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Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity.

Muku GE, Kusnadi A, Kuzu G, Tanos R, Murray IA, Gowda K, Amin S, Perdew GH.

Lab Invest. 2019 Aug 15. doi: 10.1038/s41374-019-0306-x. [Epub ahead of print]


Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus).

Tian Y, Gui W, Smith PB, Koo I, Murray IA, Cantorna MT, Perdew GH, Patterson AD.

J Agric Food Chem. 2019 Aug 21;67(33):9286-9294. doi: 10.1021/acs.jafc.9b03212. Epub 2019 Aug 8.


Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes.

Muku GE, Blazanin N, Dong F, Smith PB, Thiboutot D, Gowda K, Amin S, Murray IA, Perdew GH.

Toxicol Sci. 2019 Jun 21. pii: kfz140. doi: 10.1093/toxsci/kfz140. [Epub ahead of print]


Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline.

Hubbard TD, Liu Q, Murray IA, Dong F, Miller C 3rd, Smith PB, Gowda K, Lin JM, Amin S, Patterson AD, Perdew GH.

J Proteome Res. 2019 Apr 5;18(4):1715-1724. doi: 10.1021/acs.jproteome.8b00946. Epub 2019 Mar 4.


Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist.

Muku GE, Murray IA, Espín JC, Perdew GH.

Metabolites. 2018 Nov 29;8(4). pii: E86. doi: 10.3390/metabo8040086.


Old Receptor, New Tricks-The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29⁻31 August 2018 in Paris, France.

Esser C, Lawrence BP, Sherr DH, Perdew GH, Puga A, Barouki R, Coumoul X.

Int J Mol Sci. 2018 Nov 15;19(11). pii: E3603. doi: 10.3390/ijms19113603.


Structural and Functional Analysis of the Gut Microbiome for Toxicologists.

Nichols RG, Cai J, Murray IA, Koo I, Smith PB, Perdew GH, Patterson AD.

Curr Protoc Toxicol. 2018 Nov;78(1):e54. doi: 10.1002/cptx.54. Epub 2018 Sep 19.


Molecular Regulation of Carcinogenesis: Friend and Foe.

Patterson AD, Gonzalez FJ, Perdew GH, Peters JM.

Toxicol Sci. 2018 Oct 1;165(2):277-283. doi: 10.1093/toxsci/kfy185. Review.


Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice.

Belton KR, Tian Y, Zhang L, Anitha M, Smith PB, Perdew GH, Patterson AD.

J Proteome Res. 2018 Apr 6;17(4):1375-1382. doi: 10.1021/acs.jproteome.7b00709. Epub 2018 Mar 21.


Dietary Broccoli Impacts Microbial Community Structure and Attenuates Chemically Induced Colitis in Mice in an Ah receptor dependent manner.

Hubbard TD, Murray IA, Nichols RG, Cassel K, Podolsky M, Kuzu G, Tian Y, Smith P, Kennett MJ, Patterson AD, Perdew GH.

J Funct Foods. 2017 Oct;37:685-698. doi: 10.1016/j.jff.2017.08.038. Epub 2017 Sep 1.


Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice.

Smith KJ, Murray IA, Boyer JA, Perdew GH.

Toxicology. 2018 Feb 1;394:27-34. doi: 10.1016/j.tox.2017.11.020. Epub 2017 Nov 29.


Editor's Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin.

Smith KJ, Boyer JA, Muku GE, Murray IA, Gowda K, Desai D, Amin SG, Glick AB, Perdew GH.

Toxicol Sci. 2017 Nov 1;160(1):83-94. doi: 10.1093/toxsci/kfx160.


Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis.

Murray IA, Perdew GH.

Curr Opin Toxicol. 2017 Feb;2:15-23. doi: 10.1016/j.cotox.2017.01.003. Epub 2017 Jan 19.


Assessment of Ah receptor transcriptional activity mediated by halogenated dibenzo-p-dioxins and dibenzofurans (PXDD/Fs) in human and mouse cell systems.

Organtini KL, Hubbard TD, Perdew GH, Dorman FL.

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2017 Dec 6;52(14):1295-1302. doi: 10.1080/10934529.2017.1362290. Epub 2017 Sep 18.


Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses.

Muku GE, Lahoti TS, Murray IA, Podolsky MA, Smith KJ, Hubbard TD, Kuzu G, Gowda K, Amin SG, Perdew GH.

Lab Invest. 2017 Dec;97(12):1471-1487. doi: 10.1038/labinvest.2017.92. Epub 2017 Sep 11.


Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor.

Moyer BJ, Rojas IY, Murray IA, Lee S, Hazlett HF, Perdew GH, Tomlinson CR.

Toxicol Appl Pharmacol. 2017 May 15;323:74-80. doi: 10.1016/j.taap.2017.03.012. Epub 2017 Mar 20.


Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy.

Koga T, Yao PL, Goudarzi M, Murray IA, Balandaram G, Gonzalez FJ, Perdew GH, Fornace AJ Jr, Peters JM.

J Biol Chem. 2016 Nov 25;291(48):25255-25263. Epub 2016 Oct 20.


Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice.

Murray IA, Nichols RG, Zhang L, Patterson AD, Perdew GH.

Sci Rep. 2016 Sep 23;6:33969. doi: 10.1038/srep33969.


Divergent Ah Receptor Ligand Selectivity during Hominin Evolution.

Hubbard TD, Murray IA, Bisson WH, Sullivan AP, Sebastian A, Perry GH, Jablonski NG, Perdew GH.

Mol Biol Evol. 2016 Oct;33(10):2648-58. doi: 10.1093/molbev/msw143. Epub 2016 Aug 2.


Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice.

Balandaram G, Kramer LR, Kang BH, Murray IA, Perdew GH, Gonzalez FJ, Peters JM.

Toxicology. 2016 Jul 1;363-364:1-9. doi: 10.1016/j.tox.2016.07.010. Epub 2016 Jul 15.


A novel AhR ligand, 2AI, protects the retina from environmental stress.

Gutierrez MA, Davis SS, Rosko A, Nguyen SM, Mitchell KP, Mateen S, Neves J, Garcia TY, Mooney S, Perdew GH, Hubbard TD, Lamba DA, Ramanathan A.

Sci Rep. 2016 Jul 1;6:29025. doi: 10.1038/srep29025.


Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression.

Girer NG, Murray IA, Omiecinski CJ, Perdew GH.

J Biol Chem. 2016 Jul 15;291(29):15378-87. doi: 10.1074/jbc.M116.715151. Epub 2016 May 25.


Selective programming of CCR10(+) innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation.

Yang J, Hu S, Zhao L, Kaplan DH, Perdew GH, Xiong N.

Nat Immunol. 2016 Jan;17(1):48-56. doi: 10.1038/ni.3312. Epub 2015 Nov 2.


Aryl Hydrocarbon Receptor Activation Synergistically Induces Lipopolysaccharide-Mediated Expression of Proinflammatory Chemokine (c-c motif) Ligand 20.

Lahoti TS, Boyer JA, Kusnadi A, Muku GE, Murray IA, Perdew GH.

Toxicol Sci. 2015 Nov;148(1):229-40. doi: 10.1093/toxsci/kfv178. Epub 2015 Aug 10.


Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles.

Hubbard TD, Murray IA, Bisson WH, Lahoti TS, Gowda K, Amin SG, Patterson AD, Perdew GH.

Sci Rep. 2015 Aug 3;5:12689. doi: 10.1038/srep12689.


Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation.

Hubbard TD, Murray IA, Perdew GH.

Drug Metab Dispos. 2015 Oct;43(10):1522-35. doi: 10.1124/dmd.115.064246. Epub 2015 Jun 3. Review.


Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice.

Zhang L, Hatzakis E, Nichols RG, Hao R, Correll J, Smith PB, Chiaro CR, Perdew GH, Patterson AD.

Environ Sci Technol. 2015 Jul 7;49(13):8067-77. doi: 10.1021/acs.est.5b01389. Epub 2015 Jun 12.


Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation.

Zhang L, Nichols RG, Correll J, Murray IA, Tanaka N, Smith PB, Hubbard TD, Sebastian A, Albert I, Hatzakis E, Gonzalez FJ, Perdew GH, Patterson AD.

Environ Health Perspect. 2015 Jul;123(7):679-88. doi: 10.1289/ehp.1409055. Epub 2015 Mar 13.


Differential regulation of Th17 and T regulatory cell differentiation by aryl hydrocarbon receptor dependent xenobiotic response element dependent and independent pathways.

Mohinta S, Kannan AK, Gowda K, Amin SG, Perdew GH, August A.

Toxicol Sci. 2015 Jun;145(2):233-43. doi: 10.1093/toxsci/kfv046. Epub 2015 Feb 24.


Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation.

van den Bogaard EH, Podolsky MA, Smits JP, Cui X, John C, Gowda K, Desai D, Amin SG, Schalkwijk J, Perdew GH, Glick AB.

J Invest Dermatol. 2015 May;135(5):1320-1328. doi: 10.1038/jid.2015.6. Epub 2015 Jan 20.


Aryl hydrocarbon receptor ligands in cancer: friend and foe.

Murray IA, Patterson AD, Perdew GH.

Nat Rev Cancer. 2014 Dec;14(12):801-14. doi: 10.1038/nrc3846. Review.


A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain.

Perkins A, Phillips JL, Kerkvliet NI, Tanguay RL, Perdew GH, Kolluri SK, Bisson WH.

Biology (Basel). 2014 Oct 17;3(4):645-69. doi: 10.3390/biology3040645.


Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in keratinocytes.

Borland MG, Krishnan P, Lee C, Albrecht PP, Shan W, Bility MT, Marcus CB, Lin JM, Amin S, Gonzalez FJ, Perdew GH, Peters JM.

Carcinogenesis. 2014 Jul;35(7):1602-12. doi: 10.1093/carcin/bgu067. Epub 2014 Mar 17.


In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract.

Fang ZZ, Krausz KW, Nagaoka K, Tanaka N, Gowda K, Amin SG, Perdew GH, Gonzalez FJ.

Br J Pharmacol. 2014 Apr;171(7):1735-46. doi: 10.1111/bph.12576.


Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

Lahoti TS, Hughes JM, Kusnadi A, John K, Zhu B, Murray IA, Gowda K, Peters JM, Amin SG, Perdew GH.

J Pharmacol Exp Ther. 2014 Feb;348(2):236-45. doi: 10.1124/jpet.113.209726. Epub 2013 Dec 5.


The Ah receptor regulates growth factor expression in head and neck squamous cell carcinoma cell lines.

John K, Lahoti TS, Wagner K, Hughes JM, Perdew GH.

Mol Carcinog. 2014 Oct;53(10):765-76. doi: 10.1002/mc.22032. Epub 2013 Apr 27.


Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes.

Lahoti TS, John K, Hughes JM, Kusnadi A, Murray IA, Krishnegowda G, Amin S, Perdew GH.

Ann Rheum Dis. 2013 Oct;72(10):1708-16. doi: 10.1136/annrheumdis-2012-202639. Epub 2013 Jan 24.


Ah receptor antagonism represses head and neck tumor cell aggressive phenotype.

DiNatale BC, Smith K, John K, Krishnegowda G, Amin SG, Perdew GH.

Mol Cancer Res. 2012 Oct;10(10):1369-79. doi: 10.1158/1541-7786.MCR-12-0216. Epub 2012 Aug 21.


Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver.

Tanos R, Murray IA, Smith PB, Patterson A, Perdew GH.

Toxicol Sci. 2012 Oct;129(2):372-9. doi: 10.1093/toxsci/kfs204. Epub 2012 Jun 13.


Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure.

Narayanan GA, Murray IA, Krishnegowda G, Amin S, Perdew GH.

J Pharmacol Exp Ther. 2012 Aug;342(2):345-55. doi: 10.1124/jpet.112.193482. Epub 2012 May 2.


Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines.

Labrecque MP, Takhar MK, Hollingshead BD, Prefontaine GG, Perdew GH, Beischlag TV.

PLoS One. 2012;7(1):e29545. doi: 10.1371/journal.pone.0029545. Epub 2012 Jan 3.


Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner.

Tanos R, Patel RD, Murray IA, Smith PB, Patterson AD, Perdew GH.

Hepatology. 2012 Jun;55(6):1994-2004. doi: 10.1002/hep.25571.


Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism.

Smith KJ, Murray IA, Tanos R, Tellew J, Boitano AE, Bisson WH, Kolluri SK, Cooke MP, Perdew GH.

J Pharmacol Exp Ther. 2011 Jul;338(1):318-27. doi: 10.1124/jpet.110.178392. Epub 2011 Apr 14.


Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone.

Murray IA, Flaveny CA, Chiaro CR, Sharma AK, Tanos RS, Schroeder JC, Amin SG, Bisson WH, Kolluri SK, Perdew GH.

Mol Pharmacol. 2011 Mar;79(3):508-19. doi: 10.1124/mol.110.069369. Epub 2010 Dec 2.


Ah receptor antagonism inhibits constitutive and cytokine inducible IL6 production in head and neck tumor cell lines.

DiNatale BC, Schroeder JC, Perdew GH.

Mol Carcinog. 2011 Mar;50(3):173-83. doi: 10.1002/mc.20702. Epub 2010 Nov 23.


Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities.

Omiecinski CJ, Vanden Heuvel JP, Perdew GH, Peters JM.

Toxicol Sci. 2011 Mar;120 Suppl 1:S49-75. doi: 10.1093/toxsci/kfq338. Epub 2010 Nov 8. Review.


Estrogen receptor expression is required for low-dose resveratrol-mediated repression of aryl hydrocarbon receptor activity.

Perdew GH, Hollingshead BD, Dinatale BC, Morales JL, Labrecque MP, Takhar MK, Tam KJ, Beischlag TV.

J Pharmacol Exp Ther. 2010 Nov;335(2):273-83. doi: 10.1124/jpet.110.170654. Epub 2010 Aug 17.


Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.

Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP.

Science. 2010 Sep 10;329(5997):1345-8. doi: 10.1126/science.1191536. Epub 2010 Aug 5. Erratum in: Science. 2011 May 6;332(6030):664.


Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787.

Palkar PS, Borland MG, Naruhn S, Ferry CH, Lee C, Sk UH, Sharma AK, Amin S, Murray IA, Anderson CR, Perdew GH, Gonzalez FJ, Müller R, Peters JM.

Mol Pharmacol. 2010 Sep;78(3):419-30. doi: 10.1124/mol.110.065508. Epub 2010 Jun 1.


Mechanistic insights into the events that lead to synergistic induction of interleukin 6 transcription upon activation of the aryl hydrocarbon receptor and inflammatory signaling.

DiNatale BC, Schroeder JC, Francey LJ, Kusnadi A, Perdew GH.

J Biol Chem. 2010 Aug 6;285(32):24388-97. doi: 10.1074/jbc.M110.118570. Epub 2010 May 28.

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