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Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy.

Fadzen CM, Holden RL, Wolfe JM, Choo ZN, Schissel CK, Yao M, Hanson GJ, Pentelute BL.

Biochemistry. 2019 Sep 24;58(38):3980-3989. doi: 10.1021/acs.biochem.9b00413. Epub 2019 Sep 6.


Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa.

Romano KP, Warrier T, Poulsen BE, Nguyen PH, Loftis AR, Saebi A, Pentelute BL, Hung DT.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00511-19. doi: 10.1128/AAC.00511-19. Print 2019 Sep.


Author Correction: In-solution enrichment identifies peptide inhibitors of protein-protein interactions.

Touti F, Gates ZP, Bandyopadhyay A, Lautrette G, Pentelute BL.

Nat Chem Biol. 2019 Jul;15(7):757. doi: 10.1038/s41589-019-0302-x.


Author Correction: Affinity-based capture and identification of protein effectors of the growth regulator ppGpp.

Wang B, Dai P, Ding D, Del Rosario A, Grant RA, Pentelute BL, Laub MT.

Nat Chem Biol. 2019 Jul;15(7):756. doi: 10.1038/s41589-019-0296-4.


In-solution enrichment identifies peptide inhibitors of protein-protein interactions.

Touti F, Gates ZP, Bandyopadhyay A, Lautrette G, Pentelute BL.

Nat Chem Biol. 2019 Apr;15(4):410-418. doi: 10.1038/s41589-019-0245-2. Epub 2019 Mar 18. Erratum in: Nat Chem Biol. 2019 Jul;15(7):757.


Conformational Stabilization and Rapid Labeling of a 29-Residue Peptide by a Small Molecule Reaction Partner.

Evans ED, Gates ZP, Sun ZJ, Mijalis AJ, Pentelute BL.

Biochemistry. 2019 Mar 12;58(10):1343-1353. doi: 10.1021/acs.biochem.8b00940. Epub 2019 Feb 21.


Affinity-based capture and identification of protein effectors of the growth regulator ppGpp.

Wang B, Dai P, Ding D, Del Rosario A, Grant RA, Pentelute BL, Laub MT.

Nat Chem Biol. 2019 Feb;15(2):141-150. doi: 10.1038/s41589-018-0183-4. Epub 2018 Dec 17. Erratum in: Nat Chem Biol. 2019 Jul;15(7):756.


Arylation Chemistry for Bioconjugation.

Zhang C, Vinogradova EV, Spokoyny AM, Buchwald SL, Pentelute BL.

Angew Chem Int Ed Engl. 2019 Apr 1;58(15):4810-4839. doi: 10.1002/anie.201806009. Epub 2019 Feb 15. Review.


A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins.

Cohen DT, Zhang C, Fadzen CM, Mijalis AJ, Hie L, Johnson KD, Shriver Z, Plante O, Miller SJ, Buchwald SL, Pentelute BL.

Nat Chem. 2019 Jan;11(1):78-85. doi: 10.1038/s41557-018-0154-0. Epub 2018 Nov 5.


Blood-brain-barrier organoids for investigating the permeability of CNS therapeutics.

Bergmann S, Lawler SE, Qu Y, Fadzen CM, Wolfe JM, Regan MS, Pentelute BL, Agar NYR, Cho CF.

Nat Protoc. 2018 Dec;13(12):2827-2843. doi: 10.1038/s41596-018-0066-x.


Analyzing Dynamic Protein Complexes Assembled On and Released From Biolayer Interferometry Biosensor Using Mass Spectrometry and Electron Microscopy.

Machen AJ, O'Neil PT, Pentelute BL, Villar MT, Artigues A, Fisher MT.

J Vis Exp. 2018 Aug 6;(138). doi: 10.3791/57902.


Studies on a landscape of perfluoroaromatic-reactive peptides.

Evans ED, Pentelute BL.

Org Biomol Chem. 2019 Feb 13;17(7):1862-1868. doi: 10.1039/c8ob01678j.


Antibody-Bactericidal Macrocyclic Peptide Conjugates To Target Gram-Negative Bacteria.

Touti F, Lautrette G, Johnson KD, Delaney JC, Wollacott A, Tissire H, Viswanathan K, Shriver Z, Mong SK, Mijalis AJ, Plante OJ, Pentelute BL.

Chembiochem. 2018 Oct 4;19(19):2039-2044. doi: 10.1002/cbic.201800295. Epub 2018 Sep 14.


Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription.

Belashov IA, Crawford DW, Cavender CE, Dai P, Beardslee PC, Mathews DH, Pentelute BL, McNaughton BR, Wedekind JE.

Nucleic Acids Res. 2018 Jul 27;46(13):6401-6415. doi: 10.1093/nar/gky529.


Enhancement of Peptide Vaccine Immunogenicity by Increasing Lymphatic Drainage and Boosting Serum Stability.

Moynihan KD, Holden RL, Mehta NK, Wang C, Karver MR, Dinter J, Liang S, Abraham W, Melo MB, Zhang AQ, Li N, Gall SL, Pentelute BL, Irvine DJ.

Cancer Immunol Res. 2018 Sep;6(9):1025-1038. doi: 10.1158/2326-6066.CIR-17-0607. Epub 2018 Jun 18.


Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids.

Garcia-Castillo MD, Chinnapen DJ, Te Welscher YM, Gonzalez RJ, Softic S, Pacheco M, Mrsny RJ, Kahn CR, von Andrian UH, Lau J, Pentelute BL, Lencer WI.

Elife. 2018 May 31;7. pii: e34469. doi: 10.7554/eLife.34469.


Xenoprotein engineering via synthetic libraries.

Gates ZP, Vinogradov AA, Quartararo AJ, Bandyopadhyay A, Choo ZN, Evans ED, Halloran KH, Mijalis AJ, Mong SK, Simon MD, Standley EA, Styduhar ED, Tasker SZ, Touti F, Weber JM, Wilson JL, Jamison TF, Pentelute BL.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5298-E5306. doi: 10.1073/pnas.1722633115. Epub 2018 May 21.


Characterization of Novel Piperidine-Based Inhibitor of Cathepsin B-Dependent Bacterial Toxins and Viruses.

Hartmann S, Lopez Cruz R, Alameh S, Ho CC, Rabideau A, Pentelute BL, Bradley KA, Martchenko M.

ACS Infect Dis. 2018 Aug 10;4(8):1235-1245. doi: 10.1021/acsinfecdis.8b00053. Epub 2018 May 18.


Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery.

Wolfe JM, Fadzen CM, Choo ZN, Holden RL, Yao M, Hanson GJ, Pentelute BL.

ACS Cent Sci. 2018 Apr 25;4(4):512-520. doi: 10.1021/acscentsci.8b00098. Epub 2018 Apr 5.


Designing Well-Structured Cyclic Pentapeptides Based on Sequence-Structure Relationships.

Slough DP, McHugh SM, Cummings AE, Dai P, Pentelute BL, Kritzer JA, Lin YS.

J Phys Chem B. 2018 Apr 12;122(14):3908-3919. doi: 10.1021/acs.jpcb.8b01747. Epub 2018 Mar 28.


Amide-forming chemical ligation via O-acyl hydroxamic acids.

Dunkelmann DL, Hirata Y, Totaro KA, Cohen DT, Zhang C, Gates ZP, Pentelute BL.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3752-3757. doi: 10.1073/pnas.1718356115. Epub 2018 Mar 26.


Site-Selective Cysteine-Cyclooctyne Conjugation.

Zhang C, Dai P, Vinogradov AA, Gates ZP, Pentelute BL.

Angew Chem Int Ed Engl. 2018 May 28;57(22):6459-6463. doi: 10.1002/anie.201800860. Epub 2018 Apr 26.


Perfluoroaryl Bicyclic Cell-Penetrating Peptides for Delivery of Antisense Oligonucleotides.

Wolfe JM, Fadzen CM, Holden RL, Yao M, Hanson GJ, Pentelute BL.

Angew Chem Int Ed Engl. 2018 Apr 16;57(17):4756-4759. doi: 10.1002/anie.201801167. Epub 2018 Mar 14.


Palladium Oxidative Addition Complexes for Peptide and Protein Cross-linking.

Kubota K, Dai P, Pentelute BL, Buchwald SL.

J Am Chem Soc. 2018 Feb 28;140(8):3128-3133. doi: 10.1021/jacs.8b00172. Epub 2018 Feb 13.


Discovery of a 29-Amino-Acid Reactive Abiotic Peptide for Selective Cysteine Arylation.

Evans ED, Pentelute BL.

ACS Chem Biol. 2018 Mar 16;13(3):527-532. doi: 10.1021/acschembio.7b00520. Epub 2018 Jan 9.


Cholesterol-binding site of the influenza M2 protein in lipid bilayers from solid-state NMR.

Elkins MR, Williams JK, Gelenter MD, Dai P, Kwon B, Sergeyev IV, Pentelute BL, Hong M.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12946-12951. doi: 10.1073/pnas.1715127114. Epub 2017 Nov 20.


Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation.

Rojas AJ, Zhang C, Vinogradova EV, Buchwald NH, Reilly J, Pentelute BL, Buchwald SL.

Chem Sci. 2017 Jun 1;8(6):4257-4263. doi: 10.1039/c6sc05454d. Epub 2017 Mar 24.


Perfluoroarene-Based Peptide Macrocycles to Enhance Penetration Across the Blood-Brain Barrier.

Fadzen CM, Wolfe JM, Cho CF, Chiocca EA, Lawler SE, Pentelute BL.

J Am Chem Soc. 2017 Nov 8;139(44):15628-15631. doi: 10.1021/jacs.7b09790. Epub 2017 Oct 30.


Heterochiral Knottin Protein: Folding and Solution Structure.

Mong SK, Cochran FV, Yu H, Graziano Z, Lin YS, Cochran JR, Pentelute BL.

Biochemistry. 2017 Oct 31;56(43):5720-5725. doi: 10.1021/acs.biochem.7b00722. Epub 2017 Oct 17.


Library Design-Facilitated High-Throughput Sequencing of Synthetic Peptide Libraries.

Vinogradov AA, Gates ZP, Zhang C, Quartararo AJ, Halloran KH, Pentelute BL.

ACS Comb Sci. 2017 Nov 13;19(11):694-701. doi: 10.1021/acscombsci.7b00109. Epub 2017 Sep 29.


A structural and mechanistic study of π-clamp-mediated cysteine perfluoroarylation.

Dai P, Williams JK, Zhang C, Welborn M, Shepherd JJ, Zhu T, Van Voorhis T, Hong M, Pentelute BL.

Sci Rep. 2017 Aug 11;7(1):7954. doi: 10.1038/s41598-017-08402-2.


Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions.

Rojas AJ, Pentelute BL, Buchwald SL.

Org Lett. 2017 Aug 18;19(16):4263-4266. doi: 10.1021/acs.orglett.7b01911. Epub 2017 Aug 4.


Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents.

Cho CF, Wolfe JM, Fadzen CM, Calligaris D, Hornburg K, Chiocca EA, Agar NYR, Pentelute BL, Lawler SE.

Nat Commun. 2017 Jun 6;8:15623. doi: 10.1038/ncomms15623.


Substrate Recognition of MARTX Ras/Rap1-Specific Endopeptidase.

Biancucci M, Rabideau AE, Lu Z, Loftis AR, Pentelute BL, Satchell KJF.

Biochemistry. 2017 May 30;56(21):2747-2757. doi: 10.1021/acs.biochem.7b00246. Epub 2017 May 11.


A fully automated flow-based approach for accelerated peptide synthesis.

Mijalis AJ, Thomas DA 3rd, Simon MD, Adamo A, Beaumont R, Jensen KF, Pentelute BL.

Nat Chem Biol. 2017 May;13(5):464-466. doi: 10.1038/nchembio.2318. Epub 2017 Feb 28.


Palladium-Mediated Arylation of Lysine in Unprotected Peptides.

Lee HG, Lautrette G, Pentelute BL, Buchwald SL.

Angew Chem Int Ed Engl. 2017 Mar 13;56(12):3177-3181. doi: 10.1002/anie.201611202. Epub 2017 Feb 16.


Editorial overview: Chemistry for biopolymers to investigate and even move beyond nature.

Pentelute BL, Wang L.

Curr Opin Chem Biol. 2016 Oct;34:v-vi. doi: 10.1016/j.cbpa.2016.09.017. Epub 2016 Oct 14. No abstract available.


Salt Effect Accelerates Site-Selective Cysteine Bioconjugation.

Dai P, Zhang C, Welborn M, Shepherd JJ, Zhu T, Van Voorhis T, Pentelute BL.

ACS Cent Sci. 2016 Sep 28;2(9):637-646. Epub 2016 Aug 25.


d-Amino Acid Scan of Two Small Proteins.

Simon MD, Maki Y, Vinogradov AA, Zhang C, Yu H, Lin YS, Kajihara Y, Pentelute BL.

J Am Chem Soc. 2016 Sep 21;138(37):12099-111. doi: 10.1021/jacs.6b03765. Epub 2016 Sep 8.


Nitrogen Arylation for Macrocyclization of Unprotected Peptides.

Lautrette G, Touti F, Lee HG, Dai P, Pentelute BL.

J Am Chem Soc. 2016 Jul 13;138(27):8340-3. doi: 10.1021/jacs.6b03757. Epub 2016 Jun 30.


Delivery of Non-Native Cargo into Mammalian Cells Using Anthrax Lethal Toxin.

Rabideau AE, Pentelute BL.

ACS Chem Biol. 2016 Jun 17;11(6):1490-501. doi: 10.1021/acschembio.6b00169. Epub 2016 May 2. Review.


Systematic Investigation of EDC/sNHS-Mediated Bioconjugation Reactions for Carboxylated Peptide Substrates.

Totaro KA, Liao X, Bhattacharya K, Finneman JI, Sperry JB, Massa MA, Thorn J, Ho SV, Pentelute BL.

Bioconjug Chem. 2016 Apr 20;27(4):994-1004. doi: 10.1021/acs.bioconjchem.6b00043. Epub 2016 Mar 24.


A perfluoroaromatic abiotic analog of H2 relaxin enabled by rapid flow-based peptide synthesis.

Lühmann T, Mong SK, Simon MD, Meinel L, Pentelute BL.

Org Biomol Chem. 2016 Apr 7;14(13):3345-9. doi: 10.1039/c6ob00208k. Epub 2016 Mar 8.


Macrocyclization of Unprotected Peptide Isocyanates.

Vinogradov AA, Choo ZN, Totaro KA, Pentelute BL.

Org Lett. 2016 Mar 18;18(6):1226-9. doi: 10.1021/acs.orglett.5b03626. Epub 2016 Mar 7.


C-Terminal Modification of Fully Unprotected Peptide Hydrazides via in Situ Generation of Isocyanates.

Vinogradov AA, Simon MD, Pentelute BL.

Org Lett. 2016 Mar 18;18(6):1222-5. doi: 10.1021/acs.orglett.5b03625. Epub 2016 Mar 7.


A d-Amino Acid at the N-Terminus of a Protein Abrogates Its Degradation by the N-End Rule Pathway.

Rabideau AE, Pentelute BL.

ACS Cent Sci. 2015 Nov 25;1(8):423-430. Epub 2015 Nov 11.


Π-Clamp-mediated cysteine conjugation.

Zhang C, Welborn M, Zhu T, Yang NJ, Santos MS, Van Voorhis T, Pentelute BL.

Nat Chem. 2016 Feb;8(2):120-8. doi: 10.1038/nchem.2413. Epub 2015 Dec 21.


Organometallic palladium reagents for cysteine bioconjugation.

Vinogradova EV, Zhang C, Spokoyny AM, Pentelute BL, Buchwald SL.

Nature. 2015 Oct 29;526(7575):687-91. doi: 10.1038/nature15739.


An Umpolung Approach for the Chemoselective Arylation of Selenocysteine in Unprotected Peptides.

Cohen DT, Zhang C, Pentelute BL, Buchwald SL.

J Am Chem Soc. 2015 Aug 12;137(31):9784-7. doi: 10.1021/jacs.5b05447. Epub 2015 Jul 30.


Translocation of Non-Canonical Polypeptides into Cells Using Protective Antigen.

Rabideau AE, Liao X, Akçay G, Pentelute BL.

Sci Rep. 2015 Jul 16;5:11944. doi: 10.1038/srep11944.

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