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Items: 43


The anti-obesity effect of FGF19 does not require UCP1-dependent thermogenesis.

Antonellis PJ, Droz BA, Cosgrove R, O'Farrell LS, Coskun T, Perfield JW 2nd, Bauer S, Wade M, Chouinard TE, Brozinick JT, Adams AC, Samms RJ.

Mol Metab. 2019 Dec;30:131-139. doi: 10.1016/j.molmet.2019.09.006. Epub 2019 Sep 29.


Fibroblast growth factor-21 (FGF21) administration to early-lactating dairy cows. II. Pharmacokinetics, whole-animal performance, and lipid metabolism.

Caixeta LS, Giesy SL, Krumm CS, Perfield JW 2nd, Butterfield A, Boisclair YR.

J Dairy Sci. 2019 Dec;102(12):11597-11608. doi: 10.3168/jds.2019-16696. Epub 2019 Sep 20.


Fibroblast growth factor-21 (FGF21) administration to early-lactating dairy cows. I. Effects on signaling and indices of insulin action.

Krumm CS, Giesy SL, Caixeta LS, Perfield JW 2nd, Sauerwein H, Moore BL, Boisclair YR.

J Dairy Sci. 2019 Dec;102(12):11586-11596. doi: 10.3168/jds.2019-16695. Epub 2019 Sep 20.


Effects of heat stress and insulin sensitizers on pig adipose tissue.

Seibert JT, Abuajamieh M, Sanz Fernandez MV, Johnson JS, Kvidera SK, Horst EA, Mayorga EJ, Lei S, Patience JF, Ross JW, Rhoads RP, Johnson RC, Lonergan SM, Perfield JW 2nd, Baumgard LH.

J Anim Sci. 2018 Mar 6;96(2):510-520. doi: 10.1093/jas/skx067.


Fibroblast growth factor 21 increases hepatic oxidative capacity but not physical activity or energy expenditure in hepatic peroxisome proliferator-activated receptor γ coactivator-1α-deficient mice.

Fletcher JA, Linden MA, Sheldon RD, Meers GM, Morris EM, Butterfield A, Perfield JW 2nd, Rector RS, Thyfault JP.

Exp Physiol. 2018 Mar 1;103(3):408-418. doi: 10.1113/EP086629. Epub 2018 Jan 16.


FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans.

Samms RJ, Lewis JE, Norton L, Stephens FB, Gaffney CJ, Butterfield T, Smith DP, Cheng CC, Perfield JW 2nd, Adams AC, Ebling FJP, Tsintzas K.

J Clin Endocrinol Metab. 2017 Oct 1;102(10):3806-3813. doi: 10.1210/jc.2017-01257.


High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine.

Panasevich MR, Meers GM, Linden MA, Booth FW, Perfield JW 2nd, Fritsche KL, Wankhade UD, Chintapalli SV, Shankar K, Ibdah JA, Rector RS.

Am J Physiol Endocrinol Metab. 2018 Jan 1;314(1):E78-E92. doi: 10.1152/ajpendo.00015.2017. Epub 2017 Sep 12.


Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21.

Porter JW, Rowles JL 3rd, Fletcher JA, Zidon TM, Winn NC, McCabe LT, Park YM, Perfield JW 2nd, Thyfault JP, Rector RS, Padilla J, Vieira-Potter VJ.

J Endocrinol. 2017 Nov;235(2):97-109. doi: 10.1530/JOE-17-0190. Epub 2017 Aug 1.


Transcriptomic differences in intra-abdominal adipose tissue in extremely obese adolescents with different stages of NAFLD.

Sheldon RD, Kanosky KM, Wells KD, Miles L, Perfield JW 2nd, Xanthakos S, Inge TH, Rector RS.

Physiol Genomics. 2016 Dec 1;48(12):897-911. doi: 10.1152/physiolgenomics.00020.2016. Epub 2016 Oct 7.


Fibroblast growth factor 21 and exercise-induced hepatic mitochondrial adaptations.

Fletcher JA, Linden MA, Sheldon RD, Meers GM, Morris EM, Butterfield A, Perfield JW 2nd, Thyfault JP, Rector RS.

Am J Physiol Gastrointest Liver Physiol. 2016 May 15;310(10):G832-43. doi: 10.1152/ajpgi.00355.2015. Epub 2016 Mar 24.


Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1.

Samms RJ, Smith DP, Cheng CC, Antonellis PP, Perfield JW 2nd, Kharitonenkov A, Gimeno RE, Adams AC.

Cell Rep. 2015 May 19;11(7):991-9. doi: 10.1016/j.celrep.2015.04.046. Epub 2015 May 5.


Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function.

Kim JH, Bae KH, Choi YK, Go Y, Choe M, Jeon YH, Lee HW, Koo SH, Perfield JW 2nd, Harris RA, Lee IK, Park KG.

Diabetes Obes Metab. 2015 Feb;17(2):161-9. doi: 10.1111/dom.12408. Epub 2014 Nov 28.


Unique transcriptomic signature of omental adipose tissue in Ossabaw swine: a model of childhood obesity.

Toedebusch RG, Roberts MD, Wells KD, Company JM, Kanosky KM, Padilla J, Jenkins NT, Perfield JW 2nd, Ibdah JA, Booth FW, Rector RS.

Physiol Genomics. 2014 May 15;46(10):362-75. doi: 10.1152/physiolgenomics.00172.2013. Epub 2014 Mar 18.


Diet-induced obesity alters immune cell infiltration and expression of inflammatory cytokine genes in mouse ovarian and peri-ovarian adipose depot tissues.

Nteeba J, Ortinau LC, Perfield JW 2nd, Keating AF.

Mol Reprod Dev. 2013 Nov;80(11):948-58. doi: 10.1002/mrd.22231. Epub 2013 Sep 16.


High fat diet induced obesity alters ovarian phosphatidylinositol-3 kinase signaling gene expression.

Nteeba J, Ross JW, Perfield JW 2nd, Keating AF.

Reprod Toxicol. 2013 Dec;42:68-77. doi: 10.1016/j.reprotox.2013.07.026. Epub 2013 Aug 14.


Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine.

Padilla J, Jenkins NT, Lee S, Zhang H, Cui J, Zuidema MY, Zhang C, Hill MA, Perfield JW 2nd, Ibdah JA, Booth FW, Davis JW, Laughlin MH, Rector RS.

Physiol Genomics. 2013 Jun 3;45(11):434-46. doi: 10.1152/physiolgenomics.00038.2013. Epub 2013 Apr 16.


Sterculic oil, a natural inhibitor of SCD1, improves the metabolic state of obese OLETF rats.

Ortinau LC, Nickelson KJ, Stromsdorfer KL, Naik CY, Pickering RT, Haynes RA, Fritsche KL, Perfield JW 2nd.

Obesity (Silver Spring). 2013 Feb;21(2):344-52. doi: 10.1002/oby.20040.


Altered hepatic lipid metabolism contributes to nonalcoholic fatty liver disease in leptin-deficient Ob/Ob mice.

Perfield JW 2nd, Ortinau LC, Pickering RT, Ruebel ML, Meers GM, Rector RS.

J Obes. 2013;2013:296537. doi: 10.1155/2013/296537. Epub 2013 Jan 16.


Sterculic Oil, a Natural SCD1 Inhibitor, Improves Glucose Tolerance in Obese ob/ob Mice.

Ortinau LC, Pickering RT, Nickelson KJ, Stromsdorfer KL, Naik CY, Haynes RA, Bauman DE, Rector RS, Fritsche KL, Perfield JW 2nd.

ISRN Endocrinol. 2012;2012:947323. doi: 10.5402/2012/947323. Epub 2012 Nov 14.


A comparison of inflammatory and oxidative stress markers in adipose tissue from weight-matched obese male and female mice.

Nickelson KJ, Stromsdorfer KL, Pickering RT, Liu TW, Ortinau LC, Keating AF, Perfield JW 2nd.

Exp Diabetes Res. 2012;2012:859395. doi: 10.1155/2012/859395. Epub 2012 Jun 14.


Conversion of t11t13 CLA into c9t11 CLA in Caco-2 cells and inhibition by sterculic oil.

Schneider AC, Beguin P, Bourez S, Perfield JW 2nd, Mignolet E, Debier C, Schneider YJ, Larondelle Y.

PLoS One. 2012;7(3):e32824. doi: 10.1371/journal.pone.0032824. Epub 2012 Mar 12.


Exercise and Omega-3 Polyunsaturated Fatty Acid Supplementation for the Treatment of Hepatic Steatosis in Hyperphagic OLETF Rats.

Borengasser SJ, Rector RS, Uptergrove GM, Morris EM, Perfield JW 2nd, Booth FW, Fritsche KL, Ibdah JA, Thyfault JP.

J Nutr Metab. 2012;2012:268680. doi: 10.1155/2012/268680. Epub 2011 Sep 12.


Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.

Perfield JW 2nd, Lee Y, Shulman GI, Samuel VT, Jurczak MJ, Chang E, Xie C, Tsichlis PN, Obin MS, Greenberg AS.

Diabetes. 2011 Apr;60(4):1168-76. doi: 10.2337/db10-0715. Epub 2011 Feb 23.


Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype.

Sawada T, Miyoshi H, Shimada K, Suzuki A, Okamatsu-Ogura Y, Perfield JW 2nd, Kondo T, Nagai S, Shimizu C, Yoshioka N, Greenberg AS, Kimura K, Koike T.

PLoS One. 2010 Nov 16;5(11):e14006. doi: 10.1371/journal.pone.0014006. Erratum in: PLoS One. 2010;5(11). doi: 10.1371/annotation/45438cdc-913a-4009-b2c1-5c1bc437c926.


Loss of ovarian function in mice results in abrogated skeletal muscle PPARdelta and FoxO1-mediated gene expression.

Rogers NH, Perfield JW 2nd, Strissel KJ, Obin MS, Greenberg AS.

Biochem Biophys Res Commun. 2010 Jan 29;392(1):1-3. doi: 10.1016/j.bbrc.2009.10.072. Epub 2009 Oct 20.


Neurogenin 3-specific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity.

Danilova OV, Tai AK, Mele DA, Beinborn M, Leiter AB, Greenberg AS, Perfield JW 2nd, Defuria J, Singru PS, Lechan RM, Huber BT.

Endocrinology. 2009 Dec;150(12):5240-8. doi: 10.1210/en.2009-0386. Epub 2009 Oct 9.


Perilipin overexpression in mice protects against diet-induced obesity.

Miyoshi H, Souza SC, Endo M, Sawada T, Perfield JW 2nd, Shimizu C, Stancheva Z, Nagai S, Strissel KJ, Yoshioka N, Obin MS, Koike T, Greenberg AS.

J Lipid Res. 2010 May;51(5):975-82. doi: 10.1194/jlr.M002352. Epub 2009 Oct 1.


Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae.

DeFuria J, Bennett G, Strissel KJ, Perfield JW 2nd, Milbury PE, Greenberg AS, Obin MS.

J Nutr. 2009 Aug;139(8):1510-6. doi: 10.3945/jn.109.105155. Epub 2009 Jun 10.


Expression of enzymes and key regulators of lipid synthesis is upregulated in adipose tissue during CLA-induced milk fat depression in dairy cows.

Harvatine KJ, Perfield JW 2nd, Bauman DE.

J Nutr. 2009 May;139(5):849-54. doi: 10.3945/jn.108.099994. Epub 2009 Feb 11.


Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity.

Rogers NH, Perfield JW 2nd, Strissel KJ, Obin MS, Greenberg AS.

Endocrinology. 2009 May;150(5):2161-8. doi: 10.1210/en.2008-1405. Epub 2009 Jan 29.


Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes.

Miyoshi H, Perfield JW 2nd, Obin MS, Greenberg AS.

J Cell Biochem. 2008 Dec 15;105(6):1430-6. doi: 10.1002/jcb.21964.


Regulation of fat synthesis by conjugated linoleic acid: lactation and the ruminant model.

Bauman DE, Perfield JW 2nd, Harvatine KJ, Baumgard LH.

J Nutr. 2008 Feb;138(2):403-9.


Adipocyte death, adipose tissue remodeling, and obesity complications.

Strissel KJ, Stancheva Z, Miyoshi H, Perfield JW 2nd, DeFuria J, Jick Z, Greenberg AS, Obin MS.

Diabetes. 2007 Dec;56(12):2910-8. Epub 2007 Sep 11.


Trans-9, cis-11 conjugated linoleic acid reduces milk fat synthesis in lactating dairy cows.

Perfield JW 2nd, Lock AL, Griinari JM, Saebø A, Delmonte P, Dwyer DA, Bauman DE.

J Dairy Sci. 2007 May;90(5):2211-8.


Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue.

Souza SC, Christoffolete MA, Ribeiro MO, Miyoshi H, Strissel KJ, Stancheva ZS, Rogers NH, D'Eon TM, Perfield JW 2nd, Imachi H, Obin MS, Bianco AC, Greenberg AS.

J Lipid Res. 2007 Jun;48(6):1273-9. Epub 2007 Mar 30.


Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes.

Miyoshi H, Perfield JW 2nd, Souza SC, Shen WJ, Zhang HH, Stancheva ZS, Kraemer FB, Obin MS, Greenberg AS.

J Biol Chem. 2007 Jan 12;282(2):996-1002. Epub 2006 Nov 18.


Trans-10, trans-12 conjugated linoleic acid does not affect milk fat yield but reduces delta9-desaturase index in dairy cows.

Perfield JW 2nd, Delmonte P, Lock AL, Yurawecz MP, Bauman DE.

J Dairy Sci. 2006 Jul;89(7):2559-66.


A conjugated linoleic acid supplement containing trans-10, cis-12 reduces milk fat synthesis in lactating sheep.

Lock AL, Teles BM, Perfield JW 2nd, Bauman DE, Sinclair LA.

J Dairy Sci. 2006 May;89(5):1525-32.


Milk fat synthesis is unaffected by abomasal infusion of the conjugated diene 18:3 isomers cis-6,trans-10, cis-12 and cis-6,trans-8,cis-12.

Saebø A, Perfield JW 2nd, Delmonte P, Yurawecz MP, Lawrence P, Brenna JT, Bauman DE.

Lipids. 2005 Jan;40(1):89-95.


Effects of amide-protected and lipid-encapsulated conjugated linoleic acid supplements on milk fat synthesis.

Perfield JW 2nd, Lock AL, Pfeiffer AM, Bauman DE.

J Dairy Sci. 2004 Sep;87(9):3010-6.


Production responses of dairy cows to dietary supplementation with conjugated linoleic acid (CLA) during the transition period and early lactation.

Bernal-Santos G, Perfield JW 2nd, Barbano DM, Bauman DE, Overton TR.

J Dairy Sci. 2003 Oct;86(10):3218-28.


Effects of dietary supplementation of rumen-protected conjugated linoleic acid in dairy cows during established lactation.

Perfield JW 2nd, Bernal-Santos G, Overton TR, Bauman DE.

J Dairy Sci. 2002 Oct;85(10):2609-17.

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