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Items: 1 to 50 of 140


Alum as an adjuvant for nanoparticle based vaccines: A case study with a hybrid nanoparticle-based nicotine vaccine.

Hu Y, Smith D, Zhao Z, Harmon T, Pentel PR, Ehrich M, Zhang C.

Nanomedicine. 2019 Aug;20:102023. doi: 10.1016/j.nano.2019.102023. Epub 2019 Jun 10.


Formulation and Characterization of Conjugate Vaccines to Reduce Opioid Use Disorders Suitable for Pharmaceutical Manufacturing and Clinical Evaluation.

Baruffaldi F, Raleigh MD, King SJ, Roslawski MJ, Birnbaum AK, Hassler C, Carroll FI, Runyon SP, Winston S, Pentel PR, Pravetoni M.

Mol Pharm. 2019 Jun 3;16(6):2364-2375. doi: 10.1021/acs.molpharmaceut.8b01296. Epub 2019 May 14.


A Fentanyl Vaccine Alters Fentanyl Distribution and Protects against Fentanyl-Induced Effects in Mice and Rats.

Raleigh MD, Baruffaldi F, Peterson SJ, Le Naour M, Harmon TM, Vigliaturo JR, Pentel PR, Pravetoni M.

J Pharmacol Exp Ther. 2019 Feb;368(2):282-291. doi: 10.1124/jpet.118.253674. Epub 2018 Nov 8.


Paradox of PEGylation in fabricating hybrid nanoparticle-based nicotine vaccines.

Hu Y, Zhao Z, Harmon T, Pentel PR, Ehrich M, Zhang C.

Biomaterials. 2018 Nov;182:72-81. doi: 10.1016/j.biomaterials.2018.08.015. Epub 2018 Aug 7.


The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats.

Pentel PR, Raleigh MD, LeSage MG, Thisted T, Horrigan S, Biesova Z, Kalnik MW.

BMC Biotechnol. 2018 Jul 24;18(1):46. doi: 10.1186/s12896-018-0457-7.


Hybrid nanoparticle-based nicotine nanovaccines: Boosting the immunological efficacy by conjugation of potent carrier proteins.

Zhao Z, Hu Y, Harmon T, Pentel PR, Ehrich M, Zhang C.

Nanomedicine. 2018 Jul;14(5):1655-1665. doi: 10.1016/j.nano.2018.04.016. Epub 2018 Apr 30.


Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats.

Raleigh MD, Laudenbach M, Baruffaldi F, Peterson SJ, Roslawski MJ, Birnbaum AK, Carroll FI, Runyon SP, Winston S, Pentel PR, Pravetoni M.

J Pharmacol Exp Ther. 2018 May;365(2):346-353. doi: 10.1124/jpet.117.247049. Epub 2018 Mar 13.


Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse.

Raleigh MD, Peterson SJ, Laudenbach M, Baruffaldi F, Carroll FI, Comer SD, Navarro HA, Langston TL, Runyon SP, Winston S, Pravetoni M, Pentel PR.

PLoS One. 2017 Dec 1;12(12):e0184876. doi: 10.1371/journal.pone.0184876. eCollection 2017.


Rational incorporation of molecular adjuvants into a hybrid nanoparticle-based nicotine vaccine for immunotherapy against nicotine addiction.

Zhao Z, Harris B, Hu Y, Harmon T, Pentel PR, Ehrich M, Zhang C.

Biomaterials. 2018 Feb;155:165-175. doi: 10.1016/j.biomaterials.2017.11.021. Epub 2017 Nov 20.


Prescreening of Nicotine Hapten Linkers in Vitro To Select Hapten-Conjugate Vaccine Candidates for Pharmacokinetic Evaluation in Vivo.

Arutla V, Leal J, Liu X, Sokalingam S, Raleigh M, Adaralegbe A, Liu L, Pentel PR, Hecht SM, Chang Y.

ACS Comb Sci. 2017 May 8;19(5):286-298. doi: 10.1021/acscombsci.6b00179. Epub 2017 Apr 17.


Abuse liability assessment of an e-cigarette refill liquid using intracranial self-stimulation and self-administration models in rats.

LeSage MG, Staley M, Muelken P, Smethells JR, Stepanov I, Vogel RI, Pentel PR, Harris AC.

Drug Alcohol Depend. 2016 Nov 1;168:76-88. doi: 10.1016/j.drugalcdep.2016.08.628. Epub 2016 Sep 1.


Correction: The Anti-(+)-Methamphetamine Monoclonal Antibody mAb7F9 Attenuates Acute (+)-Methamphetamine Effects on Intracranial Self-Stimulation in Rats.

Harris AC, LeSage MG, Shelley D, Perry JL, Pentel PR, Owens SM.

PLoS One. 2015 Sep 18;10(9):e0138959. doi: 10.1371/journal.pone.0138959. eCollection 2015. No abstract available.


Predictors of the nicotine reinforcement threshold, compensation, and elasticity of demand in a rodent model of nicotine reduction policy.

Grebenstein PE, Burroughs D, Roiko SA, Pentel PR, LeSage MG.

Drug Alcohol Depend. 2015 Jun 1;151:181-93. doi: 10.1016/j.drugalcdep.2015.03.030. Epub 2015 Apr 7.


The anti-(+)-methamphetamine monoclonal antibody mAb7F9 attenuates acute (+)-methamphetamine effects on intracranial self-stimulation in rats.

Harris AC, LeSage MG, Shelley D, Perry JL, Pentel PR, Owens SM.

PLoS One. 2015 Mar 5;10(3):e0118787. doi: 10.1371/journal.pone.0118787. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0138959.


Pharmacokinetic correlates of the effects of a heroin vaccine on heroin self-administration in rats.

Raleigh MD, Pentel PR, LeSage MG.

PLoS One. 2014 Dec 23;9(12):e115696. doi: 10.1371/journal.pone.0115696. eCollection 2014.


Effects of an oxycodone conjugate vaccine on oxycodone self-administration and oxycodone-induced brain gene expression in rats.

Pravetoni M, Pentel PR, Potter DN, Chartoff EH, Tally L, LeSage MG.

PLoS One. 2014 Jul 15;9(7):e101807. doi: 10.1371/journal.pone.0101807. eCollection 2014.


Scientific overview: 2013 BBC plenary symposium on tobacco addiction.

De Biasi M, McLaughlin I, Perez EE, Crooks PA, Dwoskin LP, Bardo MT, Pentel PR, Hatsukami D.

Drug Alcohol Depend. 2014 Aug 1;141:107-17. doi: 10.1016/j.drugalcdep.2014.05.013. Epub 2014 Jun 2. Erratum in: Drug Alcohol Depend. 2014 Nov 1;144:290.


Effect of currently approved carriers and adjuvants on the pre-clinical efficacy of a conjugate vaccine against oxycodone in mice and rats.

Pravetoni M, Vervacke JS, Distefano MD, Tucker AM, Laudenbach M, Pentel PR.

PLoS One. 2014 May 5;9(5):e96547. doi: 10.1371/journal.pone.0096547. eCollection 2014.


Portion size effects on weight gain in a free living setting.

French SA, Mitchell NR, Wolfson J, Harnack LJ, Jeffery RW, Gerlach AF, Blundell JE, Pentel PR.

Obesity (Silver Spring). 2014 Jun;22(6):1400-5. doi: 10.1002/oby.20720. Epub 2014 Feb 19.


New directions in nicotine vaccine design and use.

Pentel PR, LeSage MG.

Adv Pharmacol. 2014;69:553-80. doi: 10.1016/B978-0-12-420118-7.00014-7. Review.


Immunogenicity of individual vaccine components in a bivalent nicotine vaccine differ according to vaccine formulation and administration conditions.

Cornish KE, de Villiers SH, Pravetoni M, Pentel PR.

PLoS One. 2013 Dec 2;8(12):e82557. doi: 10.1371/journal.pone.0082557. eCollection 2013.


Increased efficacy of a trivalent nicotine vaccine compared to a dose-matched monovalent vaccine when formulated with alum.

de Villiers SH, Cornish KE, Troska AJ, Pravetoni M, Pentel PR.

Vaccine. 2013 Dec 16;31(52):6185-93. doi: 10.1016/j.vaccine.2013.10.051. Epub 2013 Oct 29.


Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens.

Pravetoni M, Le Naour M, Tucker AM, Harmon TM, Hawley TM, Portoghese PS, Pentel PR.

J Med Chem. 2013 Feb 14;56(3):915-23. doi: 10.1021/jm3013745. Epub 2013 Jan 15.


Stability of heroin, 6-monoacetylmorphine, and morphine in biological samples and validation of an LC-MS assay for delayed analyses of pharmacokinetic samples in rats.

Jones JM, Raleigh MD, Pentel PR, Harmon TM, Keyler DE, Remmel RP, Birnbaum AK.

J Pharm Biomed Anal. 2013 Feb 23;74:291-7. doi: 10.1016/j.jpba.2012.10.033. Epub 2012 Nov 15.


Selective effects of a morphine conjugate vaccine on heroin and metabolite distribution and heroin-induced behaviors in rats.

Raleigh MD, Pravetoni M, Harris AC, Birnbaum AK, Pentel PR.

J Pharmacol Exp Ther. 2013 Feb;344(2):397-406. doi: 10.1124/jpet.112.201194. Epub 2012 Dec 7.


High immunogenicity of nicotine vaccines obtained by intradermal delivery with safe adjuvants.

Chen X, Pravetoni M, Bhayana B, Pentel PR, Wu MX.

Vaccine. 2012 Dec 17;31(1):159-64. doi: 10.1016/j.vaccine.2012.10.069. Epub 2012 Oct 30.


Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats.

Pravetoni M, Raleigh MD, Le Naour M, Tucker AM, Harmon TM, Jones JM, Birnbaum AK, Portoghese PS, Pentel PR.

Vaccine. 2012 Jun 29;30(31):4617-24. doi: 10.1016/j.vaccine.2012.04.101. Epub 2012 May 11.


Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist.

LeSage MG, Shelley D, Pravetoni M, Pentel PR.

Pharmacol Biochem Behav. 2012 Jul;102(1):157-62. doi: 10.1016/j.pbb.2012.03.026. Epub 2012 Apr 4.


An oxycodone conjugate vaccine elicits drug-specific antibodies that reduce oxycodone distribution to brain and hot-plate analgesia.

Pravetoni M, Le Naour M, Harmon TM, Tucker AM, Portoghese PS, Pentel PR.

J Pharmacol Exp Ther. 2012 Apr;341(1):225-32. doi: 10.1124/jpet.111.189506. Epub 2012 Jan 18.


Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities.

Pravetoni M, Keyler DE, Pidaparthi RR, Carroll FI, Runyon SP, Murtaugh MP, Earley CA, Pentel PR.

Biochem Pharmacol. 2012 Feb 15;83(4):543-50. doi: 10.1016/j.bcp.2011.11.004. Epub 2011 Nov 15.


Delivery of nicotine in an extract of a smokeless tobacco product reduces its reinforcement-attenuating and discriminative stimulus effects in rats.

Harris AC, Stepanov I, Pentel PR, Lesage MG.

Psychopharmacology (Berl). 2012 Apr;220(3):565-76. doi: 10.1007/s00213-011-2514-y. Epub 2011 Sep 30.


Combined active and passive immunization against nicotine: minimizing monoclonal antibody requirements using a target antibody concentration strategy.

Cornish KE, Harris AC, LeSage MG, Keyler DE, Burroughs D, Earley C, Pentel PR.

Int Immunopharmacol. 2011 Nov;11(11):1809-15. doi: 10.1016/j.intimp.2011.07.009. Epub 2011 Jul 28.


A lack of association between severity of nicotine withdrawal and individual differences in compensatory nicotine self-administration in rats.

Harris AC, Pentel PR, Burroughs D, Staley MD, Lesage MG.

Psychopharmacology (Berl). 2011 Sep;217(2):153-66. doi: 10.1007/s00213-011-2273-9. Epub 2011 Apr 15.


Vaccination against nicotine alters the distribution of nicotine delivered via cigarette smoke inhalation to rats.

Pravetoni M, Keyler DE, Raleigh MD, Harris AC, Lesage MG, Mattson CK, Pettersson S, Pentel PR.

Biochem Pharmacol. 2011 May 1;81(9):1164-70. doi: 10.1016/j.bcp.2011.02.004. Epub 2011 Feb 17.


Comparison of the behavioral effects of cigarette smoke and pure nicotine in rats.

Harris AC, Mattson C, Lesage MG, Keyler DE, Pentel PR.

Pharmacol Biochem Behav. 2010 Aug;96(2):217-27. doi: 10.1016/j.pbb.2010.05.008. Epub 2010 May 18.


Correlates of individual differences in compensatory nicotine self-administration in rats following a decrease in nicotine unit dose.

Harris AC, Pentel PR, LeSage MG.

Psychopharmacology (Berl). 2009 Sep;205(4):599-611. doi: 10.1007/s00213-009-1567-7. Epub 2009 May 28.


Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats.

Roiko SA, Harris AC, LeSage MG, Keyler DE, Pentel PR.

Pharmacol Biochem Behav. 2009 Aug;93(2):105-11. doi: 10.1016/j.pbb.2009.04.011. Epub 2009 Apr 23.


Developing the science base for reducing tobacco harm.

Hatsukami DK, Joseph AM, Lesage M, Jensen J, Murphy SE, Pentel PR, Kotlyar M, Borgida E, Le C, Hecht SS.

Nicotine Tob Res. 2007 Nov;9 Suppl 4:S537-53. doi: 10.1080/14622200701679040. Review.


Enhanced immunogenicity of a bivalent nicotine vaccine.

Keyler DE, Roiko SA, Earley CA, Murtaugh MP, Pentel PR.

Int Immunopharmacol. 2008 Nov;8(11):1589-94. doi: 10.1016/j.intimp.2008.07.001. Epub 2008 Jul 24.


Stability of the nicotine metabolite ratio in ad libitum and reducing smokers.

Mooney ME, Li ZZ, Murphy SE, Pentel PR, Le C, Hatsukami DK.

Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1396-400. doi: 10.1158/1055-9965.EPI-08-0242.


Combined active and passive immunization enhances the efficacy of immunotherapy against nicotine in rats.

Roiko SA, Harris AC, Keyler DE, Lesage MG, Zhang Y, Pentel PR.

J Pharmacol Exp Ther. 2008 Jun;325(3):985-93. doi: 10.1124/jpet.107.135111. Epub 2008 Feb 27.


Compensatory nicotine self-administration in rats during reduced access to nicotine: an animal model of smoking reduction.

Harris AC, Burroughs D, Pentel PR, LeSage MG.

Exp Clin Psychopharmacol. 2008 Feb;16(1):86-97. doi: 10.1037/1064-1297.16.1.86.


Effects of pregnancy on nicotine self-administration and nicotine pharmacokinetics in rats.

Lesage MG, Keyler DE, Burroughs D, Pentel PR.

Psychopharmacology (Berl). 2007 Oct;194(3):413-21. Epub 2007 Jul 7.


Effects of portion size on chronic energy intake.

Jeffery RW, Rydell S, Dunn CL, Harnack LJ, Levine AS, Pentel PR, Baxter JE, Walsh EM.

Int J Behav Nutr Phys Act. 2007 Jun 27;4:27.


Nicotine pharmacokinetics and subjective effects of three potential reduced exposure products, moist snuff and nicotine lozenge.

Kotlyar M, Mendoza-Baumgart MI, Li ZZ, Pentel PR, Barnett BC, Feuer RM, Smith EA, Hatsukami DK.

Tob Control. 2007 Apr;16(2):138-42.


Acetaldehyde, a major constituent of tobacco smoke, enhances behavioral, endocrine, and neuronal responses to nicotine in adolescent and adult rats.

Cao J, Belluzzi JD, Loughlin SE, Keyler DE, Pentel PR, Leslie FM.

Neuropsychopharmacology. 2007 Sep;32(9):2025-35. Epub 2007 Feb 7.


Effects of maternal intravenous nicotine administration on locomotor behavior in pre-weanling rats.

LeSage MG, Gustaf E, Dufek MB, Pentel PR.

Pharmacol Biochem Behav. 2006 Nov;85(3):575-83. Epub 2006 Dec 4.


Vaccination against nicotine does not prevent nicotine-induced changes in fetal nicotinic receptor binding and c-fos mRNA expression in rats.

Pentel PR, Keyler DE, Chen Y, LeSage MG, Dufek MB, Le C, Leslie FM.

Neurotoxicol Teratol. 2006 Sep-Oct;28(5):589-96. Epub 2006 Aug 15.


Changes in maternal and fetal nicotine distribution after maternal administration of monoclonal nicotine-specific antibody to rats.

Keyler DE, Lesage MG, Dufek MB, Pentel PR.

Int Immunopharmacol. 2006 Nov;6(11):1665-72. Epub 2006 Aug 4.

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