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Aeration strategy at birth influences the physiological response to surfactant in preterm lambs.

Tingay DG, Togo A, Pereira-Fantini PM, Miedema M, McCall KE, Perkins EJ, Thomson J, Dowse G, Sourial M, Dellacà RL, Davis PG, Dargaville PA.

Arch Dis Child Fetal Neonatal Ed. 2019 Feb 1. pii: fetalneonatal-2018-316240. doi: 10.1136/archdischild-2018-316240. [Epub ahead of print]


Gestational Age Influences the Early Microarchitectural Changes in Response to Mechanical Ventilation in the Preterm Lamb Lung.

Oakley RB, Tingay DG, McCall KE, Perkins EJ, Sourial M, Dargaville PA, Pereira-Fantini PM.

Front Pediatr. 2019 Aug 21;7:325. doi: 10.3389/fped.2019.00325. eCollection 2019.


AOPERA: A proposed methodology and inventory of effective tools to link chemicals to adverse outcome pathways.

Rycroft TE, Foran CM, Thrash A, Cegan JC, Zollinger R, Linkov I, Perkins EJ, Garcia-Reyero N.

ALTEX. 2019 Aug 26. doi: 10.14573/altex.1906201. [Epub ahead of print]


Difficult airway management algorithms: a directed review.

Edelman DA, Perkins EJ, Brewster DJ.

Anaesthesia. 2019 Sep;74(9):1175-1185. doi: 10.1111/anae.14779. Epub 2019 Jul 21. Review.


A dedicated respiratory function monitor to improve tidal volume delivery during neonatal anesthesia.

Atkins WK, McDougall R, Perkins EJ, Pereira-Fantini PM, Tingay DG.

Paediatr Anaesth. 2019 Sep;29(9):920-926. doi: 10.1111/pan.13707. Epub 2019 Aug 12.


Electrical impedance tomography identifies a distinct change in regional phase angle delay pattern in ventilation filling immediately prior to a spontaneous pneumothorax.

Miedema M, Adler A, McCall KE, Perkins EJ, van Kaam AH, Tingay DG.

J Appl Physiol (1985). 2019 Sep 1;127(3):707-712. doi: 10.1152/japplphysiol.00973.2018. Epub 2019 Jul 3.


Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment.

Perkins EJ, Ashauer R, Burgoon L, Conolly R, Landesmann B, Mackay C, Murphy CA, Pollesch N, Wheeler JR, Zupanic A, Scholz S.

Environ Toxicol Chem. 2019 Sep;38(9):1850-1865. doi: 10.1002/etc.4505. Epub 2019 Aug 8. Review.


Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury.

Pereira-Fantini PM, Pang B, Byars SG, Oakley RB, Perkins EJ, Dargaville PA, Davis PG, Nie S, Williamson NA, Ignjatovic V, Tingay DG.

Am J Respir Cell Mol Biol. 2019 Apr 17. doi: 10.1165/rcmb.2019-0084OC. [Epub ahead of print]


Keanu: a novel visualization tool to explore biodiversity in metagenomes.

Thrash A, Arick M 2nd, Barbato RA, Jones RM, Douglas TA, Esdale J, Perkins EJ, Garcia-Reyero N.

BMC Bioinformatics. 2019 Mar 14;20(Suppl 2):103. doi: 10.1186/s12859-019-2629-4.


Gradual Aeration at Birth Is More Lung Protective Than a Sustained Inflation in Preterm Lambs.

Tingay DG, Pereira-Fantini PM, Oakley R, McCall KE, Perkins EJ, Miedema M, Sourial M, Thomson J, Waldmann A, Dellaca RL, Davis PG, Dargaville PA.

Am J Respir Crit Care Med. 2019 Sep 1;200(5):608-616. doi: 10.1164/rccm.201807-1397OC.


Lung Recruitment Strategies During High Frequency Oscillatory Ventilation in Preterm Lambs.

Miedema M, McCall KE, Perkins EJ, Oakley RB, Pereira-Fantini PM, Rajapaksa AE, Waldmann AD, Tingay DG, van Kaam AH.

Front Pediatr. 2019 Jan 22;6:436. doi: 10.3389/fped.2018.00436. eCollection 2018.


A modular approach for assembly of quantitative adverse outcome pathways.

Foran CM, Rycroft T, Keisler J, Perkins EJ, Linkov I, Garcia-Reyero N.

ALTEX. 2019;36(3):353-362. doi: 10.14573/altex.1810181. Epub 2019 Jan 20.


Multiple environmental stressors induce complex transcriptomic responses indicative of phenotypic outcomes in Western fence lizard.

Gust KA, Chaitankar V, Ghosh P, Wilbanks MS, Chen X, Barker ND, Pham D, Scanlan LD, Rawat A, Talent LG, Quinn MJ Jr, Vulpe CD, Elasri MO, Johnson MS, Perkins EJ, McFarland CA.

BMC Genomics. 2018 Dec 5;19(1):877. doi: 10.1186/s12864-018-5270-0.


Chemical hazard prediction and hypothesis testing using quantitative adverse outcome pathways.

Perkins EJ, Gayen K, Shoemaker JE, Antczak P, Burgoon L, Falciani F, Gutsell S, Hodges G, Kienzler A, Knapen D, McBride M, Willett C, Doyle FJ, Garcia-Reyero N.

ALTEX. 2019;36(1):91-102. doi: 10.14573/altex.1808241. Epub 2018 Oct 16.


Plasma proteomics reveals gestational age-specific responses to mechanical ventilation and identifies the mechanistic pathways that initiate preterm lung injury.

Pereira-Fantini PM, Byars SG, McCall KE, Perkins EJ, Oakley RB, Dellacà RL, Dargaville PA, Davis PG, Ignjatovic V, Tingay DG.

Sci Rep. 2018 Aug 22;8(1):12616. doi: 10.1038/s41598-018-30868-x.


Surgery and magnetic resonance imaging increase the risk of hypothermia in infants.

Don Paul JM, Perkins EJ, Pereira-Fantini PM, Suka A, Farrell O, Gunn JK, Rajapaksa AE, Tingay DG.

J Paediatr Child Health. 2018 Apr;54(4):426-431. doi: 10.1111/jpc.13824. Epub 2018 Jan 13.


Physiologically Based Pharmacokinetic Modelling of Cytochrome P450 2C9-Related Tolbutamide Drug Interactions with Sulfaphenazole and Tasisulam.

Perkins EJ, Posada M, Kellie Turner P, Chappell J, Ng WT, Twelves C.

Eur J Drug Metab Pharmacokinet. 2018 Jun;43(3):355-367. doi: 10.1007/s13318-017-0447-5.


Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs.

Di L, Breen C, Chambers R, Eckley ST, Fricke R, Ghosh A, Harradine P, Kalvass JC, Ho S, Lee CA, Marathe P, Perkins EJ, Qian M, Tse S, Yan Z, Zamek-Gliszczynski MJ.

J Pharm Sci. 2017 Dec;106(12):3442-3452. doi: 10.1016/j.xphs.2017.09.005. Epub 2017 Sep 18. Review.


Is selective echocardiography in duodenal atresia the future standard of care?

Khan A, Tanny ST, Perkins EJ, Hunt RW, Hutson JM, King SK, Jones B, Teague WJ.

J Pediatr Surg. 2017 Dec;52(12):1952-1955. doi: 10.1016/j.jpedsurg.2017.08.046. Epub 2017 Sep 2.


Production of tunable nanomaterials using hierarchically assembled bacteriophages.

Lee JH, Warner CM, Jin HE, Barnes E, Poda AR, Perkins EJ, Lee SW.

Nat Protoc. 2017 Sep;12(9):1999-2013. doi: 10.1038/nprot.2017.085. Epub 2017 Aug 31.


Supraglottic Atomization of Surfactant in Spontaneously Breathing Lambs Receiving Continuous Positive Airway Pressure.

Milesi I, Tingay DG, Lavizzari A, Bianco F, Zannin E, Tagliabue P, Mosca F, Ventura ML, Rajapaksa A, Perkins EJ, Black D, Di Castri M, Sourial M, Pohlmann G Dr, Dellaca' RL.

Pediatr Crit Care Med. 2017 Sep;18(9):e428-e434. doi: 10.1097/PCC.0000000000001267.


Rapid effects of the aromatase inhibitor fadrozole on steroid production and gene expression in the ovary of female fathead minnows (Pimephales promelas).

Schroeder AL, Ankley GT, Habib T, Garcia-Reyero N, Escalon BL, Jensen KM, Kahl MD, Durhan EJ, Makynen EA, Cavallin JE, Martinovic-Weigelt D, Perkins EJ, Villeneuve DL.

Gen Comp Endocrinol. 2017 Oct 1;252:79-87. doi: 10.1016/j.ygcen.2017.07.022. Epub 2017 Jul 21.


Volume guaranteed? Accuracy of a volume-targeted ventilation mode in infants.

Farrell O, Perkins EJ, Black D, Miedema M, Paul JD, Pereira-Fantini PM, Tingay DG.

Arch Dis Child Fetal Neonatal Ed. 2018 Mar;103(2):F120-F125. doi: 10.1136/archdischild-2017-312640. Epub 2017 Jun 28.


Prioritization of Contaminants of Emerging Concern in Wastewater Treatment Plant Discharges Using Chemical:Gene Interactions in Caged Fish.

Perkins EJ, Habib T, Escalon BL, Cavallin JE, Thomas L, Weberg M, Hughes MN, Jensen KM, Kahl MD, Villeneuve DL, Ankley GT, Garcia-Reyero N.

Environ Sci Technol. 2017 Aug 1;51(15):8701-8712. doi: 10.1021/acs.est.7b01567. Epub 2017 Jul 17.


Time to lung aeration during a sustained inflation at birth is influenced by gestation in lambs.

McCall KE, Waldmann AD, Pereira-Fantini P, Oakley R, Miedema M, Perkins EJ, Davis PG, Dargaville PA, Böhm SH, Dellacà R, Sourial M, Zannin E, Rajapaksa AE, Tan A, Adler A, Frerichs I, Tingay DG.

Pediatr Res. 2017 Oct;82(4):712-720. doi: 10.1038/pr.2017.141. Epub 2017 Jul 12.


Advancing the adverse outcome pathway framework-An international horizon scanning approach.

LaLone CA, Ankley GT, Belanger SE, Embry MR, Hodges G, Knapen D, Munn S, Perkins EJ, Rudd MA, Villeneuve DL, Whelan M, Willett C, Zhang X, Hecker M.

Environ Toxicol Chem. 2017 Jun;36(6):1411-1421. doi: 10.1002/etc.3805.


The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment.

Brockmeier EK, Hodges G, Hutchinson TH, Butler E, Hecker M, Tollefsen KE, Garcia-Reyero N, Kille P, Becker D, Chipman K, Colbourne J, Collette TW, Cossins A, Cronin M, Graystock P, Gutsell S, Knapen D, Katsiadaki I, Lange A, Marshall S, Owen SF, Perkins EJ, Plaistow S, Schroeder A, Taylor D, Viant M, Ankley G, Falciani F.

Toxicol Sci. 2017 Aug 1;158(2):252-262. doi: 10.1093/toxsci/kfx097. Review.


Tidal Volume Delivery during the Anesthetic Management of Neonates Is Variable.

Abouzeid T, Perkins EJ, Pereira-Fantini PM, Rajapaksa A, Suka A, Tingay DG.

J Pediatr. 2017 May;184:51-56.e3. doi: 10.1016/j.jpeds.2017.01.074. Epub 2017 Mar 3.


Quantitative Adverse Outcome Pathways and Their Application to Predictive Toxicology.

Conolly RB, Ankley GT, Cheng W, Mayo ML, Miller DH, Perkins EJ, Villeneuve DL, Watanabe KH.

Environ Sci Technol. 2017 Apr 18;51(8):4661-4672. doi: 10.1021/acs.est.6b06230. Epub 2017 Apr 7.


Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches.

Rowland MA, Perkins EJ, Mayo ML.

BMC Syst Biol. 2017 Mar 11;11(1):35. doi: 10.1186/s12918-017-0407-3.


Comparison between Radioanalysis and 19F Nuclear Magnetic Resonance Spectroscopy in the Determination of Mass Balance, Metabolism, and Distribution of Pefloxacin.

Hu H, Katyayan KK, Czeskis BA, Perkins EJ, Kulanthaivel P.

Drug Metab Dispos. 2017 Apr;45(4):399-408. doi: 10.1124/dmd.116.073809. Epub 2017 Feb 10.


Prior knowledge-based approach for associating contaminants with biological effects: A case study in the St. Croix River basin, MN, WI, USA.

Schroeder AL, Martinović-Weigelt D, Ankley GT, Lee KE, Garcia-Reyero N, Perkins EJ, Schoenfuss HL, Villeneuve DL.

Environ Pollut. 2017 Feb;221:427-436. doi: 10.1016/j.envpol.2016.12.005. Epub 2016 Dec 8.


Effectiveness of individualized lung recruitment strategies at birth: an experimental study in preterm lambs.

Tingay DG, Rajapaksa A, Zannin E, Pereira-Fantini PM, Dellaca RL, Perkins EJ, Zonneveld CE, Adler A, Black D, Frerichs I, Lavizzari A, Sourial M, Grychtol B, Mosca F, Davis PG.

Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L32-L41. doi: 10.1152/ajplung.00416.2016. Epub 2016 Nov 23.


The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions.

Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS.

Environ Health Perspect. 2016 Nov;124(11):1671-1682. Epub 2016 Apr 19. Review.


First Real-Time Visualization of a Spontaneous Pneumothorax Developing in a Preterm Lamb Using Electrical Impedance Tomography.

Miedema M, McCall KE, Perkins EJ, Sourial M, Böhm SH, Waldmann A, van Kaam AH, Tingay DG.

Am J Respir Crit Care Med. 2016 Jul 1;194(1):116-8. doi: 10.1164/rccm.201602-0292LE. No abstract available.


Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17β-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas).

Villeneuve DL, Jensen KM, Cavallin JE, Durhan EJ, Garcia-Reyero N, Kahl MD, Leino RL, Makynen EA, Wehmas LC, Perkins EJ, Ankley GT.

Environ Toxicol Chem. 2017 Jan;36(1):231-242. doi: 10.1002/etc.3531. Epub 2016 Jul 29.


Daphnia magna's sense of competition: intra-specific interactions (ISI) alter life history strategies and increase metals toxicity.

Gust KA, Kennedy AJ, Melby NL, Wilbanks MS, Laird J, Meeks B, Muller EB, Nisbet RM, Perkins EJ.

Ecotoxicology. 2016 Aug;25(6):1126-35. doi: 10.1007/s10646-016-1667-1. Epub 2016 May 5.


Predicting chemical bioavailability using microarray gene expression data and regression modeling: A tale of three explosive compounds.

Gong P, Nan X, Barker ND, Boyd RE, Chen Y, Wilkins DE, Johnson DR, Suedel BC, Perkins EJ.

BMC Genomics. 2016 Mar 8;17:205. doi: 10.1186/s12864-016-2541-5.


Intratracheal atomized surfactant provides similar outcomes as bolus surfactant in preterm lambs with respiratory distress syndrome.

Milesi I, Tingay DG, Zannin E, Bianco F, Tagliabue P, Mosca F, Lavizzari A, Ventura ML, Zonneveld CE, Perkins EJ, Black D, Sourial M, Dellacá RL.

Pediatr Res. 2016 Jul;80(1):92-100. doi: 10.1038/pr.2016.39. Epub 2016 Mar 8.


Peri-operative management of neonates with oesophageal atresia and tracheo-oesophageal fistula.

Hunt RW, Perkins EJ, King S.

Paediatr Respir Rev. 2016 Jun;19:3-9. doi: 10.1016/j.prrv.2016.01.002. Epub 2016 Jan 29. Review.


Fish connectivity mapping: linking chemical stressors by their mechanisms of action-driven transcriptomic profiles.

Wang RL, Biales AD, Garcia-Reyero N, Perkins EJ, Villeneuve DL, Ankley GT, Bencic DC.

BMC Genomics. 2016 Jan 28;17:84. doi: 10.1186/s12864-016-2406-y.


Predicting Fecundity of Fathead Minnows (Pimephales promelas) Exposed to Endocrine-Disrupting Chemicals Using a MATLAB®-Based Model of Oocyte Growth Dynamics.

Watanabe KH, Mayo M, Jensen KM, Villeneuve DL, Ankley GT, Perkins EJ.

PLoS One. 2016 Jan 12;11(1):e0146594. doi: 10.1371/journal.pone.0146594. eCollection 2016.


A weight of evidence assessment approach for adverse outcome pathways.

Collier ZA, Gust KA, Gonzalez-Morales B, Gong P, Wilbanks MS, Linkov I, Perkins EJ.

Regul Toxicol Pharmacol. 2016 Mar;75:46-57. doi: 10.1016/j.yrtph.2015.12.014. Epub 2015 Dec 24.


Relating suborganismal processes to ecotoxicological and population level endpoints using a bioenergetic model.

Ananthasubramaniam B, McCauley E, Gust KA, Kennedy AJ, Muller EB, Perkins EJ, Nisbet RM.

Ecol Appl. 2015 Sep;25(6):1691-710. doi: 10.1890/14-0498.1. Erratum in: Ecol Appl. 2017 Jul;27(5):1703-1704.


Transcriptional Network Growing Models Using Motif-Based Preferential Attachment.

Abdelzaher AF, Al-Musawi AF, Ghosh P, Mayo ML, Perkins EJ.

Front Bioeng Biotechnol. 2015 Oct 12;3:157. doi: 10.3389/fbioe.2015.00157. eCollection 2015. Review.


Ionotropic GABA receptor antagonism-induced adverse outcome pathways for potential neurotoxicity biomarkers.

Gong P, Hong H, Perkins EJ.

Biomark Med. 2015;9(11):1225-39. doi: 10.2217/bmm.15.58. Epub 2015 Oct 28. Review.


Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence.

Perkins EJ, Antczak P, Burgoon L, Falciani F, Garcia-Reyero N, Gutsell S, Hodges G, Kienzler A, Knapen D, McBride M, Willett C.

Toxicol Sci. 2015 Nov;148(1):14-25. doi: 10.1093/toxsci/kfv181. Review.


Ecotoxicogenomics: Microarray interlaboratory comparability.

Vidal-Dorsch DE, Bay SM, Moore S, Layton B, Mehinto AC, Vulpe CD, Brown-Augustine M, Loguinov A, Poynton H, Garcia-Reyero N, Perkins EJ, Escalon L, Denslow ND, Cristina CD, Doan T, Shukradas S, Bruno J, Brown L, Van Agglen G, Jackman P, Bauer M.

Chemosphere. 2016 Feb;144:193-200. doi: 10.1016/j.chemosphere.2015.08.019. Epub 2015 Sep 10.


Systems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite.

Gust KA, Nanduri B, Rawat A, Wilbanks MS, Ang CY, Johnson DR, Pendarvis K, Chen X, Quinn MJ Jr, Johnson MS, Burgess SC, Perkins EJ.

BMC Genomics. 2015 Aug 7;16:587. doi: 10.1186/s12864-015-1798-4.


Spatiotemporal Aeration and Lung Injury Patterns Are Influenced by the First Inflation Strategy at Birth.

Tingay DG, Rajapaksa A, Zonneveld CE, Black D, Perkins EJ, Adler A, Grychtol B, Lavizzari A, Frerichs I, Zahra VA, Davis PG.

Am J Respir Cell Mol Biol. 2016 Feb;54(2):263-72. doi: 10.1165/rcmb.2015-0127OC.


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