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Items: 15


A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).

François-Moutal L, Jahanbakhsh S, Nelson ADL, Ray D, Scott DD, Hennefarth MR, Moutal A, Perez-Miller S, Ambrose AJ, Al-Shamari A, Coursodon P, Meechoovet B, Reiman R, Lyons E, Beilstein M, Chapman E, Morris QD, Van Keuren-Jensen K, Hughes TR, Khanna R, Koehler C, Jen J, Gokhale V, Khanna M.

ACS Chem Biol. 2018 Oct 19;13(10):3000-3010. doi: 10.1021/acschembio.8b00745. Epub 2018 Sep 6.


Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels.

François-Moutal L, Scott DD, Perez-Miller S, Gokhale V, Khanna M, Khanna R.

Channels (Austin). 2018;12(1):219-227. doi: 10.1080/19336950.2018.1491244. Epub 2018 Aug 6.


Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain.

François-Moutal L, Dustrude ET, Wang Y, Brustovetsky T, Dorame A, Ju W, Moutal A, Perez-Miller S, Brustovetsky N, Gokhale V, Khanna M, Khanna R.

Pain. 2018 Oct;159(10):2115-2127. doi: 10.1097/j.pain.0000000000001294.


A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.

Dustrude ET, Perez-Miller S, François-Moutal L, Moutal A, Khanna M, Khanna R.

Channels (Austin). 2017 Jul 4;11(4):316-328. doi: 10.1080/19336950.2017.1299838. Epub 2017 Feb 28.


Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.

Moutal A, Li W, Wang Y, Ju W, Luo S, Cai S, François-Moutal L, Perez-Miller S, Hu J, Dustrude ET, Vanderah TW, Gokhale V, Khanna M, Khanna R.

Br J Pharmacol. 2018 Jun;175(12):2244-2260. doi: 10.1111/bph.13737. Epub 2017 Mar 17.


(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.

Moutal A, François-Moutal L, Perez-Miller S, Cottier K, Chew LA, Yeon SK, Dai J, Park KD, Khanna M, Khanna R.

Mol Neurobiol. 2016 Apr;53(3):1959-1976. doi: 10.1007/s12035-015-9141-2. Epub 2015 Apr 7.


Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells.

Khanna M, Imasaki T, Chikwana VM, Perez-Miller S, Hunter GO, Mosley A, Takagi Y, Hurley TD.

Protein Expr Purif. 2013 Aug;90(2):78-83. doi: 10.1016/j.pep.2013.05.007. Epub 2013 May 24.


Catalytic contribution of threonine 244 in human ALDH2.

González-Segura L, Ho KK, Perez-Miller S, Weiner H, Hurley TD.

Chem Biol Interact. 2013 Feb 25;202(1-3):32-40. doi: 10.1016/j.cbi.2012.12.009. Epub 2013 Jan 4.


Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.

Khanna M, Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD.

J Biol Chem. 2011 Dec 16;286(50):43486-94. doi: 10.1074/jbc.M111.293597. Epub 2011 Oct 21.


High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones.

Perez-Miller S, Zou Q, Novotny MV, Hurley TD.

Protein Sci. 2010 Aug;19(8):1469-79. doi: 10.1002/pro.426.


Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.

Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD.

Nat Struct Mol Biol. 2010 Feb;17(2):159-64. doi: 10.1038/nsmb.1737. Epub 2010 Jan 10.


Light chain C-terminal region reinforces the stability of clathrin heavy chain trimers.

Ybe JA, Perez-Miller S, Niu Q, Coates DA, Drazer MW, Clegg ME.

Traffic. 2007 Aug;8(8):1101-10. Epub 2007 Jun 6.


Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase.

Perez-Miller SJ, Hurley TD.

Biochemistry. 2003 Jun 17;42(23):7100-9.


Order and disorder in mitochondrial aldehyde dehydrogenase.

Hurley TD, Perez-Miller S, Breen H.

Chem Biol Interact. 2001 Jan 30;130-132(1-3):3-14.


Three-dimensional structures of the three human class I alcohol dehydrogenases.

Niederhut MS, Gibbons BJ, Perez-Miller S, Hurley TD.

Protein Sci. 2001 Apr;10(4):697-706.

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