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Items: 1 to 50 of 104

1.

The role of chromatin reorganization in the process of cellular senescence.

Tominaga K, Pereira-Smith OM.

Curr Drug Targets. 2012 Dec;13(13):1593-602. Review.

PMID:
22998188
2.

Loss of the chromatin regulator MRG15 limits neural stem/progenitor cell proliferation via increased expression of the p21 Cdk inhibitor.

Chen M, Pereira-Smith OM, Tominaga K.

Stem Cell Res. 2011 Jul;7(1):75-88. doi: 10.1016/j.scr.2011.04.002. Epub 2011 Apr 25.

3.

Exploring the link between MORF4L1 and risk of breast cancer.

Martrat G, Maxwell CM, Tominaga E, Porta-de-la-Riva M, Bonifaci N, Gómez-Baldó L, Bogliolo M, Lázaro C, Blanco I, Brunet J, Aguilar H, Fernández-Rodríguez J, Seal S, Renwick A, Rahman N, Kühl J, Neveling K, Schindler D, Ramírez MJ, Castellà M, Hernández G; EMBRACE, Easton DF, Peock S, Cook M, Oliver CT, Frost D, Platte R, Evans DG, Lalloo F, Eeles R, Izatt L, Chu C, Davidson R, Ong KR, Cook J, Douglas F, Hodgson S, Brewer C, Morrison PJ, Porteous M, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Roversi G, Barile M, Viel A, Pasini B, Ottini L, Putignano AL, Savarese A, Bernard L, Radice P, Healey S, Spurdle A, Chen X, Beesley J; kConFab, Rookus MA, Verhoef S, Tilanus-Linthorst MA, Vreeswijk MP, Asperen CJ, Bodmer D, Ausems MG, van Os TA, Blok MJ, Meijers-Heijboer HE, Hogervorst FB; HEBON, Goldgar DE, Buys S, John EM, Miron A, Southey M, Daly MB; BCFR; SWE-BRCA, Harbst K, Borg A, Rantala J, Barbany-Bustinza G, Ehrencrona H, Stenmark-Askmalm M, Kaufman B, Laitman Y, Milgrom R, Friedman E, Domchek SM, Nathanson KL, Rebbeck TR, Johannsson OT, Couch FJ, Wang X, Fredericksen Z, Cuadras D, Moreno V, Pientka FK, Depping R, Caldés T, Osorio A, Benítez J, Bueren J, Heikkinen T, Nevanlinna H, Hamann U, Torres D, Caligo MA, Godwin AK, Imyanitov EN, Janavicius R; GEMO Study Collaborators, Sinilnikova OM, Stoppa-Lyonnet D, Mazoyer S, Verny-Pierre C, Castera L, de Pauw A, Bignon YJ, Uhrhammer N, Peyrat JP, Vennin P, Ferrer SF, Collonge-Rame MA, Mortemousque I, McGuffog L, Chenevix-Trench G, Pereira-Smith OM, Antoniou AC, Cerón J, Tominaga K, Surrallés J, Pujana MA.

Breast Cancer Res. 2011 Apr 5;13(2):R40. doi: 10.1186/bcr2862.

4.

MRG15 activates the cdc2 promoter via histone acetylation in human cells.

Peña AN, Tominaga K, Pereira-Smith OM.

Exp Cell Res. 2011 Jul 1;317(11):1534-40. doi: 10.1016/j.yexcr.2011.02.001. Epub 2011 Feb 14.

5.

Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster.

Zhang H, Li Y, Yang J, Tominaga K, Pereira-Smith OM, Tower J.

Exp Gerontol. 2010 Nov;45(11):825-33. doi: 10.1016/j.exger.2010.06.002. Epub 2010 Jun 23.

6.

Emerging role of the MORF/MRG gene family in various biological processes, including aging.

Chen M, Tominaga K, Pereira-Smith OM.

Ann N Y Acad Sci. 2010 Jun;1197:134-41. doi: 10.1111/j.1749-6632.2010.05197.x. Review.

7.

Expansion of CUG RNA repeats causes stress and inhibition of translation in myotonic dystrophy 1 (DM1) cells.

Huichalaf C, Sakai K, Jin B, Jones K, Wang GL, Schoser B, Schneider-Gold C, Sarkar P, Pereira-Smith OM, Timchenko N, Timchenko L.

FASEB J. 2010 Oct;24(10):3706-19. doi: 10.1096/fj.09-151159. Epub 2010 May 17.

8.

Regulation of alternative splicing by histone modifications.

Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T.

Science. 2010 Feb 19;327(5968):996-1000. doi: 10.1126/science.1184208. Epub 2010 Feb 4.

9.

The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway.

Tominaga K, Tominaga E, Ausserlechner MJ, Pereira-Smith OM.

Exp Cell Res. 2010 Jan 1;316(1):92-102. doi: 10.1016/j.yexcr.2009.09.015. Epub 2009 Sep 19.

10.

MRG15, a component of HAT and HDAC complexes, is essential for proliferation and differentiation of neural precursor cells.

Chen M, Takano-Maruyama M, Pereira-Smith OM, Gaufo GO, Tominaga K.

J Neurosci Res. 2009 May 15;87(7):1522-31. doi: 10.1002/jnr.21976.

11.

Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation.

Garcia SN, Kirtane BM, Podlutsky AJ, Pereira-Smith OM, Tominaga K.

FEBS Lett. 2007 Nov 13;581(27):5275-81. Epub 2007 Oct 18.

12.

The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging.

Pena AN, Pereira-Smith OM.

Ann N Y Acad Sci. 2007 Apr;1100:299-305. Review.

PMID:
17460191
13.

Microfluidics device for single cell gene expression analysis in Saccharomyces cerevisiae.

Ryley J, Pereira-Smith OM.

Yeast. 2006 Oct-Nov;23(14-15):1065-73.

16.

Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.

Wadhwa R, Takano S, Kaur K, Deocaris CC, Pereira-Smith OM, Reddel RR, Kaul SC.

Int J Cancer. 2006 Jun 15;118(12):2973-80.

17.

Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain.

Bowman BR, Moure CM, Kirtane BM, Welschhans RL, Tominaga K, Pereira-Smith OM, Quiocho FA.

Structure. 2006 Jan;14(1):151-8.

18.

Early-senescing human skin fibroblasts do not demonstrate accelerated telomere shortening.

Ferenac M, Polancec D, Huzak M, Pereira-Smith OM, Rubelj I.

J Gerontol A Biol Sci Med Sci. 2005 Jul;60(7):820-9.

PMID:
16079203
19.
20.

Functional analysis of MRG-1: the ortholog of human MRG15 in Caenorhabditis elegans.

Olgun A, Aleksenko T, Pereira-Smith OM, Vassilatis DK.

J Gerontol A Biol Sci Med Sci. 2005 May;60(5):543-8.

PMID:
15972600
21.

MrgX is not essential for cell growth and development in the mouse.

Tominaga K, Matzuk MM, Pereira-Smith OM.

Mol Cell Biol. 2005 Jun;25(12):4873-80.

22.

MRG15 regulates embryonic development and cell proliferation.

Tominaga K, Kirtane B, Jackson JG, Ikeno Y, Ikeda T, Hawks C, Smith JR, Matzuk MM, Pereira-Smith OM.

Mol Cell Biol. 2005 Apr;25(8):2924-37.

23.

PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice.

Tominaga K, Magee DM, Matzuk MM, Pereira-Smith OM.

Mol Cell Biol. 2004 Oct;24(19):8366-73.

24.

Role of IFI 16 in cellular senescence of human fibroblasts.

Xin H, Pereira-Smith OM, Choubey D.

Oncogene. 2004 Aug 19;23(37):6209-17.

PMID:
15208661
25.

The aging factor in health and disease: the promise of basic research on aging.

Butler RN, Warner HR, Williams TF, Austad SN, Brody JA, Campisi J, Cerami A, Cohen G, Cristofalo VJ, Drachman DA, Finch CE, Fridovich I, Harley CB, Havlik RJ, Martin GM, Miller RA, Olshansky SJ, Pereira-Smith OM, Smith JR, Sprott RL, West MD, Wilmoth JR, Wright WE.

Aging Clin Exp Res. 2004 Apr;16(2):104-11; discussion 111-2. Review. No abstract available.

PMID:
15195984
26.

DNA end joining becomes less efficient and more error-prone during cellular senescence.

Seluanov A, Mittelman D, Pereira-Smith OM, Wilson JH, Gorbunova V.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7624-9. Epub 2004 Apr 28.

27.

Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate.

Iakova P, Wang GL, Timchenko L, Michalak M, Pereira-Smith OM, Smith JR, Timchenko NA.

EMBO J. 2004 Jan 28;23(2):406-17. Epub 2004 Jan 15.

28.

MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner.

Tominaga K, Leung JK, Rookard P, Echigo J, Smith JR, Pereira-Smith OM.

J Biol Chem. 2003 Dec 5;278(49):49618-24. Epub 2003 Sep 23.

29.

Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts.

Gorbunova V, Seluanov A, Pereira-Smith OM.

J Biol Chem. 2003 Feb 28;278(9):7692-8. Epub 2002 Dec 19.

30.

Mortalin: present and prospective.

Kaul SC, Taira K, Pereira-Smith OM, Wadhwa R.

Exp Gerontol. 2002 Oct-Nov;37(10-11):1157-64. Review.

PMID:
12470827
31.

MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation.

Pardo PS, Leung JK, Lucchesi JC, Pereira-Smith OM.

J Biol Chem. 2002 Dec 27;277(52):50860-6. Epub 2002 Oct 22.

32.

The genomic organization, promoter position and expression profile of the mouse MRG15 gene.

Tominaga K, Pereira-Smith OM.

Gene. 2002 Jul 10;294(1-2):215-24.

PMID:
12234683
33.

A single-stage mechanism controls replicative senescence through Sudden Senescence Syndrome.

Rubelj I, Huzak M, Brdar B, Pereira-Smith OM.

Biogerontology. 2002;3(4):213-22.

PMID:
12232503
34.
35.

Genetics of cellular senescence.

Tominaga K, Olgun A, Smith JR, Pereira-Smith OM.

Mech Ageing Dev. 2002 Apr 30;123(8):927-36. Review.

PMID:
12044941
36.

Neurons in Alzheimer disease emerge from senescence.

Raina AK, Pardo P, Rottkamp CA, Zhu X, Pereira-Smith OM, Smith MA.

Mech Ageing Dev. 2001 Dec;123(1):3-9.

PMID:
11640946
37.

MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14.

Leung JK, Berube N, Venable S, Ahmed S, Timchenko N, Pereira-Smith OM.

J Biol Chem. 2001 Oct 19;276(42):39171-8. Epub 2001 Aug 10.

38.
39.

Identification of genes involved in cell senescence and immortalization: potential implications for tissue ageing.

Leung JK, Pereira-Smith OM.

Novartis Found Symp. 2001;235:105-10; discussion 110-5; 146-9. Review.

PMID:
11280020
40.

Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells.

Ran Q, Wadhwa R, Bischof O, Venable S, Smith JR, Pereira-Smith OM.

Exp Cell Res. 2001 Feb 1;263(1):156-62.

PMID:
11161714
41.

The Role of the MRG Gene Family in Replicative Senescence and Immortalization.

Leung JK, Pardo P, Pereira-Smith OM.

ScientificWorldJournal. 2001 Feb 2;1:66. doi: 10.1100/tsw.2001.109. eCollection 2001. No abstract available.

42.
43.

Extramitochondrial localization of mortalin/mthsp70/PBP74/GRP75.

Ran Q, Wadhwa R, Kawai R, Kaul SC, Sifers RN, Bick RJ, Smith JR, Pereira-Smith OM.

Biochem Biophys Res Commun. 2000 Aug 18;275(1):174-9.

PMID:
10944461
44.

Genetic approaches to the study of replicative senescence.

Ran Q, Pereira-Smith OM.

Exp Gerontol. 2000 Feb;35(1):7-13. Review.

PMID:
10705034
45.

Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene.

Bryce SD, Forsyth NR, Fitzsimmons SA, Clark LJ, Bertram MJ, Cuthbert AP, Newbold RF, Pereira-Smith OM, Parkinson EK.

Cancer Res. 1999 May 1;59(9):2038-40.

46.

Assembly of a BAC contig of the complementation group B cell senescence gene candidate region at 4q33-q34.1 and identification of expressed sequences.

Bertram MJ, Bérubé NG, Swanson XH, Pereira-Smith OM.

Genomics. 1999 Mar 15;56(3):353-4. No abstract available.

PMID:
10087205
47.

Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.

Bertram MJ, Bérubé NG, Hang-Swanson X, Ran Q, Leung JK, Bryce S, Spurgers K, Bick RJ, Baldini A, Ning Y, Clark LJ, Parkinson EK, Barrett JC, Smith JR, Pereira-Smith OM.

Mol Cell Biol. 1999 Feb;19(2):1479-85.

48.

Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function.

Bérubé NG, Swanson XH, Bertram MJ, Kittle JD, Didenko V, Baskin DS, Smith JR, Pereira-Smith OM.

Brain Res Mol Brain Res. 1999 Jan 8;63(2):233-40.

PMID:
9878755
49.

The genetics of cellular senescence.

Bérubé NG, Smith JR, Pereira-Smith OM.

Am J Hum Genet. 1998 May;62(5):1015-9. Review. No abstract available.

50.

Genetic theories on aging.

Pereira-Smith OM.

Aging (Milano). 1997 Dec;9(6):429-30. Review. No abstract available.

PMID:
9553623

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