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Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype.

Hommel B, Sturny-Leclère A, Volant S, Veluppillai N, Duchateau M, Yu CH, Hourdel V, Varet H, Matondo M, Perfect JR, Casadevall A, Dromer F, Alanio A.

PLoS Pathog. 2019 Jul 29;15(7):e1007945. doi: 10.1371/journal.ppat.1007945. eCollection 2019 Jul.


A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans.

Jaeger M, Matzaraki V, Aguirre-Gamboa R, Gresnigt MS, Chu X, Johnson MD, Oosting M, Smeekens SP, Withoff S, Jonkers I, Perfect JR, van de Veerdonk FL, Kullberg BJ, Joosten LAB, Li Y, Wijmenga C, Netea MG, Kumar V.

J Infect Dis. 2019 Jul 31;220(5):862-872. doi: 10.1093/infdis/jiz206.


Pharmacodynamics of Isavuconazole in a Rabbit Model of Cryptococcal Meningoencephalitis.

Kovanda LL, Giamberardino C, McEntee L, Toffaletti DL, Franke KS, Bartuska A, Smilnak G, de Castro GC, Ripple K, Hope WW, Perfect JR.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00546-19. doi: 10.1128/AAC.00546-19. Print 2019 Sep.


Performance of the T2Bacteria Panel for Diagnosing Bloodstream Infections: A Diagnostic Accuracy Study.

Nguyen MH, Clancy CJ, Pasculle AW, Pappas PG, Alangaden G, Pankey GA, Schmitt BH, Rasool A, Weinstein MP, Widen R, Hernandez DR, Wolk DM, Walsh TJ, Perfect JR, Wilson MN, Mylonakis E.

Ann Intern Med. 2019 Jun 18;170(12):845-852. doi: 10.7326/M18-2772. Epub 2019 May 14.


Genotypic diversity and clinical outcome of cryptococcosis in renal transplant recipients in Brazil.

Ponzio V, Chen Y, Rodrigues AM, Tenor JL, Toffaletti DL, Medina-Pestana JO, Colombo AL, Perfect JR.

Emerg Microbes Infect. 2019;8(1):119-129. doi: 10.1080/22221751.2018.1562849.


Invasive Fungal Infection after Lung Transplantation: Epidemiology in the Setting of Antifungal Prophylaxis.

Baker AW, Maziarz EK, Arnold CJ, Johnson MD, Workman AD, Reynolds JM, Perfect JR, Alexander BD.

Clin Infect Dis. 2019 Feb 25. pii: ciz156. doi: 10.1093/cid/ciz156. [Epub ahead of print]


Phenotypic Variability Correlates with Clinical Outcome in Cryptococcus Isolates Obtained from Botswanan HIV/AIDS Patients.

Fernandes KE, Brockway A, Haverkamp M, Cuomo CA, van Ogtrop F, Perfect JR, Carter DA.

MBio. 2018 Oct 23;9(5). pii: e02016-18. doi: 10.1128/mBio.02016-18.


Real-world implications of QT prolongation in patients receiving voriconazole and amiodarone.

Mourad A, Stiber JA, Perfect JR, Johnson MD.

J Antimicrob Chemother. 2019 Jan 1;74(1):228-233. doi: 10.1093/jac/dky392.


Pulmonary blastomycosis presenting as primary lung cancer.

Hussaini SMQ, Madut D, Tong BC, Pavlisko EN, Schell WA, Perfect JR, Thielman NM.

BMC Infect Dis. 2018 Jul 18;18(1):336. doi: 10.1186/s12879-018-3244-0.


Present and Future Therapy of Cryptococcus Infections.

Mourad A, Perfect JR.

J Fungi (Basel). 2018 Jul 3;4(3). pii: E79. doi: 10.3390/jof4030079. Review.


On-demand release of Candida albicans biofilms from urinary catheters by mechanical surface deformation.

Maskarinec SA, Parlak Z, Tu Q, Levering V, Zauscher S, López GP, Fowler VG Jr, Perfect JR.

Biofouling. 2018 Jul;34(6):595-604. doi: 10.1080/08927014.2018.1474461. Epub 2018 Jun 13.


In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus.

Shaw KJ, Schell WA, Covel J, Duboc G, Giamberardino C, Kapoor M, Moloney M, Soltow QA, Tenor JL, Toffaletti DL, Trzoss M, Webb P, Perfect JR.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00523-18. doi: 10.1128/AAC.00523-18. Print 2018 Aug.


Genomic characterization of recurrent mold infections in thoracic transplant recipients.

Messina JA, Wolfe CR, Hemmersbach-Miller M, Milano C, Todd JL, Reynolds J, Alexander BD, Schell WA, Cuomo CA, Perfect JR.

Transpl Infect Dis. 2018 Oct;20(5):e12935. doi: 10.1111/tid.12935. Epub 2018 Jun 19.


Novel Treatment of Cryptococcal Meningitis via Neurapheresis Therapy.

Smilnak GJ, Charalambous LT, Cutshaw D, Premji AM, Giamberardino CD, Ballard CG, Bartuska AP, Ejikeme TU, Sheng H, Verbick LZ, Hedstrom BA, Pagadala PC, McCabe AR, Perfect JR, Lad SP.

J Infect Dis. 2018 Aug 24;218(7):1147-1154. doi: 10.1093/infdis/jiy286.


Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators.

Hommel B, Mukaremera L, Cordero RJB, Coelho C, Desjardins CA, Sturny-Leclère A, Janbon G, Perfect JR, Fraser JA, Casadevall A, Cuomo CA, Dromer F, Nielsen K, Alanio A.

PLoS Pathog. 2018 May 18;14(5):e1006982. doi: 10.1371/journal.ppat.1006982. eCollection 2018 May.


Outcomes of cryptococcosis in renal transplant recipients in a less-resourced health care system.

Ponzio V, Camargo LF, Medina-Pestana J, Perfect JR, Colombo AL.

Transpl Infect Dis. 2018 Aug;20(4):e12910. doi: 10.1111/tid.12910. Epub 2018 May 30.


Isavuconazole for treatment of rare invasive fungal diseases.

Cornely OA, Mullane KM, Ostrosky-Zeichner L, Maher RM, Croos-Dabrera R, Lu Q, Lademacher C, Perfect JR, Oren I, Schmitt-Hoffmann AH, Giladi M, Marty FM, Rahav G.

Mycoses. 2018 Aug;61(8):518-533. doi: 10.1111/myc.12778.


Isavuconazole for treatment of invasive fungal diseases caused by more than one fungal species.

Marty FM, Cornely OA, Mullane KM, Ostrosky-Zeichner L, Maher RM, Croos-Dabrera R, Lu Q, Lademacher C, Oren I, Schmitt-Hoffmann AH, Giladi M, Rahav G, Perfect JR.

Mycoses. 2018 Jul;61(7):485-497. doi: 10.1111/myc.12777. Epub 2018 Apr 26.


Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans.

Garcia-Santamarina S, Festa RA, Smith AD, Yu CH, Probst C, Ding C, Homer CM, Yin J, Noonan JP, Madhani H, Perfect JR, Thiele DJ.

Mol Microbiol. 2018 Jun;108(5):473-494. doi: 10.1111/mmi.13960. Epub 2018 Apr 24.


Isavuconazole treatment for rare fungal diseases and for invasive aspergillosis in patients with renal impairment: Challenges and lessons of the VITAL trial.

Perfect JR, Cornely OA, Heep M, Ostrosky-Zeichner L, Mullane KM, Maher R, Croos-Dabrera R, Lademacher C, Engelhardt M, Chen C, Marty FM.

Mycoses. 2018 Jul;61(7):420-429. doi: 10.1111/myc.12769. Epub 2018 Apr 19. Review.


The war on cryptococcosis: A Review of the antifungal arsenal.

Mourad A, Perfect JR.

Mem Inst Oswaldo Cruz. 2018;113(7):e170391. doi: 10.1590/0074-02760170391. Epub 2018 Feb 19. Review.


Tolerability profile of the current antifungal armoury.

Mourad A, Perfect JR.

J Antimicrob Chemother. 2018 Jan 1;73(suppl_1):i26-i32. doi: 10.1093/jac/dkx446. Review.


Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States.

Charalambous LT, Premji A, Tybout C, Hunt A, Cutshaw D, Elsamadicy AA, Yang S, Xie J, Giamberardino C, Pagadala P, Perfect JR, Lad SP.

J Med Microbiol. 2018 Feb;67(2):215-227. doi: 10.1099/jmm.0.000656. Epub 2017 Dec 15.


Management of an Outbreak of Exophiala dermatitidis Bloodstream Infections at an Outpatient Oncology Clinic.

Vasquez A, Zavasky D, Chow NA, Gade L, Zlatanic E, Elkind S, Litvintseva AP, Pappas PG, Perfect JR, Revankar S, Lockhart SR, Chiller T, Ackelsberg J, Vallabhaneni S.

Clin Infect Dis. 2018 Mar 5;66(6):959-962. doi: 10.1093/cid/cix948.


Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi.

McCarthy MW, Kontoyiannis DP, Cornely OA, Perfect JR, Walsh TJ.

J Infect Dis. 2017 Aug 15;216(suppl_3):S474-S483. doi: 10.1093/infdis/jix130. Review.


Emergence of the Molds Other than Aspergillus in Immunocompromised Patients.

Arif S, Perfect JR.

Clin Chest Med. 2017 Sep;38(3):555-573. doi: 10.1016/j.ccm.2017.04.014. Epub 2017 Jun 2. Review.


Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.

Miao Y, Tenor JL, Toffaletti DL, Maskarinec SA, Liu J, Lee RE, Perfect JR, Brennan RG.

MBio. 2017 Jul 25;8(4). pii: e00643-17. doi: 10.1128/mBio.00643-17.


An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility.

Matzaraki V, Gresnigt MS, Jaeger M, Ricaño-Ponce I, Johnson MD, Oosting M, Franke L, Withoff S, Perfect JR, Joosten LAB, Kullberg BJ, van de Veerdonk FL, Jonkers I, Li Y, Wijmenga C, Netea MG, Kumar V.

PLoS One. 2017 Jul 20;12(7):e0180824. doi: 10.1371/journal.pone.0180824. eCollection 2017.


Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level.

Rhodes J, Desjardins CA, Sykes SM, Beale MA, Vanhove M, Sakthikumar S, Chen Y, Gujja S, Saif S, Chowdhary A, Lawson DJ, Ponzio V, Colombo AL, Meyer W, Engelthaler DM, Hagen F, Illnait-Zaragozi MT, Alanio A, Vreulink JM, Heitman J, Perfect JR, Litvintseva AP, Bicanic T, Harrison TS, Fisher MC, Cuomo CA.

Genetics. 2017 Sep;207(1):327-346. doi: 10.1534/genetics.117.203836. Epub 2017 Jul 5.


Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans.

Desjardins CA, Giamberardino C, Sykes SM, Yu CH, Tenor JL, Chen Y, Yang T, Jones AM, Sun S, Haverkamp MR, Heitman J, Litvintseva AP, Perfect JR, Cuomo CA.

Genome Res. 2017 Jul;27(7):1207-1219. doi: 10.1101/gr.218727.116.


Fungi that Infect Humans.

Köhler JR, Hube B, Puccia R, Casadevall A, Perfect JR.

Microbiol Spectr. 2017 Jun;5(3). doi: 10.1128/microbiolspec.FUNK-0014-2016. Review.


The antifungal pipeline: a reality check.

Perfect JR.

Nat Rev Drug Discov. 2017 Sep;16(9):603-616. doi: 10.1038/nrd.2017.46. Epub 2017 May 12. Review.


Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib.

Messina JA, Maziarz EK, Spec A, Kontoyiannis DP, Perfect JR.

Open Forum Infect Dis. 2017 Feb 9;4(1):ofw261. doi: 10.1093/ofid/ofw261. eCollection 2017 Winter.


Experimental Models of Short Courses of Liposomal Amphotericin B for Induction Therapy for Cryptococcal Meningitis.

Lestner J, McEntee L, Johnson A, Livermore J, Whalley S, Schwartz J, Perfect JR, Harrison T, Hope W.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00090-17. doi: 10.1128/AAC.00090-17. Print 2017 Jun.


Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development.

Thammahong A, Puttikamonkul S, Perfect JR, Brennan RG, Cramer RA.

Microbiol Mol Biol Rev. 2017 Mar 15;81(2). pii: e00053-16. doi: 10.1128/MMBR.00053-16. Print 2017 Jun. Review.


Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. grubii and C. gattii.

Chen Y, Farrer RA, Giamberardino C, Sakthikumar S, Jones A, Yang T, Tenor JL, Wagih O, Van Wyk M, Govender NP, Mitchell TG, Litvintseva AP, Cuomo CA, Perfect JR.

MBio. 2017 Mar 7;8(2). pii: e00166-17. doi: 10.1128/mBio.00166-17.


The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis.

Kwon-Chung KJ, Bennett JE, Wickes BL, Meyer W, Cuomo CA, Wollenburg KR, Bicanic TA, Castañeda E, Chang YC, Chen J, Cogliati M, Dromer F, Ellis D, Filler SG, Fisher MC, Harrison TS, Holland SM, Kohno S, Kronstad JW, Lazera M, Levitz SM, Lionakis MS, May RC, Ngamskulrongroj P, Pappas PG, Perfect JR, Rickerts V, Sorrell TC, Walsh TJ, Williamson PR, Xu J, Zelazny AM, Casadevall A.

mSphere. 2017 Jan 11;2(1). pii: e00357-16. doi: 10.1128/mSphere.00357-16. eCollection 2017 Jan-Feb.


The current treatment landscape: other fungal diseases (cryptococcosis, fusariosis and mucormycosis).

Lortholary O, Fernández-Ruiz M, Perfect JR.

J Antimicrob Chemother. 2016 Nov;71(suppl 2):ii31-ii36.


Comparing outcomes of early, late, and non-surgical management of intraspinal abscess.

Farber SH, Murphy KR, Suryadevara CM, Babu R, Yang S, Feng L, Xie J, Perfect JR, Lad SP.

J Clin Neurosci. 2017 Feb;36:64-71. doi: 10.1016/j.jocn.2016.10.035. Epub 2016 Nov 9.


Familial Adenomatous Polyposis Manifesting as Lactococcus Endocarditis: A Case Report and Review of the Association of Lactococcus with Underlying Gastrointestinal Disease.

Bazemore TC, Maskarinec SA, Zietlow K, Hendershot EF, Perfect JR.

Case Rep Infect Dis. 2016;2016:5805326. Epub 2016 Oct 12.


Simple Strategy for Taming Membrane-Disrupting Antibiotics.

Yu Y, Sabulski MJ, Schell WA, Pires MM, Perfect JR, Regen SL.

Bioconjug Chem. 2016 Dec 21;27(12):2850-2853. doi: 10.1021/acs.bioconjchem.6b00629. Epub 2016 Nov 9.


Curious Crosses: Injection-Induced Lesions.

Bhatt AS, Perkins S, McKinnon E, Perfect JR.

Am J Med. 2017 Jan;130(1):31-33. doi: 10.1016/j.amjmed.2016.08.023. Epub 2016 Sep 9. No abstract available.


Repeated therapeutic lumbar punctures in cryptococcal meningitis - necessity and/or opportunity?

Chang CC, Perfect JR.

Curr Opin Infect Dis. 2016 Dec;29(6):539-545. Review.


Copy number variation contributes to cryptic genetic variation in outbreak lineages of Cryptococcus gattii from the North American Pacific Northwest.

Steenwyk JL, Soghigian JS, Perfect JR, Gibbons JG.

BMC Genomics. 2016 Sep 2;17:700. doi: 10.1186/s12864-016-3044-0.


Genetic Susceptibility to Fungal Infections: What is in the Genes?

Maskarinec SA, Johnson MD, Perfect JR.

Curr Clin Microbiol Rep. 2016 Jun;3(2):81-91. Epub 2016 Mar 29.


Reply to Argüelles.

Perfect JR.

Virulence. 2017 Feb 17;8(2):239. doi: 10.1080/21505594.2016.1221249. Epub 2016 Aug 5. No abstract available.


Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.

Miao Y, Tenor JL, Toffaletti DL, Washington EJ, Liu J, Shadrick WR, Schumacher MA, Lee RE, Perfect JR, Brennan RG.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7148-53. doi: 10.1073/pnas.1601774113. Epub 2016 Jun 15.


The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans.

Caza M, Hu G, Price M, Perfect JR, Kronstad JW.

mSphere. 2016 Jan 13;1(1). pii: e00080-15. doi: 10.1128/mSphere.00080-15. eCollection 2016 Jan-Feb.


Trehalose pathway as an antifungal target.

Perfect JR, Tenor JL, Miao Y, Brennan RG.

Virulence. 2017 Feb 17;8(2):143-149. doi: 10.1080/21505594.2016.1195529. Epub 2016 Jun 1. Review.

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