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Items: 1 to 50 of 62


Multiplexed and tunable transcriptional activation by promoter insertion using nuclease-assisted vector integration.

Brown A, Winter J, Gapinske M, Tague N, Woods WS, Perez-Pinera P.

Nucleic Acids Res. 2019 Jul 9;47(12):e67. doi: 10.1093/nar/gkz210.


The continuously evolving CRISPR barcoding toolbox.

Gaj T, Perez-Pinera P.

Genome Biol. 2018 Sep 25;19(1):143. doi: 10.1186/s13059-018-1541-y.


Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner.

Mancini A, Xavier-Magalhães A, Woods WS, Nguyen KT, Amen AM, Hayes JL, Fellmann C, Gapinske M, McKinney AM, Hong C, Jones LE, Walsh KM, Bell RJA, Doudna JA, Costa BM, Song JS, Perez-Pinera P, Costello JF.

Cancer Cell. 2018 Sep 10;34(3):513-528.e8. doi: 10.1016/j.ccell.2018.08.003.


CRISPR-SKIP: programmable gene splicing with single base editors.

Gapinske M, Luu A, Winter J, Woods WS, Kostan KA, Shiva N, Song JS, Perez-Pinera P.

Genome Biol. 2018 Aug 15;19(1):107. doi: 10.1186/s13059-018-1482-5.


Targeted Gene Knock Out Using Nuclease-Assisted Vector Integration: Hemi- and Homozygous Deletion of JAG1.

Gapinske M, Tague N, Winter J, Underhill GH, Perez-Pinera P.

Methods Mol Biol. 2018;1772:233-248. doi: 10.1007/978-1-4939-7795-6_13.


Versatile and on-demand biologics co-production in yeast.

Cao J, Perez-Pinera P, Lowenhaupt K, Wu MR, Purcell O, de la Fuente-Nunez C, Lu TK.

Nat Commun. 2018 Jan 8;9(1):77. doi: 10.1038/s41467-017-02587-w.


Production of Functional Anti-Ebola Antibodies in Pichia pastoris.

Purcell O, Opdensteinen P, Chen W, Lowenhaupt K, Brown A, Hermann M, Cao J, Tenhaef N, Kallweit E, Kastilan R, Sinskey AJ, Perez-Pinera P, Buyel JF, Lu TK.

ACS Synth Biol. 2017 Dec 15;6(12):2183-2190. doi: 10.1021/acssynbio.7b00234. Epub 2017 Aug 17.


Mammalian Synthetic Biology: Engineering Biological Systems.

Black JB, Perez-Pinera P, Gersbach CA.

Annu Rev Biomed Eng. 2017 Jun 21;19:249-277. doi: 10.1146/annurev-bioeng-071516-044649. Review.


Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3.

Chaudhary R, Gryder B, Woods WS, Subramanian M, Jones MF, Li XL, Jenkins LM, Shabalina SA, Mo M, Dasso M, Yang Y, Wakefield LM, Zhu Y, Frier SM, Moriarity BS, Prasanth KV, Perez-Pinera P, Lal A.

Elife. 2017 Jun 5;6. pii: e23244. doi: 10.7554/eLife.23244.


Design and integration of a problem-based biofabrication course into an undergraduate biomedical engineering curriculum.

Raman R, Mitchell M, Perez-Pinera P, Bashir R, DeStefano L.

J Biol Eng. 2016 Sep 21;10:10. doi: 10.1186/s13036-016-0032-5. eCollection 2016.


Targeted Gene Activation Using RNA-Guided Nucleases.

Brown A, Woods WS, Perez-Pinera P.

Methods Mol Biol. 2017;1468:235-50. doi: 10.1007/978-1-4939-4035-6_16.


Biomedical applications of gene editing.

Perez-Pinera P, Chen ZY.

Hum Genet. 2016 Sep;135(9):967-9. doi: 10.1007/s00439-016-1723-1. No abstract available.


Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care.

Perez-Pinera P, Han N, Cleto S, Cao J, Purcell O, Shah KA, Lee K, Ram R, Lu TK.

Nat Commun. 2016 Jul 29;7:12211. doi: 10.1038/ncomms12211.


Multiplexed Targeted Genome Engineering Using a Universal Nuclease-Assisted Vector Integration System.

Brown A, Woods WS, Perez-Pinera P.

ACS Synth Biol. 2016 Jul 15;5(7):582-8. doi: 10.1021/acssynbio.6b00056. Epub 2016 May 9.


In Vivo Zinc Finger Nuclease-mediated Targeted Integration of a Glucose-6-phosphatase Transgene Promotes Survival in Mice With Glycogen Storage Disease Type IA.

Landau DJ, Brooks ED, Perez-Pinera P, Amarasekara H, Mefferd A, Li S, Bird A, Gersbach CA, Koeberl DD.

Mol Ther. 2016 Apr;24(4):697-706. doi: 10.1038/mt.2016.35. Epub 2016 Feb 11.


Engineering Synthetic Gene Circuits in Living Cells with CRISPR Technology.

Jusiak B, Cleto S, Perez-Piñera P, Lu TK.

Trends Biotechnol. 2016 Jul;34(7):535-547. doi: 10.1016/j.tibtech.2015.12.014. Epub 2016 Jan 22. Review.


Putting Non-coding RNA on Display with CRISPR.

Perez-Pinera P, Jones MF, Lal A, Lu TK.

Mol Cell. 2015 Jul 16;59(2):146-8. doi: 10.1016/j.molcel.2015.07.002.


Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators.

Polstein LR, Perez-Pinera P, Kocak DD, Vockley CM, Bledsoe P, Song L, Safi A, Crawford GE, Reddy TE, Gersbach CA.

Genome Res. 2015 Aug;25(8):1158-69. doi: 10.1101/gr.179044.114. Epub 2015 May 29.


Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases.

Ousterout DG, Kabadi AM, Thakore PI, Perez-Pinera P, Brown MT, Majoros WH, Reddy TE, Gersbach CA.

Mol Ther. 2015 Mar;23(3):523-32. doi: 10.1038/mt.2014.234. Epub 2014 Dec 10.


Activating human genes with zinc finger proteins, transcription activator-like effectors and CRISPR/Cas9 for gene therapy and regenerative medicine.

Gersbach CA, Perez-Pinera P.

Expert Opin Ther Targets. 2014 Aug;18(8):835-9. doi: 10.1517/14728222.2014.913572. Epub 2014 Jun 11.


Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells.

Nissim L, Perli SD, Fridkin A, Perez-Pinera P, Lu TK.

Mol Cell. 2014 May 22;54(4):698-710. doi: 10.1016/j.molcel.2014.04.022. Epub 2014 May 15.


Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage.

Brunger JM, Huynh NP, Guenther CM, Perez-Pinera P, Moutos FT, Sanchez-Adams J, Gersbach CA, Guilak F.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):E798-806. doi: 10.1073/pnas.1321744111. Epub 2014 Feb 18.


RNA-guided gene activation by CRISPR-Cas9-based transcription factors.

Perez-Pinera P, Kocak DD, Vockley CM, Adler AF, Kabadi AM, Polstein LR, Thakore PI, Glass KA, Ousterout DG, Leong KW, Guilak F, Crawford GE, Reddy TE, Gersbach CA.

Nat Methods. 2013 Oct;10(10):973-6. doi: 10.1038/nmeth.2600. Epub 2013 Jul 25.


Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients.

Ousterout DG, Perez-Pinera P, Thakore PI, Kabadi AM, Brown MT, Qin X, Fedrigo O, Mouly V, Tremblay JP, Gersbach CA.

Mol Ther. 2013 Sep;21(9):1718-26. doi: 10.1038/mt.2013.111. Epub 2013 Jun 4. Erratum in: Mol Ther. 2013 Nov;21(11):2130.


Synergistic and tunable human gene activation by combinations of synthetic transcription factors.

Perez-Pinera P, Ousterout DG, Brunger JM, Farin AM, Glass KA, Guilak F, Crawford GE, Hartemink AJ, Gersbach CA.

Nat Methods. 2013 Mar;10(3):239-42. doi: 10.1038/nmeth.2361. Epub 2013 Feb 3.


Clinical implication of Meissner`s corpuscles.

Vega JA, López-Muñiz A, Calavia MG, García-Suárez O, Cobo J, Otero J, Arias-Carrión O, Pérez-Piñera P, Menéndez-González M.

CNS Neurol Disord Drug Targets. 2012 Nov 1;11(7):856-68. Review.


Advances in targeted genome editing.

Perez-Pinera P, Ousterout DG, Gersbach CA.

Curr Opin Chem Biol. 2012 Aug;16(3-4):268-77. doi: 10.1016/j.cbpa.2012.06.007. Epub 2012 Jul 20. Review.


Pleiotrophin expression during odontogenesis.

Erlandsen H, Ames JE, Tamkenath A, Mamaeva O, Stidham K, Wilson ME, Perez-Pinera P, Deuel TF, Macdougall M.

J Histochem Cytochem. 2012 May;60(5):366-75. doi: 10.1369/0022155412439316. Epub 2012 Feb 29.


Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases.

Perez-Pinera P, Ousterout DG, Brown MT, Gersbach CA.

Nucleic Acids Res. 2012 Apr;40(8):3741-52. doi: 10.1093/nar/gkr1214. Epub 2011 Dec 14.


Immunotherapy for Alzheimer's disease: rational basis in ongoing clinical trials.

Menéndez-González M, Pérez-Piñera P, Martínez-Rivera M, Muñiz AL, Vega JA.

Curr Pharm Des. 2011;17(5):508-20. Review.


Human odontoblasts express transient receptor protein and acid-sensing ion channel mechanosensor proteins.

Solé-Magdalena A, Revuelta EG, Menénez-Díaz I, Calavia MG, Cobo T, García-Suárez O, Pérez-Piñera P, De Carlos F, Cobo J, Vega JA.

Microsc Res Tech. 2011 May;74(5):457-63. doi: 10.1002/jemt.20931. Epub 2010 Sep 10.


Expression and cell localization of brain-derived neurotrophic factor and TrkB during zebrafish retinal development.

Germanà A, Sánchez-Ramos C, Guerrera MC, Calavia MG, Navarro M, Zichichi R, García-Suárez O, Pérez-Piñera P, Vega JA.

J Anat. 2010 Sep;217(3):214-22. doi: 10.1111/j.1469-7580.2010.01268.x. Epub 2010 Jul 21.


Differential localization of Acid-sensing ion channels 1 and 2 in human cutaneus pacinian corpuscles.

Calavia MG, Montaño JA, García-Suárez O, Feito J, Guervós MA, Germanà A, Del Valle M, Pérez-Piñera P, Cobo J, Vega JA.

Cell Mol Neurobiol. 2010 Aug;30(6):841-8. doi: 10.1007/s10571-010-9511-2. Epub 2010 Mar 21.


The neurotrophic factor pleiotrophin modulates amphetamine-seeking behaviour and amphetamine-induced neurotoxic effects: evidence from pleiotrophin knockout mice.

Gramage E, Putelli A, Polanco MJ, González-Martín C, Ezquerra L, Alguacil LF, Pérez-Pinera P, Deuel TF, Herradón G.

Addict Biol. 2010 Oct;15(4):403-12. doi: 10.1111/j.1369-1600.2009.00202.x.


Immunohistochemical profile of human pancreatic pacinian corpuscles.

García-Suárez O, Calavia MG, Pérez-Moltó FJ, Alvarez-Abad C, Pérez-Piñera P, Cobo JM, Vega JA.

Pancreas. 2010 Apr;39(3):403-10. doi: 10.1097/MPA.0b013e3181bc0372.


The lamellar cells in human Meissner corpuscles express TrkB.

Calavia MG, Feito J, López-Iglesias L, de Carlos F, García-Suarez O, Pérez-Piñera P, Cobo J, Vega JA.

Neurosci Lett. 2010 Jan 4;468(2):106-9. doi: 10.1016/j.neulet.2009.10.076. Epub 2009 Oct 29.


Development and neuronal dependence of cutaneous sensory nerve formations: Lessons from neurotrophins.

Montaño JA, Pérez-Piñera P, García-Suárez O, Cobo J, Vega JA.

Microsc Res Tech. 2010 May;73(5):513-29. doi: 10.1002/jemt.20790. Review.


The expression of ENa(+)C and ASIC2 proteins in Pacinian corpuscles is differently regulated by TrkB and its ligands BDNF and NT-4.

Montaño JA, Calavia MG, García-Suárez O, Suarez-Quintanilla JA, Gálvez A, Pérez-Piñera P, Cobo J, Vega JA.

Neurosci Lett. 2009 Oct 2;463(2):114-8. doi: 10.1016/j.neulet.2009.07.073. Epub 2009 Jul 29.


TrkB is necessary for the normal development of the lung.

García-Suárez O, Pérez-Pinera P, Laurà R, Germana A, Esteban I, Cabo R, Silos-Santiago I, Cobo JL, Vega JA.

Respir Physiol Neurobiol. 2009 Jul 31;167(3):281-91. doi: 10.1016/j.resp.2009.06.001. Epub 2009 Jun 10.


Enteric glial cells express full-length TrkB and depend on TrkB expression for normal development.

Levanti MB, Esteban I, Ciriaco E, Pérez-Piñera P, Cabo R, García-Suarez O, Pardo B, Silos-Santiago I, Cobo J, Vega JA.

Neurosci Lett. 2009 Apr 17;454(1):16-21. doi: 10.1016/j.neulet.2009.02.051. Epub 2009 Feb 27.


Pleiotrophin inhibits hippocampal long-term potentiation: a role of pleiotrophin in learning and memory.

del Olmo N, Gramage E, Alguacil LF, Pérez-Pinera P, Deuel TF, Herradón G.

Growth Factors. 2009 Jun;27(3):189-94. doi: 10.1080/08977190902906859.


Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis.

Chen H, Campbell RA, Chang Y, Li M, Wang CS, Li J, Sanchez E, Share M, Steinberg J, Berenson A, Shalitin D, Zeng Z, Gui D, Perez-Pinera P, Berenson RJ, Said J, Bonavida B, Deuel TF, Berenson JR.

Blood. 2009 Feb 26;113(9):1992-2002. doi: 10.1182/blood-2008-02-133751. Epub 2008 Dec 5.


Plasmatic level of neurosin predicts outcome of mild cognitive impairment.

Menendez-Gonzalez M, Castro-Santos P, Calatayud MT, Perez-Piñera P, Ribacoba R, Martinez-Rivera M, Gutierrez C, Lopez-Muñiz A, Suarez A.

Int Arch Med. 2008 Jul 11;1(1):11. doi: 10.1186/1755-7682-1-11.


Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease.

Menendez-Gonzalez M, Castro-Santos P, Suarez A, Calatayud MT, Perez-Pinera P, Martinez M, Ribacoba R, Gutierrez C.

J Alzheimers Dis. 2008 May;14(1):59-67.


Pleiotrophin, a multifunctional angiogenic factor: mechanisms and pathways in normal and pathological angiogenesis.

Perez-Pinera P, Berenson JR, Deuel TF.

Curr Opin Hematol. 2008 May;15(3):210-4. doi: 10.1097/MOH.0b013e3282fdc69e. Review.


Characterization of sensory deficits in TrkB knockout mice.

Perez-Pinera P, García-Suarez O, Germanà A, Díaz-Esnal B, de Carlos F, Silos-Santiago I, del Valle ME, Cobo J, Vega JA.

Neurosci Lett. 2008 Mar 5;433(1):43-7. doi: 10.1016/j.neulet.2007.12.035. Epub 2008 Jan 14.


The receptor protein tyrosine phosphatase (RPTP)beta/zeta is expressed in different subtypes of human breast cancer.

Perez-Pinera P, Garcia-Suarez O, Menendez-Rodriguez P, Mortimer J, Chang Y, Astudillo A, Deuel TF.

Biochem Biophys Res Commun. 2007 Oct 12;362(1):5-10. doi: 10.1016/j.bbrc.2007.06.050. Epub 2007 Jun 18.


Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment.

Chang Y, Zuka M, Perez-Pinera P, Astudillo A, Mortimer J, Berenson JR, Deuel TF.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10888-93. Epub 2007 Jun 19.

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