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Items: 1 to 50 of 51

1.

Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ(+)CD8αα(+) intraepithelial lymphocytes.

Grandjean CL, Sumaria N, Martin S, Pennington DJ.

Sci Rep. 2017 Sep 6;7(1):10659. doi: 10.1038/s41598-017-09368-x.

2.

Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB, O'Dwyer M, Nourshargh S, Pennington DJ, Barnes MR, Brohi K.

PLoS Med. 2017 Jul 17;14(7):e1002352. doi: 10.1371/journal.pmed.1002352. eCollection 2017 Jul.

3.

Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells.

Sumaria N, Grandjean CL, Silva-Santos B, Pennington DJ.

Cell Rep. 2017 Jun 20;19(12):2469-2476. doi: 10.1016/j.celrep.2017.05.071.

4.

Thymic Determinants of γδ T Cell Differentiation.

Muñoz-Ruiz M, Sumaria N, Pennington DJ, Silva-Santos B.

Trends Immunol. 2017 May;38(5):336-344. doi: 10.1016/j.it.2017.01.007. Epub 2017 Mar 9. Review.

PMID:
28285814
5.

IFNγ Regulates Activated Vδ2+ T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells.

Fechter K, Dorronsoro A, Jakobsson E, Ferrin I, Lang V, Sepulveda P, Pennington DJ, Trigueros C.

PLoS One. 2017 Jan 11;12(1):e0169362. doi: 10.1371/journal.pone.0169362. eCollection 2017.

6.

Heterogeneous yet stable Vδ2(+) T-cell profiles define distinct cytotoxic effector potentials in healthy human individuals.

Ryan PL, Sumaria N, Holland CJ, Bradford CM, Izotova N, Grandjean CL, Jawad AS, Bergmeier LA, Pennington DJ.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14378-14383. Epub 2016 Nov 28.

7.

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets.

Muñoz-Ruiz M, Ribot JC, Grosso AR, Gonçalves-Sousa N, Pamplona A, Pennington DJ, Regueiro JR, Fernández-Malavé E, Silva-Santos B.

Nat Immunol. 2016 Jun;17(6):721-727. doi: 10.1038/ni.3424. Epub 2016 Apr 4.

8.

The emerging Protumor role of γδ T lymphocytes: implications for cancer immunotherapy.

Rei M, Pennington DJ, Silva-Santos B.

Cancer Res. 2015 Mar 1;75(5):798-802. doi: 10.1158/0008-5472.CAN-14-3228. Epub 2015 Feb 6. Review.

9.

Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.

Rei M, Gonçalves-Sousa N, Lança T, Thompson RG, Mensurado S, Balkwill FR, Kulbe H, Pennington DJ, Silva-Santos B.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3562-70. doi: 10.1073/pnas.1403424111. Epub 2014 Aug 11.

10.

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.

Turner MD, Nedjai B, Hurst T, Pennington DJ.

Biochim Biophys Acta. 2014 Nov;1843(11):2563-2582. doi: 10.1016/j.bbamcr.2014.05.014. Epub 2014 Jun 2. Review.

11.

Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets.

Schmolka N, Serre K, Grosso AR, Rei M, Pennington DJ, Gomes AQ, Silva-Santos B.

Nat Immunol. 2013 Oct;14(10):1093-1100. doi: 10.1038/ni.2702. Epub 2013 Sep 1.

12.

Functional development of γδ T cells.

Prinz I, Silva-Santos B, Pennington DJ.

Eur J Immunol. 2013 Aug;43(8):1988-94. doi: 10.1002/eji.201343759. Review.

13.

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway.

Coquet JM, Ribot JC, Bąbała N, Middendorp S, van der Horst G, Xiao Y, Neves JF, Fonseca-Pereira D, Jacobs H, Pennington DJ, Silva-Santos B, Borst J.

J Exp Med. 2013 Apr 8;210(4):715-28. doi: 10.1084/jem.20112061. Epub 2013 Apr 1.

14.

Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells.

Michel ML, Pang DJ, Haque SF, Potocnik AJ, Pennington DJ, Hayday AC.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17549-54. doi: 10.1073/pnas.1204327109. Epub 2012 Oct 9.

15.

Understanding the complexity of γδ T-cell subsets in mouse and human.

Pang DJ, Neves JF, Sumaria N, Pennington DJ.

Immunology. 2012 Jul;136(3):283-90. doi: 10.1111/j.1365-2567.2012.03582.x. Review.

16.

T cell receptor signalling in γδ cell development: strength isn't everything.

Turchinovich G, Pennington DJ.

Trends Immunol. 2011 Dec;32(12):567-73. doi: 10.1016/j.it.2011.09.005. Epub 2011 Nov 4.

PMID:
22056207
17.

PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization.

Mahtani-Patching J, Neves JF, Pang DJ, Stoenchev KV, Aguirre-Blanco AM, Silva-Santos B, Pennington DJ.

Sci Signal. 2011 Jul 19;4(182):ra47. doi: 10.1126/scisignal.2001765.

18.

For neonates undergoing cardiac surgery does thymectomy as opposed to thymic preservation have any adverse immunological consequences?

Afifi A, Raja SG, Pennington DJ, Tsang VT.

Interact Cardiovasc Thorac Surg. 2010 Sep;11(3):287-91. doi: 10.1510/icvts.2010.237172. Epub 2010 Jun 24. Review.

PMID:
20576655
19.

Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk.

Cárcamo-Orive I, Gaztelumendi A, Delgado J, Tejados N, Dorronsoro A, Fernández-Rueda J, Pennington DJ, Trigueros C.

J Bone Miner Res. 2010 Oct;25(10):2115-25. doi: 10.1002/jbmr.120.

20.

CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets.

Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J, Hayday AC, Pennington DJ, Silva-Santos B.

Nat Immunol. 2009 Apr;10(4):427-36. doi: 10.1038/ni.1717. Epub 2009 Mar 8.

21.

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.

Sancho D, Mourão-Sá D, Joffre OP, Schulz O, Rogers NC, Pennington DJ, Carlyle JR, Reis e Sousa C.

J Clin Invest. 2008 Jun;118(6):2098-110. doi: 10.1172/JCI34584.

22.

Newly identified genetic risk variants for celiac disease related to the immune response.

Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA.

Nat Genet. 2008 Apr;40(4):395-402. doi: 10.1038/ng.102. Epub 2008 Mar 2.

23.

HIV- I Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism.

Pennington DJ, Jenkins SA, Brady HJ, Miles CG, Dzierzak EA, Abraham DJ.

Genes Funct. 1997 Dec;1(5-6):321-35.

PMID:
17366702
24.

Key factors in the organized chaos of early T cell development.

Hayday AC, Pennington DJ.

Nat Immunol. 2007 Feb;8(2):137-44. Review.

PMID:
17242687
25.

Early events in the thymus affect the balance of effector and regulatory T cells.

Pennington DJ, Silva-Santos B, Silberzahn T, Escórcio-Correia M, Woodward MJ, Roberts SJ, Smith AL, Dyson PJ, Hayday AC.

Nature. 2006 Dec 21;444(7122):1073-7.

PMID:
17190001
26.

The integration of conventional and unconventional T cells that characterizes cell-mediated responses.

Pennington DJ, Vermijlen D, Wise EL, Clarke SL, Tigelaar RE, Hayday AC.

Adv Immunol. 2005;87:27-59. Review.

PMID:
16102571
27.

Gammadelta T cell development--having the strength to get there.

Pennington DJ, Silva-Santos B, Hayday AC.

Curr Opin Immunol. 2005 Apr;17(2):108-15. Review.

PMID:
15766668
28.

Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors.

Silva-Santos B, Pennington DJ, Hayday AC.

Science. 2005 Feb 11;307(5711):925-8. Epub 2004 Dec 9.

29.

Genomics and immunology.

Hayday AC, Pennington DJ, Giuggio VM.

Semin Immunol. 2003 Aug;15(4):201-8. No abstract available.

PMID:
14690044
30.

How well do we prepare pediatric radiologists regarding child abuse? Results of a survey of recently trained fellows.

Pennington DJ, Lonergan GJ, Mendelson KL.

Pediatr Radiol. 2004 Jan;34(1):59-65. Epub 2003 Oct 10.

PMID:
14551757
31.

The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells.

Pennington DJ, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Wise EL, Tigelaar RE, Owen MJ, Hayday AC.

Nat Immunol. 2003 Oct;4(10):991-8. Epub 2003 Sep 21.

PMID:
14502287
32.

Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage.

Trigueros C, Hozumi K, Silva-Santos B, Bruno L, Hayday AC, Owen MJ, Pennington DJ.

Eur J Immunol. 2003 Jul;33(7):1968-77.

33.

PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages.

Comalada M, Xaus J, Valledor AF, López-López C, Pennington DJ, Celada A.

Am J Physiol Cell Physiol. 2003 Nov;285(5):C1235-45. Epub 2003 Jul 16.

34.

Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells.

Aliberti J, Schulz O, Pennington DJ, Tsujimura H, Reis e Sousa C, Ozato K, Sher A.

Blood. 2003 Jan 1;101(1):305-10. Epub 2002 Jun 28.

35.
36.
37.

Postmortem radiography after unexpected death in neonates, infants, and children: should imaging be routine?

McGraw EP, Pless JE, Pennington DJ, White SJ.

AJR Am J Roentgenol. 2002 Jun;178(6):1517-21.

PMID:
12034631
38.

Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection.

Castrillo A, Pennington DJ, Otto F, Parker PJ, Owen MJ, Boscá L.

J Exp Med. 2001 Nov 5;194(9):1231-42.

39.
40.

Renal disease potentiates the injury caused by SWL.

Evan AP, Connors BA, Pennington DJ, Blomgren PM, Lingeman JE, Fineberg NS, Willis LR.

J Endourol. 1999 Nov;13(9):619-28.

PMID:
10608512
41.

Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development.

Buckland J, Pennington DJ, Bruno L, Owen MJ.

Eur J Immunol. 2000 Jan;30(1):8-18. Erratum in: Eur J Immunol 2000 Mar;30(3):974.

42.

Imaging of the urinary tract in children.

Pennington DJ, Zerin JM.

Pediatr Ann. 1999 Nov;28(11):678-86. No abstract available.

PMID:
10578496
43.

Pulmonary disease in the immunocompromised child.

Pennington DJ, Lonergan GJ, Benya EC.

J Thorac Imaging. 1999 Jan;14(1):37-50. Review.

PMID:
9894952
44.

Childhood pyelonephritis: comparison of gadolinium-enhanced MR imaging and renal cortical scintigraphy for diagnosis.

Lonergan GJ, Pennington DJ, Morrison JC, Haws RM, Grimley MS, Kao TC.

Radiology. 1998 May;207(2):377-84.

PMID:
9577484
45.

Experimental pyelonephritis in piglets: diagnosis with MR imaging.

Pennington DJ, Lonergan GJ, Flack CE, Waguespack RL, Jackson CB.

Radiology. 1996 Oct;201(1):199-205.

PMID:
8816544
46.

Hepatocellular carcinoma in a child with Niemann-Pick disease: imaging findings.

Pennington DJ, Sivit CJ, Chandra RS.

Pediatr Radiol. 1996;26(3):220-1.

PMID:
8599014
47.

Altered cytokine expression in T lymphocytes from human immunodeficiency virus Tat transgenic mice.

Brady HJ, Abraham DJ, Pennington DJ, Miles CG, Jenkins S, Dzierzak EA.

J Virol. 1995 Dec;69(12):7622-9.

48.

Transgenic mice as models of human immunodeficiency virus expression and related cellular effects.

Brady HJ, Pennington DJ, Dzierzak EA.

J Gen Virol. 1994 Oct;75 ( Pt 10):2549-58. Review. No abstract available.

PMID:
7931142
49.

Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses.

Brady HJ, Miles CG, Pennington DJ, Dzierzak EA.

Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):365-9.

50.

CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.

Brady HJ, Pennington DJ, Miles CG, Dzierzak EA.

EMBO J. 1993 Dec 15;12(13):4923-32.

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