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Biosci Rep. 2019 Jan 25;39(1). pii: BSR20181849. doi: 10.1042/BSR20181849. Print 2019 Jan 31.

Stilbene derivative as a photosensitive compound to control the excitability of neonatal rat cardiomyocytes.

Author information

1
Moscow Institute of Physics and Technology, Russian Federation, Dolgoprudny, Institutski lane, 9, Russia.
2
Moscow Institute of Physics and Technology, Russian Federation, Dolgoprudny, Institutski lane, 9, Russia agladze@yahoo.com.

Abstract

Substances that can be used as photosensitizers for cardiac tissue are very helpful in modeling various excitation patterns in a cardiac tissue culture and may have prospective use in the temporary and permanent ablation of unwanted excitation sources in the heart.The aim of the present work is to study the effect of stilbene derivative c-TAB (2- {4- [(E) -2- (4-ethoxyphenyl) vinyl] phenoxy} ethyl) trimethylammonium bromide) on the cardiomyocyte layers and voltage-gated ion channels in cardiac cells. C-TAB is a structural analog to AzoTAB, reported previously as a photoswitch for cardiac and neural cells, in which the azobenzene moiety is replaced by a stilbene grouping. Such a replacement makes c-TAB less toxic to living cells. c-TAB has been shown to successfully inhibit excitation in cardiac cells in both trans- and cis- forms. The excitation inhibition of cardiac cells under c-TAB is reversible and can be overturned easily by washing out the c-TAB; however, not by light illumination. The irradiation of cardiac cells with near-UV, when the trans- form of c-TAB is applied, changes reversible inhibition to a permanent one that cannot be overturned by a washout.

KEYWORDS:

Excitation wave propagation; Neonatal rat cardiomyocyte; Stilbene derivative; voltage-gated channels

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