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Items: 1 to 50 of 229

1.

Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface.

Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM.

Cancer Res. 2019 Sep 9. pii: canres.1112.2019. doi: 10.1158/0008-5472.CAN-19-1112. [Epub ahead of print]

PMID:
31501192
2.

Dynamic structural determinants underlie the neurotoxicity of the N-terminal tau 26-44 peptide in Alzheimer's disease and other human tauopathies.

Perini G, Ciasca G, Minelli E, Papi M, Palmieri V, Maulucci G, Nardini M, Latina V, Corsetti V, Florenzano F, Calissano P, De Spirito M, Amadoro G.

Int J Biol Macromol. 2019 Aug 27;141:278-289. doi: 10.1016/j.ijbiomac.2019.08.220. [Epub ahead of print]

PMID:
31470053
3.

Converting the personalized biomolecular corona of graphene oxide nanoflakes into a high-throughput diagnostic test for early cancer detection.

Papi M, Palmieri V, Digiacomo L, Giulimondi F, Palchetti S, Ciasca G, Perini G, Caputo D, Cartillone MC, Cascone C, Coppola R, Capriotti AL, Laganà A, Pozzi D, Caracciolo G.

Nanoscale. 2019 Aug 15;11(32):15339-15346. doi: 10.1039/c9nr01413f.

PMID:
31386742
4.

Unilateral arm rehabilitation for persons with multiple sclerosis using serious games in a virtual reality approach: Bilateral treatment effect?

Jonsdottir J, Perini G, Ascolese A, Bowman T, Montesano A, Lawo M, Bertoni R.

Mult Scler Relat Disord. 2019 Jul 20;35:76-82. doi: 10.1016/j.msard.2019.07.010. [Epub ahead of print]

PMID:
31352180
5.

JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma.

Wong M, Sun Y, Xi Z, Milazzo G, Poulos RC, Bartenhagen C, Bell JL, Mayoh C, Ho N, Tee AE, Chen X, Li Y, Ciaccio R, Liu PY, Jiang CC, Lan Q, Jayatilleke N, Cheung BB, Haber M, Norris MD, Zhang XD, Marshall GM, Wang JY, Hüttelmaier S, Fischer M, Wong JWH, Xu H, Perini G, Dong Q, George RE, Liu T.

Nat Commun. 2019 Jul 25;10(1):3319. doi: 10.1038/s41467-019-11132-w.

6.

Transcatheter arterial chemoembolization of hepatocellular carcinoma in a patient with celiac trunk occlusion: a therapeutic challenge.

Moraes AO, do Nascimento EA, Zubiolo TFM, de Paula MFM, Brito AFB, Petta BFV, Perini GM, Martins DR.

J Vasc Bras. 2019 May 22;18:e20180090. doi: 10.1590/1677-5449.180090.

7.

Cognitive impairment in depression: recent advances and novel treatments.

Perini G, Cotta Ramusino M, Sinforiani E, Bernini S, Petrachi R, Costa A.

Neuropsychiatr Dis Treat. 2019 May 10;15:1249-1258. doi: 10.2147/NDT.S199746. eCollection 2019. Review.

8.

A Case Report of Neurosyphilis Limbic Encephalitis With Reversible Geschwind Syndrome and Mood Disorder.

Toffanin T, Miola A, Follador H, Ferri G, Scupola N, Martino N, Baratto A, Perini GI.

J Psychiatr Pract. 2019 May;25(3):222-226. doi: 10.1097/PRA.0000000000000390.

PMID:
31083037
9.

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients.

Costa A, Bosone D, Cotta Ramusino M, Perini G, Ghiotto N, Zoppi A, D Apos Angelo A, Fogari R.

Pharmacology. 2019;104(1-2):1-6. doi: 10.1159/000499371. Epub 2019 Apr 3.

PMID:
30943497
10.

Biocompatible N-acetyl cysteine reduces graphene oxide and persists at the surface as a green radical scavenger.

Palmieri V, Dalchiele EA, Perini G, Motta A, De Spirito M, Zanoni R, Marrani AG, Papi M.

Chem Commun (Camb). 2019 Apr 4;55(29):4186-4189. doi: 10.1039/c9cc00429g.

PMID:
30892320
11.

The Treatment of Trigeminal Autonomic Cephalalgias: An Overview.

Ramusino MC, Perini G, Antonaci F, Costa A.

J Oral Facial Pain Headache. 2019 Winter;33(1):89-104. doi: 10.11607/ofph.1922.

PMID:
30703174
12.

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma.

Gamble LD, Purgato S, Murray J, Xiao L, Yu DMT, Hanssen KM, Giorgi FM, Carter DR, Gifford AJ, Valli E, Milazzo G, Kamili A, Mayoh C, Liu B, Eden G, Sarraf S, Allan S, Di Giacomo S, Flemming CL, Russell AJ, Cheung BB, Oberthuer A, London WB, Fischer M, Trahair TN, Fletcher JI, Marshall GM, Ziegler DS, Hogarty MD, Burns MR, Perini G, Norris MD, Haber M.

Sci Transl Med. 2019 Jan 30;11(477). pii: eaau1099. doi: 10.1126/scitranslmed.aau1099.

PMID:
30700572
13.

Microfluidic manufacturing of surface-functionalized graphene oxide nanoflakes for gene delivery.

Di Santo R, Digiacomo L, Palchetti S, Palmieri V, Perini G, Pozzi D, Papi M, Caracciolo G.

Nanoscale. 2019 Feb 7;11(6):2733-2741. doi: 10.1039/c8nr09245a.

PMID:
30672541
14.

Role of Cerebrospinal Fluid Biomarkers and (18)F-florbetapir PET Imaging in the Diagnosis of Primary Progressive Aphasia: A Retrospective Analysis.

Perini G, Cotta Ramusino M, Sinforiani E, Franciotta D, Trifirò G, Ceroni M, Costa A.

Alzheimer Dis Assoc Disord. 2019 Jul-Sep;33(3):282-284. doi: 10.1097/WAD.0000000000000289.

PMID:
30640253
15.

Hepatic and cardiac and iron overload detected by T2* magnetic resonance (MRI) in patients with myelodisplastic syndrome: A cross-sectional study.

Mantovani LF, Santos FPS, Perini GF, Nascimento CMB, Silva LP, Wroclawski CK, Esposito BP, Ribeiro MSS, Velloso EDRP, Nomura CH, Kay FU, Baroni RH, Hamerschlak N, Schuster S.

Leuk Res. 2019 Jan;76:53-57. doi: 10.1016/j.leukres.2018.12.001. Epub 2018 Dec 4.

PMID:
30572266
16.

Graphene oxide coatings prevent Candida albicans biofilm formation with a controlled release of curcumin-loaded nanocomposites.

Palmieri V, Bugli F, Cacaci M, Perini G, Maio F, Delogu G, Torelli R, Conti C, Sanguinetti M, Spirito M, Zanoni R, Papi M.

Nanomedicine (Lond). 2018 Nov;13(22):2867-2879. doi: 10.2217/nnm-2018-0183. Epub 2018 Nov 15.

PMID:
30431405
17.

A new BCR-ABL1 Drosophila model as a powerful tool to elucidate the pathogenesis and progression of chronic myeloid leukemia.

Bernardoni R, Giordani G, Signorino E, Monticelli S, Messa F, Pradotto M, Rosso V, Bracco E, Giangrande A, Perini G, Saglio G, Cilloni D.

Haematologica. 2019 Apr;104(4):717-728. doi: 10.3324/haematol.2018.198267. Epub 2018 Nov 8.

18.

Correction: MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.

Agarwal S, Milazzo G, Rajapakshe K, Bernardi R, Chen Z, Eveline B, Koster J, Perini G, Coarfa C, Shohet JM.

Oncotarget. 2018 Jul 6;9(52):30024. doi: 10.18632/oncotarget.25776. eCollection 2018 Jul 6.

19.

Diazepam as an oral hypnotic increases nocturnal blood pressure in the elderly.

Fogari R, Costa A, Zoppi A, D'Angelo A, Ghiotto N, Battaglia D, Cotta Ramusino M, Perini G, Bosone D.

Aging Clin Exp Res. 2019 Apr;31(4):463-468. doi: 10.1007/s40520-018-0991-0. Epub 2018 Jun 29.

PMID:
29959667
20.

Nanoscale mechanics of brain abscess: An atomic force microscopy study.

Minelli E, Sassun TE, Papi M, Palmieri V, Palermo F, Perini G, Antonelli M, Gianno F, Maulucci G, Ciasca G, De Spirito M.

Micron. 2018 Oct;113:34-40. doi: 10.1016/j.micron.2018.06.012. Epub 2018 Jun 20.

PMID:
29957562
21.

"Marvin, the Paranoid Android": The Case of an Alpha-PVP User in the Expanding Galaxy of NPS.

Pierluigi S, Laura B, Attilio N, Gurjeet K B, Gloria P, Davide M, Borgherini G, Giovanni M, Fabrizio S, Perini G, Ornella C.

J Psychoactive Drugs. 2018 Sep-Oct;50(4):306-313. doi: 10.1080/02791072.2018.1447172. Epub 2018 May 16.

PMID:
29768112
22.

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.

Agarwal S, Milazzo G, Rajapakshe K, Bernardi R, Chen Z, Barbieri E, Koster J, Perini G, Coarfa C, Shohet JM.

Oncotarget. 2018 Apr 17;9(29):20323-20338. doi: 10.18632/oncotarget.24859. eCollection 2018 Apr 17. Erratum in: Oncotarget. 2018 Jul 6;9(52):30024. Eveline, Barberi [corrected to Eveline, Barbieri].

23.

BCL-2 as therapeutic target for hematological malignancies.

Perini GF, Ribeiro GN, Pinto Neto JV, Campos LT, Hamerschlak N.

J Hematol Oncol. 2018 May 11;11(1):65. doi: 10.1186/s13045-018-0608-2. Review.

24.

Effect of flunitrazepam as an oral hypnotic on 24-hour blood pressure in healthy volunteers.

Bosone D, Fogari R, Zoppi A, D'Angelo A, Ghiotto N, Perini G, Ramusino MC, Costa A.

Eur J Clin Pharmacol. 2018 Aug;74(8):995-1000. doi: 10.1007/s00228-018-2466-9. Epub 2018 Apr 30.

PMID:
29713800
25.

MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma.

Ferrucci F, Ciaccio R, Monticelli S, Pigini P, di Giacomo S, Purgato S, Erriquez D, Bernardoni R, Norris M, Haber M, Milazzo G, Perini G.

Biochim Biophys Acta Gene Regul Mech. 2018 Mar;1861(3):235-245. doi: 10.1016/j.bbagrm.2018.01.007. Epub 2018 Feb 3.

PMID:
29408445
26.

The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer.

Macchia G, Severgnini M, Purgato S, Tolomeo D, Casciaro H, Cifola I, L'Abbate A, Loverro A, Palumbo O, Carella M, Bianchini L, Perini G, De Bellis G, Mertens F, Rocchi M, Storlazzi CT.

Genetics. 2018 Mar;208(3):951-961. doi: 10.1534/genetics.117.300552. Epub 2017 Dec 26.

27.

Transcriptional and epigenetic analyses of the DMD locus reveal novel cis‑acting DNA elements that govern muscle dystrophin expression.

Gherardi S, Bovolenta M, Passarelli C, Falzarano MS, Pigini P, Scotton C, Neri M, Armaroli A, Osman H, Selvatici R, Gualandi F, Recchia A, Mora M, Bernasconi P, Maggi L, Morandi L, Ferlini A, Perini G.

Biochim Biophys Acta Gene Regul Mech. 2017 Nov;1860(11):1138-1147. doi: 10.1016/j.bbagrm.2017.08.010. Epub 2017 Sep 1.

PMID:
28867298
28.

Everolimus as a single agent in refractory or relapsed Hodgkin's lymphoma: the Brazilian Named Patient Program Experience.

Rocha TMBDSD, Fortier SC, Fischer TRDC, Perini GF, Gaiolla RD, Fogliatto L, Delamain MT, Costa AFD, Castro NS, Barretos WG, Souza CA, Buccheri V, Chiattone CS.

Rev Bras Hematol Hemoter. 2017 Jul - Sep;39(3):216-222. doi: 10.1016/j.bjhh.2017.03.008. Epub 2017 May 11.

29.

Hippocampal Gray Volumes Increase in Treatment-Resistant Depression Responding to Vagus Nerve Stimulation.

Perini GI, Toffanin T, Pigato G, Ferri G, Follador H, Zonta F, Pastorelli C, Piazzon G, Denaro L, Rolma G, Ermani M, DʼAvella D.

J ECT. 2017 Sep;33(3):160-166. doi: 10.1097/YCT.0000000000000424.

PMID:
28658013
30.

Treatment outcomes for Hodgkin lymphoma: First report from the Brazilian Prospective Registry.

Biasoli I, Castro N, Delamain M, Silveira T, Farley J, Simões BP, Solza C, Praxedes M, Baiocchi O, Gaiolla R, Franceschi F, Sola CB, Boquimpani C, Clementino N, Perini G, Pagnano K, Steffenello G, Tabacof J, de Freitas Colli G, Soares A, de Souza C, Chiattone CS, Milito C, Morais JC, Spector N.

Hematol Oncol. 2018 Feb;36(1):189-195. doi: 10.1002/hon.2450. Epub 2017 Jun 23.

PMID:
28643458
31.

A life-threatening case of TAFRO syndrome with dramatic response to tocilizumab, rituximab, and pulse steroids: The first case report in Latin America.

José FF, Kerbauy LN, Perini GF, Blumenschein DI, Pasqualin DD, Malheiros DM, Campos Neto GC, de Souza Santos FP, Piovesan R, Hamerschlak N.

Medicine (Baltimore). 2017 Mar;96(13):e6271. doi: 10.1097/MD.0000000000006271.

32.

The Histone Methyltransferase DOT1L Promotes Neuroblastoma by Regulating Gene Transcription.

Wong M, Tee AEL, Milazzo G, Bell JL, Poulos RC, Atmadibrata B, Sun Y, Jing D, Ho N, Ling D, Liu PY, Zhang XD, Hüttelmaier S, Wong JWH, Wang J, Polly P, Perini G, Scarlett CJ, Liu T.

Cancer Res. 2017 May 1;77(9):2522-2533. doi: 10.1158/0008-5472.CAN-16-1663. Epub 2017 Feb 16.

33.

Epigenetic origin of evolutionary novel centromeres.

Tolomeo D, Capozzi O, Stanyon RR, Archidiacono N, D'Addabbo P, Catacchio CR, Purgato S, Perini G, Schempp W, Huddleston J, Malig M, Eichler EE, Rocchi M.

Sci Rep. 2017 Feb 3;7:41980. doi: 10.1038/srep41980.

34.

Challenges and opportunities in primary CNS lymphoma: A systematic review.

Kerbauy MN, Moraes FY, Lok BH, Ma J, Kerbauy LN, Spratt DE, Santos FP, Perini GF, Berlin A, Chung C, Hamerschlak N, Yahalom J.

Radiother Oncol. 2017 Mar;122(3):352-361. doi: 10.1016/j.radonc.2016.12.033. Epub 2017 Jan 16. Review.

PMID:
28104300
35.

Depression in cancer: The many biobehavioral pathways driving tumor progression.

Bortolato B, Hyphantis TN, Valpione S, Perini G, Maes M, Morris G, Kubera M, Köhler CA, Fernandes BS, Stubbs B, Pavlidis N, Carvalho AF.

Cancer Treat Rev. 2017 Jan;52:58-70. doi: 10.1016/j.ctrv.2016.11.004. Epub 2016 Nov 16. Review.

PMID:
27894012
36.

Letting the breaks off MYCN.

Perini G, Milazzo G, Narayan N, Ekert PG.

Cell Death Differ. 2016 Dec;23(12):1904-1905. doi: 10.1038/cdd.2016.112. Epub 2016 Oct 14. No abstract available.

37.

The human Smoothened inhibitor PF-04449913 induces exit from quiescence and loss of multipotent Drosophila hematopoietic progenitor cells.

Giordani G, Barraco M, Giangrande A, Martinelli G, Guadagnuolo V, Simonetti G, Perini G, Bernardoni R.

Oncotarget. 2016 Aug 23;7(34):55313-55327. doi: 10.18632/oncotarget.10879.

38.

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.

Trazzi S, Fuchs C, Viggiano R, De Franceschi M, Valli E, Jedynak P, Hansen FK, Perini G, Rimondini R, Kurz T, Bartesaghi R, Ciani E.

Hum Mol Genet. 2016 Sep 15;25(18):3887-3907. doi: 10.1093/hmg/ddw231. Epub 2016 Jul 27.

PMID:
27466189
39.

MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4.

Xue C, Yu DM, Gherardi S, Koach J, Milazzo G, Gamble L, Liu B, Valli E, Russell AJ, London WB, Liu T, Cheung BB, Marshall GM, Perini G, Haber M, Norris MD.

Oncotarget. 2016 Aug 23;7(34):54937-54951. doi: 10.18632/oncotarget.10709.

40.

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.

O'Brien R, Tran SL, Maritz MF, Liu B, Kong CF, Purgato S, Yang C, Murray J, Russell AJ, Flemming CL, von Jonquieres G, Pickett HA, London WB, Haber M, Gunaratne PH, Norris MD, Perini G, Fletcher JI, MacKenzie KL.

Cancer Res. 2016 Jun 15;76(12):3604-17. doi: 10.1158/0008-5472.CAN-15-0879. Epub 2016 Apr 13.

41.

Clinical response to everolimus in a patient with Hodgkin's lymphoma harboring a TSC2 mutation.

Perini GF, Campregher PV, Ross JS, Ali S, Hamerschlak N, Santos FP.

Blood Cancer J. 2016 May 13;6:e420. doi: 10.1038/bcj.2016.25. No abstract available.

42.

Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients.

Trino S, Iacobucci I, Erriquez D, Laurenzana I, De Luca L, Ferrari A, Ghelli Luserna Di Rorà A, Papayannidis C, Derenzini E, Simonetti G, Lonetti A, Venturi C, Cattina F, Ottaviani E, Abbenante MC, Russo D, Perini G, Musto P, Martinelli G.

Oncotarget. 2016 Mar 15;7(11):12951-61. doi: 10.18632/oncotarget.7339.

43.

Misidentification Delusions: Prevalence in Different Types of Dementia and Validation of a Structured Questionnaire.

Perini G, Carlini A, Pomati S, Alberoni M, Mariani C, Nemni R, Farina E.

Alzheimer Dis Assoc Disord. 2016 Oct-Dec;30(4):331-337.

PMID:
26859554
44.

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.

Sun Y, Bell JL, Carter D, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T, Zhao Q, Shohet JM, Haupt Y, Schulte JH, Brown PJ, Arrowsmith CH, Vedadi M, MacKenzie KL, Hüttelmaier S, Perini G, Marshall GM, Braithwaite A, Liu T.

Cancer Res. 2015 Dec 1;75(23):5143-54. doi: 10.1158/0008-5472.CAN-15-0423. Epub 2015 Oct 15.

45.

The Involvement of TNF-α in Cognitive Dysfunction Associated with Major Depressive Disorder: An Opportunity for Domain Specific Treatments.

Bortolato B, Carvalho AF, Soczynska JK, Perini GI, McIntyre RS.

Curr Neuropharmacol. 2015;13(5):558-76. Review.

46.

Imbalance of Pro- and Anti-Inflammatory Cytokines in Patients With cHL Persists Despite Treatment Compared With Control Subjects.

da Silva PB, Perini GF, Pereira Lde A, Sacconato EM, Penna AM, Garibaldi J, Cavalcante E, Baiocchi OC.

Clin Lymphoma Myeloma Leuk. 2015 Jun;15 Suppl:S151-7. doi: 10.1016/j.clml.2015.02.002.

PMID:
26297269
47.

Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma.

Amente S, Milazzo G, Sorrentino MC, Ambrosio S, Di Palo G, Lania L, Perini G, Majello B.

Oncotarget. 2015 Jun 10;6(16):14572-83.

48.

MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma.

Lau DT, Flemming CL, Gherardi S, Perini G, Oberthuer A, Fischer M, Juraeva D, Brors B, Xue C, Norris MD, Marshall GM, Haber M, Fletcher JI, Ashton LJ.

Oncotarget. 2015 Jun 20;6(17):15510-23.

49.

SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma.

Evans L, Chen L, Milazzo G, Gherardi S, Perini G, Willmore E, Newell DR, Tweddle DA.

Cancer Lett. 2015 Jul 10;363(1):37-45. doi: 10.1016/j.canlet.2015.03.044. Epub 2015 Apr 2.

PMID:
25843293
50.

A Long Term Effects of a New Onset Psychosis after DBS Treated with Quetiapine in a Patient with Parkinson's Disease.

Piccoli S, Perini G, Pizzighello S, Vestri A, Ferri G, Toffanin T, Follador H, Martinuzzi A.

Psychiatry Investig. 2015 Jan;12(1):146-9. doi: 10.4306/pi.2015.12.1.146. Epub 2015 Jan 12.

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