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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1975 1
1976 2
1978 5
1979 1
1981 3
1982 1
1983 5
1984 2
1985 3
1986 7
1987 5
1989 5
1990 2
1991 5
1992 1
1993 5
1994 6
1995 2
1996 4
1997 3
1998 1
1999 4
2000 3
2001 4
2002 2
2003 2
2004 3
2005 2
2006 7
2007 4
2008 5
2009 5
2010 12
2011 12
2012 8
2013 7
2014 12
2015 12
2016 3
2017 11
2018 7
2019 13
2020 16
2021 15
2022 23
2023 29
2024 8

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266 results

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Page 1
Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance.
Pellegrinelli V, Rodriguez-Cuenca S, Rouault C, Figueroa-Juarez E, Schilbert H, Virtue S, Moreno-Navarrete JM, Bidault G, Vázquez-Borrego MC, Dias AR, Pucker B, Dale M, Campbell M, Carobbio S, Lin YH, Vacca M, Aron-Wisnewsky J, Mora S, Masiero MM, Emmanouilidou A, Mukhopadhyay S, Dougan G, den Hoed M, Loos RJF, Fernández-Real JM, Chiarugi D, Clément K, Vidal-Puig A. Pellegrinelli V, et al. Nat Metab. 2022 Apr;4(4):476-494. doi: 10.1038/s42255-022-00561-5. Epub 2022 Apr 25. Nat Metab. 2022. PMID: 35478031 Free article.
Here we show that in human and mouse obesity, PEPD expression and activity decrease in AT, and PEPD is released into the systemic circulation, which promotes fibrosis and AT IR. Loss of the enzymatic function of PEPD by genetic ablation or pharmacological inh …
Here we show that in human and mouse obesity, PEPD expression and activity decrease in AT, and PEPD is released into the syste …
PEPD is a pivotal regulator of p53 tumor suppressor.
Yang L, Li Y, Bhattacharya A, Zhang Y. Yang L, et al. Nat Commun. 2017 Dec 12;8(1):2052. doi: 10.1038/s41467-017-02097-9. Nat Commun. 2017. PMID: 29233996 Free PMC article.
Eliminating PEPD causes cell death and tumor regression due to p53 activation. ...Thus, PEPD stores p53 for the stress response, but this also renders cells dependent on PEPD for survival, as it suppresses p53. ...
Eliminating PEPD causes cell death and tumor regression due to p53 activation. ...Thus, PEPD stores p53 for the stress respons …
Habitual daily intake of a sweet and fatty snack modulates reward processing in humans.
Edwin Thanarajah S, DiFeliceantonio AG, Albus K, Kuzmanovic B, Rigoux L, Iglesias S, Hanßen R, Schlamann M, Cornely OA, Brüning JC, Tittgemeyer M, Small DM. Edwin Thanarajah S, et al. Cell Metab. 2023 Apr 4;35(4):571-584.e6. doi: 10.1016/j.cmet.2023.02.015. Epub 2023 Mar 22. Cell Metab. 2023. PMID: 36958330 Free article. Clinical Trial.
Extracellular Prolidase (PEPD) Induces Anabolic Processes through EGFR, beta(1)-integrin, and IGF-1R Signaling Pathways in an Experimental Model of Wounded Fibroblasts.
Baszanowska W, Misiura M, Oscilowska I, Palka J, Miltyk W. Baszanowska W, et al. Int J Mol Sci. 2021 Jan 19;22(2):942. doi: 10.3390/ijms22020942. Int J Mol Sci. 2021. PMID: 33477899 Free PMC article.
The cells were treated with PEPD (1-100 nM) and analysis of cell viability, proliferation, migration, collagen biosynthesis, PEPD activity, and the expressions of EGFR, insulin-like growth factor 1 (IGF-1), and beta(1)-integrin receptor including downstream signalin …
The cells were treated with PEPD (1-100 nM) and analysis of cell viability, proliferation, migration, collagen biosynthesis, PEPD …
PepD participates in the mycobacterial stress response mediated through MprAB and SigE.
White MJ, He H, Penoske RM, Twining SS, Zahrt TC. White MJ, et al. J Bacteriol. 2010 Mar;192(6):1498-510. doi: 10.1128/JB.01167-09. Epub 2010 Jan 8. J Bacteriol. 2010. PMID: 20061478 Free PMC article.
MprAB regulates a large and diverse group of genetic determinants in response to membrane stress, including the extracytoplasmic function (ECF) sigma factor sigE and the HtrA-like serine protease pepD. Recent studies have demonstrated that PepD functions as both a p …
MprAB regulates a large and diverse group of genetic determinants in response to membrane stress, including the extracytoplasmic function (E …
Prolidase Deficiency.
Rossignol F, Wang H, Ferreira C. Rossignol F, et al. 2015 Jun 25 [updated 2022 Jul 7]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2015 Jun 25 [updated 2022 Jul 7]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 26110198 Free Books & Documents. Review.
The molecular diagnosis can be established in a proband with suggestive findings and biallelic pathogenic variants in PEPD identified by molecular genetic testing. MANAGEMENT: Treatment of manifestations: Skin ulcers may require treatment by a wound care specialist; topica …
The molecular diagnosis can be established in a proband with suggestive findings and biallelic pathogenic variants in PEPD identified …
Prolidase deficiency: A novel PEPD missense variant in exon 2.
Ido F, Tessier S, Yoder N, Ramzy J, Longo S. Ido F, et al. Am J Med Genet A. 2023 May;191(5):1388-1394. doi: 10.1002/ajmg.a.63137. Epub 2023 Feb 9. Am J Med Genet A. 2023. PMID: 36757671
Genetic testing revealed a homozygous missense variant in the PEPD gene at nucleotide position 200, whereby adenine was replaced by guanine (c.200A > G). ...
Genetic testing revealed a homozygous missense variant in the PEPD gene at nucleotide position 200, whereby adenine was replaced by g …
A novel SCN9A gene variant identified in a Chinese girl with paroxysmal extreme pain disorder (PEPD): a rare case report.
Hua Y, Cui D, Han L, Xu L, Mao S, Yang C, Gao F, Yuan Z. Hua Y, et al. BMC Med Genomics. 2022 Jul 15;15(1):159. doi: 10.1186/s12920-022-01302-z. BMC Med Genomics. 2022. PMID: 35840956 Free PMC article.
PEPD is a sodium channel dysfunctional disorder caused by SCN9A gene variants. ...However, the patient's mother, who carries the same SCN9A variant as her daughter, only showed bradycardia and sinus arrest but no PEPD-related pain. CONCLUSIONS: This is the second …
PEPD is a sodium channel dysfunctional disorder caused by SCN9A gene variants. ...However, the patient's mother, who carries the same …
SCN9A Neuropathic Pain Syndromes.
Hisama FM, Dib-Hajj SD, Waxman SG. Hisama FM, et al. 2006 May 6 [updated 2020 Jan 23]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2006 May 6 [updated 2020 Jan 23]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301342 Free Books & Documents. Review.
Medications to consider are nonselective sodium channel blockers (e.g., carbamazepine, lidocaine infusion, or oral mexiletine). SCN9A-PEPD. Use of stool softeners and passing stool slowly to reduce the likelihood of triggering an attack. ...Agents/circumstances to avoid: T …
Medications to consider are nonselective sodium channel blockers (e.g., carbamazepine, lidocaine infusion, or oral mexiletine). SCN9A-PEP …
266 results