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Items: 1 to 50 of 186

1.

GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation.

Giacomello E, Ronchi P, Pepperkok R.

J Cell Sci. 2019 Jan 23;132(2). pii: jcs222083. doi: 10.1242/jcs.222083.

PMID:
30630895
2.

A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic.

Lérias JR, Pinto MC, Botelho HM, Awatade NT, Quaresma MC, Silva IAL, Wanitchakool P, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD.

Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):421-431. doi: 10.1016/j.bbamcr.2017.11.009. Epub 2017 Nov 15.

3.

Quantitative 3D-imaging for cell biology and ecology of environmental microbial eukaryotes.

Colin S, Coelho LP, Sunagawa S, Bowler C, Karsenti E, Bork P, Pepperkok R, de Vargas C.

Elife. 2017 Oct 31;6. pii: e26066. doi: 10.7554/eLife.26066.

4.

Targeted Ablation Using Laser Nanosurgery.

Gayathri Vegesna NV, Ronchi P, Durdu S, Terjung S, Pepperkok R.

Methods Mol Biol. 2017;1563:107-125. doi: 10.1007/978-1-4939-6810-7_8.

PMID:
28324605
5.

Profiling DNA damage response following mitotic perturbations.

S Pedersen R, Karemore G, Gudjonsson T, Rask MB, Neumann B, Hériché JK, Pepperkok R, Ellenberg J, Gerlich DW, Lukas J, Lukas C.

Nat Commun. 2016 Dec 15;7:13887. doi: 10.1038/ncomms13887.

6.

Let there be light-at the right place.

Hufnagel L, Pepperkok R.

Nat Biotechnol. 2016 Dec 7;34(12):1246-1247. doi: 10.1038/nbt.3738. No abstract available.

PMID:
27926712
7.

The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.

Scharaw S, Iskar M, Ori A, Boncompain G, Laketa V, Poser I, Lundberg E, Perez F, Beck M, Bork P, Pepperkok R.

J Cell Biol. 2016 Nov 21;215(4):543-558. Epub 2016 Nov 8.

8.

Institutional core facilities: prerequisite for breakthroughs in the life sciences: Core facilities play an increasingly important role in biomedical research by providing scientists access to sophisticated technology and expertise.

Meder D, Morales M, Pepperkok R, Schlapbach R, Tiran A, Van Minnebruggen G.

EMBO Rep. 2016 Aug;17(8):1088-93. doi: 10.15252/embr.201642857. Epub 2016 Jul 13. No abstract available.

9.

A microtubule-independent role of p150glued in secretory cargo concentration at endoplasmic reticulum exit sites.

Verissimo F, Halavatyi A, Pepperkok R, Weiss M.

J Cell Sci. 2015 Nov 15;128(22):4160-70. doi: 10.1242/jcs.172395. Epub 2015 Oct 12.

10.

Erratum: Novel microscopy-based screening method reveals regulators of contact-dependent intercellular transfer.

Frei DM, Hodneland E, Rios-Mondragon I, Burtey A, Neumann B, Bulkescher J, Schölermann J, Pepperkok R, Gerdes HH, Kögel T.

Sci Rep. 2015 Sep 21;5:14158. doi: 10.1038/srep14158. No abstract available.

11.

Novel microscopy-based screening method reveals regulators of contact-dependent intercellular transfer.

Frei DM, Hodneland E, Rios-Mondragon I, Burtey A, Neumann B, Bulkescher J, Schölermann J, Pepperkok R, Gerdes HH, Kögel T.

Sci Rep. 2015 Aug 14;5:12879. doi: 10.1038/srep12879. Erratum in: Sci Rep. 2015;5:14158.

12.

High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells.

Wachsmuth M, Conrad C, Bulkescher J, Koch B, Mahen R, Isokane M, Pepperkok R, Ellenberg J.

Nat Biotechnol. 2015 Apr;33(4):384-9. doi: 10.1038/nbt.3146. Epub 2015 Mar 16.

PMID:
25774713
13.

Protein traffic disorders: an effective high-throughput fluorescence microscopy pipeline for drug discovery.

Botelho HM, Uliyakina I, Awatade NT, Proença MC, Tischer C, Sirianant L, Kunzelmann K, Pepperkok R, Amaral MD.

Sci Rep. 2015 Mar 12;5:9038. doi: 10.1038/srep09038.

14.

A Fluorescent Live Imaging Screening Assay Based on Translocation Criteria Identifies Novel Cytoplasmic Proteins Implicated in G Protein-coupled Receptor Signaling Pathways.

Lecat S, Matthes HW, Pepperkok R, Simpson JC, Galzi JL.

Mol Cell Proteomics. 2015 May;14(5):1385-99. doi: 10.1074/mcp.M114.046698. Epub 2015 Mar 10.

15.

Self-organization of core Golgi material is independent of COPII-mediated endoplasmic reticulum export.

Schuberth CE, Tängemo C, Coneva C, Tischer C, Pepperkok R.

J Cell Sci. 2015 Apr 1;128(7):1279-93. doi: 10.1242/jcs.154443. Epub 2015 Feb 25.

16.

Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction.

Thormaehlen AS, Schuberth C, Won HH, Blattmann P, Joggerst-Thomalla B, Theiss S, Asselta R, Duga S, Merlini PA, Ardissino D, Lander ES, Gabriel S, Rader DJ, Peloso GM, Pepperkok R, Kathiresan S, Runz H.

PLoS Genet. 2015 Feb 3;11(2):e1004855. doi: 10.1371/journal.pgen.1004855. eCollection 2015 Feb. Erratum in: PLoS Genet. 2015 Mar;11(3):e1005060.

17.

A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2.

Zacherl S, La Venuta G, Müller HM, Wegehingel S, Dimou E, Sehr P, Lewis JD, Erfle H, Pepperkok R, Nickel W.

J Biol Chem. 2015 Feb 6;290(6):3654-65. doi: 10.1074/jbc.M114.590067. Epub 2014 Dec 22.

18.

Positive feedback between Golgi membranes, microtubules and ER exit sites directs de novo biogenesis of the Golgi.

Ronchi P, Tischer C, Acehan D, Pepperkok R.

J Cell Sci. 2014 Nov 1;127(Pt 21):4620-33. doi: 10.1242/jcs.150474. Epub 2014 Sep 4.

19.

Adaptive fluorescence microscopy by online feedback image analysis.

Tischer C, Hilsenstein V, Hanson K, Pepperkok R.

Methods Cell Biol. 2014;123:489-503. doi: 10.1016/B978-0-12-420138-5.00026-4.

PMID:
24974044
20.

An RNAi screen identifies KIF15 as a novel regulator of the endocytic trafficking of integrin.

Eskova A, Knapp B, Matelska D, Reusing S, Arjonen A, Lisauskas T, Pepperkok R, Russell R, Eils R, Ivaska J, Kaderali L, Erfle H, Starkuviene V.

J Cell Sci. 2014 Jun 1;127(Pt 11):2433-47. doi: 10.1242/jcs.137281. Epub 2014 Mar 21.

21.

PIP₃ induces the recycling of receptor tyrosine kinases.

Laketa V, Zarbakhsh S, Traynor-Kaplan A, Macnamara A, Subramanian D, Putyrski M, Mueller R, Nadler A, Mentel M, Saez-Rodriguez J, Pepperkok R, Schultz C.

Sci Signal. 2014 Jan 14;7(308):ra5. doi: 10.1126/scisignal.2004532.

PMID:
24425787
22.

CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum.

Sauvageau E, Rochdi MD, Oueslati M, Hamdan FF, Percherancier Y, Simpson JC, Pepperkok R, Bouvier M.

Traffic. 2014 Apr;15(4):383-400. doi: 10.1111/tra.12148. Epub 2014 Feb 6.

23.

Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation.

Michel G, Matthes HW, Hachet-Haas M, El Baghdadi K, de Mey J, Pepperkok R, Simpson JC, Galzi JL, Lecat S.

J Cell Sci. 2014 Feb 15;127(Pt 4):773-87. doi: 10.1242/jcs.136432. Epub 2013 Dec 11.

24.

Golgi depletion from living cells with laser nanosurgery.

Ronchi P, Pepperkok R.

Methods Cell Biol. 2013;118:311-24. doi: 10.1016/B978-0-12-417164-0.00019-7.

PMID:
24295315
25.

Imaging ER-to-Golgi transport: towards a systems view.

Verissimo F, Pepperkok R.

J Cell Sci. 2013 Nov 15;126(Pt 22):5091-100. doi: 10.1242/jcs.121061.

26.

PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex.

He S, Ni D, Ma B, Lee JH, Zhang T, Ghozalli I, Pirooz SD, Zhao Z, Bharatham N, Li B, Oh S, Lee WH, Takahashi Y, Wang HG, Minassian A, Feng P, Deretic V, Pepperkok R, Tagaya M, Yoon HS, Liang C.

Nat Cell Biol. 2013 Oct;15(10):1206-1219. doi: 10.1038/ncb2848. Epub 2013 Sep 22.

27.

High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets.

Almaça J, Faria D, Sousa M, Uliyakina I, Conrad C, Sirianant L, Clarke LA, Martins JP, Santos M, Heriché JK, Huber W, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD.

Cell. 2013 Sep 12;154(6):1390-400. doi: 10.1016/j.cell.2013.08.045.

28.

Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding.

Iskar M, Zeller G, Blattmann P, Campillos M, Kuhn M, Kaminska KH, Runz H, Gavin AC, Pepperkok R, van Noort V, Bork P.

Mol Syst Biol. 2013;9:662. doi: 10.1038/msb.2013.20.

29.

RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function.

Blattmann P, Schuberth C, Pepperkok R, Runz H.

PLoS Genet. 2013;9(2):e1003338. doi: 10.1371/journal.pgen.1003338. Epub 2013 Feb 28.

30.

Cell-to-cell communication: current views and future perspectives.

Gerdes HH, Pepperkok R.

Cell Tissue Res. 2013 Apr;352(1):1-3. doi: 10.1007/s00441-013-1590-1. Epub 2013 Feb 26. No abstract available.

PMID:
23435994
31.

Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells.

Stadler C, Rexhepaj E, Singan VR, Murphy RF, Pepperkok R, Uhlén M, Simpson JC, Lundberg E.

Nat Methods. 2013 Apr;10(4):315-23. doi: 10.1038/nmeth.2377. Epub 2013 Feb 24.

PMID:
23435261
32.

At the cutting edge: applications and perspectives of laser nanosurgery in cell biology.

Ronchi P, Terjung S, Pepperkok R.

Biol Chem. 2012 Apr;393(4):235-48. doi: 10.1515/hsz-2011-0237. Review.

PMID:
23029645
33.

Chemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia A.

Roth SD, Schüttrumpf J, Milanov P, Abriss D, Ungerer C, Quade-Lyssy P, Simpson JC, Pepperkok R, Seifried E, Tonn T.

PLoS One. 2012;7(9):e44505. doi: 10.1371/journal.pone.0044505. Epub 2012 Sep 4.

34.

Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway.

Simpson JC, Joggerst B, Laketa V, Verissimo F, Cetin C, Erfle H, Bexiga MG, Singan VR, Hériché JK, Neumann B, Mateos A, Blake J, Bechtel S, Benes V, Wiemann S, Ellenberg J, Pepperkok R.

Nat Cell Biol. 2012 Jun 3;14(7):764-74. doi: 10.1038/ncb2510.

PMID:
22660414
35.

Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy.

Stadler C, Hjelmare M, Neumann B, Jonasson K, Pepperkok R, Uhlén M, Lundberg E.

J Proteomics. 2012 Apr 3;75(7):2236-51. doi: 10.1016/j.jprot.2012.01.030. Epub 2012 Feb 15.

PMID:
22361696
36.

Quantifying the influence of yellow fluorescent protein photoconversion on acceptor photobleaching-based fluorescence resonance energy transfer measurements.

Seitz A, Terjung S, Zimmermann T, Pepperkok R.

J Biomed Opt. 2012 Jan;17(1):011010. doi: 10.1117/1.JBO.17.1.011010.

PMID:
22352644
37.

Molecular recognition of a single sphingolipid species by a protein's transmembrane domain.

Contreras FX, Ernst AM, Haberkant P, Björkholm P, Lindahl E, Gönen B, Tischer C, Elofsson A, von Heijne G, Thiele C, Pepperkok R, Wieland F, Brügger B.

Nature. 2012 Jan 9;481(7382):525-9. doi: 10.1038/nature10742.

PMID:
22230960
38.

A new approach to manipulate the fate of single neural stem cells in tissue.

Taverna E, Haffner C, Pepperkok R, Huttner WB.

Nat Neurosci. 2011 Dec 18;15(2):329-37. doi: 10.1038/nn.3008.

PMID:
22179113
39.

Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1.

Moudry P, Lukas C, Macurek L, Neumann B, Heriche JK, Pepperkok R, Ellenberg J, Hodny Z, Lukas J, Bartek J.

Cell Death Differ. 2012 May;19(5):798-807. doi: 10.1038/cdd.2011.150. Epub 2011 Nov 11.

40.

Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases.

Ritzerfeld J, Remmele S, Wang T, Temmerman K, Brügger B, Wegehingel S, Tournaviti S, Strating JR, Wieland FT, Neumann B, Ellenberg J, Lawerenz C, Hesser J, Erfle H, Pepperkok R, Nickel W.

Genome Res. 2011 Nov;21(11):1955-68. doi: 10.1101/gr.116087.110. Epub 2011 Jul 27.

41.

Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.

Moore HM, Bai B, Boisvert FM, Latonen L, Rantanen V, Simpson JC, Pepperkok R, Lamond AI, Laiho M.

Mol Cell Proteomics. 2011 Oct;10(10):M111.009241. doi: 10.1074/mcp.M111.009241. Epub 2011 Jul 21.

42.

Functional genomics assays to study CFTR traffic and ENaC function.

Almaça J, Dahimène S, Appel N, Conrad C, Kunzelmann K, Pepperkok R, Amaral MD.

Methods Mol Biol. 2011;742:249-64. doi: 10.1007/978-1-61779-120-8_15.

PMID:
21547737
43.

A novel laser nanosurgery approach supports de novo Golgi biogenesis in mammalian cells.

Tängemo C, Ronchi P, Colombelli J, Haselmann U, Simpson JC, Antony C, Stelzer EH, Pepperkok R, Reynaud EG.

J Cell Sci. 2011 Mar 15;124(Pt 6):978-87. doi: 10.1242/jcs.079640.

44.

Micropilot: automation of fluorescence microscopy-based imaging for systems biology.

Conrad C, Wünsche A, Tan TH, Bulkescher J, Sieckmann F, Verissimo F, Edelstein A, Walter T, Liebel U, Pepperkok R, Ellenberg J.

Nat Methods. 2011 Mar;8(3):246-9. doi: 10.1038/nmeth.1558. Epub 2011 Jan 23.

45.

Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.

Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R.

Cell Host Microbe. 2011 Jan 20;9(1):32-45. doi: 10.1016/j.chom.2010.12.002.

46.

High-throughput microscopy using live mammalian cells.

Terjung S, Walter T, Seitz A, Neumann B, Pepperkok R, Ellenberg J.

Cold Spring Harb Protoc. 2010 Aug 1;2010(7):pdb.top84. doi: 10.1101/pdb.top84. No abstract available.

PMID:
20679389
47.

In situ analysis of tyrosine phosphorylation networks by FLIM on cell arrays.

Grecco HE, Roda-Navarro P, Girod A, Hou J, Frahm T, Truxius DC, Pepperkok R, Squire A, Bastiaens PI.

Nat Methods. 2010 Jun;7(6):467-72. doi: 10.1038/nmeth.1458. Epub 2010 May 9.

PMID:
20453867
48.

Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells.

Subramanian D, Laketa V, Müller R, Tischer C, Zarbakhsh S, Pepperkok R, Schultz C.

Nat Chem Biol. 2010 May;6(5):324-6. doi: 10.1038/nchembio.348. Epub 2010 Apr 4.

PMID:
20364126
49.

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.

Neumann B, Walter T, Hériché JK, Bulkescher J, Erfle H, Conrad C, Rogers P, Poser I, Held M, Liebel U, Cetin C, Sieckmann F, Pau G, Kabbe R, Wünsche A, Satagopam V, Schmitz MH, Chapuis C, Gerlich DW, Schneider R, Eils R, Huber W, Peters JM, Hyman AA, Durbin R, Pepperkok R, Ellenberg J.

Nature. 2010 Apr 1;464(7289):721-7. doi: 10.1038/nature08869.

50.

Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion.

Ebert AD, Laussmann M, Wegehingel S, Kaderali L, Erfle H, Reichert J, Lechner J, Beer HD, Pepperkok R, Nickel W.

Traffic. 2010 Jun;11(6):813-26. doi: 10.1111/j.1600-0854.2010.01059.x. Epub 2010 Mar 10.

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