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Items: 1 to 50 of 79

1.

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact.

Salo VT, Li S, Vihinen H, Hölttä-Vuori M, Szkalisity A, Horvath P, Belevich I, Peränen J, Thiele C, Somerharju P, Zhao H, Santinho A, Thiam AR, Jokitalo E, Ikonen E.

Dev Cell. 2019 Aug 19;50(4):478-493.e9. doi: 10.1016/j.devcel.2019.05.016. Epub 2019 Jun 6.

PMID:
31178403
2.

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol.

Koponen A, Arora A, Takahashi K, Kentala H, Kivelä AM, Jääskeläinen E, Peränen J, Somerharju P, Ikonen E, Viitala T, Olkkonen VM.

Biochimie. 2019 Mar;158:90-101. doi: 10.1016/j.biochi.2018.12.013. Epub 2018 Dec 24.

PMID:
30590084
3.

Endocytic turnover of Rab8 controls cell polarization.

Vidal-Quadras M, Holst MR, Francis MK, Larsson E, Hachimi M, Yau WL, Peränen J, Martín-Belmonte F, Lundmark R.

J Cell Sci. 2017 Mar 15;130(6):1147-1157. doi: 10.1242/jcs.195420. Epub 2017 Jan 30.

4.

Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA.

Jiu Y, Peränen J, Schaible N, Cheng F, Eriksson JE, Krishnan R, Lappalainen P.

J Cell Sci. 2017 Mar 1;130(5):892-902. doi: 10.1242/jcs.196881. Epub 2017 Jan 17.

5.

Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease.

Runeberg-Roos P, Piccinini E, Penttinen AM, Mätlik K, Heikkinen H, Kuure S, Bespalov MM, Peränen J, Garea-Rodríguez E, Fuchs E, Airavaara M, Kalkkinen N, Penn R, Saarma M.

Neurobiol Dis. 2016 Dec;96:335-345. doi: 10.1016/j.nbd.2016.07.008. Epub 2016 Jul 15.

PMID:
27425888
6.

LDL-cholesterol transport to the endoplasmic reticulum: current concepts.

Pfisterer SG, Peränen J, Ikonen E.

Curr Opin Lipidol. 2016 Jun;27(3):282-7. doi: 10.1097/MOL.0000000000000292. Review.

7.

Small GTPases in peroxisome dynamics.

Just WW, Peränen J.

Biochim Biophys Acta. 2016 May;1863(5):1006-13. doi: 10.1016/j.bbamcr.2016.01.004. Epub 2016 Jan 8. Review.

8.

Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity.

Mätlik K, Yu LY, Eesmaa A, Hellman M, Lindholm P, Peränen J, Galli E, Anttila J, Saarma M, Permi P, Airavaara M, Arumäe U.

Cell Death Dis. 2015 Dec 31;6:e2032. doi: 10.1038/cddis.2015.371.

9.

Kinetic activation of Rab8 guanine nucleotide exchange factor Rabin8 by Rab11.

Feng S, Wu B, Peränen J, Guo W.

Methods Mol Biol. 2015;1298:99-106. doi: 10.1007/978-1-4939-2569-8_8.

PMID:
25800835
10.

Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.

Barbelanne M, Hossain D, Chan DP, Peränen J, Tsang WY.

Hum Mol Genet. 2015 Apr 15;24(8):2185-200. doi: 10.1093/hmg/ddu738. Epub 2014 Dec 30.

11.

Activation of Rab8 guanine nucleotide exchange factor Rabin8 by ERK1/2 in response to EGF signaling.

Wang J, Ren J, Wu B, Feng S, Cai G, Tuluc F, Peränen J, Guo W.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):148-53. doi: 10.1073/pnas.1412089112. Epub 2014 Dec 22.

12.

OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.

Weber-Boyvat M, Kentala H, Lilja J, Vihervaara T, Hanninen R, Zhou Y, Peränen J, Nyman TA, Ivaska J, Olkkonen VM.

Exp Cell Res. 2015 Feb 15;331(2):278-91. doi: 10.1016/j.yexcr.2014.10.019. Epub 2014 Oct 29.

PMID:
25447204
13.

Ligand-dependent localization and function of ORP-VAP complexes at membrane contact sites.

Weber-Boyvat M, Kentala H, Peränen J, Olkkonen VM.

Cell Mol Life Sci. 2015 May;72(10):1967-87. doi: 10.1007/s00018-014-1786-x. Epub 2014 Nov 25.

PMID:
25420878
14.

Tristetraprolin is a novel regulator of BDNF.

Kumar A, Varendi K, Peränen J, Andressoo JO.

Springerplus. 2014 Sep 6;3:502. doi: 10.1186/2193-1801-3-502. eCollection 2014.

15.

Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion.

Ihermann-Hella A, Lume M, Miinalainen IJ, Pirttiniemi A, Gui Y, Peränen J, Charron J, Saarma M, Costantini F, Kuure S.

PLoS Genet. 2014 Mar 6;10(3):e1004193. doi: 10.1371/journal.pgen.1004193. eCollection 2014 Mar.

16.

LDL cholesterol recycles to the plasma membrane via a Rab8a-Myosin5b-actin-dependent membrane transport route.

Kanerva K, Uronen RL, Blom T, Li S, Bittman R, Lappalainen P, Peränen J, Raposo G, Ikonen E.

Dev Cell. 2013 Nov 11;27(3):249-62. doi: 10.1016/j.devcel.2013.09.016. Epub 2013 Oct 24.

17.

Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease.

Bäck S, Peränen J, Galli E, Pulkkila P, Lonka-Nevalaita L, Tamminen T, Voutilainen MH, Raasmaja A, Saarma M, Männistö PT, Tuominen RK.

Brain Behav. 2013 Mar;3(2):75-88. doi: 10.1002/brb3.117. Epub 2013 Jan 14.

18.

A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells.

Khandelwal P, Prakasam HS, Clayton DR, Ruiz WG, Gallo LI, van Roekel D, Lukianov S, Peränen J, Goldenring JR, Apodaca G.

Mol Biol Cell. 2013 Apr;24(7):1007-19. doi: 10.1091/mbc.E12-08-0568. Epub 2013 Feb 6.

19.

A conserved regulatory mode in exocytic membrane fusion revealed by Mso1p membrane interactions.

Weber-Boyvat M, Zhao H, Aro N, Yuan Q, Chernov K, Peränen J, Lappalainen P, Jäntti J.

Mol Biol Cell. 2013 Feb;24(3):331-41. doi: 10.1091/mbc.E12-05-0415. Epub 2012 Nov 28.

20.

A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis.

Feng S, Knödler A, Ren J, Zhang J, Zhang X, Hong Y, Huang S, Peränen J, Guo W.

J Biol Chem. 2012 May 4;287(19):15602-9. doi: 10.1074/jbc.M111.333245. Epub 2012 Mar 19.

21.

Rab8 GTPase as a regulator of cell shape.

Peränen J.

Cytoskeleton (Hoboken). 2011 Oct;68(10):527-39. doi: 10.1002/cm.20529. Epub 2011 Sep 9. Review.

PMID:
21850707
22.

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.

Pykäläinen A, Boczkowska M, Zhao H, Saarikangas J, Rebowski G, Jansen M, Hakanen J, Koskela EV, Peränen J, Vihinen H, Jokitalo E, Salminen M, Ikonen E, Dominguez R, Lappalainen P.

Nat Struct Mol Biol. 2011 Jul 10;18(8):902-7. doi: 10.1038/nsmb.2079.

23.

Accumulation of the Raf-1 kinase inhibitory protein (Rkip) is associated with Cep290-mediated photoreceptor degeneration in ciliopathies.

Murga-Zamalloa CA, Ghosh AK, Patil SB, Reed NA, Chan LS, Davuluri S, Peränen J, Hurd TW, Rachel RA, Khanna H.

J Biol Chem. 2011 Aug 12;286(32):28276-86. doi: 10.1074/jbc.M111.237560. Epub 2011 Jun 17.

24.

Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers.

Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, Demmers J, Peränen J, Pasterkamp RJ, van der Sluijs P, Hoogenraad CC, Akhmanova A.

Curr Biol. 2011 Jun 7;21(11):967-74. doi: 10.1016/j.cub.2011.04.030. Epub 2011 May 19.

25.

Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease.

Voutilainen MH, Bäck S, Peränen J, Lindholm P, Raasmaja A, Männistö PT, Saarma M, Tuominen RK.

Exp Neurol. 2011 Mar;228(1):99-108. doi: 10.1016/j.expneurol.2010.12.013. Epub 2010 Dec 24.

PMID:
21185834
26.

RhoA regulates peroxisome association to microtubules and the actin cytoskeleton.

Schollenberger L, Gronemeyer T, Huber CM, Lay D, Wiese S, Meyer HE, Warscheid B, Saffrich R, Peränen J, Gorgas K, Just WW.

PLoS One. 2010 Nov 8;5(11):e13886. doi: 10.1371/journal.pone.0013886.

27.

Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons.

Hellman M, Arumäe U, Yu LY, Lindholm P, Peränen J, Saarma M, Permi P.

J Biol Chem. 2011 Jan 28;286(4):2675-80. doi: 10.1074/jbc.M110.146738. Epub 2010 Nov 3.

28.

A molecular network for de novo generation of the apical surface and lumen.

Bryant DM, Datta A, Rodríguez-Fraticelli AE, Peränen J, Martín-Belmonte F, Mostov KE.

Nat Cell Biol. 2010 Nov;12(11):1035-45. doi: 10.1038/ncb2106. Epub 2010 Oct 3.

29.

Characterization of the intracellular localization, processing, and secretion of two glial cell line-derived neurotrophic factor splice isoforms.

Lonka-Nevalaita L, Lume M, Leppänen S, Jokitalo E, Peränen J, Saarma M.

J Neurosci. 2010 Aug 25;30(34):11403-13. doi: 10.1523/JNEUROSCI.5888-09.2010.

30.

Widespread cortical expression of MANF by AAV serotype 7: localization and protection against ischemic brain injury.

Airavaara M, Chiocco MJ, Howard DB, Zuchowski KL, Peränen J, Liu C, Fang S, Hoffer BJ, Wang Y, Harvey BK.

Exp Neurol. 2010 Sep;225(1):104-13. doi: 10.1016/j.expneurol.2010.05.020. Epub 2010 Jun 2.

31.

Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration.

Murga-Zamalloa CA, Atkins SJ, Peranen J, Swaroop A, Khanna H.

Hum Mol Genet. 2010 Sep 15;19(18):3591-8. doi: 10.1093/hmg/ddq275. Epub 2010 Jul 14.

32.

1H, 13C and 15N resonance assignments of the human mesencephalic astrocyte-derived neurotrophic factor.

Hellman M, Peränen J, Saarma M, Permi P.

Biomol NMR Assign. 2010 Oct;4(2):215-7. doi: 10.1007/s12104-010-9251-8. Epub 2010 Jul 9.

PMID:
20617400
33.

Coordination of Rab8 and Rab11 in primary ciliogenesis.

Knödler A, Feng S, Zhang J, Zhang X, Das A, Peränen J, Guo W.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6346-51. doi: 10.1073/pnas.1002401107. Epub 2010 Mar 22.

34.

Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease.

Voutilainen MH, Bäck S, Pörsti E, Toppinen L, Lindgren L, Lindholm P, Peränen J, Saarma M, Tuominen RK.

J Neurosci. 2009 Jul 29;29(30):9651-9. doi: 10.1523/JNEUROSCI.0833-09.2009.

35.

Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats.

Airavaara M, Shen H, Kuo CC, Peränen J, Saarma M, Hoffer B, Wang Y.

J Comp Neurol. 2009 Jul 1;515(1):116-24. doi: 10.1002/cne.22039.

36.

Clathrin-independent entry of baculovirus triggers uptake of E. coli in non-phagocytic human cells.

Laakkonen JP, Mäkelä AR, Kakkonen E, Turkki P, Kukkonen S, Peränen J, Ylä-Herttuala S, Airenne KJ, Oker-Blom C, Vihinen-Ranta M, Marjomäki V.

PLoS One. 2009;4(4):e5093. doi: 10.1371/journal.pone.0005093. Epub 2009 Apr 7.

37.

Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages.

Linder MD, Mäyränpää MI, Peränen J, Pietilä TE, Pietiäinen VM, Uronen RL, Olkkonen VM, Kovanen PT, Ikonen E.

Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):883-8. doi: 10.1161/ATVBAHA.108.179481. Epub 2009 Mar 19.

PMID:
19304576
38.

The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional.

Parkash V, Lindholm P, Peränen J, Kalkkinen N, Oksanen E, Saarma M, Leppänen VM, Goldman A.

Protein Eng Des Sel. 2009 Apr;22(4):233-41. doi: 10.1093/protein/gzn080. Epub 2009 Mar 3.

PMID:
19258449
39.

Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons.

Palgi M, Lindström R, Peränen J, Piepponen TP, Saarma M, Heino TI.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2429-34. doi: 10.1073/pnas.0810996106. Epub 2009 Jan 22.

40.

MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain.

Lindholm P, Peränen J, Andressoo JO, Kalkkinen N, Kokaia Z, Lindvall O, Timmusk T, Saarma M.

Mol Cell Neurosci. 2008 Nov;39(3):356-71. doi: 10.1016/j.mcn.2008.07.016. Epub 2008 Jul 30.

PMID:
18718866
41.

CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease.

Tsang WY, Bossard C, Khanna H, Peränen J, Swaroop A, Malhotra V, Dynlacht BD.

Dev Cell. 2008 Aug;15(2):187-97. doi: 10.1016/j.devcel.2008.07.004.

42.
43.

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.

Lindholm P, Voutilainen MH, Laurén J, Peränen J, Leppänen VM, Andressoo JO, Lindahl M, Janhunen S, Kalkkinen N, Timmusk T, Tuominen RK, Saarma M.

Nature. 2007 Jul 5;448(7149):73-7.

PMID:
17611540
44.

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.

Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK.

Cell. 2007 Jun 15;129(6):1201-13.

45.

Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.

Roland JT, Kenworthy AK, Peranen J, Caplan S, Goldenring JR.

Mol Biol Cell. 2007 Aug;18(8):2828-37. Epub 2007 May 16.

46.

Identification of endosomal epidermal growth factor receptor signaling targets by functional organelle proteomics.

Stasyk T, Schiefermeier N, Skvortsov S, Zwierzina H, Peränen J, Bonn GK, Huber LA.

Mol Cell Proteomics. 2007 May;6(5):908-22. Epub 2007 Feb 10.

47.

Characterization of the Rab8-specific membrane traffic route linked to protrusion formation.

Hattula K, Furuhjelm J, Tikkanen J, Tanhuanpää K, Laakkonen P, Peränen J.

J Cell Sci. 2006 Dec 1;119(Pt 23):4866-77. Epub 2006 Nov 14.

48.

Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells.

Linder MD, Uronen RL, Hölttä-Vuori M, van der Sluijs P, Peränen J, Ikonen E.

Mol Biol Cell. 2007 Jan;18(1):47-56. Epub 2006 Oct 18.

49.
50.

AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.

Mîinea CP, Sano H, Kane S, Sano E, Fukuda M, Peränen J, Lane WS, Lienhard GE.

Biochem J. 2005 Oct 1;391(Pt 1):87-93.

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