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Items: 1 to 50 of 267

1.

Sex and Gender Differences in the Brain Cholinergic System and in the Response to Therapy of Alzheimer Disease with Cholinesterase Inhibitors.

Giacobini E, Pepeu GC.

Curr Alzheimer Res. 2018 Jun 12. doi: 10.2174/1567205015666180613111504. [Epub ahead of print]

PMID:
29895246
2.

The fate of the brain cholinergic neurons in neurodegenerative diseases.

Pepeu G, Grazia Giovannini M.

Brain Res. 2017 Sep 1;1670:173-184. doi: 10.1016/j.brainres.2017.06.023. Epub 2017 Jun 23. Review.

PMID:
28652219
3.

The integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory.

Giovannini MG, Lana D, Pepeu G.

Neurobiol Learn Mem. 2015 Mar;119:18-33. doi: 10.1016/j.nlm.2014.12.014. Epub 2015 Jan 13. Review.

PMID:
25595880
4.

Do cholinesterase inhibitors act primarily on attention deficit? A naturalistic study in Alzheimer's disease patients.

Bracco L, Bessi V, Padiglioni S, Marini S, Pepeu G.

J Alzheimers Dis. 2014;40(3):737-42. doi: 10.3233/JAD-131154.

PMID:
24577458
5.

Effect of cholinesterase inhibitors on attention.

Pepeu G, Giovannini MG, Bracco L.

Chem Biol Interact. 2013 Mar 25;203(1):361-4. doi: 10.1016/j.cbi.2012.09.016. Epub 2012 Oct 6. Review.

PMID:
23047023
6.

Cholinesterase inhibitors and memory.

Pepeu G, Giovannini MG.

Chem Biol Interact. 2010 Sep 6;187(1-3):403-8. doi: 10.1016/j.cbi.2009.11.018. Epub 2009 Nov 24. Review.

PMID:
19941841
7.

Cholinesterase inhibitors and beyond.

Pepeu G, Giovannini MG.

Curr Alzheimer Res. 2009 Apr;6(2):86-96. Review.

PMID:
19355843
8.

Extracellular levels of brain aspartate, glutamate and GABA during an inhibitory avoidance response in the rat.

Ballini C, Corte LD, Pazzagli M, Colivicchi MA, Pepeu G, Tipton KF, Giovannini MG.

J Neurochem. 2008 Aug;106(3):1035-43. doi: 10.1111/j.1471-4159.2008.05452.x. Epub 2008 May 3.

9.

N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine.

Cerbai F, Giovannini MG, Melani C, Enz A, Pepeu G.

Eur J Pharmacol. 2007 Oct 31;572(2-3):142-50. Epub 2007 Jul 4.

PMID:
17643410
10.

Acetylcholine release from fetal tissue homotopically grafted to the motoneuron-depleted lumbar spinal cord. An in vivo microdialysis study in the awake rat.

Gulino R, Cataudella T, Casamenti F, Pepeu G, Stanzani S, Leanza G.

Exp Neurol. 2007 Mar;204(1):326-38. Epub 2007 Jan 16.

PMID:
17234186
11.

Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice.

Bellucci A, Luccarini I, Scali C, Prosperi C, Giovannini MG, Pepeu G, Casamenti F.

Neurobiol Dis. 2006 Aug;23(2):260-72.

PMID:
16766197
12.

Neuronal control of the cardiac responses to osmotic stress in the gastropod limpet Patella caerulea.

Bini G, Pugliese AM, Pepeu G, Chelazzi G.

J Exp Zool A Comp Exp Biol. 2006 Jun 1;305(6):472-9.

PMID:
16646089
13.

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent.

Greig NH, Utsuki T, Ingram DK, Wang Y, Pepeu G, Scali C, Yu QS, Mamczarz J, Holloway HW, Giordano T, Chen D, Furukawa K, Sambamurti K, Brossi A, Lahiri DK.

Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17213-8. Epub 2005 Nov 7.

14.

Inhibition of acetylcholine-induced activation of extracellular regulated protein kinase prevents the encoding of an inhibitory avoidance response in the rat.

Giovannini MG, Pazzagli M, Malmberg-Aiello P, Della Corte L, Rakovska AD, Cerbai F, Casamenti F, Pepeu G.

Neuroscience. 2005;136(1):15-32. Epub 2005 Sep 29.

PMID:
16198498
15.

Alzheimer Symposium. Etiopathogenetic mechanisms of Alzheimer's disease.

Pepeu G.

IDrugs. 2000 Jul;3(7):742. No abstract available.

PMID:
16080040
16.

Tetrodotoxin prevents copper-induced bradycardia in gastropod limpets.

Bini G, Pugliese AM, Pepeu G, Chelazzi G.

Environ Pollut. 2006 Jan;139(1):79-85. Epub 2005 Jul 1.

PMID:
15993526
17.

Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide (1-42) into rat brain: implications for Alzheimer's disease.

Boyd-Kimball D, Sultana R, Poon HF, Lynn BC, Casamenti F, Pepeu G, Klein JB, Butterfield DA.

Neuroscience. 2005;132(2):313-24.

PMID:
15802185
18.

A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone.

Luparini MR, Garrone B, Pazzagli M, Pinza M, Pepeu G.

Prog Neuropsychopharmacol Biol Psychiatry. 2004 Nov;28(7):1117-27.

PMID:
15610924
19.

Mild cognitive impairment: animal models.

Pepeu G.

Dialogues Clin Neurosci. 2004 Dec;6(4):369-77.

20.

Comparison between flurbiprofen and its nitric oxide-releasing derivatives HCT-1026 and NCX-2216 on Abeta(1-42)-induced brain inflammation and neuronal damage in the rat.

Prosperi C, Scali C, Barba M, Bellucci A, Giovannini MG, Pepeu G, Casamenti F.

Int J Immunopathol Pharmacol. 2004 Sep-Dec;17(3):317-30.

PMID:
15461866
21.

S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat.

Rosi S, Giovannini MG, Lestage PJ, Muñoz C, Corte LD, Pepeu G.

Neurosci Lett. 2004 May 6;361(1-3):120-3.

PMID:
15135908
22.

Changes in acetylcholine extracellular levels during cognitive processes.

Pepeu G, Giovannini MG.

Learn Mem. 2004 Jan-Feb;11(1):21-7. Review.

PMID:
14747513
23.

Experimental brain inflammation and neurodegeneration as model of Alzheimer's disease: protective effects of selective COX-2 inhibitors.

Giovannini MG, Scali C, Prosperi C, Bellucci A, Pepeu G, Casamenti F.

Int J Immunopathol Pharmacol. 2003 May-Aug;16(2 Suppl):31-40. Review.

PMID:
14552702
24.

Investigation on acetylcholine, aspartate, glutamate and GABA extracellular levels from ventral hippocampus during repeated exploratory activity in the rat.

Bianchi L, Ballini C, Colivicchi MA, Della Corte L, Giovannini MG, Pepeu G.

Neurochem Res. 2003 Apr;28(3-4):565-73.

PMID:
12675146
25.

The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo.

Scali C, Giovannini MG, Prosperi C, Bellucci A, Pepeu G, Casamenti F.

Neuroscience. 2003;117(4):909-19.

PMID:
12654342
26.

Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway.

Giovannini MG, Scali C, Prosperi C, Bellucci A, Vannucchi MG, Rosi S, Pepeu G, Casamenti F.

Neurobiol Dis. 2002 Nov;11(2):257-74.

PMID:
12505419
27.

An autocrine role for pituitary GABA: activation of GABA-B receptors and regulation of growth hormone levels.

Gamel-Didelon K, Corsi C, Pepeu G, Jung H, Gratzl M, Mayerhofer A.

Neuroendocrinology. 2002 Sep;76(3):170-7.

PMID:
12218349
28.

Rivastigmine antagonizes deficits in prepulse inhibition induced by selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis.

Ballmaier M, Casamenti F, Scali C, Mazzoncini R, Zoli M, Pepeu G, Spano PF.

Neuroscience. 2002;114(1):91-8.

PMID:
12207957
29.

Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats.

Scali C, Casamenti F, Bellucci A, Costagli C, Schmidt B, Pepeu G.

J Neural Transm (Vienna). 2002 Jul;109(7-8):1067-80.

PMID:
12111444
30.

Neutrophils CD11b and fibroblasts PGE(2) are elevated in Alzheimer's disease.

Scali C, Prosperi C, Bracco L, Piccini C, Baronti R, Ginestroni A, Sorbi S, Pepeu G, Casamenti F.

Neurobiol Aging. 2002 Jul-Aug;23(4):523-30.

PMID:
12009501
31.

Bidirectional modulation of spatial working memory by ethanol.

Rossetti ZL, Carboni S, Stancampiano R, Sori P, Pepeu G, Fadda F.

Alcohol Clin Exp Res. 2002 Feb;26(2):181-5.

PMID:
11964557
32.

Selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis impairs prepulse inhibition of acoustic startle.

Ballmaier M, Casamenti F, Zoli M, Pepeu G, Spano P.

Neuroscience. 2001;108(2):299-305.

PMID:
11734362
33.

Effects of novelty and habituation on acetylcholine, GABA, and glutamate release from the frontal cortex and hippocampus of freely moving rats.

Giovannini MG, Rakovska A, Benton RS, Pazzagli M, Bianchi L, Pepeu G.

Neuroscience. 2001;106(1):43-53.

PMID:
11564415
34.

NO-flurbiprofen attenuates excitotoxin-induced brain inflammation, and releases nitric oxide in the brain.

Prosperi C, Scali C, Pepeu G, Casamenti F.

Jpn J Pharmacol. 2001 Jun;86(2):230-5.

35.

Changes in presynaptic proteins, SNAP-25 and synaptophysin, in the hippocampal CA1 area in ischemic gerbils.

Ishimaru H, Casamenti F, Uéda K, Maruyama Y, Pepeu G.

Brain Res. 2001 Jun 8;903(1-2):94-101.

PMID:
11382392
36.

Overview and perspective on the therapy of Alzheimer's disease from a preclinical viewpoint.

Pepeu G.

Prog Neuropsychopharmacol Biol Psychiatry. 2001 Jan;25(1):193-209. Review.

PMID:
11263752
37.

NO synthesis inhibition decreases cortical ACh release and impairs retention of a conditioned response.

Kopf SR, Benton RS, Kalfin R, Giovannini MG, Pepeu G.

Brain Res. 2001 Mar 9;894(1):141-4.

PMID:
11245824
38.
39.

Effect of adenosine A2A receptor stimulation on GABA release from the striatum of young and aged rats in vivo.

Corsi C, Melani A, Bianchi L, Pepeu G, Pedata F.

Neuroreport. 1999 Dec 16;10(18):3933-7.

PMID:
10716236
40.

NGF treatment potentiates c-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid.

Giovannelli L, Veltri M, Casamenti F, Pepeu G.

Brain Res. 2000 Jan 17;853(1):136-41.

PMID:
10627317
41.

Trazodone increases extracellular serotonin levels in the frontal cortex of rats.

Pazzagli M, Giovannini MG, Pepeu G.

Eur J Pharmacol. 1999 Nov 3;383(3):249-57.

PMID:
10594316
42.
43.
44.

Adenosine and memory storage: effect of A(1) and A(2) receptor antagonists.

Kopf SR, Melani A, Pedata F, Pepeu G.

Psychopharmacology (Berl). 1999 Sep;146(2):214-9.

PMID:
10525758
45.

The phosphatidylserine story.

Pepeu G.

Nutrition. 1999 Oct;15(10):789. No abstract available.

PMID:
10501294
46.

Is there still a role for Academia?

Pepeu G.

Pharm Sci Technolo Today. 1999 Aug;2(8):305-306. No abstract available.

PMID:
10441271
47.

Systemic chlorophenylpiperazine increases acetylcholine release from rat hippocampus-implication of 5-HT2C receptors.

Zhelyazkova-Savova M, Giovannini MG, Pepeu G.

Pharmacol Res. 1999 Aug;40(2):165-70.

PMID:
10433876
48.

Beta(1-40) amyloid peptide injection into the nucleus basalis of rats induces microglia reaction and enhances cortical gamma-aminobutyric acid release in vivo.

Scali C, Prosperi C, Giovannelli L, Bianchi L, Pepeu G, Casamenti F.

Brain Res. 1999 Jun 12;831(1-2):319-21.

PMID:
10412015
49.

Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer's disease.

Casamenti F, Prosperi C, Scali C, Giovannelli L, Colivicchi MA, Faussone-Pellegrini MS, Pepeu G.

Neuroscience. 1999;91(3):831-42.

PMID:
10391466
50.

Striatal A2A adenosine receptors differentially regulate spontaneous and K+-evoked glutamate release in vivo in young and aged rats.

Corsi C, Melani A, Bianchi L, Pepeu G, Pedata F.

Neuroreport. 1999 Mar 17;10(4):687-91.

PMID:
10208531

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