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Items: 1 to 50 of 79

1.

The increasing impact of lethal mutagenesis of viruses.

Perales C, Gallego I, de Ávila AI, Soria ME, Gregori J, Quer J, Domingo E.

Future Med Chem. 2019 Jul;11(13):1645-1657. doi: 10.4155/fmc-2018-0457.

PMID:
31469331
2.

The archaeology of coding RNA.

Ariza-Mateos A, Briones C, Perales C, Domingo E, Gómez J.

Ann N Y Acad Sci. 2019 Jul;1447(1):119-134. doi: 10.1111/nyas.14173. Epub 2019 Jun 25. Review.

PMID:
31237363
3.

Viral fitness: history and relevance for viral pathogenesis and antiviral interventions.

Domingo E, de Ávila AI, Gallego I, Sheldon J, Perales C.

Pathog Dis. 2019 Mar 1;77(2). pii: ftz021. doi: 10.1093/femspd/ftz021.

PMID:
30980658
4.

Extracellular vesicles: Vehicles of en bloc viral transmission.

Altan-Bonnet N, Perales C, Domingo E.

Virus Res. 2019 May;265:143-149. doi: 10.1016/j.virusres.2019.03.023. Epub 2019 Mar 27. Review.

PMID:
30928427
5.

Baseline hepatitis C virus resistance-associated substitutions present at frequencies lower than 15% may be clinically significant.

Perales C, Chen Q, Soria ME, Gregori J, Garcia-Cehic D, Nieto-Aponte L, Castells L, Imaz A, Llorens-Revull M, Domingo E, Buti M, Esteban JI, Rodriguez-Frias F, Quer J.

Infect Drug Resist. 2018 Nov 8;11:2207-2210. doi: 10.2147/IDR.S172226. eCollection 2018.

6.

Quasispecies dynamics and clinical significance of hepatitis C virus (HCV) antiviral resistance.

Perales C.

Int J Antimicrob Agents. 2018 Oct 10. pii: S0924-8579(18)30297-8. doi: 10.1016/j.ijantimicag.2018.10.005. [Epub ahead of print]

PMID:
30315919
7.

Rare haplotype load as marker for lethal mutagenesis.

Gregori J, Soria ME, Gallego I, Guerrero-Murillo M, Esteban JI, Quer J, Perales C, Domingo E.

PLoS One. 2018 Oct 3;13(10):e0204877. doi: 10.1371/journal.pone.0204877. eCollection 2018.

8.

Toll-Like Receptor 7 (TLR-7) and TLR-9 Agonists Improve Hepatitis C Virus Replication and Infectivity Inhibition by Plasmacytoid Dendritic Cells.

Dominguez-Molina B, Machmach K, Perales C, Tarancon-Diez L, Gallego I, Sheldon JL, Leal M, Domingo E, Ruiz-Mateos E.

J Virol. 2018 Nov 12;92(23). pii: e01219-18. doi: 10.1128/JVI.01219-18. Print 2018 Dec 1.

9.

Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus.

Soria ME, Gregori J, Chen Q, García-Cehic D, Llorens M, de Ávila AI, Beach NM, Domingo E, Rodríguez-Frías F, Buti M, Esteban R, Esteban JI, Quer J, Perales C.

BMC Infect Dis. 2018 Sep 3;18(1):446. doi: 10.1186/s12879-018-3356-6.

10.

Hepatitis C virus early kinetics and resistance-associated substitution dynamics during antiviral therapy with direct-acting antivirals.

Perpiñán E, Caro-Pérez N, García-González N, Gregori J, González P, Bartres C, Soria ME, Perales C, Lens S, Mariño Z, Londoño MC, Ariza X, Koutsoudakis G, Quer J, González-Candelas F, Forns X, Pérez-Del-Pulgar S.

J Viral Hepat. 2018 Dec;25(12):1515-1525. doi: 10.1111/jvh.12986. Epub 2018 Oct 4.

PMID:
30141252
11.

Resistance of high fitness hepatitis C virus to lethal mutagenesis.

Gallego I, Gregori J, Soria ME, García-Crespo C, García-Álvarez M, Gómez-González A, Valiergue R, Gómez J, Esteban JI, Quer J, Domingo E, Perales C.

Virology. 2018 Oct;523:100-109. doi: 10.1016/j.virol.2018.07.030. Epub 2018 Aug 11.

PMID:
30107298
12.

Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis.

de la Higuera I, Ferrer-Orta C, Moreno E, de Ávila AI, Soria ME, Singh K, Caridi F, Sobrino F, Sarafianos SG, Perales C, Verdaguer N, Domingo E.

J Virol. 2018 Sep 26;92(20). pii: e01119-18. doi: 10.1128/JVI.01119-18. Print 2018 Oct 15.

13.

Quasispecies and virus.

Domingo E, Perales C.

Eur Biophys J. 2018 May;47(4):443-457. doi: 10.1007/s00249-018-1282-6. Epub 2018 Feb 3. Review.

PMID:
29397419
14.

New hepatitis C virus genotype 1 subtype naturally harbouring resistance-associated mutations to NS5A inhibitors.

Ordeig L, Garcia-Cehic D, Gregori J, Soria ME, Nieto-Aponte L, Perales C, Llorens M, Chen Q, Riveiro-Barciela M, Buti M, Esteban R, Esteban JI, Rodriguez-Frias F, Quer J.

J Gen Virol. 2018 Jan;99(1):97-102. doi: 10.1099/jgv.0.000996. Epub 2017 Dec 14.

PMID:
29239718
15.

Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.

de la Higuera I, Ferrer-Orta C, de Ávila AI, Perales C, Sierra M, Singh K, Sarafianos SG, Dehouck Y, Bastolla U, Verdaguer N, Domingo E.

Genome Biol Evol. 2017 May 1;9(5):1212-1228. doi: 10.1093/gbe/evx075.

16.

Favipiravir can evoke lethal mutagenesis and extinction of foot-and-mouth disease virus.

de Avila AI, Moreno E, Perales C, Domingo E.

Virus Res. 2017 Apr 2;233:105-112. doi: 10.1016/j.virusres.2017.03.014. Epub 2017 Mar 18.

PMID:
28322918
17.

Internal Disequilibria and Phenotypic Diversification during Replication of Hepatitis C Virus in a Noncoevolving Cellular Environment.

Moreno E, Gallego I, Gregori J, Lucía-Sanz A, Soria ME, Castro V, Beach NM, Manrubia S, Quer J, Esteban JI, Rice CM, Gómez J, Gastaminza P, Domingo E, Perales C.

J Virol. 2017 Apr 28;91(10). pii: e02505-16. doi: 10.1128/JVI.02505-16. Print 2017 May 15.

18.

High HCV subtype heterogeneity in a chronically infected general population revealed by high-resolution hepatitis C virus subtyping.

Rodriguez-Frias F, Nieto-Aponte L, Gregori J, Garcia-Cehic D, Casillas R, Tabernero D, Homs M, Blasi M, Vila M, Chen Q, Vargas V, Castells L, Viladomiu L, Genesca J, Minguez B, Augustin S, Riveiro-Barciela M, Carbonell J, Perales C, Soria ME, Asensio M, Llorens M, Ordeig L, Godoy C, Buti M, Esteban R, Pumarola T, Esteban JI, Quer J.

Clin Microbiol Infect. 2017 Oct;23(10):775.e1-775.e6. doi: 10.1016/j.cmi.2017.02.007. Epub 2017 Feb 10.

19.

Deep sequencing in the management of hepatitis virus infections.

Quer J, Rodríguez-Frias F, Gregori J, Tabernero D, Soria ME, García-Cehic D, Homs M, Bosch A, Pintó RM, Esteban JI, Domingo E, Perales C.

Virus Res. 2017 Jul 15;239:115-125. doi: 10.1016/j.virusres.2016.12.020. Epub 2016 Dec 28. Review.

PMID:
28040474
20.

An Efficient Microarray-Based Genotyping Platform for the Identification of Drug-Resistance Mutations in Majority and Minority Subpopulations of HIV-1 Quasispecies.

Martín V, Perales C, Fernández-Algar M, Dos Santos HG, Garrido P, Pernas M, Parro V, Moreno M, García-Pérez J, Alcamí J, Torán JL, Abia D, Domingo E, Briones C.

PLoS One. 2016 Dec 13;11(12):e0166902. doi: 10.1371/journal.pone.0166902. eCollection 2016.

21.

New real-time-PCR method to identify single point mutations in hepatitis C virus.

Chen Q, Belmonte I, Buti M, Nieto L, Garcia-Cehic D, Gregori J, Perales C, Ordeig L, Llorens M, Soria ME, Esteban R, Esteban JI, Rodriguez-Frias F, Quer J.

World J Gastroenterol. 2016 Nov 21;22(43):9604-9612.

22.

Lethal Mutagenesis of Hepatitis C Virus Induced by Favipiravir.

de Ávila AI, Gallego I, Soria ME, Gregori J, Quer J, Esteban JI, Rice CM, Domingo E, Perales C.

PLoS One. 2016 Oct 18;11(10):e0164691. doi: 10.1371/journal.pone.0164691. eCollection 2016.

23.

Correction for Quer at al., High-Resolution Hepatitis C Virus Subtyping Using NS5B Deep Sequencing and Phylogeny, an Alternative to Current Methods.

Quer J, Gregori J, Rodríguez-Frias F, Buti M, Madejon A, Perez-Del-Pulgar S, Garcia-Cehic D, Casillas R, Blasi M, Homs M, Tabernero D, Alvarez-Tejado M, Muñoz JM, Cubero M, Caballero A, delCampo JA, Domingo E, Belmonte I, Nieto L, Lens S, Muñoz-de-Rueda P, Sanz-Cameno P, Sauleda S, Bes M, Gomez J, Briones C, Perales C, Sheldon J, Castells L, Viladomiu L, Salmeron J, Ruiz-Extremera A, Quiles-Pérez R, Moreno-Otero R, López-Rodríguez R, Allende H, Romero-Gómez M, Guardia J, Esteban R, Garcia-Samaniego J, Forns X, Esteban JI.

J Clin Microbiol. 2016 Jul;54(7):1933. doi: 10.1128/JCM.01007-16. No abstract available.

24.

Distance effects during polyprotein processing in the complementation between defective FMDV RNAs.

Moreno E, Perales C.

J Gen Virol. 2016 Jul;97(7):1575-83. doi: 10.1099/jgv.0.000480. Epub 2016 Apr 12.

PMID:
27073008
25.

Barrier-Independent, Fitness-Associated Differences in Sofosbuvir Efficacy against Hepatitis C Virus.

Gallego I, Sheldon J, Moreno E, Gregori J, Quer J, Esteban JI, Rice CM, Domingo E, Perales C.

Antimicrob Agents Chemother. 2016 May 23;60(6):3786-93. doi: 10.1128/AAC.00581-16. Print 2016 Jun.

26.

Viral quasispecies complexity measures.

Gregori J, Perales C, Rodriguez-Frias F, Esteban JI, Quer J, Domingo E.

Virology. 2016 Jun;493:227-37. doi: 10.1016/j.virol.2016.03.017. Epub 2016 Apr 6. Review.

27.

Hepatitis C Virus RNA-Dependent RNA Polymerase Interacts with the Akt/PKB Kinase and Induces Its Subcellular Relocalization.

Valero ML, Sabariegos R, Cimas FJ, Perales C, Domingo E, Sánchez-Prieto R, Mas A.

Antimicrob Agents Chemother. 2016 May 23;60(6):3540-50. doi: 10.1128/AAC.03019-15. Print 2016 Jun.

28.

Resistance of Hepatitis C Virus to Inhibitors: Complexity and Clinical Implications.

Perales C, Quer J, Gregori J, Esteban JI, Domingo E.

Viruses. 2015 Nov 6;7(11):5746-66. doi: 10.3390/v7112902. Review.

29.

Antiviral Strategies Based on Lethal Mutagenesis and Error Threshold.

Perales C, Domingo E.

Curr Top Microbiol Immunol. 2016;392:323-39. doi: 10.1007/82_2015_459. Review.

PMID:
26294225
30.

Clonality and intracellular polyploidy in virus evolution and pathogenesis.

Perales C, Moreno E, Domingo E.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):8887-92. doi: 10.1073/pnas.1501715112. Epub 2015 Jul 20.

31.

Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.

Ferrer-Orta C, de la Higuera I, Caridi F, Sánchez-Aparicio MT, Moreno E, Perales C, Singh K, Sarafianos SG, Sobrino F, Domingo E, Verdaguer N.

J Virol. 2015 Jul;89(13):6848-59. doi: 10.1128/JVI.03283-14. Epub 2015 Apr 22.

32.

Hepatitis C virus-mediated Aurora B kinase inhibition modulates inflammatory pathway and viral infectivity.

Madejón A, Sheldon J, Francisco-Recuero I, Perales C, Domínguez-Beato M, Lasa M, Sánchez-Perez I, Muntané J, Domingo E, García-Samaniego J, Sánchez-Pacheco A.

J Hepatol. 2015 Aug;63(2):312-9. doi: 10.1016/j.jhep.2015.02.036. Epub 2015 Feb 27.

PMID:
25733156
33.

High-resolution hepatitis C virus subtyping using NS5B deep sequencing and phylogeny, an alternative to current methods.

Quer J, Gregori J, Rodríguez-Frias F, Buti M, Madejon A, Perez-del-Pulgar S, Garcia-Cehic D, Casillas R, Blasi M, Homs M, Tabernero D, Alvarez-Tejado M, Muñoz JM, Cubero M, Caballero A, del Campo JA, Domingo E, Belmonte I, Nieto L, Lens S, Muñoz-de-Rueda P, Sanz-Cameno P, Sauleda S, Bes M, Gomez J, Briones C, Perales C, Sheldon J, Castells L, Viladomiu L, Salmeron J, Ruiz-Extremera A, Quiles-Pérez R, Moreno-Otero R, López-Rodríguez R, Allende H, Romero-Gómez M, Guardia J, Esteban R, Garcia-Samaniego J, Forns X, Esteban JI.

J Clin Microbiol. 2015 Jan;53(1):219-26. doi: 10.1128/JCM.02093-14. Epub 2014 Nov 5. Erratum in: J Clin Microbiol. 2016 Jul;54(7):1933.

34.

Increased replicative fitness can lead to decreased drug sensitivity of hepatitis C virus.

Sheldon J, Beach NM, Moreno E, Gallego I, Piñeiro D, Martínez-Salas E, Gregori J, Quer J, Esteban JI, Rice CM, Domingo E, Perales C.

J Virol. 2014 Oct;88(20):12098-111. doi: 10.1128/JVI.01860-14. Epub 2014 Aug 13.

35.

Visceral leishmaniasis infection during adalimumab therapy: a case report and literature review.

Tung Chen Y, Perales C, Lacruz J, Senent L, Salavert M.

Int J Rheum Dis. 2014 Sep;17(7):822-4. doi: 10.1111/1756-185X.12427. Epub 2014 Jul 1. Review. No abstract available.

PMID:
24980576
36.

Molecular basis of interferon resistance in hepatitis C virus.

Perales C, Beach NM, Sheldon J, Domingo E.

Curr Opin Virol. 2014 Oct;8:38-44. doi: 10.1016/j.coviro.2014.05.003. Epub 2014 Jun 23. Review.

PMID:
24968186
37.

Exploration of sequence space as the basis of viral RNA genome segmentation.

Moreno E, Ojosnegros S, García-Arriaza J, Escarmís C, Domingo E, Perales C.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6678-83. doi: 10.1073/pnas.1323136111. Epub 2014 Apr 22.

38.

Ultra-deep pyrosequencing (UDPS) data treatment to study amplicon HCV minor variants.

Gregori J, Esteban JI, Cubero M, Garcia-Cehic D, Perales C, Casillas R, Alvarez-Tejado M, Rodríguez-Frías F, Guardia J, Domingo E, Quer J.

PLoS One. 2013 Dec 31;8(12):e83361. doi: 10.1371/journal.pone.0083361. eCollection 2013.

39.

Identification of host and viral factors involved in a dissimilar resolution of a hepatitis C virus infection.

Cubero M, Gregori J, Esteban JI, García-Cehic D, Bes M, Perales C, Domingo E, Rodríguez-Frías F, Sauleda S, Casillas R, Sanchez A, Ortega I, Esteban R, Guardia J, Quer J.

Liver Int. 2014 Jul;34(6):896-906. doi: 10.1111/liv.12362. Epub 2013 Nov 20.

PMID:
24134179
40.

Extinction of hepatitis C virus by ribavirin in hepatoma cells involves lethal mutagenesis.

Ortega-Prieto AM, Sheldon J, Grande-Pérez A, Tejero H, Gregori J, Quer J, Esteban JI, Domingo E, Perales C.

PLoS One. 2013 Aug 16;8(8):e71039. doi: 10.1371/journal.pone.0071039. eCollection 2013.

41.

Response of hepatitis C virus to long-term passage in the presence of alpha interferon: multiple mutations and a common phenotype.

Perales C, Beach NM, Gallego I, Soria ME, Quer J, Esteban JI, Rice C, Domingo E, Sheldon J.

J Virol. 2013 Jul;87(13):7593-607. doi: 10.1128/JVI.02824-12. Epub 2013 May 1.

42.

The impact of quasispecies dynamics on the use of therapeutics.

Perales C, Iranzo J, Manrubia SC, Domingo E.

Trends Microbiol. 2012 Dec;20(12):595-603. doi: 10.1016/j.tim.2012.08.010. Epub 2012 Sep 16. Review.

PMID:
22989762
43.

Viral quasispecies evolution.

Domingo E, Sheldon J, Perales C.

Microbiol Mol Biol Rev. 2012 Jun;76(2):159-216. doi: 10.1128/MMBR.05023-11. Review.

44.

Lethal mutagenesis of viruses.

Perales C, Martín V, Domingo E.

Curr Opin Virol. 2011 Nov;1(5):419-22. doi: 10.1016/j.coviro.2011.09.001. Epub 2011 Oct 4. Review.

PMID:
22440845
45.

Quasispecies as a matter of fact: viruses and beyond.

Ojosnegros S, Perales C, Mas A, Domingo E.

Virus Res. 2011 Dec;162(1-2):203-15. doi: 10.1016/j.virusres.2011.09.018. Epub 2011 Sep 16. Review.

PMID:
21945638
46.

Lethal mutagenesis of foot-and-mouth disease virus involves shifts in sequence space.

Perales C, Henry M, Domingo E, Wain-Hobson S, Vartanian JP.

J Virol. 2011 Dec;85(23):12227-40. doi: 10.1128/JVI.00716-11. Epub 2011 Sep 14.

47.

Tempo and mode of inhibitor-mutagen antiviral therapies: a multidisciplinary approach.

Iranzo J, Perales C, Domingo E, Manrubia SC.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16008-13. doi: 10.1073/pnas.1110489108. Epub 2011 Sep 12.

48.

Viral genome segmentation can result from a trade-off between genetic content and particle stability.

Ojosnegros S, García-Arriaza J, Escarmís C, Manrubia SC, Perales C, Arias A, Mateu MG, Domingo E.

PLoS Genet. 2011 Mar;7(3):e1001344. doi: 10.1371/journal.pgen.1001344. Epub 2011 Mar 17.

49.

Influence of mutagenesis and viral load on the sustained low-level replication of an RNA virus.

Perales C, Agudo R, Manrubia SC, Domingo E.

J Mol Biol. 2011 Mar 18;407(1):60-78. doi: 10.1016/j.jmb.2011.01.026. Epub 2011 Jan 19.

PMID:
21256131
50.

A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.

Agudo R, Ferrer-Orta C, Arias A, de la Higuera I, Perales C, Pérez-Luque R, Verdaguer N, Domingo E.

PLoS Pathog. 2010 Aug 26;6(8):e1001072. doi: 10.1371/journal.ppat.1001072.

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