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Items: 8

1.

Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold.

Perchiacca JM, Lee CC, Tessier PM.

Protein Eng Des Sel. 2014 Feb;27(2):29-39. doi: 10.1093/protein/gzt058. Epub 2014 Jan 6.

PMID:
24398633
2.

Toward aggregation-resistant antibodies by design.

Lee CC, Perchiacca JM, Tessier PM.

Trends Biotechnol. 2013 Nov;31(11):612-20. doi: 10.1016/j.tibtech.2013.07.002. Epub 2013 Aug 7. Review.

PMID:
23932102
3.

Rational design of potent domain antibody inhibitors of amyloid fibril assembly.

Ladiwala AR, Bhattacharya M, Perchiacca JM, Cao P, Raleigh DP, Abedini A, Schmidt AM, Varkey J, Langen R, Tessier PM.

Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):19965-70. doi: 10.1073/pnas.1208797109. Epub 2012 Nov 15. Erratum in: Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1560.

4.

Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions.

Perchiacca JM, Ladiwala AR, Bhattacharya M, Tessier PM.

Protein Eng Des Sel. 2012 Oct;25(10):591-601. Epub 2012 Jul 27.

PMID:
22843678
5.

Engineering aggregation-resistant antibodies.

Perchiacca JM, Tessier PM.

Annu Rev Chem Biomol Eng. 2012;3:263-86. doi: 10.1146/annurev-chembioeng-062011-081052. Epub 2012 Mar 29. Review.

PMID:
22468604
6.

Polyphenolic disaccharides endow proteins with unusual resistance to aggregation.

Ladiwala AR, Perchiacca JM, Fishman ZS, Bhattacharya M, Hickey AM, Domigan BG, Dordick JS, Tessier PM.

Biotechnol Bioeng. 2012 Jul;109(7):1869-74. doi: 10.1002/bit.24460. Epub 2012 Mar 2.

PMID:
22331747
7.

Structure-based design of conformation- and sequence-specific antibodies against amyloid β.

Perchiacca JM, Ladiwala AR, Bhattacharya M, Tessier PM.

Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):84-9. doi: 10.1073/pnas.1111232108. Epub 2011 Dec 14.

8.

Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions.

Perchiacca JM, Bhattacharya M, Tessier PM.

Proteins. 2011 Sep;79(9):2637-47. doi: 10.1002/prot.23085. Epub 2011 Jul 5.

PMID:
21732420

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