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Items: 45


Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.

Folgueras AR, Fueyo A, García-Suárez O, Cox J, Astudillo A, Tortorella P, Campestre C, Gutiérrez-Fernández A, Fanjul-Fernández M, Pennington CJ, Edwards DR, Overall CM, López-Otín C.

J Biol Chem. 2018 Jul 27;293(30):11968-11969. doi: 10.1074/jbc.AAC118.004703. No abstract available.


Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence.

Allen MD, Thomas GJ, Clark S, Dawoud MM, Vallath S, Payne SJ, Gomm JJ, Dreger SA, Dickinson S, Edwards DR, Pennington CJ, Sestak I, Cuzick J, Marshall JF, Hart IR, Jones JL.

Clin Cancer Res. 2014 Jan 15;20(2):344-57. doi: 10.1158/1078-0432.CCR-13-1504. Epub 2013 Oct 22.


Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells.

Thirkettle S, Decock J, Arnold H, Pennington CJ, Jaworski DM, Edwards DR.

J Biol Chem. 2013 Jun 7;288(23):16282-94. doi: 10.1074/jbc.M113.464230. Epub 2013 Apr 30.


Sex peptide of Drosophila melanogaster males is a global regulator of reproductive processes in females.

Gioti A, Wigby S, Wertheim B, Schuster E, Martinez P, Pennington CJ, Partridge L, Chapman T.

Proc Biol Sci. 2012 Nov 7;279(1746):4423-32. Epub 2012 Sep 12.


mRNA profiling of the cancer degradome in oesophago-gastric adenocarcinoma.

Baren JP, Stewart GD, Stokes A, Gray K, Pennington CJ, O'Neill R, Deans DA, Paterson-Brown S, Riddick AC, Edwards DR, Fearon KC, Ross JA, Skipworth RJ.

Br J Cancer. 2012 Jun 26;107(1):143-9. doi: 10.1038/bjc.2012.239. Epub 2012 Jun 7.


Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro.

Cooley LS, Handsley MM, Zhou Z, Lafleur MA, Pennington CJ, Thompson EW, Pöschl E, Edwards DR.

J Cell Sci. 2010 Nov 1;123(Pt 21):3808-16. doi: 10.1242/jcs.064279. Epub 2010 Oct 12.


Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases.

Atkinson JM, Falconer RA, Edwards DR, Pennington CJ, Siller CS, Shnyder SD, Bibby MC, Patterson LH, Loadman PM, Gill JH.

Cancer Res. 2010 Sep 1;70(17):6902-12. doi: 10.1158/0008-5472.CAN-10-1440. Epub 2010 Jul 27.


Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks.

Green JA, Elkington PT, Pennington CJ, Roncaroli F, Dholakia S, Moores RC, Bullen A, Porter JC, Agranoff D, Edwards DR, Friedland JS.

J Immunol. 2010 Jun 1;184(11):6492-503. doi: 10.4049/jimmunol.0903811. Epub 2010 May 5.


Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.

Stokes A, Joutsa J, Ala-Aho R, Pitchers M, Pennington CJ, Martin C, Premachandra DJ, Okada Y, Peltonen J, Grénman R, James HA, Edwards DR, Kähäri VM.

Clin Cancer Res. 2010 Apr 1;16(7):2022-35. doi: 10.1158/1078-0432.CCR-09-2525. Epub 2010 Mar 21.


Real-time PCR expression profiling of MMPs and TIMPs.

Pennington CJ, Edwards DR.

Methods Mol Biol. 2010;622:159-73. doi: 10.1007/978-1-60327-299-5_9.


Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage.

Harvey AJ, Pennington CJ, Porter S, Burmi RS, Edwards DR, Court W, Eccles SA, Crompton MR.

Am J Pathol. 2009 Sep;175(3):1226-34. doi: 10.2353/ajpath.2009.080811. Epub 2009 Aug 6.


Degradome expression profiling in human articular cartilage.

Swingler TE, Waters JG, Davidson RK, Pennington CJ, Puente XS, Darrah C, Cooper A, Donell ST, Guile GR, Wang W, Clark IM.

Arthritis Res Ther. 2009;11(3):R96. doi: 10.1186/ar2741. Epub 2009 Jun 23.


Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms.

Hancox RA, Allen MD, Holliday DL, Edwards DR, Pennington CJ, Guttery DS, Shaw JA, Walker RA, Pringle JH, Jones JL.

Breast Cancer Res. 2009;11(2):R24. doi: 10.1186/bcr2251. Epub 2009 Apr 30.


TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice.

Frutkin AD, Otsuka G, Stempien-Otero A, Sesti C, Du L, Jaffe M, Dichek HL, Pennington CJ, Edwards DR, Nieves-Cintrón M, Minter D, Preusch M, Hu JH, Marie JC, Dichek DA.

Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1251-7. doi: 10.1161/ATVBAHA.109.186593. Epub 2009 Mar 26.


Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein.

Boutet P, Agüera-González S, Atkinson S, Pennington CJ, Edwards DR, Murphy G, Reyburn HT, Valés-Gómez M.

J Immunol. 2009 Jan 1;182(1):49-53.


Spontaneous metastasis in matrix metalloproteinase 3-deficient mice.

Juncker-Jensen A, Rømer J, Pennington CJ, Lund LR, Almholt K.

Mol Carcinog. 2009 Jul;48(7):618-25. doi: 10.1002/mc.20503.


Analysis of hypoxia-associated gene expression in prostate cancer: lysyl oxidase and glucose transporter-1 expression correlate with Gleason score.

Stewart GD, Gray K, Pennington CJ, Edwards DR, Riddick AC, Ross JA, Habib FK.

Oncol Rep. 2008 Dec;20(6):1561-7.


The ADAM metalloproteinases.

Edwards DR, Handsley MM, Pennington CJ.

Mol Aspects Med. 2008 Oct;29(5):258-89. doi: 10.1016/j.mam.2008.08.001. Epub 2008 Aug 15. Review.


Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.

Nielsen BS, Egeblad M, Rank F, Askautrud HA, Pennington CJ, Pedersen TX, Christensen IJ, Edwards DR, Werb Z, Lund LR.

PLoS One. 2008 Aug 13;3(8):e2959. doi: 10.1371/journal.pone.0002959.


Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines.

Stewart GD, Skipworth RJ, Pennington CJ, Lowrie AG, Deans DA, Edwards DR, Habib FK, Riddick AC, Fearon KC, Ross JA.

Br J Cancer. 2008 Jul 8;99(1):126-32. doi: 10.1038/sj.bjc.6604458.


Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.

Gutiérrez-Fernández A, Fueyo A, Folgueras AR, Garabaya C, Pennington CJ, Pilgrim S, Edwards DR, Holliday DL, Jones JL, Span PN, Sweep FC, Puente XS, López-Otín C.

Cancer Res. 2008 Apr 15;68(8):2755-63. doi: 10.1158/0008-5472.CAN-07-5154.


Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.

Zhong JL, Poghosyan Z, Pennington CJ, Scott X, Handsley MM, Warn A, Gavrilovic J, Honert K, Krüger A, Span PN, Sweep FC, Edwards DR.

Mol Cancer Res. 2008 Mar;6(3):383-94. doi: 10.1158/1541-7786.MCR-07-2028. Epub 2008 Feb 22.


Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.

Folgueras AR, Fueyo A, García-Suárez O, Cox J, Astudillo A, Tortorella P, Campestre C, Gutiérrez-Fernández A, Fanjul-Fernández M, Pennington CJ, Edwards DR, Overall CM, López-Otín C.

J Biol Chem. 2008 Apr 4;283(14):9465-74. doi: 10.1074/jbc.M709522200. Epub 2008 Feb 1. Erratum in: J Biol Chem. 2018 Jul 27;293(30):11968-11969.


Laser-capture microdissection in prostate cancer research: establishment and validation of a powerful tool for the assessment of tumour-stroma interactions.

Shukla CJ, Pennington CJ, Riddick AC, Sethia KK, Ball RY, Edwards DR.

BJU Int. 2008 Mar;101(6):765-74. doi: 10.1111/j.1464-410X.2007.07372.x. Epub 2008 Jan 8.


Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.

Kopitz C, Gerg M, Bandapalli OR, Ister D, Pennington CJ, Hauser S, Flechsig C, Krell HW, Antolovic D, Brew K, Nagase H, Stangl M, von Weyhern CW, Brücher BL, Brand K, Coussens LM, Edwards DR, Krüger A.

Cancer Res. 2007 Sep 15;67(18):8615-23.


MMP and TIMP expression in quiescent, dividing, and differentiating human lens cells.

Hodgkinson LM, Duncan G, Wang L, Pennington CJ, Edwards DR, Wormstone IM.

Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4192-9.


Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: correlation of MMP-14 mRNA expression and proteolytic activity.

Atkinson JM, Pennington CJ, Martin SW, Anikin VA, Mearns AJ, Loadman PM, Edwards DR, Gill JH.

Eur J Cancer. 2007 Jul;43(11):1764-71. Epub 2007 Jun 27.


Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases.

Chabottaux V, Sounni NE, Pennington CJ, English WR, van den Brûle F, Blacher S, Gilles C, Munaut C, Maquoi E, Lopez-Otin C, Murphy G, Edwards DR, Foidart JM, Noël A.

Cancer Res. 2006 May 15;66(10):5165-72.


Chronic pouchitis after ileal pouch-anal anastomosis for ulcerative colitis: effect on quality of life.

Turina M, Pennington CJ, Kimberling J, Stromberg AJ, Petras RE, Galandiuk S.

J Gastrointest Surg. 2006 Apr;10(4):600-6.


Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon.

Jones GC, Corps AN, Pennington CJ, Clark IM, Edwards DR, Bradley MM, Hazleman BL, Riley GP.

Arthritis Rheum. 2006 Mar;54(3):832-42.


Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma.

Wallard MJ, Pennington CJ, Veerakumarasivam A, Burtt G, Mills IG, Warren A, Leung HY, Murphy G, Edwards DR, Neal DE, Kelly JD.

Br J Cancer. 2006 Feb 27;94(4):569-77.


ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.

Porter S, Span PN, Sweep FC, Tjan-Heijnen VC, Pennington CJ, Pedersen TX, Johnsen M, Lund LR, Rømer J, Edwards DR.

Int J Cancer. 2006 Mar 1;118(5):1241-7.


Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues.

Riddick AC, Shukla CJ, Pennington CJ, Bass R, Nuttall RK, Hogan A, Sethia KK, Ellis V, Collins AT, Maitland NJ, Ball RY, Edwards DR.

Br J Cancer. 2005 Jun 20;92(12):2171-80.


Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption.

Young DA, Lakey RL, Pennington CJ, Jones D, Kevorkian L, Edwards DR, Cawston TE, Clark IM.

Arthritis Res Ther. 2005;7(3):R503-12. Epub 2005 Feb 22.


Extracellular protease mRNAs are predominantly expressed in the stromal areas of microdissected mouse breast carcinomas.

Pedersen TX, Pennington CJ, Almholt K, Christensen IJ, Nielsen BS, Edwards DR, Rømer J, Danø K, Johnsen M.

Carcinogenesis. 2005 Jul;26(7):1233-40. Epub 2005 Mar 10.


Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration.

Mohammed FF, Pennington CJ, Kassiri Z, Rubin JS, Soloway PD, Ruther U, Edwards DR, Khokha R.

Hepatology. 2005 Apr;41(4):857-67.


Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes.

Young DA, Gavrilov S, Pennington CJ, Nuttall RK, Edwards DR, Kitsis RN, Clark IM.

Biochem Biophys Res Commun. 2004 Sep 24;322(3):759-65.


Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.

Nuttall RK, Sampieri CL, Pennington CJ, Gill SE, Schultz GA, Edwards DR.

FEBS Lett. 2004 Apr 9;563(1-3):129-34.


Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis.

Bar-Or A, Nuttall RK, Duddy M, Alter A, Kim HJ, Ifergan I, Pennington CJ, Bourgoin P, Edwards DR, Yong VW.

Brain. 2003 Dec;126(Pt 12):2738-49. Epub 2003 Sep 23.


Determinants of human B cell migration across brain endothelial cells.

Alter A, Duddy M, Hebert S, Biernacki K, Prat A, Antel JP, Yong VW, Nuttall RK, Pennington CJ, Edwards DR, Bar-Or A.

J Immunol. 2003 May 1;170(9):4497-505.


Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells.

Nuttall RK, Pennington CJ, Taplin J, Wheal A, Yong VW, Forsyth PA, Edwards DR.

Mol Cancer Res. 2003 Mar;1(5):333-45.


Expression profile of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue.

Palosaari H, Pennington CJ, Larmas M, Edwards DR, Tjäderhane L, Salo T.

Eur J Oral Sci. 2003 Apr;111(2):117-27.


Microvascular repair of jejunal and ileal vessels for near complete mesenteric avulsion after seat-belt injury.

Pennington CJ, Gwaltney N, Sweitzer D.

J Trauma. 2000 Feb;48(2):327-9. No abstract available.


An intrahepatic biloma following a gunshot wound to the liver.

Pennington CJ, Lewis JV.

Tenn Med. 1998 Mar;91(3):110-1. No abstract available.


Induction of euglena transfer RNA's by light.

Barnett WE, Pennington CJ Jr, Fairfield SA.

Proc Natl Acad Sci U S A. 1969 Aug;63(4):1261-8.

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