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Acid-Base and Electrolyte Changes Drive Early Pathology in Ischemic Stroke.

Martha SR, Fraser JF, Pennypacker KR.

Neuromolecular Med. 2019 Jul 6. doi: 10.1007/s12017-019-08555-5. [Epub ahead of print] Review.


Azithromycin Polarizes Macrophages to an M2 Phenotype via Inhibition of the STAT1 and NF-κB Signaling Pathways.

Haydar D, Cory TJ, Birket SE, Murphy BS, Pennypacker KR, Sinai AP, Feola DJ.

J Immunol. 2019 Aug 15;203(4):1021-1030. doi: 10.4049/jimmunol.1801228. Epub 2019 Jul 1.


Early acid/base and electrolyte changes in permanent middle cerebral artery occlusion: Aged male and female rats.

Martha SR, Collier LA, Davis SM, Goodwin SJ, Powell D, Lukins D, Fraser JF, Pennypacker KR.

J Neurosci Res. 2019 Apr 3. doi: 10.1002/jnr.24422. [Epub ahead of print]


Neuroprotective activity of leukemia inhibitory factor is relayed through myeloid zinc finger-1 in a rat model of stroke.

Davis SM, Collier LA, Foran EA, Leonardo CC, Ajmo CT Jr, Pennypacker KR.

Metab Brain Dis. 2019 Apr;34(2):631-640. doi: 10.1007/s11011-018-0376-2. Epub 2019 Jan 5.


Efficacy of leukemia inhibitory factor as a therapeutic for permanent large vessel stroke differs among aged male and female rats.

Davis SM, Collier LA, Goodwin S, Lukins DE, Powell DK, Pennypacker KR.

Brain Res. 2019 Mar 15;1707:62-73. doi: 10.1016/j.brainres.2018.11.017. Epub 2018 Nov 13.


Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion.

Davis SM, Collier LA, Winford ED, Leonardo CC, Ajmo CT Jr, Foran EA, Kopper TJ, Gensel JC, Pennypacker KR.

J Neuroinflammation. 2018 Oct 15;15(1):288. doi: 10.1186/s12974-018-1326-y.


Translational Evaluation of Acid/Base and Electrolyte Alterations in Rodent Model of Focal Ischemia.

Martha SR, Collier LA, Davis SM, Seifert HA, Leonardo CC, Ajmo CT Jr, Foran EA, Fraser JF, Pennypacker KR.

J Stroke Cerebrovasc Dis. 2018 Oct;27(10):2746-2754. doi: 10.1016/j.jstrokecerebrovasdis.2018.05.045. Epub 2018 Jul 29.


The Blood And Clot Thrombectomy Registry And Collaboration (BACTRAC) protocol: novel method for evaluating human stroke.

Fraser JF, Collier LA, Gorman AA, Martha SR, Salmeron KE, Trout AL, Edwards DN, Davis SM, Lukins DE, Alhajeri A, Grupke S, Roberts JM, Bix GJ, Pennypacker KR.

J Neurointerv Surg. 2019 Mar;11(3):265-270. doi: 10.1136/neurintsurg-2018-014118. Epub 2018 Jul 31.


Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical.

Bix GJ, Fraser JF, Mack WJ, Carmichael ST, Perez-Pinzon M, Offner H, Sansing L, Bosetti F, Ayata C, Pennypacker KR.

Transl Stroke Res. 2018 Jun;9(3):258-266. doi: 10.1007/s12975-018-0628-9. Epub 2018 Apr 10.


Leukemia Inhibitory Factor-Loaded Nanoparticles with Enhanced Cytokine Metabolic Stability and Anti-Inflammatory Activity.

Davis SM, Reichel D, Bae Y, Pennypacker KR.

Pharm Res. 2018 Jan 2;35(1):6. doi: 10.1007/s11095-017-2282-4.


The role of the leukemia inhibitory factor receptor in neuroprotective signaling.

Davis SM, Pennypacker KR.

Pharmacol Ther. 2018 Mar;183:50-57. doi: 10.1016/j.pharmthera.2017.08.008. Epub 2017 Aug 19. Review.


Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke.

Davis SM, Pennypacker KR.

Neurochem Int. 2017 Jul;107:23-32. doi: 10.1016/j.neuint.2016.12.007. Epub 2016 Dec 30. Review.


Correcting the Trajectory of Stroke Therapeutic Research.

Pennypacker KR, Bix G, Fraser JF.

Transl Stroke Res. 2017 Feb;8(1):65-66. doi: 10.1007/s12975-016-0517-z. Epub 2016 Dec 30. No abstract available.


Leukemia Inhibitory Factor Protects Neurons from Ischemic Damage via Upregulation of Superoxide Dismutase 3.

Davis SM, Collier LA, Leonardo CC, Seifert HA, Ajmo CT Jr, Pennypacker KR.

Mol Neurobiol. 2017 Jan;54(1):608-622. doi: 10.1007/s12035-015-9587-2. Epub 2016 Jan 9.


The Effects of Clinically Relevant Hypertonic Saline and Conivaptan Administration on Ischemic Stroke.

Decker D, Collier L, Lau T, Olivera R, Roma G, Leonardo C, Seifert H, Rowe D, Pennypacker KR.

Acta Neurochir Suppl. 2016;121:243-50. doi: 10.1007/978-3-319-18497-5_43.


The role of the spleen in ischemic stroke.

Pennypacker KR, Offner H.

J Cereb Blood Flow Metab. 2015 Feb;35(2):186-7. doi: 10.1038/jcbfm.2014.212. Epub 2014 Dec 3. Review.


Human umbilical cord blood cells induce neuroprotective change in gene expression profile in neurons after ischemia through activation of Akt pathway.

Shahaduzzaman MD, Mehta V, Golden JE, Rowe DD, Green S, Tadinada R, Foran EA, Sanberg PR, Pennypacker KR, Willing AE.

Cell Transplant. 2015;24(4):721-35. doi: 10.3727/096368914X685311. Epub 2015 Feb 26.


Commentary: Different immunological mechanisms govern protection from experimental stroke in young and older mice with recombinant TCR ligand therapy.

Pennypacker KR.

Front Cell Neurosci. 2014 Oct 17;8:339. doi: 10.3389/fncel.2014.00339. eCollection 2014. No abstract available.


Targeting the peripheral inflammatory response to stroke: role of the spleen.

Pennypacker KR.

Transl Stroke Res. 2014 Dec;5(6):635-7. doi: 10.1007/s12975-014-0372-8. Epub 2014 Sep 26. No abstract available.


Pro-inflammatory interferon gamma signaling is directly associated with stroke induced neurodegeneration.

Seifert HA, Collier LA, Chapman CB, Benkovic SA, Willing AE, Pennypacker KR.

J Neuroimmune Pharmacol. 2014 Dec;9(5):679-89. doi: 10.1007/s11481-014-9560-2. Epub 2014 Aug 8.


Leukemia inhibitor factor promotes functional recovery and oligodendrocyte survival in rat models of focal ischemia.

Rowe DD, Collier LA, Seifert HA, Chapman CB, Leonardo CC, Willing AE, Pennypacker KR.

Eur J Neurosci. 2014 Oct;40(7):3111-9. doi: 10.1111/ejn.12675. Epub 2014 Jul 16.


Molecular and cellular immune responses to ischemic brain injury.

Seifert HA, Pennypacker KR.

Transl Stroke Res. 2014 Oct;5(5):543-53. doi: 10.1007/s12975-014-0349-7. Epub 2014 Jun 5. Review.


Monocytes are essential for the neuroprotective effect of human cord blood cells following middle cerebral artery occlusion in rat.

Womble TA, Green S, Shahaduzzaman M, Grieco J, Sanberg PR, Pennypacker KR, Willing AE.

Mol Cell Neurosci. 2014 Mar;59:76-84. doi: 10.1016/j.mcn.2014.01.004. Epub 2014 Jan 25.


Human umbilical cord blood cells alter blood and spleen cell populations after stroke.

Golden JE, Shahaduzzaman M, Wabnitz A, Green S, Womble TA, Sanberg PR, Pennypacker KR, Willing AE.

Transl Stroke Res. 2012 Dec;3(4):491-9. doi: 10.1007/s12975-012-0208-3. Epub 2012 Sep 4.


A transient decrease in spleen size following stroke corresponds to splenocyte release into systemic circulation.

Seifert HA, Hall AA, Chapman CB, Collier LA, Willing AE, Pennypacker KR.

J Neuroimmune Pharmacol. 2012 Dec;7(4):1017-24. doi: 10.1007/s11481-012-9406-8. Epub 2012 Oct 6.


CCL20 Is Associated with Neurodegeneration Following Experimental Traumatic Brain Injury and Promotes Cellular Toxicity In Vitro.

Leonardo CC, Musso J, Das M, Rowe DD, Collier LA, Mohapatra S, Pennypacker KR.

Transl Stroke Res. 2012 Sep;3(3):357-63. doi: 10.1007/s12975-012-0203-8. Epub 2012 Aug 9.


Peripheral immune response to CNS injury.

Pennypacker KR.

Transl Stroke Res. 2012 Sep;3(3):305. doi: 10.1007/s12975-012-0204-7. Epub 2012 Aug 11. No abstract available.


The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling.

Seifert HA, Leonardo CC, Hall AA, Rowe DD, Collier LA, Benkovic SA, Willing AE, Pennypacker KR.

Metab Brain Dis. 2012 Jun;27(2):131-41. doi: 10.1007/s11011-012-9283-0. Epub 2012 Feb 22.


Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction.

Rowe DD, Leonardo CC, Recio JA, Collier LA, Willing AE, Pennypacker KR.

J Biol Chem. 2012 Feb 3;287(6):4177-87. doi: 10.1074/jbc.M111.296434. Epub 2011 Dec 12.


Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats.

Das M, Leonardo CC, Rangooni S, Pennypacker KR, Mohapatra S, Mohapatra SS.

J Neuroinflammation. 2011 Oct 31;8:148. doi: 10.1186/1742-2094-8-148.


The splenic response to ischemic stroke: what have we learned from rodent models?

Leonardo CC, Pennypacker KR.

Transl Stroke Res. 2011 Sep;2(3):328-38. doi: 10.1007/s12975-011-0075-3. Epub 2011 Apr 3.


Cord blood administration induces oligodendrocyte survival through alterations in gene expression.

Rowe DD, Leonardo CC, Hall AA, Shahaduzzaman MD, Collier LA, Willing AE, Pennypacker KR.

Brain Res. 2010 Dec 17;1366:172-88. doi: 10.1016/j.brainres.2010.09.078. Epub 2010 Sep 29.


Administration of a Sigma Receptor Agonist Delays MCAO-Induced Neurodegeneration and White Matter Injury.

Leonardo CC, Hall AA, Collier LA, Green SM, Willing AE, Pennypacker KR.

Transl Stroke Res. 2010 Jun;1(2):135-45. doi: 10.1007/s12975-009-0005-9.


Implications of immune system in stroke for novel therapeutic approaches.

Hall AA, Pennypacker KR.

Transl Stroke Res. 2010 Jun;1(2):85-95. doi: 10.1007/s12975-009-0003-y. Epub 2010 Jan 13.


Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw.

Ajmo JM, Bailey LA, Howell MD, Cortez LK, Pennypacker KR, Mehta HN, Morgan D, Gordon MN, Gottschall PE.

J Neurochem. 2010 May;113(3):784-95. doi: 10.1111/j.1471-4159.2010.06647.x. Epub 2010 Feb 17.


Copper-catalyzed guanidinylation of aryl iodides: the formation of N,N'-disubstituted guanidines.

Cortes-Salva M, Nguyen BL, Cuevas J, Pennypacker KR, Antilla JC.

Org Lett. 2010 Mar 19;12(6):1316-9. doi: 10.1021/ol1002175.


Human umbilical cord blood cell therapy blocks the morphological change and recruitment of CD11b-expressing, isolectin-binding proinflammatory cells after middle cerebral artery occlusion.

Leonardo CC, Hall AA, Collier LA, Ajmo CT Jr, Willing AE, Pennypacker KR.

J Neurosci Res. 2010 May 1;88(6):1213-22. doi: 10.1002/jnr.22306.


Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation.

Hall AA, Leonardo CC, Collier LA, Rowe DD, Willing AE, Pennypacker KR.

Neuroscience. 2009 Dec 1;164(2):470-7. doi: 10.1016/j.neuroscience.2009.08.051. Epub 2009 Aug 29.


Blockade of adrenoreceptors inhibits the splenic response to stroke.

Ajmo CT Jr, Collier LA, Leonardo CC, Hall AA, Green SM, Womble TA, Cuevas J, Willing AE, Pennypacker KR.

Exp Neurol. 2009 Jul;218(1):47-55. doi: 10.1016/j.expneurol.2009.03.044. Epub 2009 Apr 14.


Neuroinflammation and MMPs: potential therapeutic targets in neonatal hypoxic-ischemic injury.

Leonardo CC, Pennypacker KR.

J Neuroinflammation. 2009 Apr 15;6:13. doi: 10.1186/1742-2094-6-13. Review.


Inhibition of gelatinase activity reduces neural injury in an ex vivo model of hypoxia-ischemia.

Leonardo CC, Hall AA, Collier LA, Gottschall PE, Pennypacker KR.

Neuroscience. 2009 Jun 2;160(4):755-66. doi: 10.1016/j.neuroscience.2009.02.080. Epub 2009 Mar 9.


Sigma receptors suppress multiple aspects of microglial activation.

Hall AA, Herrera Y, Ajmo CT Jr, Cuevas J, Pennypacker KR.

Glia. 2009 May;57(7):744-54. doi: 10.1002/glia.20802.


Human umbilical cord blood cells directly suppress ischemic oligodendrocyte cell death.

Hall AA, Guyer AG, Leonardo CC, Ajmo CT Jr, Collier LA, Willing AE, Pennypacker KR.

J Neurosci Res. 2009 Feb;87(2):333-41. doi: 10.1002/jnr.21857.


sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-induced Ca2+ influx in rat cortical neurons.

Herrera Y, Katnik C, Rodriguez JD, Hall AA, Willing A, Pennypacker KR, Cuevas J.

J Pharmacol Exp Ther. 2008 Nov;327(2):491-502. doi: 10.1124/jpet.108.143974. Epub 2008 Aug 22.


Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat.

Leonardo CC, Eakin AK, Ajmo JM, Collier LA, Pennypacker KR, Strongin AY, Gottschall PE.

J Neuroinflammation. 2008 Aug 11;5:34. doi: 10.1186/1742-2094-5-34.


The spleen contributes to stroke-induced neurodegeneration.

Ajmo CT Jr, Vernon DO, Collier L, Hall AA, Garbuzova-Davis S, Willing A, Pennypacker KR.

J Neurosci Res. 2008 Aug 1;86(10):2227-34. doi: 10.1002/jnr.21661.


Alternate approach to understanding the molecular mechanisms of stroke-induced injury.

Willing AE, Pennypacker KR.

Histol Histopathol. 2007 Jun;22(6):697-701. doi: 10.14670/HH-22.697. Review.


Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia.

Katnik C, Guerrero WR, Pennypacker KR, Herrera Y, Cuevas J.

J Pharmacol Exp Ther. 2006 Dec;319(3):1355-65. Epub 2006 Sep 20.


Reduced Nuclear Factor kappa B activation in dentate gyrus after active avoidance training.

Vernon DO, Garbuzova-Davis S, Desjarlais T, Singh Rasile R, Sanberg PR, Willing AE, Pennypacker KR.

Brain Res. 2006 Aug 9;1104(1):39-44. Epub 2006 Jun 30.


Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats.

Ajmo CT Jr, Vernon DO, Collier L, Pennypacker KR, Cuevas J.

Curr Neurovasc Res. 2006 May;3(2):89-98.


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