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Items: 42

1.

Novel Synthetic DNA Immunogens Targeting Latent Expressed Antigens of Epstein-Barr Virus Elicit Potent Cellular Responses and Inhibit Tumor Growth.

Wojtak K, Perales-Puchalt A, Weiner DB.

Vaccines (Basel). 2019 May 24;7(2). pii: E44. doi: 10.3390/vaccines7020044.

2.

DNA-encoded bispecific T cell engagers and antibodies present long-term antitumor activity.

Perales-Puchalt A, Duperret EK, Yang X, Hernandez P, Wojtak K, Zhu X, Jung SH, Tello-Ruiz E, Wise MC, Montaner LJ, Muthumani K, Weiner DB.

JCI Insight. 2019 Apr 18;4(8). pii: 126086. doi: 10.1172/jci.insight.126086. eCollection 2019 Apr 18.

3.

Maternal telomere length is shorter in intrauterine growth restriction versus uncomplicated pregnancies, but not in the offspring or in IVF-conceived newborns.

Perales-Puchalt A, Soberón N, Monterde M, Hervas-Marin D, Foronda M, Desantes D, Soler I, Perales-Marin A, Pellicer A, Blasco MA.

Reprod Biomed Online. 2019 Apr;38(4):606-612. doi: 10.1016/j.rbmo.2018.12.008. Epub 2018 Dec 21.

PMID:
30826299
4.

Engineered transfer RNAs for suppression of premature termination codons.

Lueck JD, Yoon JS, Perales-Puchalt A, Mackey AL, Infield DT, Behlke MA, Pope MR, Weiner DB, Skach WR, McCray PB Jr, Ahern CA.

Nat Commun. 2019 Feb 18;10(1):822. doi: 10.1038/s41467-019-08329-4.

5.

Simplifying checkpoint inhibitor delivery through in vivo generation of synthetic DNA-encoded monoclonal antibodies (DMAbs).

Perales-Puchalt A, Duperret EK, Muthumani K, Weiner DB.

Oncotarget. 2019 Jan 1;10(1):13-16. doi: 10.18632/oncotarget.26535. eCollection 2019 Jan 1.

6.

A Synthetic DNA, Multi-Neoantigen Vaccine Drives Predominately MHC Class I CD8+ T-cell Responses, Impacting Tumor Challenge.

Duperret EK, Perales-Puchalt A, Stoltz R, G H H, Mandloi N, Barlow J, Chaudhuri A, Sardesai NY, Weiner DB.

Cancer Immunol Res. 2019 Feb;7(2):174-182. doi: 10.1158/2326-6066.CIR-18-0283. Epub 2019 Jan 24.

PMID:
30679156
7.

Engineered DNA Vaccination against Follicle-Stimulating Hormone Receptor Delays Ovarian Cancer Progression in Animal Models.

Perales-Puchalt A, Wojtak K, Duperret EK, Yang X, Slager AM, Yan J, Muthumani K, Montaner LJ, Weiner DB.

Mol Ther. 2019 Feb 6;27(2):314-325. doi: 10.1016/j.ymthe.2018.11.014. Epub 2018 Dec 13.

PMID:
30554854
8.

IL-33 delays metastatic peritoneal cancer progression inducing an allergic microenvironment.

Perales-Puchalt A, Svoronos N, Villarreal DO, Zankharia U, Reuschel E, Wojtak K, Payne KK, Duperret EK, Muthumani K, Conejo-Garcia JR, Weiner DB.

Oncoimmunology. 2018 Sep 6;8(1):e1515058. doi: 10.1080/2162402X.2018.1515058. eCollection 2019.

9.

Synthetic DNA-Encoded Monoclonal Antibody Delivery of Anti-CTLA-4 Antibodies Induces Tumor Shrinkage In Vivo.

Duperret EK, Trautz A, Stoltz R, Patel A, Wise MC, Perales-Puchalt A, Smith T, Broderick KE, Masteller E, Kim JJ, Humeau L, Muthumani K, Weiner DB.

Cancer Res. 2018 Nov 15;78(22):6363-6370. doi: 10.1158/0008-5472.CAN-18-1429. Epub 2018 Oct 4.

PMID:
30287678
10.

A Designer Cross-reactive DNA Immunotherapeutic Vaccine that Targets Multiple MAGE-A Family Members Simultaneously for Cancer Therapy.

Duperret EK, Liu S, Paik M, Trautz A, Stoltz R, Liu X, Ze K, Perales-Puchalt A, Reed C, Yan J, Xu X, Weiner DB.

Clin Cancer Res. 2018 Dec 1;24(23):6015-6027. doi: 10.1158/1078-0432.CCR-18-1013. Epub 2018 Sep 27.

PMID:
30262507
11.

Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-Ig.

Xu Z, Wise MC, Choi H, Perales-Puchalt A, Patel A, Tello-Ruiz E, Chu JD, Muthumani K, Weiner DB.

EBioMedicine. 2018 Sep;35:97-105. doi: 10.1016/j.ebiom.2018.08.027. Epub 2018 Aug 30.

12.

Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy.

Perales-Puchalt A, Perez-Sanz J, Payne KK, Svoronos N, Allegrezza MJ, Chaurio RA, Anadon C, Calmette J, Biswas S, Mine JA, Costich TL, Nickels L, Wickramasinghe J, Rutkowski MR, Conejo-Garcia JR.

J Leukoc Biol. 2018 May;103(5):799-805. doi: 10.1002/JLB.5HI1117-446RR. Epub 2018 Mar 14.

13.

Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast Activation Protein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice.

Duperret EK, Trautz A, Ammons D, Perales-Puchalt A, Wise MC, Yan J, Reed C, Weiner DB.

Clin Cancer Res. 2018 Mar 1;24(5):1190-1201. doi: 10.1158/1078-0432.CCR-17-2033. Epub 2017 Dec 21.

14.

Novel prostate cancer immunotherapy with a DNA-encoded anti-prostate-specific membrane antigen monoclonal antibody.

Muthumani K, Marnin L, Kudchodkar SB, Perales-Puchalt A, Choi H, Agarwal S, Scott VL, Reuschel EL, Zaidi FI, Duperret EK, Wise MC, Kraynyak KA, Ugen KE, Sardesai NY, Joseph Kim J, Weiner DB.

Cancer Immunol Immunother. 2017 Dec;66(12):1577-1588. doi: 10.1007/s00262-017-2042-7. Epub 2017 Aug 17.

15.

SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells.

Stephen TL, Payne KK, Chaurio RA, Allegrezza MJ, Zhu H, Perez-Sanz J, Perales-Puchalt A, Nguyen JM, Vara-Ailor AE, Eruslanov EB, Borowsky ME, Zhang R, Laufer TM, Conejo-Garcia JR.

Immunity. 2017 Jan 17;46(1):51-64. doi: 10.1016/j.immuni.2016.12.015.

16.

Trametinib Drives T-cell-Dependent Control of KRAS-Mutated Tumors by Inhibiting Pathological Myelopoiesis.

Allegrezza MJ, Rutkowski MR, Stephen TL, Svoronos N, Perales-Puchalt A, Nguyen JM, Payne KK, Singhal S, Eruslanov EB, Tchou J, Conejo-Garcia JR.

Cancer Res. 2016 Nov 1;76(21):6253-6265.

17.

Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells.

Svoronos N, Perales-Puchalt A, Allegrezza MJ, Rutkowski MR, Payne KK, Tesone AJ, Nguyen JM, Curiel TJ, Cadungog MG, Singhal S, Eruslanov EB, Zhang P, Tchou J, Zhang R, Conejo-Garcia JR.

Cancer Discov. 2017 Jan;7(1):72-85. doi: 10.1158/2159-8290.CD-16-0502. Epub 2016 Sep 30.

18.

Follicle-Stimulating Hormone Receptor Is Expressed by Most Ovarian Cancer Subtypes and Is a Safe and Effective Immunotherapeutic Target.

Perales-Puchalt A, Svoronos N, Rutkowski MR, Allegrezza MJ, Tesone AJ, Payne KK, Wickramasinghe J, Nguyen JM, O'Brien SW, Gumireddy K, Huang Q, Cadungog MG, Connolly DC, Tchou J, Curiel TJ, Conejo-Garcia JR.

Clin Cancer Res. 2017 Jan 15;23(2):441-453. doi: 10.1158/1078-0432.CCR-16-0492. Epub 2016 Jul 19.

19.

IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors.

Allegrezza MJ, Rutkowski MR, Stephen TL, Svoronos N, Tesone AJ, Perales-Puchalt A, Nguyen JM, Sarmin F, Sheen MR, Jeng EK, Tchou J, Wong HC, Fiering SN, Conejo-Garcia JR.

Cancer Res. 2016 May 1;76(9):2561-72. doi: 10.1158/0008-5472.CAN-15-2808. Epub 2016 Mar 15.

20.

Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells.

Tesone AJ, Rutkowski MR, Brencicova E, Svoronos N, Perales-Puchalt A, Stephen TL, Allegrezza MJ, Payne KK, Nguyen JM, Wickramasinghe J, Tchou J, Borowsky ME, Rabinovich GA, Kossenkov AV, Conejo-Garcia JR.

Cell Rep. 2016 Feb 23;14(7):1774-1786. doi: 10.1016/j.celrep.2016.01.056. Epub 2016 Feb 11.

21.

Risk factors for vertical transmission of hepatitis C virus: a single center experience with 710 HCV-infected mothers.

Garcia-Tejedor A, Maiques-Montesinos V, Diago-Almela VJ, Pereda-Perez A, Alberola-Cuñat V, López-Hontangas JL, Perales-Puchalt A, Perales A.

Eur J Obstet Gynecol Reprod Biol. 2015 Nov;194:173-7. doi: 10.1016/j.ejogrb.2015.09.009. Epub 2015 Sep 11.

PMID:
26409061
22.

The Tumor Macroenvironment: Cancer-Promoting Networks Beyond Tumor Beds.

Rutkowski MR, Svoronos N, Perales-Puchalt A, Conejo-Garcia JR.

Adv Cancer Res. 2015;128:235-62. doi: 10.1016/bs.acr.2015.04.011. Epub 2015 May 21. Review.

23.

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.

Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, Ellenson LH, Caputo T, Lee AH, Conejo-Garcia JR, Glimcher LH.

Cell. 2015 Jun 18;161(7):1527-38. doi: 10.1016/j.cell.2015.05.025. Epub 2015 Jun 11.

24.

Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.

Rutkowski MR, Stephen TL, Svoronos N, Allegrezza MJ, Tesone AJ, Perales-Puchalt A, Brencicova E, Escovar-Fadul X, Nguyen JM, Cadungog MG, Zhang R, Salatino M, Tchou J, Rabinovich GA, Conejo-Garcia JR.

Cancer Cell. 2015 Jan 12;27(1):27-40. doi: 10.1016/j.ccell.2014.11.009. Epub 2014 Dec 18.

25.

Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.

Stephen TL, Rutkowski MR, Allegrezza MJ, Perales-Puchalt A, Tesone AJ, Svoronos N, Nguyen JM, Sarmin F, Borowsky ME, Tchou J, Conejo-Garcia JR.

Immunity. 2014 Sep 18;41(3):427-439. doi: 10.1016/j.immuni.2014.08.012.

26.

Good prognosis of cerclage in cases of cervical insufficiency when intra-amniotic inflammation/infection is ruled out.

Diago Almela VJ, Martinez-Varea A, Perales-Puchalt A, Alonso-Diaz R, Perales A.

J Matern Fetal Neonatal Med. 2015 Sep;28(13):1563-8.

PMID:
25212978
27.

Mesothelin expression is associated with poor outcomes in breast cancer.

Li YR, Xian RR, Ziober A, Conejo-Garcia J, Perales-Puchalt A, June CH, Zhang PJ, Tchou J.

Breast Cancer Res Treat. 2014 Oct;147(3):675-84. doi: 10.1007/s10549-014-3077-5. Epub 2014 Sep 6.

28.

Initiation of metastatic breast carcinoma by targeting of the ductal epithelium with adenovirus-cre: a novel transgenic mouse model of breast cancer.

Rutkowski MR, Allegrezza MJ, Svoronos N, Tesone AJ, Stephen TL, Perales-Puchalt A, Nguyen J, Zhang PJ, Fiering SN, Tchou J, Conejo-Garcia JR.

J Vis Exp. 2014 Mar 26;(85). doi: 10.3791/51171.

29.

Angiogenic growth factors in maternal and fetal serum in pregnancies complicated with intrauterine growth restriction.

Borras D, Perales-Puchalt A, Ruiz Sacedón N, Perales A.

J Obstet Gynaecol. 2014 Apr;34(3):218-20. doi: 10.3109/01443615.2013.834304. Epub 2014 Jan 31.

PMID:
24484391
30.

Clinical outcome, fertility and uterine artery Doppler scans in women with obstetric bilateral internal iliac artery ligation or embolisation.

Domingo S, Perales-Puchalt A, Soler I, Marcos B, Tamarit G, Pellicer A.

J Obstet Gynaecol. 2013 Oct;33(7):701-4. doi: 10.3109/01443615.2013.817976.

PMID:
24127959
31.

Angiogenic growth factors in maternal and fetal serum in concordant and discordant twin pregnancies.

Ruiz-Sacedón N, Perales-Puchalt A, Borras D, Gómez R, Perales A.

J Matern Fetal Neonatal Med. 2014 Jun;27(9):870-3. doi: 10.3109/14767058.2013.845156. Epub 2013 Oct 22.

PMID:
24041202
32.

Ovulation induction in women with polycystic ovary syndrome.

Perales-Puchalt A, Legro RS.

Steroids. 2013 Aug;78(8):767-72. doi: 10.1016/j.steroids.2013.05.005. Epub 2013 May 21. Review.

PMID:
23707553
33.

Spontaneous arrest of flow in a TRAP sequence.

Vila-Vives JM, Hidalgo-Mora JJ, Perales-Puchalt A, Diago V, Plana A, Perales A.

J Obstet Gynaecol. 2013 Apr;33(3):313-4. doi: 10.3109/01443615.2012.761182. No abstract available.

PMID:
23550871
34.

The negative predictive value of cervical interleukin-6 for the risk assessment of preterm birth.

Perales-Puchalt A, Brik M, Diago VJ, Perales A.

J Matern Fetal Neonatal Med. 2013 Sep;26(13):1278-81. doi: 10.3109/14767058.2013.783798. Epub 2013 Apr 12.

PMID:
23480455
35.

Low birth weight: is it related to assisted reproductive technology or underlying infertility?

Kondapalli LA, Perales-Puchalt A.

Fertil Steril. 2013 Feb;99(2):303-10. doi: 10.1016/j.fertnstert.2012.12.035. Review.

36.

The effects of acellular dermal matrix in expander-implant breast reconstruction after total skin-sparing mastectomy.

Pérez-García A, del Mar Luis-Hidalgo M, Perales-Puchalt A.

Plast Reconstr Surg. 2013 Feb;131(2):278e-279e. doi: 10.1097/PRS.0b013e318278d62e. No abstract available.

PMID:
23358027
37.

Effect of delayed umbilical cord clamping on blood gas analysis.

Valero J, Desantes D, Perales-Puchalt A, Rubio J, Diago Almela VJ, Perales A.

Eur J Obstet Gynecol Reprod Biol. 2012 May;162(1):21-3. doi: 10.1016/j.ejogrb.2012.01.020. Epub 2012 Mar 8.

PMID:
22405491
38.

Threshold values of follicle count for the definition of PCO.

Perales-Puchalt A.

Hum Reprod. 2012 May;27(5):1543; author reply 1543-4. doi: 10.1093/humrep/des052. Epub 2012 Mar 7. No abstract available.

PMID:
22398257
39.

Pregnancy outcomes after kidney transplantation-immunosuppressive therapy comparison.

Perales-Puchalt A, Vila Vives JM, López Montes J, Diago Almela VJ, Perales A.

J Matern Fetal Neonatal Med. 2012 Aug;25(8):1363-6. doi: 10.3109/14767058.2011.634461. Epub 2011 Nov 25.

PMID:
22117162
40.

Reproductive medicine and inheritance of infertility by offspring: the role of fetal programming.

Díaz-García C, Estella C, Perales-Puchalt A, Simón C.

Fertil Steril. 2011 Sep;96(3):536-45. doi: 10.1016/j.fertnstert.2011.06.066. Epub 2011 Jul 27. Review.

PMID:
21794856
41.

Cervical interleukin-6 as a predictive test for preterm delivery in symptomatic women: preliminary results.

Brik M, Antonio P, Perales-Puchalt A, Diago V, Perales A.

Eur J Obstet Gynecol Reprod Biol. 2011 Mar;155(1):14-8. doi: 10.1016/j.ejogrb.2010.11.001. Epub 2010 Dec 4.

PMID:
21130555
42.

Perioperative cesarean delivery morbidity among HIV-infected women under highly active antiretroviral treatment: a case-control study.

Maiques V, Garcia-Tejedor A, Diago V, Molina JM, Borras D, Perales-Puchalt A, Perales A.

Eur J Obstet Gynecol Reprod Biol. 2010 Nov;153(1):27-31. doi: 10.1016/j.ejogrb.2010.07.001. Epub 2010 Aug 2.

PMID:
20675036

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