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Items: 3

1.

Oral co-administration of fluconazole with tramadol markedly increases plasma and urine concentrations of tramadol and the O-desmethyltramadol metabolite (M1) in healthy dogs.

Perez Jimenez TE, Kukanich B, Joo H, Mealey KL, Grubb TL, Greene SA, Court MH.

Drug Metab Dispos. 2018 Oct 26. pii: dmd.118.083444. doi: 10.1124/dmd.118.083444. [Epub ahead of print]

PMID:
30366901
2.

Identification of canine cytochrome P-450s (CYPs) metabolizing the tramadol (+)-M1 and (+)-M2 metabolites to the tramadol (+)-M5 metabolite in dog liver microsomes.

Perez Jimenez TE, Mealey KL, Schnider D, Grubb TL, Greene SA, Court MH.

J Vet Pharmacol Ther. 2018 Dec;41(6):815-824. doi: 10.1111/jvp.12706. Epub 2018 Aug 16.

PMID:
30113702
3.

Tramadol metabolism to O-desmethyl tramadol (M1) and N-desmethyl tramadol (M2) by dog liver microsomes: Species comparison and identification of responsible canine cytochrome P-450s (CYPs).

Perez Jimenez TE, Mealey KL, Grubb TL, Greene SA, Court MH.

Drug Metab Dispos. 2016 Dec;44(12):1963-1972. doi: 10.1124/dmd.116.071902. Epub 2016 Oct 6. Erratum in: Drug Metab Dispos. 2017 Jul;45(7):706.

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