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Items: 1 to 50 of 87

1.

Partial Loss of USP9X Function Leads to a Male Neurodevelopmental and Behavioral Disorder Converging on Transforming Growth Factor β Signaling.

Johnson BV, Kumar R, Oishi S, Alexander S, Kasherman M, Vega MS, Ivancevic A, Gardner A, Domingo D, Corbett M, Parnell E, Yoon S, Oh T, Lines M, Lefroy H, Kini U, Van Allen M, Grønborg S, Mercier S, Küry S, Bézieau S, Pasquier L, Raynaud M, Afenjar A, Billette de Villemeur T, Keren B, Désir J, Van Maldergem L, Marangoni M, Dikow N, Koolen DA, VanHasselt PM, Weiss M, Zwijnenburg P, Sa J, Reis CF, López-Otín C, Santiago-Fernández O, Fernández-Jaén A, Rauch A, Steindl K, Joset P, Goldstein A, Madan-Khetarpal S, Infante E, Zackai E, Mcdougall C, Narayanan V, Ramsey K, Mercimek-Andrews S, Pena L, Shashi V; Undiagnosed Diseases Network, Schoch K, Sullivan JA, Pinto E Vairo F, Pichurin PN, Ewing SA, Barnett SS, Klee EW, Perry MS, Koenig MK, Keegan CE, Schuette JL, Asher S, Perilla-Young Y, Smith LD, Rosenfeld JA, Bhoj E, Kaplan P, Li D, Oegema R, van Binsbergen E, van der Zwaag B, Smeland MF, Cutcutache I, Page M, Armstrong M, Lin AE, Steeves MA, Hollander ND, Hoffer MJV, Reijnders MRF, Demirdas S, Koboldt DC, Bartholomew D, Mosher TM, Hickey SE, Shieh C, Sanchez-Lara PA, Graham JM Jr, Tezcan K, Schaefer GB, Danylchuk NR, Asamoah A, Jackson KE, Yachelevich N, Au M, Pérez-Jurado LA, Kleefstra T, Penzes P, Wood SA, Burne T, Pierson TM, Piper M, Gécz J, Jolly LA.

Biol Psychiatry. 2019 Jun 29. pii: S0006-3223(19)31479-9. doi: 10.1016/j.biopsych.2019.05.028. [Epub ahead of print]

PMID:
31443933
2.

Exchange protein directly activated by cAMP 2 is required for corticotropin-releasing hormone-mediated spine loss.

Xie Z, Penzes P, Srivastava DP.

Eur J Neurosci. 2019 Jun 14. doi: 10.1111/ejn.14487. [Epub ahead of print] Review.

PMID:
31199033
3.

Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density.

Jones KA, Sumiya M, Woolfrey KM, Srivastava DP, Penzes P.

Mol Cell Neurosci. 2019 Jul;98:19-31. doi: 10.1016/j.mcn.2019.05.001. Epub 2019 May 4.

4.

A novel role for the late-onset Alzheimer's disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling.

Schürmann B, Bermingham DP, Kopeikina KJ, Myczek K, Yoon S, Horan KE, Kelly CJ, Martin-de-Saavedra MD, Forrest MP, Fawcett-Patel JM, Smith KR, Gao R, Bach A, Burette AC, Rappoport JZ, Weinberg RJ, Martina M, Penzes P.

Mol Psychiatry. 2019 Apr 9. doi: 10.1038/s41380-019-0407-3. [Epub ahead of print]

PMID:
30967682
5.

The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons.

Gao R, Zaccard CR, Shapiro LP, Dionisio LE, Martin-de-Saavedra MD, Piguel NH, Pratt CP, Horan KE, Penzes P.

Neurosci Lett. 2019 May 14;701:92-99. doi: 10.1016/j.neulet.2019.02.025. Epub 2019 Feb 16.

6.

Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers.

Xie Z, Shapiro LP, Cahill ME, Russell TA, Lacor PN, Klein WL, Penzes P.

Eur J Neurosci. 2019 May;49(9):1091-1101. doi: 10.1111/ejn.14311. Epub 2019 Jan 20.

PMID:
30565792
7.

Neurodevelopmental disorder-associated ZBTB20 gene variants affect dendritic and synaptic structure.

Jones KA, Luo Y, Dukes-Rimsky L, Srivastava DP, Koul-Tewari R, Russell TA, Shapiro LP, Srivastava AK, Penzes P.

PLoS One. 2018 Oct 3;13(10):e0203760. doi: 10.1371/journal.pone.0203760. eCollection 2018.

8.

Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling.

Garza JC, Qi X, Gjeluci K, Leussis MP, Basu H, Reis SA, Zhao WN, Piguel NH, Penzes P, Haggarty SJ, Martens GJ, Poelmans G, Petryshen TL.

Transl Psychiatry. 2018 Jul 25;8(1):135. doi: 10.1038/s41398-018-0182-y.

9.

Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer's Disease.

Krivinko JM, Erickson SL, Ding Y, Sun Z, Penzes P, MacDonald ML, Yates NA, Ikonomovic MD, Lopez OL, Sweet RA, Kofler J.

Am J Psychiatry. 2018 Oct 1;175(10):999-1009. doi: 10.1176/appi.ajp.2018.17080858. Epub 2018 Jul 19.

PMID:
30021459
10.

Ankyrins: Roles in synaptic biology and pathology.

Smith KR, Penzes P.

Mol Cell Neurosci. 2018 Sep;91:131-139. doi: 10.1016/j.mcn.2018.04.010. Epub 2018 May 3. Review.

11.

CNTNAP2 stabilizes interneuron dendritic arbors through CASK.

Gao R, Piguel NH, Melendez-Zaidi AE, Martin-de-Saavedra MD, Yoon S, Forrest MP, Myczek K, Zhang G, Russell TA, Csernansky JG, Surmeier DJ, Penzes P.

Mol Psychiatry. 2018 Sep;23(9):1832-1850. doi: 10.1038/s41380-018-0027-3. Epub 2018 Apr 9.

12.

Dendritic structural plasticity and neuropsychiatric disease.

Forrest MP, Parnell E, Penzes P.

Nat Rev Neurosci. 2018 Mar 16;19(4):215-234. doi: 10.1038/nrn.2018.16. Review.

13.

A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability.

Russell TA, Grubisha MJ, Remmers CL, Kang SK, Forrest MP, Smith KR, Kopeikina KJ, Gao R, Sweet RA, Penzes P.

Biol Psychiatry. 2018 Mar 15;83(6):499-508. doi: 10.1016/j.biopsych.2017.10.024. Epub 2017 Nov 7.

14.

Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins.

Smith KR, Jones KA, Kopeikina KJ, Burette AC, Copits BA, Yoon S, Forrest MP, Fawcett-Patel JM, Hanley JG, Weinberg RJ, Swanson GT, Penzes P.

J Neurosci. 2017 Nov 15;37(46):11127-11139. doi: 10.1523/JNEUROSCI.1153-17.2017. Epub 2017 Oct 13.

15.

Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci.

Forrest MP, Zhang H, Moy W, McGowan H, Leites C, Dionisio LE, Xu Z, Shi J, Sanders AR, Greenleaf WJ, Cowan CA, Pang ZP, Gejman PV, Penzes P, Duan J.

Cell Stem Cell. 2017 Sep 7;21(3):305-318.e8. doi: 10.1016/j.stem.2017.07.008. Epub 2017 Aug 10.

16.

Selective Loss of Smaller Spines in Schizophrenia.

MacDonald ML, Alhassan J, Newman JT, Richard M, Gu H, Kelly RM, Sampson AR, Fish KN, Penzes P, Wills ZP, Lewis DA, Sweet RA.

Am J Psychiatry. 2017 Jun 1;174(6):586-594. doi: 10.1176/appi.ajp.2017.16070814. Epub 2017 Mar 31.

17.

Kalirin reduction rescues psychosis-associated behavioral deficits in APPswe/PSEN1dE9 transgenic mice.

Krivinko JM, Erickson SL, Abrahamson EE, Wills ZP, Ikonomovic MD, Penzes P, Sweet RA.

Neurobiol Aging. 2017 Jun;54:59-70. doi: 10.1016/j.neurobiolaging.2017.02.006. Epub 2017 Feb 16.

18.

Age-dependent increase in Kalirin-9 and Kalirin-12 transcripts in human orbitofrontal cortex.

Grubisha MJ, Lin CW, Tseng GC, Penzes P, Sibille E, Sweet RA.

Eur J Neurosci. 2016 Oct;44(7):2483-2492. doi: 10.1111/ejn.13351. Epub 2016 Aug 18.

19.

Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub.

Blizinsky KD, Diaz-Castro B, Forrest MP, Schürmann B, Bach AP, Martin-de-Saavedra MD, Wang L, Csernansky JG, Duan J, Penzes P.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8520-5. doi: 10.1073/pnas.1607014113. Epub 2016 Jul 11.

20.

Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area.

Liu X, Chen Y, Tong J, Reynolds AM, Proudfoot SC, Qi J, Penzes P, Lu Y, Liu QS.

J Neurosci. 2016 Apr 27;36(17):4802-15. doi: 10.1523/JNEUROSCI.3186-15.2016.

21.

Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons.

Varea O, Martin-de-Saavedra MD, Kopeikina KJ, Schürmann B, Fleming HJ, Fawcett-Patel JM, Bach A, Jang S, Peles E, Kim E, Penzes P.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6176-81. doi: 10.1073/pnas.1423205112. Epub 2015 Apr 27.

22.

Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia.

Shelton MA, Newman JT, Gu H, Sampson AR, Fish KN, MacDonald ML, Moyer CE, DiBitetto JV, Dorph-Petersen KA, Penzes P, Lewis DA, Sweet RA.

Biol Psychiatry. 2015 Sep 15;78(6):374-85. doi: 10.1016/j.biopsych.2014.12.029. Epub 2015 Jan 30.

23.

Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice.

Moyer CE, Erickson SL, Fish KN, Thiels E, Penzes P, Sweet RA.

Cereb Cortex. 2016 May;26(5):2115-26. doi: 10.1093/cercor/bhv040. Epub 2015 Mar 10.

24.
25.

Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.

MacDonald ML, Ding Y, Newman J, Hemby S, Penzes P, Lewis DA, Yates NA, Sweet RA.

Biol Psychiatry. 2015 Jun 1;77(11):959-68. doi: 10.1016/j.biopsych.2014.09.006. Epub 2014 Nov 26.

26.

Scaffold protein X11α interacts with kalirin-7 in dendrites and recruits it to Golgi outposts.

Jones KA, Eng AG, Raval P, Srivastava DP, Penzes P.

J Biol Chem. 2014 Dec 19;289(51):35517-29. doi: 10.1074/jbc.M114.587709. Epub 2014 Nov 5.

27.

Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses.

Smith KR, Kopeikina KJ, Fawcett-Patel JM, Leaderbrand K, Gao R, Schürmann B, Myczek K, Radulovic J, Swanson GT, Penzes P.

Neuron. 2014 Oct 22;84(2):399-415. doi: 10.1016/j.neuron.2014.10.010. Epub 2014 Oct 22.

28.

A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness.

Russell TA, Blizinsky KD, Cobia DJ, Cahill ME, Xie Z, Sweet RA, Duan J, Gejman PV, Wang L, Csernansky JG, Penzes P.

Nat Commun. 2014 Sep 16;5:4858. doi: 10.1038/ncomms5858.

29.

Coordinated nuclear and synaptic shuttling of afadin promotes spine plasticity and histone modifications.

VanLeeuwen JE, Rafalovich I, Sellers K, Jones KA, Griffith TN, Huda R, Miller RJ, Srivastava DP, Penzes P.

J Biol Chem. 2014 Apr 11;289(15):10831-42. doi: 10.1074/jbc.M113.536391. Epub 2014 Feb 24.

30.

Abnormal kalirin signaling in neuropsychiatric disorders.

Remmers C, Sweet RA, Penzes P.

Brain Res Bull. 2014 Apr;103:29-38. doi: 10.1016/j.brainresbull.2013.12.006. Epub 2013 Dec 12. Review.

31.

Insights into rapid modulation of neuroplasticity by brain estrogens.

Srivastava DP, Woolfrey KM, Penzes P.

Pharmacol Rev. 2013 Sep 27;65(4):1318-50. doi: 10.1124/pr.111.005272. Print 2013. Review.

32.

Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization.

Wang X, Cahill ME, Werner CT, Christoffel DJ, Golden SA, Xie Z, Loweth JA, Marinelli M, Russo SJ, Penzes P, Wolf ME.

J Neurosci. 2013 Jul 3;33(27):11012-22. doi: 10.1523/JNEUROSCI.1097-13.2013. Erratum in: J Neurosci. 2014 Jan 8;34(2):688.

33.

Neuregulin1 signaling promotes dendritic spine growth through kalirin.

Cahill ME, Remmers C, Jones KA, Xie Z, Sweet RA, Penzes P.

J Neurochem. 2013 Sep;126(5):625-35. doi: 10.1111/jnc.12330. Epub 2013 Jun 27.

34.

PAK1 protein expression in the auditory cortex of schizophrenia subjects.

Deo AJ, Goldszer IM, Li S, DiBitetto JV, Henteleff R, Sampson A, Lewis DA, Penzes P, Sweet RA.

PLoS One. 2013 Apr 22;8(4):e59458. doi: 10.1371/journal.pone.0059458. Print 2013.

35.

Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders.

Penzes P, Buonanno A, Passafaro M, Sala C, Sweet RA.

J Neurochem. 2013 Jul;126(2):165-82. doi: 10.1111/jnc.12261. Epub 2013 May 22. Review.

36.

Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein.

Barbolina MV, Liu Y, Gurler H, Kim M, Kajdacsy-Balla AA, Rooper L, Shepard J, Weiss M, Shea LD, Penzes P, Ravosa MJ, Stack MS.

J Biol Chem. 2013 Jan 4;288(1):141-51. doi: 10.1074/jbc.M112.431411. Epub 2012 Nov 14.

37.

Afadin is required for maintenance of dendritic structure and excitatory tone.

Srivastava DP, Copits BA, Xie Z, Huda R, Jones KA, Mukherji S, Cahill ME, VanLeeuwen JE, Woolfrey KM, Rafalovich I, Swanson GT, Penzes P.

J Biol Chem. 2012 Oct 19;287(43):35964-74. doi: 10.1074/jbc.M112.363358. Epub 2012 Sep 4.

38.

Social, communication, and cortical structural impairments in Epac2-deficient mice.

Srivastava DP, Jones KA, Woolfrey KM, Burgdorf J, Russell TA, Kalmbach A, Lee H, Yang C, Bradberry MM, Wokosin D, Moskal JR, Casanova MF, Waters J, Penzes P.

J Neurosci. 2012 Aug 22;32(34):11864-78.

39.

Long-term perturbation of spine plasticity results in distinct impairments of cognitive function.

Vanleeuwen JE, Penzes P.

J Neurochem. 2012 Dec;123(5):781-9. doi: 10.1111/j.1471-4159.2012.07899.x. Epub 2012 Oct 11.

40.

An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice.

Srivastava DP, Woolfrey KM, Jones KA, Anderson CT, Smith KR, Russell TA, Lee H, Yasvoina MV, Wokosin DL, Ozdinler PH, Shepherd GM, Penzes P.

PLoS Biol. 2012;10(6):e1001350. doi: 10.1371/journal.pbio.1001350. Epub 2012 Jun 26.

41.

Spatially restricted actin-regulatory signaling contributes to synapse morphology.

Nicholson DA, Cahill ME, Tulisiak CT, Geinisman Y, Penzes P.

J Neurochem. 2012 Jun;121(6):852-60. doi: 10.1111/j.1471-4159.2012.07743.x. Epub 2012 Apr 27.

42.

β-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis.

Murray PS, Kirkwood CM, Gray MC, Ikonomovic MD, Paljug WR, Abrahamson EE, Henteleff RA, Hamilton RL, Kofler JK, Klunk WE, Lopez OL, Penzes P, Sweet RA.

Neurobiol Aging. 2012 Dec;33(12):2807-16. doi: 10.1016/j.neurobiolaging.2012.02.015. Epub 2012 Mar 17.

43.

Regulation of the actin cytoskeleton in dendritic spines.

Penzes P, Rafalovich I.

Adv Exp Med Biol. 2012;970:81-95. doi: 10.1007/978-3-7091-0932-8_4. Review.

44.

Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines.

Penzes P, Cahill ME.

Cytoskeleton (Hoboken). 2012 Jul;69(7):426-41. doi: 10.1002/cm.21015. Epub 2012 Mar 12. Review.

45.

Kalirin signaling: implications for synaptic pathology.

Penzes P, Remmers C.

Mol Neurobiol. 2012 Feb;45(1):109-18. doi: 10.1007/s12035-011-8223-z. Epub 2011 Dec 23. Review.

46.

Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: its role in dendritic pathology.

Deo AJ, Cahill ME, Li S, Goldszer I, Henteleff R, Vanleeuwen JE, Rafalovich I, Gao R, Stachowski EK, Sampson AR, Lewis DA, Penzes P, Sweet RA.

Neurobiol Dis. 2012 Feb;45(2):796-803. doi: 10.1016/j.nbd.2011.11.003. Epub 2011 Nov 13.

47.

Analysis of dendritic spine morphology in cultured CNS neurons.

Srivastava DP, Woolfrey KM, Penzes P.

J Vis Exp. 2011 Jul 13;(53):e2794. doi: 10.3791/2794.

48.

Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition.

Cahill ME, Jones KA, Rafalovich I, Xie Z, Barros CS, Müller U, Penzes P.

Mol Psychiatry. 2012 Jan;17(1):1, 99-107. doi: 10.1038/mp.2011.35. Epub 2011 Apr 12.

49.

Dendritic spine pathology in neuropsychiatric disorders.

Penzes P, Cahill ME, Jones KA, VanLeeuwen JE, Woolfrey KM.

Nat Neurosci. 2011 Mar;14(3):285-93. doi: 10.1038/nn.2741. Review.

50.

Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease.

Penzes P, Vanleeuwen JE.

Brain Res Rev. 2011 Jun 24;67(1-2):184-92. doi: 10.1016/j.brainresrev.2011.01.003. Epub 2011 Jan 26. Review.

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