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Items: 1 to 50 of 148

1.

Inhibition of T-Type calcium channels in mEC layer II stellate neurons reduces neuronal hyperexcitability associated with epilepsy.

Nigam A, Hargus NJ, Barker BS, Ottolini M, Hounshell JA, Bertram EH 3rd, Perez-Reyes E, Patel MK.

Epilepsy Res. 2019 Aug;154:132-138. doi: 10.1016/j.eplepsyres.2019.05.006. Epub 2019 May 18.

PMID:
31132598
2.

Primary aldosteronism associated with a germline variant in CACNA1H.

Wulczyn K, Perez-Reyes E, Nussbaum RL, Park M.

BMJ Case Rep. 2019 May 23;12(5). pii: e229031. doi: 10.1136/bcr-2018-229031.

PMID:
31126930
3.

LMO7 deficiency reveals the significance of the cuticular plate for hearing function.

Du TT, Dewey JB, Wagner EL, Cui R, Heo J, Park JJ, Francis SP, Perez-Reyes E, Guillot SJ, Sherman NE, Xu W, Oghalai JS, Kachar B, Shin JB.

Nat Commun. 2019 Mar 8;10(1):1117. doi: 10.1038/s41467-019-09074-4.

4.

CACHD1 is an α2δ-Like Protein That Modulates CaV3 Voltage-Gated Calcium Channel Activity.

Cottrell GS, Soubrane CH, Hounshell JA, Lin H, Owenson V, Rigby M, Cox PJ, Barker BS, Ottolini M, Ince S, Bauer CC, Perez-Reyes E, Patel MK, Stevens EB, Stephens GJ.

J Neurosci. 2018 Oct 24;38(43):9186-9201. doi: 10.1523/JNEUROSCI.3572-15.2018. Epub 2018 Sep 4.

5.

Functional variants in HCN4 and CACNA1H may contribute to genetic generalized epilepsy.

Becker F, Reid CA, Hallmann K, Tae HS, Phillips AM, Teodorescu G, Weber YG, Kleefuss-Lie A, Elger C, Perez-Reyes E, Petrou S, Kunz WS, Lerche H, Maljevic S.

Epilepsia Open. 2017 Aug 5;2(3):334-342. doi: 10.1002/epi4.12068. eCollection 2017 Sep.

6.

A novel therapeutic approach for treatment of catamenial epilepsy.

Joshi S, Sun H, Rajasekaran K, Williamson J, Perez-Reyes E, Kapur J.

Neurobiol Dis. 2018 Mar;111:127-137. doi: 10.1016/j.nbd.2017.12.009. Epub 2017 Dec 21.

7.

Calmodulin regulates Cav3 T-type channels at their gating brake.

Chemin J, Taiakina V, Monteil A, Piazza M, Guan W, Stephens RF, Kitmitto A, Pang ZP, Dolphin AC, Perez-Reyes E, Dieckmann T, Guillemette JG, Spafford JD.

J Biol Chem. 2017 Dec 8;292(49):20010-20031. doi: 10.1074/jbc.M117.807925. Epub 2017 Sep 25.

8.

Ca2+ Regulation of Cav3.3 T-type Ca2+ Channel Is Mediated by Calmodulin.

Lee N, Jeong S, Kim KC, Kim JA, Park JY, Kang HW, Perez-Reyes E, Lee JH.

Mol Pharmacol. 2017 Sep;92(3):347-357. doi: 10.1124/mol.117.108530. Epub 2017 Jul 10.

PMID:
28696213
9.

Malnutrition negatively impacts the quality of life of patients with cirrhosis: An observational study.

Rojas-Loureiro G, Servín-Caamaño A, Pérez-Reyes E, Servín-Abad L, Higuera-de la Tijera F.

World J Hepatol. 2017 Feb 18;9(5):263-269. doi: 10.4254/wjh.v9.i5.263.

10.

Nalcn Is a "Leak" Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing.

Shi Y, Abe C, Holloway BB, Shu S, Kumar NN, Weaver JL, Sen J, Perez-Reyes E, Stornetta RL, Guyenet PG, Bayliss DA.

J Neurosci. 2016 Aug 3;36(31):8174-87. doi: 10.1523/JNEUROSCI.1096-16.2016.

11.

Central Mechanisms Mediating Thrombospondin-4-induced Pain States.

Park J, Yu YP, Zhou CY, Li KW, Wang D, Chang E, Kim DS, Vo B, Zhang X, Gong N, Sharp K, Steward O, Vitko I, Perez-Reyes E, Eroglu C, Barres B, Zaucke F, Feng G, Luo ZD.

J Biol Chem. 2016 Jun 17;291(25):13335-48. doi: 10.1074/jbc.M116.723478. Epub 2016 Apr 19.

12.

Activation of Pyramidal Neurons in Mouse Medial Prefrontal Cortex Enhances Food-Seeking Behavior While Reducing Impulsivity in the Absence of an Effect on Food Intake.

Warthen DM, Lambeth PS, Ottolini M, Shi Y, Barker BS, Gaykema RP, Newmyer BA, Joy-Gaba J, Ohmura Y, Perez-Reyes E, Güler AD, Patel MK, Scott MM.

Front Behav Neurosci. 2016 Mar 30;10:63. doi: 10.3389/fnbeh.2016.00063. eCollection 2016.

13.

Contrasting the roles of the I-II loop gating brake in CaV3.1 and CaV3.3 calcium channels.

Karmažínová M, Jašková K, Griac P, Perez-Reyes E, Lacinová Ľ.

Pflugers Arch. 2015 Dec;467(12):2519-27. doi: 10.1007/s00424-015-1728-y. Epub 2015 Aug 26.

PMID:
26306541
14.

CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy.

Wang G, Bochorishvili G, Chen Y, Salvati KA, Zhang P, Dubel SJ, Perez-Reyes E, Snutch TP, Stornetta RL, Deisseroth K, Erisir A, Todorovic SM, Luo JH, Kapur J, Beenhakker MP, Zhu JJ.

Genes Dev. 2015 Jul 15;29(14):1535-51. doi: 10.1101/gad.260869.115.

15.

PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.

Kumar NN, Velic A, Soliz J, Shi Y, Li K, Wang S, Weaver JL, Sen J, Abbott SB, Lazarenko RM, Ludwig MG, Perez-Reyes E, Mohebbi N, Bettoni C, Gassmann M, Suply T, Seuwen K, Guyenet PG, Wagner CA, Bayliss DA.

Science. 2015 Jun 12;348(6240):1255-60. doi: 10.1126/science.aaa0922. Epub 2015 Jun 11.

16.

[Reversal of acute liver failure with N-acetylcysteine and prednisone in a patient with DRESS syndrome: a case report and literature review].

Pérez-Reyes E, Casanova-Lara A, Pérez-Torres E, Córdova J.

Rev Gastroenterol Mex. 2014 Jul-Sep;79(3):208-10. doi: 10.1016/j.rgmx.2014.01.003. Epub 2014 May 22. Review. Spanish. No abstract available.

17.

Ins and outs of T-channel structure function.

Perez-Reyes E, Lee JH.

Pflugers Arch. 2014 Apr;466(4):627-33. doi: 10.1007/s00424-013-1419-5. Epub 2013 Dec 14. Review.

PMID:
24337909
18.

A potassium leak channel silences hyperactive neurons and ameliorates status epilepticus.

Dey D, Eckle VS, Vitko I, Sullivan KA, Lasiecka ZM, Winckler B, Stornetta RL, Williamson JM, Kapur J, Perez-Reyes E.

Epilepsia. 2014 Feb;55(2):203-13. doi: 10.1111/epi.12472. Epub 2013 Dec 2.

19.

Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility.

Eckle VS, Shcheglovitov A, Vitko I, Dey D, Yap CC, Winckler B, Perez-Reyes E.

J Physiol. 2014 Feb 15;592(4):795-809. doi: 10.1113/jphysiol.2013.264176. Epub 2013 Nov 25.

20.

Effects of eugenol on T-type Ca2+ channel isoforms.

Seo H, Li HY, Perez-Reyes E, Lee JH.

J Pharmacol Exp Ther. 2013 Nov;347(2):310-7. doi: 10.1124/jpet.113.207936. Epub 2013 Sep 6.

PMID:
24014106
21.

Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels.

Shcheglovitov A, Vitko I, Lazarenko RM, Orestes P, Todorovic SM, Perez-Reyes E.

J Gen Physiol. 2012 Mar;139(3):219-34. doi: 10.1085/jgp.201110699. Erratum in: J Gen Physiol. 2012 May;139(5):389.

22.

Enhanced actions of adenosine in medial entorhinal cortex layer II stellate neurons in temporal lobe epilepsy are mediated via A(1)-receptor activation.

Hargus NJ, Jennings C, Perez-Reyes E, Bertram EH, Patel MK.

Epilepsia. 2012 Jan;53(1):168-76. doi: 10.1111/j.1528-1167.2011.03337.x. Epub 2011 Nov 29.

23.

The voltage dependence of gating currents of the neuronal CA(v)3.3 channel is determined by the gating brake in the I-II loop.

Karmažínová M, Baumgart JP, Perez-Reyes E, Lacinová L.

Pflugers Arch. 2011 Apr;461(4):461-8. doi: 10.1007/s00424-011-0937-2. Epub 2011 Feb 23.

24.

Characterization of the gating brake in the I-II loop of CaV3 T-type calcium channels.

Perez-Reyes E.

Channels (Austin). 2010 Nov-Dec;4(6):453-8. Epub 2010 Nov 1. Review.

25.

T-type Ca(2+) channel modulation by otilonium bromide.

Strege PR, Sha L, Beyder A, Bernard CE, Perez-Reyes E, Evangelista S, Gibbons SJ, Szurszewski JH, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G706-13. doi: 10.1152/ajpgi.00437.2009. Epub 2010 Mar 4.

26.

Role of voltage-gated calcium channels in epilepsy.

Zamponi GW, Lory P, Perez-Reyes E.

Pflugers Arch. 2010 Jul;460(2):395-403. doi: 10.1007/s00424-009-0772-x. Epub 2009 Dec 20. Review.

27.

Structural determinants of the high affinity extracellular zinc binding site on Cav3.2 T-type calcium channels.

Kang HW, Vitko I, Lee SS, Perez-Reyes E, Lee JH.

J Biol Chem. 2010 Jan 29;285(5):3271-81. doi: 10.1074/jbc.M109.067660. Epub 2009 Nov 23.

28.

G protein-mediated inhibition of Cav3.2 T-type channels revisited.

Perez-Reyes E.

Mol Pharmacol. 2010 Feb;77(2):136-8. doi: 10.1124/mol.109.062133. Epub 2009 Nov 10. Review.

PMID:
19903827
29.

Orientation of palmitoylated CaVbeta2a relative to CaV2.2 is critical for slow pathway modulation of N-type Ca2+ current by tachykinin receptor activation.

Mitra-Ganguli T, Vitko I, Perez-Reyes E, Rittenhouse AR.

J Gen Physiol. 2009 Nov;134(5):385-96. doi: 10.1085/jgp.200910204.

30.

Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway.

Lee WY, Orestes P, Latham J, Naik AK, Nelson MT, Vitko I, Perez-Reyes E, Jevtovic-Todorovic V, Todorovic SM.

J Neurosci. 2009 Jul 29;29(30):9500-9. doi: 10.1523/JNEUROSCI.5803-08.2009.

31.

Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs.

Perez-Reyes E, Van Deusen AL, Vitko I.

J Pharmacol Exp Ther. 2009 Feb;328(2):621-7. doi: 10.1124/jpet.108.145672. Epub 2008 Oct 30.

32.

Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity.

Vitko I, Shcheglovitov A, Baumgart JP, Arias-Olguín II, Murbartián J, Arias JM, Perez-Reyes E.

PLoS One. 2008;3(10):e3560. doi: 10.1371/journal.pone.0003560. Epub 2008 Oct 29.

33.

Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels.

Shcheglovitov A, Vitko I, Bidaud I, Baumgart JP, Navarro-Gonzalez MF, Grayson TH, Lory P, Hill CE, Perez-Reyes E.

FEBS Lett. 2008 Nov 12;582(27):3765-70. doi: 10.1016/j.febslet.2008.10.013. Epub 2008 Oct 16.

34.

T-type calcium channels: from discovery to channelopathies, 25 years of research.

Shuba YM, Perez-Reyes E, Lory P, Noebels J.

Channels (Austin). 2008 Jul-Aug;2(4):299-302. Epub 2008 Jul 10. No abstract available.

PMID:
18769138
35.

I-II loop structural determinants in the gating and surface expression of low voltage-activated calcium channels.

Baumgart JP, Vitko I, Bidaud I, Kondratskyi A, Lory P, Perez-Reyes E.

PLoS One. 2008 Aug 20;3(8):e2976. doi: 10.1371/journal.pone.0002976.

36.

Characterization of the gating brake in the I-II loop of Ca(v)3.2 T-type Ca(2+) channels.

Arias-Olguín II, Vitko I, Fortuna M, Baumgart JP, Sokolova S, Shumilin IA, Van Deusen A, Soriano-García M, Gomora JC, Perez-Reyes E.

J Biol Chem. 2008 Mar 28;283(13):8136-44. doi: 10.1074/jbc.M708761200. Epub 2008 Jan 24.

37.

Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate.

Nelson MT, Joksovic PM, Su P, Kang HW, Van Deusen A, Baumgart JP, David LS, Snutch TP, Barrett PQ, Lee JH, Zorumski CF, Perez-Reyes E, Todorovic SM.

J Neurosci. 2007 Nov 14;27(46):12577-83.

38.

Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels.

Nelson MT, Woo J, Kang HW, Vitko I, Barrett PQ, Perez-Reyes E, Lee JH, Shin HS, Todorovic SM.

J Neurosci. 2007 Aug 1;27(31):8250-60.

39.

Validation of high throughput screening assays against three subtypes of Ca(v)3 T-type channels using molecular and pharmacologic approaches.

Xie X, Van Deusen AL, Vitko I, Babu DA, Davies LA, Huynh N, Cheng H, Yang N, Barrett PQ, Perez-Reyes E.

Assay Drug Dev Technol. 2007 Apr;5(2):191-203.

PMID:
17477828
40.

The I-II loop controls plasma membrane expression and gating of Ca(v)3.2 T-type Ca2+ channels: a paradigm for childhood absence epilepsy mutations.

Vitko I, Bidaud I, Arias JM, Mezghrani A, Lory P, Perez-Reyes E.

J Neurosci. 2007 Jan 10;27(2):322-30.

41.

Molecular biology of T-type calcium channels.

Perez-Reyes E, Lory P.

CNS Neurol Disord Drug Targets. 2006 Dec;5(6):605-9. Review.

PMID:
17168745
42.

Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms.

Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K.

Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7.

PMID:
16899990
43.

The role of T-type calcium channels in epilepsy and pain.

Nelson MT, Todorovic SM, Perez-Reyes E.

Curr Pharm Des. 2006;12(18):2189-97. Review.

PMID:
16787249
44.

Molecular characterization of T-type calcium channels.

Perez-Reyes E.

Cell Calcium. 2006 Aug;40(2):89-96. Epub 2006 Jun 8. Review.

PMID:
16759699
45.

CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus.

Joksovic PM, Nelson MT, Jevtovic-Todorovic V, Patel MK, Perez-Reyes E, Campbell KP, Chen CC, Todorovic SM.

J Physiol. 2006 Jul 15;574(Pt 2):415-30. Epub 2006 Apr 27.

46.

T-type Ca2+ channels encode prior neuronal activity as modulated recovery rates.

Uebachs M, Schaub C, Perez-Reyes E, Beck H.

J Physiol. 2006 Mar 15;571(Pt 3):519-36. Epub 2006 Jan 19.

47.

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J.

Pharmacol Rev. 2005 Dec;57(4):411-25. Review.

PMID:
16382099
48.

A molecular determinant of nickel inhibition in Cav3.2 T-type calcium channels.

Kang HW, Park JY, Jeong SW, Kim JA, Moon HJ, Perez-Reyes E, Lee JH.

J Biol Chem. 2006 Feb 24;281(8):4823-30. Epub 2005 Dec 23.

49.
50.

Transfer of beta subunit regulation from high to low voltage-gated Ca2+ channels.

Arias JM, Murbartián J, Vitko I, Lee JH, Perez-Reyes E.

FEBS Lett. 2005 Jul 18;579(18):3907-12.

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