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HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry.

Paoletti A, Allouch A, Caillet M, Saïdi H, Subra F, Nardacci R, Wu Q, Muradova Z, Voisin L, Raza SQ, Law F, Thoreau M, Dakhli H, Delelis O, Poirier-Beaudouin B, Dereuddre-Bosquet N, Le Grand R, Lambotte O, Saez-Cirion A, Pancino G, Ojcius DM, Solary E, Deutsch E, Piacentini M, Gougeon ML, Kroemer G, Perfettini JL.

Cell Rep. 2019 Sep 24;28(13):3381-3394.e7. doi: 10.1016/j.celrep.2019.02.095.


CSRP3 mediates polyphenols-induced cardioprotection in hypertension.

Oudot C, Gomes A, Nicolas V, Le Gall M, Chaffey P, Broussard C, Calamita G, Mastrodonato M, Gena P, Perfettini JL, Hamelin J, Lemoine A, Fischmeister R, Vieira HLA, Santos CN, Brenner C.

J Nutr Biochem. 2019 Apr;66:29-42. doi: 10.1016/j.jnutbio.2019.01.001. Epub 2019 Jan 8.


AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine.

Lux F, Tran VL, Thomas E, Dufort S, Rossetti F, Martini M, Truillet C, Doussineau T, Bort G, Denat F, Boschetti F, Angelovski G, Detappe A, Crémillieux Y, Mignet N, Doan BT, Larrat B, Meriaux S, Barbier E, Roux S, Fries P, Müller A, Abadjian MC, Anderson C, Canet-Soulas E, Bouziotis P, Barberi-Heyob M, Frochot C, Verry C, Balosso J, Evans M, Sidi-Boumedine J, Janier M, Butterworth K, McMahon S, Prise K, Aloy MT, Ardail D, Rodriguez-Lafrasse C, Porcel E, Lacombe S, Berbeco R, Allouch A, Perfettini JL, Chargari C, Deutsch E, Le Duc G, Tillement O.

Br J Radiol. 2018 Sep 18:20180365. doi: 10.1259/bjr.20180365. [Epub ahead of print]


Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death.

Martins I, Raza SQ, Voisin L, Dakhli H, Allouch A, Law F, Sabino D, De Jong D, Thoreau M, Mintet E, Dugué D, Piacentini M, Gougeon ML, Jaulin F, Bertrand P, Brenner C, Ojcius DM, Kroemer G, Modjtahedi N, Deutsch E, Perfettini JL.

Cell Death Dis. 2018 Jun 18;9(7):716. doi: 10.1038/s41419-018-0747-y.


Tumour spheres with inverted polarity drive the formation of peritoneal metastases in patients with hypermethylated colorectal carcinomas.

Zajac O, Raingeaud J, Libanje F, Lefebvre C, Sabino D, Martins I, Roy P, Benatar C, Canet-Jourdan C, Azorin P, Polrot M, Gonin P, Benbarche S, Souquere S, Pierron G, Nowak D, Bigot L, Ducreux M, Malka D, Lobry C, Scoazec JY, Eveno C, Pocard M, Perfettini JL, Elias D, Dartigues P, Goéré D, Jaulin F.

Nat Cell Biol. 2018 Mar;20(3):296-306. doi: 10.1038/s41556-017-0027-6. Epub 2018 Feb 5.


[Eating and sleeping, two vital tumor activities favoring anticancer treatment failure].

Wassmer G, Hmitti Z, Voisin L, Perfettini JL.

Med Sci (Paris). 2018 Jan;34(1):37-40. doi: 10.1051/medsci/20183401011. Epub 2018 Jan 31. French. No abstract available.


Bimodal fluorescence/129Xe NMR probe for molecular imaging and biological inhibition of EGFR in Non-Small Cell Lung Cancer.

Milanole G, Gao B, Paoletti A, Pieters G, Dugave C, Deutsch E, Rivera S, Law F, Perfettini JL, Mari E, Léonce E, Boutin C, Berthault P, Volland H, Fenaille F, Brotin T, Rousseau B.

Bioorg Med Chem. 2017 Dec 15;25(24):6653-6660. doi: 10.1016/j.bmc.2017.11.002. Epub 2017 Nov 6.


Macrophage biology plays a central role during ionizing radiation-elicited tumor response.

Wu Q, Allouch A, Martins I, Modjtahedi N, Deutsch E, Perfettini JL.

Biomed J. 2017 Aug;40(4):200-211. doi: 10.1016/ Epub 2017 Jul 29. Review.


Time dependent modulation of tumor radiosensitivity by a pan HDAC inhibitor: abexinostat.

Rivera S, Leteur C, Mégnin F, Law F, Martins I, Kloos I, Depil S, Modjtahedi N, Perfettini JL, Hennequin C, Deutsch E.

Oncotarget. 2017 Jan 25;8(34):56210-56227. doi: 10.18632/oncotarget.14813. eCollection 2017 Aug 22.


Entosis: The emerging face of non-cell-autonomous type IV programmed death.

Martins I, Raza SQ, Voisin L, Dakhli H, Law F, De Jong D, Allouch A, Thoreau M, Brenner C, Deutsch E, Perfettini JL.

Biomed J. 2017 Jun;40(3):133-140. doi: 10.1016/ Epub 2017 May 31. Review.


Modulating Both Tumor Cell Death and Innate Immunity Is Essential for Improving Radiation Therapy Effectiveness.

Wu Q, Allouch A, Martins I, Brenner C, Modjtahedi N, Deutsch E, Perfettini JL.

Front Immunol. 2017 May 26;8:613. doi: 10.3389/fimmu.2017.00613. eCollection 2017. Review.


NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy.

Wu Q, Allouch A, Paoletti A, Leteur C, Mirjolet C, Martins I, Voisin L, Law F, Dakhli H, Mintet E, Thoreau M, Muradova Z, Gauthier M, Caron O, Milliat F, Ojcius DM, Rosselli F, Solary E, Modjtahedi N, Deutsch E, Perfettini JL.

Cell Death Differ. 2017 Sep;24(9):1632-1644. doi: 10.1038/cdd.2017.91. Epub 2017 Jun 2.


Post-operative avascular necrosis of the maxilla: a rare complication following orthognathic surgery.

Teemul TA, Perfettini J, Morris DO, Russell JL.

J Surg Case Rep. 2017 Jan 24;2017(1). pii: rjw240. doi: 10.1093/jscr/rjw240.


Can immunostimulatory agents enhance the abscopal effect of radiotherapy?

Levy A, Chargari C, Marabelle A, Perfettini JL, Magné N, Deutsch E.

Eur J Cancer. 2016 Jul;62:36-45. doi: 10.1016/j.ejca.2016.03.067. Epub 2016 May 18. Review.


Is the inflammasome relevant for epithelial cell function?

Santana PT, Martel J, Lai HC, Perfettini JL, Kanellopoulos JM, Young JD, Coutinho-Silva R, Ojcius DM.

Microbes Infect. 2016 Feb;18(2):93-101. doi: 10.1016/j.micinf.2015.10.007. Epub 2015 Nov 10. Review.


Syncytial apoptosis signaling network induced by the HIV-1 envelope glycoprotein complex: an overview.

Nardacci R, Perfettini JL, Grieco L, Thieffry D, Kroemer G, Piacentini M.

Cell Death Dis. 2015 Aug 6;6:e1846. doi: 10.1038/cddis.2015.204. Review.


Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis.

Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam NV, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini JL, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N.

Mol Cell. 2015 Jun 18;58(6):1001-14. doi: 10.1016/j.molcel.2015.04.020. Epub 2015 May 21.


Synergy of Radiotherapy and a Cancer Vaccine for the Treatment of HPV-Associated Head and Neck Cancer.

Mondini M, Nizard M, Tran T, Mauge L, Loi M, Clémenson C, Dugue D, Maroun P, Louvet E, Adam J, Badoual C, Helley D, Dransart E, Johannes L, Vozenin MC, Perfettini JL, Tartour E, Deutsch E.

Mol Cancer Ther. 2015 Jun;14(6):1336-45. doi: 10.1158/1535-7163.MCT-14-1015. Epub 2015 Apr 1.


Entosis, a key player in cancer cell competition.

Kroemer G, Perfettini JL.

Cell Res. 2014 Nov;24(11):1280-1. doi: 10.1038/cr.2014.133. Epub 2014 Oct 24.


Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer.

Loriot Y, Mordant P, Dugue D, Geneste O, Gombos A, Opolon P, Guegan J, Perfettini JL, Pierre A, Berthier LK, Kroemer G, Soria JC, Depil S, Deutsch E.

Cell Death Dis. 2014 Sep 18;5:e1423. doi: 10.1038/cddis.2014.365.


The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy.

Sancey L, Lux F, Kotb S, Roux S, Dufort S, Bianchi A, Crémillieux Y, Fries P, Coll JL, Rodriguez-Lafrasse C, Janier M, Dutreix M, Barberi-Heyob M, Boschetti F, Denat F, Louis C, Porcel E, Lacombe S, Le Duc G, Deutsch E, Perfettini JL, Detappe A, Verry C, Berbeco R, Butterworth KT, McMahon SJ, Prise KM, Perriat P, Tillement O.

Br J Radiol. 2014 Sep;87(1041):20140134. doi: 10.1259/bjr.20140134. Epub 2014 Jul 3. Review.


Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling.

Ko A, Kanehisa A, Martins I, Senovilla L, Chargari C, Dugue D, Mariño G, Kepp O, Michaud M, Perfettini JL, Kroemer G, Deutsch E.

Cell Death Differ. 2014 Jan;21(1):92-9. doi: 10.1038/cdd.2013.124. Epub 2013 Sep 13.


Editorial: Pannexin-1--the hidden gatekeeper for HIV-1.

Paoletti A, Raza SQ, Voisin L, Law F, Caillet M, Martins I, Deutsch E, Perfettini JL.

J Leukoc Biol. 2013 Sep;94(3):390-2. doi: 10.1189/jlb.0313148. No abstract available.


Molecular mechanisms of ATP secretion during immunogenic cell death.

Martins I, Wang Y, Michaud M, Ma Y, Sukkurwala AQ, Shen S, Kepp O, Métivier D, Galluzzi L, Perfettini JL, Zitvogel L, Kroemer G.

Cell Death Differ. 2014 Jan;21(1):79-91. doi: 10.1038/cdd.2013.75. Epub 2013 Jul 12.


Understanding the functions of tumor stroma in resistance to ionizing radiation: emerging targets for pharmacological modulation.

Chargari C, Clemenson C, Martins I, Perfettini JL, Deutsch E.

Drug Resist Updat. 2013 Feb-Apr;16(1-2):10-21. doi: 10.1016/j.drup.2013.01.001. Epub 2013 Feb 20. Review.


Cellular alarms and whispers contribute to the polyphonic melody of danger signals required for immunity.

Coutinho-Silva R, Kanellopoulos JM, Perfettini JL.

Microbes Infect. 2012 Nov;14(14):1239-40. doi: 10.1016/j.micinf.2012.10.002. Epub 2012 Oct 23. No abstract available.


Multifaceted roles of purinergic receptors in viral infection.

Paoletti A, Raza SQ, Voisin L, Law F, Pipoli da Fonseca J, Caillet M, Kroemer G, Perfettini JL.

Microbes Infect. 2012 Nov;14(14):1278-83. doi: 10.1016/j.micinf.2012.05.010. Epub 2012 Jun 7. Review.


Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection.

Séror C, Melki MT, Subra F, Raza SQ, Bras M, Saïdi H, Nardacci R, Voisin L, Paoletti A, Law F, Martins I, Amendola A, Abdul-Sater AA, Ciccosanti F, Delelis O, Niedergang F, Thierry S, Said-Sadier N, Lamaze C, Métivier D, Estaquier J, Fimia GM, Falasca L, Casetti R, Modjtahedi N, Kanellopoulos J, Mouscadet JF, Ojcius DM, Piacentini M, Gougeon ML, Kroemer G, Perfettini JL.

J Exp Med. 2011 Aug 29;208(9):1823-34. doi: 10.1084/jem.20101805. Epub 2011 Aug 22.


Proteomic analysis identifies prohibitin down-regulation as a crucial event in the mitochondrial damage observed in HIV-infected patients.

Ciccosanti F, Corazzari M, Soldani F, Matarrese P, Pagliarini V, Iadevaia V, Tinari A, Zaccarelli M, Perfettini JL, Malorni W, Kroemer G, Antinori A, Fimia GM, Piacentini M.

Antivir Ther. 2010;15(3):377-90. doi: 10.3851/IMP1530.


A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2.

Hangen E, De Zio D, Bordi M, Zhu C, Dessen P, Caffin F, Lachkar S, Perfettini JL, Lazar V, Benard J, Fimia GM, Piacentini M, Harper F, Pierron G, Vicencio JM, Bénit P, de Andrade A, Höglinger G, Culmsee C, Rustin P, Blomgren K, Cecconi F, Kroemer G, Modjtahedi N.

Cell Death Differ. 2010 Jul;17(7):1155-66. doi: 10.1038/cdd.2009.211. Epub 2010 Jan 29.


53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope.

Perfettini JL, Nardacci R, Séror C, Raza SQ, Sepe S, Saïdi H, Brottes F, Amendola A, Subra F, Del Nonno F, Chessa L, D'Incecco A, Gougeon ML, Piacentini M, Kroemer G.

Cell Death Differ. 2010 May;17(5):811-20. doi: 10.1038/cdd.2009.159. Epub 2009 Oct 30.


Chemotherapy induces ATP release from tumor cells.

Martins I, Tesniere A, Kepp O, Michaud M, Schlemmer F, Senovilla L, Séror C, Métivier D, Perfettini JL, Zitvogel L, Kroemer G.

Cell Cycle. 2009 Nov 15;8(22):3723-8. Epub 2009 Nov 8. Erratum in: Cell Cycle. 2012 Oct 15;11(20):3901.


Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.

Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Génin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, André F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L.

Nat Med. 2009 Oct;15(10):1170-8. doi: 10.1038/nm.2028. Epub 2009 Sep 20.


Pro-apoptotic function of checkpoint kinase-2 in syncytia elicited by the HIV-1 envelope.

Séror C, Raza SQ, Brottes F, Subra F, Piacentini M, Perfettini JL, Kroemer G.

Cell Cycle. 2009 Feb 1;8(3):438-42. Epub 2009 Feb 15.


ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia.

Grosjean-Raillard J, Tailler M, Adès L, Perfettini JL, Fabre C, Braun T, De Botton S, Fenaux P, Kroemer G.

Oncogene. 2009 Feb 26;28(8):1099-109. doi: 10.1038/onc.2008.457. Epub 2008 Dec 15.


The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope.

Perfettini JL, Nardacci R, Séror C, Bourouba M, Subra F, Gros L, Manic G, Amendola A, Masdehors P, Rosselli F, Ojcius DM, Auclair C, de Thé H, Gougeon ML, Piacentini M, Kroemer G.

Cell Death Differ. 2009 Feb;16(2):298-311. doi: 10.1038/cdd.2008.158. Epub 2008 Nov 21.


Methods to dissect mitochondrial membrane permeabilization in the course of apoptosis.

Galluzzi L, Vitale I, Kepp O, Séror C, Hangen E, Perfettini JL, Modjtahedi N, Kroemer G.

Methods Enzymol. 2008;442:355-74. doi: 10.1016/S0076-6879(08)01418-3.


A novel effect of DNA methyltransferase and histone deacetylase inhibitors: NFkappaB inhibition in malignant myeloblasts.

Fabre C, Grosjean J, Tailler M, Boehrer S, Adès L, Perfettini JL, de Botton S, Fenaux P, Kroemer G.

Cell Cycle. 2008 Jul 15;7(14):2139-45. Epub 2008 May 9.


Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia.

Perfettini JL, Nardacci R, Bourouba M, Subra F, Gros L, Séror C, Manic G, Rosselli F, Amendola A, Masdehors P, Chessa L, Novelli G, Ojcius DM, Siwicki JK, Chechlinska M, Auclair C, Regueiro JR, de Thé H, Gougeon ML, Piacentini M, Kroemer G.

PLoS One. 2008 Jun 18;3(6):e2458. doi: 10.1371/journal.pone.0002458.


Calreticulin exposure dictates the immunogenicity of cancer cell death.

Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini JL, Castedo M, Mignot G, Panaretakis T, Casares N, Métivier D, Larochette N, van Endert P, Ciccosanti F, Piacentini M, Zitvogel L, Kroemer G.

Nat Med. 2007 Jan;13(1):54-61. Epub 2006 Dec 24.


Characterization of cell death pathways in human immunodeficiency virus-associated encephalitis.

Nardacci R, Antinori A, Larocca LM, Arena V, Amendola A, Perfettini JL, Kroemer G, Piacentini M.

Am J Pathol. 2005 Sep;167(3):695-704.


HIV-1 protease inhibitors and cytomegalovirus vMIA induce mitochondrial fragmentation without triggering apoptosis.

Roumier T, Szabadkai G, Simoni AM, Perfettini JL, Paulau AL, Castedo M, Métivier D, Badley A, Rizzuto R, Kroemer G.

Cell Death Differ. 2006 Feb;13(2):348-51. No abstract available.


PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor.

Gonzalez-Polo RA, Carvalho G, Braun T, Decaudin D, Fabre C, Larochette N, Perfettini JL, Djavaheri-Mergny M, Youlyouz-Marfak I, Codogno P, Raphael M, Feuillard J, Kroemer G.

Oncogene. 2005 Nov 17;24(51):7503-13.


p53-A pro-apoptotic signal transducer involved in AIDS.

Castedo M, Perfettini JL, Piacentini M, Kroemer G.

Biochem Biophys Res Commun. 2005 Jun 10;331(3):701-6. Review.


Mitochondrial fusion and fission in the control of apoptosis.

Perfettini JL, Roumier T, Kroemer G.

Trends Cell Biol. 2005 Apr;15(4):179-83. Review.


Mechanisms of apoptosis induction by the HIV-1 envelope.

Perfettini JL, Castedo M, Roumier T, Andreau K, Nardacci R, Piacentini M, Kroemer G.

Cell Death Differ. 2005 Aug;12 Suppl 1:916-23. Review.


Inhibition of macroautophagy triggers apoptosis.

Boya P, González-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Métivier D, Meley D, Souquere S, Yoshimori T, Pierron G, Codogno P, Kroemer G.

Mol Cell Biol. 2005 Feb;25(3):1025-40.


Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope.

Perfettini JL, Castedo M, Nardacci R, Ciccosanti F, Boya P, Roumier T, Larochette N, Piacentini M, Kroemer G.

J Exp Med. 2005 Jan 17;201(2):279-89. Epub 2005 Jan 10.


A cellular machine generating apoptosis-prone aneuploid cells.

Roumier T, Valent A, Perfettini JL, Métivier D, Castedo M, Kroemer G.

Cell Death Differ. 2005 Jan;12(1):91-3. No abstract available.


Preapoptotic chromatin condensation upstream of the mitochondrial checkpoint.

Andreau K, Castedo M, Perfettini JL, Roumier T, Pichart E, Souquere S, Vivet S, Larochette N, Kroemer G.

J Biol Chem. 2004 Dec 31;279(53):55937-45. Epub 2004 Oct 21.

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