement I, Evison F, Gao Smith F, Gibbins C, Hayton E, Jones J, Lilford R, Mullhi R, Packer G, Perkins G, Shelton J, Snelson C, Sullivan P, Vlaev I, Wolstenholme D, Wright SE, Bion J; On-behalf-of the PEARL Collaboration.

BMJ Open. 2019 Jul 24;9(7):e030679. doi: 10.1136/bmjopen-2019-030679.


The impact of resuscitation guideline terminology on quality of dispatcher-assisted cardiopulmonary resuscitation: A randomised controlled manikin study.

Trethewey SP, Vyas H, Evans S, Hall M, Melody T, Perkins GD, Couper K.

Resuscitation. 2019 Jul 19;142:91-96. doi: 10.1016/j.resuscitation.2019.07.016. [Epub ahead of print]


Derivation and internal validation of the screening to enhance prehospital identification of sepsis (SEPSIS) score in adults on arrival at the emergency department.

Smyth MA, Gallacher D, Kimani PK, Ragoo M, Ward M, Perkins GD.

Scand J Trauma Resusc Emerg Med. 2019 Jul 16;27(1):67. doi: 10.1186/s13049-019-0642-2.


Guidelines on the management of acute respiratory distress syndrome.

Griffiths MJD, McAuley DF, Perkins GD, Barrett N, Blackwood B, Boyle A, Chee N, Connolly B, Dark P, Finney S, Salam A, Silversides J, Tarmey N, Wise MP, Baudouin SV.

BMJ Open Respir Res. 2019 May 24;6(1):e000420. doi: 10.1136/bmjresp-2019-000420. eCollection 2019.


Time to Change From Do-Not-Resuscitate Orders to Emergency Care Treatment Plans.

Perkins GD, Fritz Z.

JAMA Netw Open. 2019 Jun 5;2(6):e195170. doi: 10.1001/jamanetworkopen.2019.5170. No abstract available.


The effects of adrenaline in out of hospital cardiac arrest with shockable and non-shockable rhythms: Findings from the PACA and PARAMEDIC-2 randomised controlled trials.

Perkins GD, Kenna C, Ji C, Deakin CD, Nolan JP, Quinn T, Fothergill R, Gunson I, Pocock H, Rees N, Charlton K, Finn J, Gates S, Lall R.

Resuscitation. 2019 Jul;140:55-63. doi: 10.1016/j.resuscitation.2019.05.007. Epub 2019 May 19.


Implementing an intervention to improve decision making around referral and admission to intensive care: Results of feasibility testing in three NHS hospitals.

Rees S, Bassford C, Dale J, Fritz Z, Griffiths F, Parsons H, Perkins GD, Slowther AM.

J Eval Clin Pract. 2019 May 17. doi: 10.1111/jep.13167. [Epub ahead of print]


Prophylactic antibiotic use following cardiac arrest: A systematic review and meta-analysis.

Couper K, Laloo R, Field R, Perkins GD, Thomas M, Yeung J.

Resuscitation. 2019 Aug;141:166-173. doi: 10.1016/j.resuscitation.2019.04.047. Epub 2019 May 11. Review.


Vasopressin in septic shock: an individual patient data meta-analysis of randomised controlled trials.

Nagendran M, Russell JA, Walley KR, Brett SJ, Perkins GD, Hajjar L, Mason AJ, Ashby D, Gordon AC.

Intensive Care Med. 2019 Jun;45(6):844-855. doi: 10.1007/s00134-019-05620-2. Epub 2019 May 6. Review.


The EXACT protocol: A multi-centre, single-blind, randomised, parallel-group, controlled trial to determine whether early oxygen titration improves survival to hospital discharge in adult OHCA patients.

Bray JE, Smith K, Hein C, Finn J, Stephenson M, Cameron P, Stub D, Perkins GD, Grantham H, Bailey P, Brink D, Dodge N, Bernard S; EXACT investigators.

Resuscitation. 2019 Jun;139:208-213. doi: 10.1016/j.resuscitation.2019.04.023. Epub 2019 Apr 19.


Nexilin Is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation.

Liu C, Spinozzi S, Chen JY, Fang X, Feng W, Perkins G, Cattaneo P, Guimarães-Camboa N, Dalton ND, Peterson KL, Wu T, Ouyang K, Fu XD, Evans SM, Chen J.

Circulation. 2019 Jul 2;140(1):55-66. doi: 10.1161/CIRCULATIONAHA.119.039751. Epub 2019 Apr 15.


Why study inner ear hair cell mitochondria?

Lesus J, Arias K, Kulaga J, Sobkiv S, Patel A, Babu V, Kambalyal A, Patel M, Padron F, Mozaffari P, Jayakumar A, Ghatalah L, Laban N, Bahari R, Perkins G, Lysakowski A.

HNO. 2019 Jun;67(6):429-433. doi: 10.1007/s00106-019-0662-2. Review.


Author response: A critique of the recent 2018 ERC CPR guidelines.

Soar J, Perkins GD, Monsieurs KG, Nolan JP.

Resuscitation. 2019 Jun;139:368. doi: 10.1016/j.resuscitation.2019.04.005. Epub 2019 Apr 6. No abstract available.


Intranasal IgG4/7 antibody responses protect horses against equid herpesvirus-1 (EHV-1) infection including nasal virus shedding and cell-associated viremia.

Perkins G, Babasyan S, Stout AE, Freer H, Rollins A, Wimer CL, Wagner B.

Virology. 2019 May;531:219-232. doi: 10.1016/j.virol.2019.03.014. Epub 2019 Mar 22.


An international, consensus-derived Core Outcome Set for Cardiac Arrest effectiveness trials: the COSCA initiative.

Haywood KL, Whitehead L, Perkins GD.

Curr Opin Crit Care. 2019 Jun;25(3):226-233. doi: 10.1097/MCC.0000000000000612.


Attitudes to Cardiopulmonary Resuscitation and Defibrillator Use: A Survey of UK Adults in 2017.

Hawkes CA, Brown TP, Booth S, Fothergill RT, Siriwardena N, Zakaria S, Askew S, Williams J, Rees N, Ji C, Perkins GD.

J Am Heart Assoc. 2019 Apr 2;8(7):e008267. doi: 10.1161/JAHA.117.008267.


Adipocyte lipolysis affects Perilipin 5 and cristae organization at the cardiac lipid droplet-mitochondrial interface.

Varghese M, Kimler VA, Ghazi FR, Rathore GK, Perkins GA, Ellisman MH, Granneman JG.

Sci Rep. 2019 Mar 18;9(1):4734. doi: 10.1038/s41598-019-41329-4.


Outcomes of Curative-Intent Treatment for Patients With Breast Cancer Presenting With Sternal or Mediastinal Involvement.

Christopherson K, Lei X, Barcenas C, Buchholz TA, Garg N, Hoffman KE, Kuerer HM, Mittendorf E, Perkins G, Shaitelman SF, Smith GL, Stauder M, Strom EA, Tereffe W, Woodward WA, Smith BD.

Int J Radiat Oncol Biol Phys. 2019 Jul 1;104(3):574-581. doi: 10.1016/j.ijrobp.2019.02.049. Epub 2019 Mar 6.


Dysregulated alveolar function and complications in smokers following oesophagectomy.

Lugg ST, Alridge KA, Howells PA, Parekh D, Scott A, Mahida RY, Park D, Tucker O, Gao F, Perkins GD, Thickett DR, Dancer RCA.

ERJ Open Res. 2019 Mar 4;5(1). pii: 00089-2018. doi: 10.1183/23120541.00089-2018. eCollection 2019 Feb.


Can we classify ampullary tumours better? Clinical, pathological and molecular features. Results of an AGEO study.

Perkins G, Svrcek M, Bouchet-Doumenq C, Voron T, Colussi O, Debove C, Merabtene F, Dumont S, Sauvanet A, Hammel P, Cros J, André T, Bachet JB, Bardier A, Douard R, Meatchi T, Peschaud F, Emile JF, Cojean-Zelek I, Laurent-Puig P, Taieb J.

Br J Cancer. 2019 Apr;120(7):697-702. doi: 10.1038/s41416-019-0415-8. Epub 2019 Mar 6.


Over 675,000 lay people trained in cardiopulmonary resuscitation worldwide - The "World Restart a Heart (WRAH)" initiative 2018.

Böttiger BW, Lockey A, Aickin R, Bertaut T, Castren M, de Caen A, Censullo E, Escalante R, Gent L, Georgiou M, Kern KB, Khan AMS, Lim SH, Nadkarni V, Nation K, Neumar RW, Nolan JP, Rao SSCC, Stanton D, Toporas C, Wang TL, Wong G, Perkins GD.

Resuscitation. 2019 May;138:15-17. doi: 10.1016/j.resuscitation.2019.02.033. Epub 2019 Mar 2. No abstract available.


Repeated adrenaline doses and survival from an out-of-hospital cardiac arrest.

Fothergill RT, Emmerson AC, Iyer R, Lazarus J, Whitbread M, Nolan JP, Deakin CD, Perkins GD.

Resuscitation. 2019 May;138:316-321. doi: 10.1016/j.resuscitation.2019.01.022. Epub 2019 Jan 29.


Resuscitation highlights in 2018.

Nolan JP, Ornato JP, Parr MJA, Perkins GD, Soar J.

Resuscitation. 2019 Feb;135:168-175. doi: 10.1016/j.resuscitation.2019.01.019. Epub 2019 Jan 26. No abstract available.


Epinephrine in Out-of-Hospital Cardiac Arrest.

Perkins GD, Nolan JP, Finn J.

N Engl J Med. 2019 Jan 24;380(4):397-8. doi: 10.1056/NEJMc1816187. No abstract available.


Adrenaline and vasopressin for cardiac arrest.

Finn J, Jacobs I, Williams TA, Gates S, Perkins GD.

Cochrane Database Syst Rev. 2019 Jan 17;1:CD003179. doi: 10.1002/14651858.CD003179.pub2.


When is a bystander not a bystander any more? A European survey.

Maurer H, Masterson S, Tjelmeland IB, Gräsner JT, Lefering R, Böttiger BW, Bossaert L, Herlitz J, Koster RW, Rosell-Ortiz F, Perkins GD, Wnent J; EuReCa national coordinators.

Resuscitation. 2019 Mar;136:78-84. doi: 10.1016/j.resuscitation.2018.12.009. Epub 2018 Dec 17.


Prevention of post-operative complications by using a HMG-CoA reductase inhibitor in patients undergoing one-lung ventilation for non-cardiac surgery: study protocol for a randomised controlled trial.

Shyamsundar M, O'Kane C, Perkins GD, Kennedy G, Campbell C, Agus A, Phair G, McAuley D.

Trials. 2018 Dec 18;19(1):690. doi: 10.1186/s13063-018-3078-5.


[Lynch syndrome: What is new?]

Pellat A, Netter J, Perkins G, Cohen R, Coulet F, Parc Y, Svrcek M, Duval A, André T.

Bull Cancer. 2019 Jul - Aug;106(7-8):647-655. doi: 10.1016/j.bulcan.2018.10.009. Epub 2018 Dec 4. Review. French.


Open-field PET: Simultaneous brain functional imaging and behavioural response measurements in freely moving small animals.

Kyme AZ, Angelis GI, Eisenhuth J, Fulton RR, Zhou V, Hart G, Popovic K, Akhtar M, Ryder WJ, Clemens KJ, Balleine BW, Parmar A, Pascali G, Perkins G, Meikle SR.

Neuroimage. 2019 Mar;188:92-101. doi: 10.1016/j.neuroimage.2018.11.051. Epub 2018 Nov 28.


European Resuscitation Council Guidelines for Resuscitation: 2018 Update - Antiarrhythmic drugs for cardiac arrest.

Soar J, Perkins GD, Maconochie I, Böttiger BW, Deakin CD, Sandroni C, Olasveengen TM, Wyllie J, Greif R, Lockey A, Semeraro F, Van de Voorde P, Lott C, Bossaert L, Monsieurs KG, Nolan JP; European Resuscitation Council.

Resuscitation. 2019 Jan;134:99-103. doi: 10.1016/j.resuscitation.2018.11.018. Epub 2018 Nov 26.


Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT.

Gordon AC, Santhakumaran S, Al-Beidh F, Orme RML, Perkins GD, Singer M, McAuley DF, Mason AJ, Ward JK, O’Dea KP, Felton T, Cross M, Best-Lane J, Lexow J, Campbell A, Ashby D.

Southampton (UK): NIHR Journals Library; 2018 Nov.


The deletion of the ORF1 and ORF71 genes reduces virulence of the neuropathogenic EHV-1 strain Ab4 without compromising host immunity in horses.

Wimer CL, Schnabel CL, Perkins G, Babasyan S, Freer H, Stout AE, Rollins A, Osterrieder N, Goodman LB, Glaser A, Wagner B.

PLoS One. 2018 Nov 15;13(11):e0206679. doi: 10.1371/journal.pone.0206679. eCollection 2018.


Non-invasive ventilation as a strategy for weaning from invasive mechanical ventilation: a systematic review and Bayesian meta-analysis.

Yeung J, Couper K, Ryan EG, Gates S, Hart N, Perkins GD.

Intensive Care Med. 2018 Dec;44(12):2192-2204. doi: 10.1007/s00134-018-5434-z. Epub 2018 Oct 31. Review.


Three-Year Outcomes With Hypofractionated Versus Conventionally Fractionated Whole-Breast Irradiation: Results of a Randomized, Noninferiority Clinical Trial.

Shaitelman SF, Lei X, Thompson A, Schlembach P, Bloom ES, Arzu IY, Buchholz D, Chronowski G, Dvorak T, Grade E, Hoffman K, Perkins G, Reed VK, Shah SJ, Stauder MC, Strom EA, Tereffe W, Woodward WA, Amaya DN, Shen Y, Hortobagyi GN, Hunt KK, Buchholz TA, Smith BD.

J Clin Oncol. 2018 Oct 31:JCO1800317. doi: 10.1200/JCO.18.00317. [Epub ahead of print]


Future Vision for ILCOR and Its Role in the Global Resuscitation Community.

Neumar RW, Perkins GD.

Circulation. 2018 Sep 11;138(11):1085-1087. doi: 10.1161/CIRCULATIONAHA.118.029786. No abstract available.


Targeting Mcl-1 and other Bcl-2 family member proteins in cancer therapy.

Yamaguchi R, Lartigue L, Perkins G.

Pharmacol Ther. 2019 Mar;195:13-20. doi: 10.1016/j.pharmthera.2018.10.009. Epub 2018 Oct 19. Review.


Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure: The Breathe Randomized Clinical Trial.

Perkins GD, Mistry D, Gates S, Gao F, Snelson C, Hart N, Camporota L, Varley J, Carle C, Paramasivam E, Hoddell B, McAuley DF, Walsh TS, Blackwood B, Rose L, Lamb SE, Petrou S, Young D, Lall R; Breathe Collaborators.

JAMA. 2018 Nov 13;320(18):1881-1888. doi: 10.1001/jama.2018.13763.


CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice.

Gilmore-Hall S, Kuo J, Ward JM, Zahra R, Morrison RS, Perkins G, La Spada AR.

J Cell Biol. 2019 Jan 7;218(1):206-219. doi: 10.1083/jcb.201709028. Epub 2018 Oct 18.


Reply to: Letter to the Editor re out-of-hospital cardiac arrest termination of resuscitation with ongoing CPR: An observational study.

Yates EJ, Smyth MA, Perkins GD.

Resuscitation. 2018 Dec;133:e10. doi: 10.1016/j.resuscitation.2018.10.013. Epub 2018 Oct 15. No abstract available.


'We're going to do CPR': A linguistic study of the words used to initiate dispatcher-assisted CPR and their association with caller agreement.

Riou M, Ball S, Whiteside A, Bray J, Perkins GD, Smith K, O'Halloran KL, Fatovich DM, Inoue M, Bailey P, Cameron P, Brink D, Finn J.

Resuscitation. 2018 Dec;133:95-100. doi: 10.1016/j.resuscitation.2018.10.011. Epub 2018 Oct 11.


Vitamin D to Prevent Lung Injury Following Esophagectomy-A Randomized, Placebo-Controlled Trial.

Parekh D, Dancer RCA, Scott A, D'Souza VK, Howells PA, Mahida RY, Tang JCY, Cooper MS, Fraser WD, Tan L, Gao F, Martineau AR, Tucker O, Perkins GD, Thickett DR.

Crit Care Med. 2018 Dec;46(12):e1128-e1135. doi: 10.1097/CCM.0000000000003405.


A component of lobular carcinoma in clinically lymph node-negative patients predicts for an increased likelihood of upstaging to pathologic stage III breast cancer.

Van Wyhe RD, Caudle AS, Shaitelman SF, Perkins GH, Buchholz TA, Hoffman KE, Strom EA, Smith BD, Tereffe W, Woodward WA, Stauder MC.

Adv Radiat Oncol. 2018 Feb 26;3(3):252-257. doi: 10.1016/j.adro.2018.02.007. eCollection 2018 Jul-Sep.


Mechanical versus manual chest compressions in the treatment of in-hospital cardiac arrest patients in a non-shockable rhythm: a randomised controlled feasibility trial (COMPRESS-RCT).

Couper K, Quinn T, Lall R, Devrell A, Orriss B, Seers K, Yeung J, Perkins GD; COMPRESS-RCT collaborators.

Scand J Trauma Resusc Emerg Med. 2018 Aug 30;26(1):70. doi: 10.1186/s13049-018-0538-6.


Deletion of the ORF2 gene of the neuropathogenic equine herpesvirus type 1 strain Ab4 reduces virulence while maintaining strong immunogenicity.

Schnabel CL, Wimer CL, Perkins G, Babasyan S, Freer H, Watts C, Rollins A, Osterrieder N, Wagner B.

BMC Vet Res. 2018 Aug 22;14(1):245. doi: 10.1186/s12917-018-1563-4.


Vemurafenib and cobimetinib overcome resistance to vemurafenib in BRAF-mutant ganglioglioma.

Touat M, Gratieux J, Condette Auliac S, Sejean K, Aldea S, Savatovsky J, Perkins G, Blons H, Ligon KL, Idbaih A, Hollebecque A, Gimenez-Roqueplo AP, Laurent-Puig P, Sanson M, Villa C, Di Stefano AL.

Neurology. 2018 Sep 11;91(11):523-525. doi: 10.1212/WNL.0000000000006171. Epub 2018 Aug 17. No abstract available.


Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line.

Shim MS, Kim KY, Noh M, Ko JY, Ahn S, An MA, Iwata T, Perkins GA, Weinreb RN, Ju WK.

Biochem Biophys Res Commun. 2018 Sep 18;503(4):2690-2697. doi: 10.1016/j.bbrc.2018.08.025. Epub 2018 Aug 9.


AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission.

Flippo KH, Gnanasekaran A, Perkins GA, Ajmal A, Merrill RA, Dickey AS, Taylor SS, McKnight GS, Chauhan AK, Usachev YM, Strack S.

J Neurosci. 2018 Sep 19;38(38):8233-8242. doi: 10.1523/JNEUROSCI.0649-18.2018. Epub 2018 Aug 9.

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