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Items: 23


Role and Regulation of Pro-survival BCL-2 Proteins in Multiple Myeloma.

Slomp A, Peperzak V.

Front Oncol. 2018 Nov 20;8:533. doi: 10.3389/fonc.2018.00533. eCollection 2018. Review.


Wnt signaling in multiple myeloma: a central player in disease with therapeutic potential.

Spaan I, Raymakers RA, van de Stolpe A, Peperzak V.

J Hematol Oncol. 2018 May 18;11(1):67. doi: 10.1186/s13045-018-0615-3. Review.


From MGUS to Multiple Myeloma, a Paradigm for Clonal Evolution of Premalignant Cells.

van Nieuwenhuijzen N, Spaan I, Raymakers R, Peperzak V.

Cancer Res. 2018 May 15;78(10):2449-2456. doi: 10.1158/0008-5472.CAN-17-3115. Epub 2018 Apr 27. Review.


DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice.

Ottina E, Peperzak V, Schoeler K, Carrington E, Sgonc R, Pellegrini M, Preston S, Herold MJ, Strasser A, Villunger A.

Nat Commun. 2017 Oct 18;8(1):1028. doi: 10.1038/s41467-017-01022-4.


c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses.

Piovesan D, Tempany J, Di Pietro A, Baas I, Yiannis C, O'Donnell K, Chen Y, Peperzak V, Belz GT, Mackay CR, Smyth GK, Groom JR, Tarlinton DM, Good-Jacobson KL.

Cell Rep. 2017 Apr 18;19(3):461-470. doi: 10.1016/j.celrep.2017.03.060.


Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling.

Peperzak V, Slinger E, Ter Burg J, Eldering E.

Cell Death Differ. 2017 Jan;24(1):111-119. doi: 10.1038/cdd.2016.105. Epub 2016 Sep 30.


MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

Vikström IB, Slomp A, Carrington EM, Moesbergen LM, Chang C, Kelly GL, Glaser SP, Jansen JH, Leusen JH, Strasser A, Huang DC, Lew AM, Peperzak V, Tarlinton DM.

Cell Death Dis. 2016 Aug 25;7(8):e2345. doi: 10.1038/cddis.2016.237.


The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice.

Infantino S, Jones SA, Walker JA, Maxwell MJ, Light A, O'Donnell K, Tsantikos E, Peperzak V, Phesse T, Ernst M, Mackay F, Hibbs ML, Fairfax KA, Tarlinton DM.

Sci Signal. 2014 Aug 12;7(338):ra77. doi: 10.1126/scisignal.2005105.


CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool.

Peperzak V, Veraar EA, Xiao Y, Babala N, Thiadens K, Brugmans M, Borst J.

J Immunol. 2013 Sep 15;191(6):3025-36. doi: 10.4049/jimmunol.1202222. Epub 2013 Aug 12.


Mcl-1 is essential for the survival of plasma cells.

Peperzak V, Vikström I, Walker J, Glaser SP, LePage M, Coquery CM, Erickson LD, Fairfax K, Mackay F, Strasser A, Nutt SL, Tarlinton DM.

Nat Immunol. 2013 Mar;14(3):290-7. doi: 10.1038/ni.2527. Epub 2013 Feb 3. Erratum in: Nat Immunol. 2013 Aug;14(8):877.


Through a glass less darkly: apoptosis and the germinal center response to antigen.

Peperzak V, Vikstrom IB, Tarlinton DM.

Immunol Rev. 2012 May;247(1):93-106. doi: 10.1111/j.1600-065X.2012.01123.x. Review.


The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation.

Peperzak V, Veraar EA, Keller AM, Xiao Y, Borst J.

J Immunol. 2010 Dec 1;185(11):6670-8. doi: 10.4049/jimmunol.1000159. Epub 2010 Nov 3.


The invariant chain transports TNF family member CD70 to MHC class II compartments in dendritic cells.

Zwart W, Peperzak V, de Vries E, Keller AM, van der Horst G, Veraar EA, Geumann U, Janssen H, Janssen L, Naik SH, Neefjes J, Borst J.

J Cell Sci. 2010 Nov 1;123(Pt 21):3817-27. doi: 10.1242/jcs.068510.


Mcl-1 is essential for germinal center formation and B cell memory.

Vikstrom I, Carotta S, Lüthje K, Peperzak V, Jost PJ, Glaser S, Busslinger M, Bouillet P, Strasser A, Nutt SL, Tarlinton DM.

Science. 2010 Nov 19;330(6007):1095-9. doi: 10.1126/science.1191793. Epub 2010 Oct 7.


Dexamethasone treatment during the expansion phase maintains stemness of bone marrow mesenchymal stem cells.

Xiao Y, Peperzak V, van Rijn L, Borst J, de Bruijn JD.

J Tissue Eng Regen Med. 2010 Jul;4(5):374-86. doi: 10.1002/term.250.


CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production.

Peperzak V, Xiao Y, Veraar EA, Borst J.

J Clin Invest. 2010 Jan;120(1):168-78. doi: 10.1172/JCI40178. Epub 2009 Dec 1.


Mice deficient for CD137 ligand are predisposed to develop germinal center-derived B-cell lymphoma.

Middendorp S, Xiao Y, Song JY, Peperzak V, Krijger PH, Jacobs H, Borst J.

Blood. 2009 Sep 10;114(11):2280-9. doi: 10.1182/blood-2009-03-208215. Epub 2009 Jul 16.


Costimulatory ligand CD70 allows induction of CD8+ T-cell immunity by immature dendritic cells in a vaccination setting.

Keller AM, Xiao Y, Peperzak V, Naik SH, Borst J.

Blood. 2009 May 21;113(21):5167-75. doi: 10.1182/blood-2008-03-148007. Epub 2009 Mar 11.


CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets.

Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J, Hayday AC, Pennington DJ, Silva-Santos B.

Nat Immunol. 2009 Apr;10(4):427-36. doi: 10.1038/ni.1717. Epub 2009 Mar 8.


CD27 instructs CD4+ T cells to provide help for the memory CD8+ T cell response after protein immunization.

Xiao Y, Peperzak V, Keller AM, Borst J.

J Immunol. 2008 Jul 15;181(2):1071-82.


Profiling proteasome activity in tissue with fluorescent probes.

Berkers CR, van Leeuwen FW, Groothuis TA, Peperzak V, van Tilburg EW, Borst J, Neefjes JJ, Ovaa H.

Mol Pharm. 2007 Sep-Oct;4(5):739-48. Epub 2007 Aug 21.


Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation.

Kim YM, Pan JY, Korbel GA, Peperzak V, Boes M, Ploegh HL.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3327-32. Epub 2006 Feb 21.


In vivo control of endosomal architecture by class II-associated invariant chain and cathepsin S.

Boes M, van der Wel N, Peperzak V, Kim YM, Peters PJ, Ploegh H.

Eur J Immunol. 2005 Sep;35(9):2552-62.

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