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Items: 18


Effects of Host, Sample, and in vitro Culture on Genomic Diversity of Pathogenic Mycobacteria.

Shockey AC, Dabney J, Pepperell CS.

Front Genet. 2019 Jun 4;10:477. doi: 10.3389/fgene.2019.00477. eCollection 2019.


Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin-6 as a Potential Susceptibility Locus.

Merkhofer RM Jr, O'Neill MB, Xiong D, Hernandez-Santos N, Dobson H, Fites JS, Shockey AC, Wuethrich M, Pepperell CS, Klein BS.

MBio. 2019 Jun 18;10(3). pii: e01224-19. doi: 10.1128/mBio.01224-19.


Lineage specific histories of Mycobacterium tuberculosis dispersal in Africa and Eurasia.

O'Neill MB, Shockey A, Zarley A, Aylward W, Eldholm V, Kitchen A, Pepperell CS.

Mol Ecol. 2019 Jul;28(13):3241-3256. doi: 10.1111/mec.15120. Epub 2019 Jul 9.


Multiple exposures, reinfection and risk of progression to active tuberculosis.

Ackley SF, Lee RS, Worden L, Zwick E, Porco TC, Behr MA, Pepperell CS.

R Soc Open Sci. 2019 Mar 20;6(3):180999. doi: 10.1098/rsos.180999. eCollection 2019 Mar.


China's tuberculosis epidemic stems from historical expansion of four strains of Mycobacterium tuberculosis.

Liu Q, Ma A, Wei L, Pang Y, Wu B, Luo T, Zhou Y, Zheng HX, Jiang Q, Gan M, Zuo T, Liu M, Yang C, Jin L, Comas I, Gagneux S, Zhao Y, Pepperell CS, Gao Q.

Nat Ecol Evol. 2018 Dec;2(12):1982-1992. doi: 10.1038/s41559-018-0680-6. Epub 2018 Nov 5.


Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation.

Brynildsrud OB, Pepperell CS, Suffys P, Grandjean L, Monteserin J, Debech N, Bohlin J, Alfsnes K, Pettersson JO, Kirkeleite I, Fandinho F, da Silva MA, Perdigao J, Portugal I, Viveiros M, Clark T, Caws M, Dunstan S, Thai PVK, Lopez B, Ritacco V, Kitchen A, Brown TS, van Soolingen D, O'Neill MB, Holt KE, Feil EJ, Mathema B, Balloux F, Eldholm V.

Sci Adv. 2018 Oct 17;4(10):eaat5869. doi: 10.1126/sciadv.aat5869. eCollection 2018 Oct.


Epidemiological and genomic determinants of tuberculosis outbreaks in First Nations communities in Canada.

Doroshenko A, Pepperell CS, Heffernan C, Egedahl ML, Mortimer TD, Smith TM, Bussan HE, Tyrrell GJ, Long R.

BMC Med. 2018 Aug 8;16(1):128. doi: 10.1186/s12916-018-1112-9.


Signatures of Selection at Drug Resistance Loci in Mycobacterium tuberculosis.

Mortimer TD, Weber AM, Pepperell CS.

mSystems. 2018 Jan 30;3(1). pii: e00108-17. doi: 10.1128/mSystems.00108-17. eCollection 2018 Jan-Feb.


Adaptation in a Fibronectin Binding Autolysin of Staphylococcus saprophyticus.

Mortimer TD, Annis DS, O'Neill MB, Bohr LL, Smith TM, Poinar HN, Mosher DF, Pepperell CS.

mSphere. 2017 Nov 29;2(6). pii: e00511-17. doi: 10.1128/mSphere.00511-17. eCollection 2017 Nov-Dec.


Evolutionary Thrift: Mycobacteria Repurpose Plasmid Diversity during Adaptation of Type VII Secretion Systems.

Mortimer TD, Weber AM, Pepperell CS.

Genome Biol Evol. 2017 Mar 1;9(3):398-413. doi: 10.1093/gbe/evx001.


A molecular portrait of maternal sepsis from Byzantine Troy.

Devault AM, Mortimer TD, Kitchen A, Kiesewetter H, Enk JM, Golding GB, Southon J, Kuch M, Duggan AT, Aylward W, Gardner SN, Allen JE, King AM, Wright G, Kuroda M, Kato K, Briggs DE, Fornaciari G, Holmes EC, Poinar HN, Pepperell CS.

Elife. 2017 Jan 10;6. pii: e20983. doi: 10.7554/eLife.20983.


Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis.

Eldholm V, Pettersson JH, Brynildsrud OB, Kitchen A, Rasmussen EM, Lillebaek T, Rønning JO, Crudu V, Mengshoel AT, Debech N, Alfsnes K, Bohlin J, Pepperell CS, Balloux F.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13881-13886. Epub 2016 Nov 21.


Estimation of Gene Insertion/Deletion Rates with Missing Data.

Dang UJ, Devault AM, Mortimer TD, Pepperell CS, Poinar HN, Golding GB.

Genetics. 2016 Oct;204(2):513-529. Epub 2016 Aug 26.


Diversity of Mycobacterium tuberculosis across Evolutionary Scales.

O'Neill MB, Mortimer TD, Pepperell CS.

PLoS Pathog. 2015 Nov 12;11(11):e1005257. doi: 10.1371/journal.ppat.1005257. eCollection 2015.


Modeling historical tuberculosis epidemics among Canadian First Nations: effects of malnutrition and genetic variation.

Ackley SF, Liu F, Porco TC, Pepperell CS.

PeerJ. 2015 Sep 24;3:e1237. doi: 10.7717/peerj.1237. eCollection 2015.


Genomic signatures of distributive conjugal transfer among mycobacteria.

Mortimer TD, Pepperell CS.

Genome Biol Evol. 2014 Aug 30;6(9):2489-500. doi: 10.1093/gbe/evu175.


The role of selection in shaping diversity of natural M. tuberculosis populations.

Pepperell CS, Casto AM, Kitchen A, Granka JM, Cornejo OE, Holmes EC, Birren B, Galagan J, Feldman MW.

PLoS Pathog. 2013 Aug;9(8):e1003543. doi: 10.1371/journal.ppat.1003543. Epub 2013 Aug 15. Erratum in: PLoS Pathog. 2013 Aug;9(8). doi:10.1371/annotation/cff22061-44d5-4301-b853-41702d160203. Holmes, Eddie C [corrected to Holmes, Edward C].


Dispersal of Mycobacterium tuberculosis via the Canadian fur trade.

Pepperell CS, Granka JM, Alexander DC, Behr MA, Chui L, Gordon J, Guthrie JL, Jamieson FB, Langlois-Klassen D, Long R, Nguyen D, Wobeser W, Feldman MW.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6526-31. doi: 10.1073/pnas.1016708108. Epub 2011 Apr 4.

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