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Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors.

Tsolakos N, Durrant TN, Chessa T, Suire SM, Oxley D, Kulkarni S, Downward J, Perisic O, Williams RL, Stephens L, Hawkins PT.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12176-12181. doi: 10.1073/pnas.1803446115. Epub 2018 Nov 15.


Heterodimer Binding Scaffolds Recognition via the Analysis of Kinetically Hot Residues.

Perišić O.

Pharmaceuticals (Basel). 2018 Mar 16;11(1). pii: E29. doi: 10.3390/ph11010029.


Dependence of the Linker Histone and Chromatin Condensation on the Nucleosome Environment.

Perišić O, Schlick T.

J Phys Chem B. 2017 Aug 24;121(33):7823-7832. doi: 10.1021/acs.jpcb.7b04917. Epub 2017 Aug 11.


Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex.

Ohashi Y, Soler N, García Ortegón M, Zhang L, Kirsten ML, Perisic O, Masson GR, Burke JE, Jakobi AJ, Apostolakis AA, Johnson CM, Ohashi M, Ktistakis NT, Sachse C, Williams RL.

Autophagy. 2016 Nov;12(11):2129-2144. Epub 2016 Sep 14.


Parallel targeted next generation sequencing of childhood and adult acute myeloid leukemia patients reveals uniform genomic profile of the disease.

Marjanovic I, Kostic J, Stanic B, Pejanovic N, Lucic B, Karan-Djurasevic T, Janic D, Dokmanovic L, Jankovic S, Vukovic NS, Tomin D, Perisic O, Rakocevic G, Popovic M, Pavlovic S, Tosic N.

Tumour Biol. 2016 Oct;37(10):13391-13401. Epub 2016 Jul 27.


Computational strategies to address chromatin structure problems.

Perišić O, Schlick T.

Phys Biol. 2016 Jun 25;13(3):035006. doi: 10.1088/1478-3975/13/3/035006.


Gene Mutation Profiles in Primary Diffuse Large B Cell Lymphoma of Central Nervous System: Next Generation Sequencing Analyses.

Todorovic Balint M, Jelicic J, Mihaljevic B, Kostic J, Stanic B, Balint B, Pejanovic N, Lucic B, Tosic N, Marjanovic I, Stojiljkovic M, Karan-Djurasevic T, Perisic O, Rakocevic G, Popovic M, Raicevic S, Bila J, Antic D, Andjelic B, Pavlovic S.

Int J Mol Sci. 2016 May 6;17(5). pii: E683. doi: 10.3390/ijms17050683.


The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.

Masson GR, Perisic O, Burke JE, Williams RL.

Biochem J. 2016 Jan 15;473(2):135-44. doi: 10.1042/BJ20150931. Epub 2015 Nov 2.


On the improvement of free-energy calculation from steered molecular dynamics simulations using adaptive stochastic perturbation protocols.

Perišić O, Lu H.

PLoS One. 2014 Sep 18;9(9):e101810. doi: 10.1371/journal.pone.0101810. eCollection 2014.


Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors.

Burke JE, Inglis AJ, Perisic O, Masson GR, McLaughlin SH, Rutaganira F, Shokat KM, Williams RL.

Science. 2014 May 30;344(6187):1035-8. doi: 10.1126/science.1253397.


Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18862-7. doi: 10.1073/pnas.1304801110. Epub 2013 Nov 4.


Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.

Angulo I, Vadas O, Garçon F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debré M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A, Nejentsev S.

Science. 2013 Nov 15;342(6160):866-71. doi: 10.1126/science.1243292. Epub 2013 Oct 17.


Allosteric activation of PI3Kα by oncogenic mutations.

Burke JE, Perisic O, Williams RL.

Oncotarget. 2013 Feb;4(2):180-1. No abstract available.


Pulling-spring modulation as a method for improving the potential-of-mean-force reconstruction in single-molecule manipulation experiments.

Perišić O.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Jan;87(1):013303. Epub 2013 Jan 4.


G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM.

Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264.


ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes.

Hadders MA, Agromayor M, Obita T, Perisic O, Caballe A, Kloc M, Lamers MH, Williams RL, Martin-Serrano J.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17424-9. doi: 10.1073/pnas.1206839109. Epub 2012 Oct 8.


Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).

Burke JE, Perisic O, Masson GR, Vadas O, Williams RL.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15259-64. Epub 2012 Sep 4.


The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.

Agromayor M, Soler N, Caballe A, Kueck T, Freund SM, Allen MD, Bycroft M, Perisic O, Ye Y, McDonald B, Scheel H, Hofmann K, Neil SJ, Martin-Serrano J, Williams RL.

Structure. 2012 Mar 7;20(3):414-28. doi: 10.1016/j.str.2011.12.013.


Efficient free-energy-profile reconstruction using adaptive stochastic perturbation protocols.

Perišić O, Lu H.

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Nov;84(5 Pt 2):056705. Epub 2011 Nov 21.


Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α.

Burke JE, Vadas O, Berndt A, Finegan T, Perisic O, Williams RL.

Structure. 2011 Aug 10;19(8):1127-37. doi: 10.1016/j.str.2011.06.003.


Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.

Zhang X, Vadas O, Perisic O, Anderson KE, Clark J, Hawkins PT, Stephens LR, Williams RL.

Mol Cell. 2011 Mar 4;41(5):567-78. doi: 10.1016/j.molcel.2011.01.026.


Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation.

Abad-Zapatero C, Perišić O, Wass J, Bento AP, Overington J, Al-Lazikani B, Johnson ME.

Drug Discov Today. 2010 Oct;15(19-20):804-11. doi: 10.1016/j.drudis.2010.08.004. Epub 2010 Aug 19.


Modeling studies of chromatin fiber structure as a function of DNA linker length.

Perišić O, Collepardo-Guevara R, Schlick T.

J Mol Biol. 2010 Nov 12;403(5):777-802. doi: 10.1016/j.jmb.2010.07.057. Epub 2010 Aug 13.


Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor.

Miller S, Oleksy A, Perisic O, Williams RL.

Autophagy. 2010 Aug;6(6):805-7. doi: 10.1126/science.1184429. Epub 2010 Aug 3.


Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34.

Miller S, Tavshanjian B, Oleksy A, Perisic O, Houseman BT, Shokat KM, Williams RL.

Science. 2010 Mar 26;327(5973):1638-42. doi: 10.1126/science.1184429.


Mesoscale simulations of two nucleosome-repeat length oligonucleosomes.

Schlick T, Perisić O.

Phys Chem Chem Phys. 2009 Dec 7;11(45):10729-37. doi: 10.1039/b918629h. Epub 2009 Oct 20.


Mechanical signaling on the single protein level studied using steered molecular dynamics.

Genchev GZ, Källberg M, Gürsoy G, Mittal A, Dubey L, Perisic O, Feng G, Langlois R, Lu H.

Cell Biochem Biophys. 2009;55(3):141-52. doi: 10.1007/s12013-009-9064-5. Epub 2009 Aug 11. Review.


Evolution and assembly of ESCRTs.

Ghazi-Tabatabai S, Obita T, Pobbati AV, Perisic O, Samson RY, Bell SD, Williams RL.

Biochem Soc Trans. 2009 Feb;37(Pt 1):151-5. doi: 10.1042/BST0370151.


[Roles of ESCRT complexes in the MVB pathway].

Obita T, Perisic O, Williams RL.

Tanpakushitsu Kakusan Koso. 2008 Dec;53(16 Suppl):2089-93. Review. Japanese. No abstract available.


Improved protein fold assignment using support vector machines.

Langlois RE, Diec A, Perisic O, Dai Y; Hui Lu.

Int J Bioinform Res Appl. 2005;1(3):319-34.


Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4.

Obita T, Saksena S, Ghazi-Tabatabai S, Gill DJ, Perisic O, Emr SD, Williams RL.

Nature. 2007 Oct 11;449(7163):735-9.


Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.

Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL.

Science. 2007 Jul 13;317(5835):239-42.


Single-molecule force spectroscopy reveals a mechanically stable protein fold and the rational tuning of its mechanical stability.

Sharma D, Perisic O, Peng Q, Cao Y, Lam C, Lu H, Li H.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9278-83. Epub 2007 May 21.


Structural studies of phosphoinositide 3-kinase-dependent traffic to multivesicular bodies.

Gill DJ, Teo H, Sun J, Perisic O, Veprintsev DB, Vallis Y, Emr SD, Williams RL.

Biochem Soc Symp. 2007;(74):47-57. Review.


Structural insight into the ESCRT-I/-II link and its role in MVB trafficking.

Gill DJ, Teo H, Sun J, Perisic O, Veprintsev DB, Emr SD, Williams RL.

EMBO J. 2007 Jan 24;26(2):600-12. Epub 2007 Jan 11.


ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes.

Teo H, Gill DJ, Sun J, Perisic O, Veprintsev DB, Vallis Y, Emr SD, Williams RL.

Cell. 2006 Apr 7;125(1):99-111.


Robotic nanolitre protein crystallisation at the MRC Laboratory of Molecular Biology.

Stock D, Perisic O, Löwe J.

Prog Biophys Mol Biol. 2005 Jul;88(3):311-27. Epub 2004 Sep 30. Review.


The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase.

Perisic O, Wilson MI, Karathanassis D, Bravo J, Pacold ME, Ellson CD, Hawkins PT, Stephens L, Williams RL.

Adv Enzyme Regul. 2004;44:279-98. Review. No abstract available.


Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus.

Panic B, Perisic O, Veprintsev DB, Williams RL, Munro S.

Mol Cell. 2003 Oct;12(4):863-74.


Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction.

Karathanassis D, Stahelin RV, Bravo J, Perisic O, Pacold CM, Cho W, Williams RL.

EMBO J. 2002 Oct 1;21(19):5057-68.


The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.

Bravo J, Karathanassis D, Pacold CM, Pacold ME, Ellson CD, Anderson KE, Butler PJ, Lavenir I, Perisic O, Hawkins PT, Stephens L, Williams RL.

Mol Cell. 2001 Oct;8(4):829-39.


Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.

Rodriguez R, Matsuda M, Perisic O, Bravo J, Paul A, Jones NP, Light Y, Swann K, Williams RL, Katan M.

J Biol Chem. 2001 Dec 21;276(51):47982-92. Epub 2001 Oct 17.


Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma.

Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, Walker EH, Hawkins PT, Stephens L, Eccleston JF, Williams RL.

Cell. 2000 Dec 8;103(6):931-43.


Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.

Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL.

Mol Cell. 2000 Oct;6(4):909-19.


Structural insights into phosphoinositide 3-kinase catalysis and signalling.

Walker EH, Perisic O, Ried C, Stephens L, Williams RL.

Nature. 1999 Nov 18;402(6759):313-20.


Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2.

Perisic O, Paterson HF, Mosedale G, Lara-González S, Williams RL.

J Biol Chem. 1999 May 21;274(21):14979-87.


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