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Sensory evaluation of e-liquid flavors by smelling and vaping yields similar results.

Krüsemann EJZ, Wenng FM, Pennings JLA, de Graaf K, Talhout R, Boesveldt S.

Nicotine Tob Res. 2019 Aug 22. pii: ntz155. doi: 10.1093/ntr/ntz155. [Epub ahead of print]


Antibody Specificity Following a Recent Bordetella pertussis Infection in Adolescence Is Correlated With the Pertussis Vaccine Received in Childhood.

Raeven RHM, van der Maas L, Pennings JLA, Fuursted K, Jørgensen CS, van Riet E, Metz B, Kersten GFA, Dalby T.

Front Immunol. 2019 Jun 17;10:1364. doi: 10.3389/fimmu.2019.01364. eCollection 2019.


The transcriptomic response to irinotecan in colon carcinoma bearing mice preconditioned by fasting.

Jongbloed F, Huisman SA, van Steeg H, Pennings JLA, IJzermans JNM, Dollé MET, de Bruin RWF.

Oncotarget. 2019 Mar 15;10(22):2224-2234. doi: 10.18632/oncotarget.26776. eCollection 2019 Mar 15.


Chronic sleep restriction in the rotenone Parkinson's disease model in rats reveals peripheral early-phase biomarkers.

Fagotti J, Targa ADS, Rodrigues LS, Noseda ACD, Dorieux FWC, Scarante FF, Ilkiw JL, Louzada FM, Chowdhury NR, van der Veen DR, Middleton B, Pennings JLA, Swann JR, Skene DJ, Lima MMS.

Sci Rep. 2019 Feb 13;9(1):1898. doi: 10.1038/s41598-018-37657-6.


Transcriptomics in lung tissue upon respiratory syncytial virus infection reveals aging as important modulator of immune activation and matrix maintenance.

Pennings JLA, Mariman R, Hodemaekers HM, Reemers SSN, Janssen R, Guichelaar T.

Sci Rep. 2018 Nov 9;8(1):16653. doi: 10.1038/s41598-018-35180-2.


Application of the comparison approach to open TG-GATEs: A useful toxicogenomics tool for detecting modes of action in chemical risk assessment.

Heusinkveld HJ, Wackers PFK, Schoonen WG, van der Ven L, Pennings JLA, Luijten M.

Food Chem Toxicol. 2018 Nov;121:115-123. doi: 10.1016/j.fct.2018.08.007. Epub 2018 Aug 8.


Vaccine antigens modulate the innate response of monocytes to Al(OH)3.

Kooijman S, Brummelman J, van Els CACM, Marino F, Heck AJR, van Riet E, Metz B, Kersten GFA, Pennings JLA, Meiring HD.

PLoS One. 2018 May 29;13(5):e0197885. doi: 10.1371/journal.pone.0197885. eCollection 2018.


Cigarette Filter Ventilation and Smoking Protocol Influence Aldehyde Smoke Yields.

Pauwels CGGM, Klerx WNM, Pennings JLA, Boots AW, van Schooten FJ, Opperhuizen A, Talhout R.

Chem Res Toxicol. 2018 Jun 18;31(6):462-471. doi: 10.1021/acs.chemrestox.7b00342. Epub 2018 May 17.


Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome.

Aziz NM, Guedj F, Pennings JLA, Olmos-Serrano JL, Siegel A, Haydar TF, Bianchi DW.

Dis Model Mech. 2018 Jun 12;11(6). pii: dmm031013. doi: 10.1242/dmm.031013.


Molecular and cellular signatures underlying superior immunity against Bordetella pertussis upon pulmonary vaccination.

Raeven RHM, Brummelman J, Pennings JLA, van der Maas L, Helm K, Tilstra W, van der Ark A, Sloots A, van der Ley P, van Eden W, Jiskoot W, van Riet E, van Els CACM, Kersten GFA, Han WGH, Metz B.

Mucosal Immunol. 2018 May;11(3):1009. doi: 10.1038/mi.2017.110. Epub 2018 Feb 7.


Novel identified aluminum hydroxide-induced pathways prove monocyte activation and pro-inflammatory preparedness.

Kooijman S, Brummelman J, van Els CACM, Marino F, Heck AJR, Mommen GPM, Metz B, Kersten GFA, Pennings JLA, Meiring HD.

J Proteomics. 2018 Mar 20;175:144-155. doi: 10.1016/j.jprot.2017.12.021. Epub 2018 Jan 6.


A transcriptomic approach for evaluating the relative potency and mechanism of action of azoles in the rat Whole Embryo Culture.

Dimopoulou M, Verhoef A, Pennings JLA, van Ravenzwaay B, Rietjens IMCM, Piersma AH.

Toxicology. 2017 Dec 1;392:96-105. doi: 10.1016/j.tox.2017.09.014. Epub 2017 Sep 29.


Molecular and cellular signatures underlying superior immunity against Bordetella pertussis upon pulmonary vaccination.

Raeven RH, Brummelman J, Pennings JLA, van der Maas L, Helm K, Tilstra W, van der Ark A, Sloots A, van der Ley P, van Eden W, Jiskoot W, van Riet E, van Els CA, Kersten GF, Han WG, Metz B.

Mucosal Immunol. 2018 May;11(3):979-993. doi: 10.1038/mi.2017.81. Epub 2017 Sep 20. Erratum in: Mucosal Immunol. 2018 Feb 07;:.


Embryotoxic and pharmacologic potency ranking of six azoles in the rat whole embryo culture by morphological and transcriptomic analysis.

Dimopoulou M, Verhoef A, Pennings JLA, van Ravenzwaay B, Rietjens IMCM, Piersma AH.

Toxicol Appl Pharmacol. 2017 May 1;322:15-26. doi: 10.1016/j.taap.2017.03.001. Epub 2017 Mar 3. Erratum in: Toxicol Appl Pharmacol. 2018 Sep 15;355:287.


Meta-Analysis of Pulmonary Transcriptomes from Differently Primed Mice Identifies Molecular Signatures to Differentiate Immune Responses following Bordetella pertussis Challenge.

Raeven RH, Pennings JL, van Riet E, Kersten GF, Metz B.

J Immunol Res. 2017;2017:8512847. doi: 10.1155/2017/8512847. Epub 2017 Jan 24.


Metabolic profiling of presymptomatic Huntington's disease sheep reveals novel biomarkers.

Skene DJ, Middleton B, Fraser CK, Pennings JL, Kuchel TR, Rudiger SR, Bawden CS, Morton AJ.

Sci Rep. 2017 Feb 22;7:43030. doi: 10.1038/srep43030.


A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction.

Jongbloed F, Saat TC, Verweij M, Payan-Gomez C, Hoeijmakers JH, van den Engel S, van Oostrom CT, Ambagtsheer G, Imholz S, Pennings JL, van Steeg H, IJzermans JN, Dollé ME, de Bruin RW.

Sci Rep. 2017 Jan 19;7:40901. doi: 10.1038/srep40901.


Proteome Analysis Is a Valuable Tool to Monitor Antigen Expression during Upstream Processing of Whole-Cell Pertussis Vaccines.

Metz B, Hoonakker M, Uittenbogaard JP, Weyts M, Mommen GP, Meiring HD, Tilstra W, Pennings JL, van der Pol LA, Kuipers B, Sloots A, van den IJssel J, van de Waterbeemd B, van der Ark A.

J Proteome Res. 2017 Feb 3;16(2):528-537. doi: 10.1021/acs.jproteome.6b00668. Epub 2016 Dec 23.


Bordetella pertussis outer membrane vesicle vaccine confers equal efficacy in mice with milder inflammatory responses compared to a whole-cell vaccine.

Raeven RH, Brummelman J, Pennings JL, van der Maas L, Tilstra W, Helm K, van Riet E, Jiskoot W, van Els CA, Han WG, Kersten GF, Metz B.

Sci Rep. 2016 Dec 1;6:38240. doi: 10.1038/srep38240.


Programmed Effects in Neurobehavior and Antioxidative Physiology in Zebrafish Embryonically Exposed to Cadmium: Observations and Hypothesized Adverse Outcome Pathway Framework.

Ruiter S, Sippel J, Bouwmeester MC, Lommelaars T, Beekhof P, Hodemaekers HM, Bakker F, van den Brandhof EJ, Pennings JL, van der Ven LT.

Int J Mol Sci. 2016 Nov 2;17(11). pii: E1830.


Immunological Signatures after Bordetella pertussis Infection Demonstrate Importance of Pulmonary Innate Immune Cells.

Raeven RH, Brummelman J, van der Maas L, Tilstra W, Pennings JL, Han WG, van Els CA, van Riet E, Kersten GF, Metz B.

PLoS One. 2016 Oct 6;11(10):e0164027. doi: 10.1371/journal.pone.0164027. eCollection 2016.


An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome.

Guedj F, Pennings JL, Massingham LJ, Wick HC, Siegel AE, Tantravahi U, Bianchi DW.

Sci Rep. 2016 Sep 2;6:32353. doi: 10.1038/srep32353.


Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice.

Vermeij WP, Dollé ME, Reiling E, Jaarsma D, Payan-Gomez C, Bombardieri CR, Wu H, Roks AJ, Botter SM, van der Eerden BC, Youssef SA, Kuiper RV, Nagarajah B, van Oostrom CT, Brandt RM, Barnhoorn S, Imholz S, Pennings JL, de Bruin A, Gyenis Á, Pothof J, Vijg J, van Steeg H, Hoeijmakers JH.

Nature. 2016 Sep 15;537(7620):427-431. doi: 10.1038/nature19329. Epub 2016 Aug 24.


Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach.

Vatakuti S, Olinga P, Pennings JLA, Groothuis GMM.

Arch Toxicol. 2017 Mar;91(3):1401-1412. doi: 10.1007/s00204-016-1778-8. Epub 2016 Jun 25.


Transcriptome signature for dampened Th2 dominance in acellular pertussis vaccine-induced CD4(+) T cell responses through TLR4 ligation.

Brummelman J, Raeven RH, Helm K, Pennings JL, Metz B, van Eden W, van Els CA, Han WG.

Sci Rep. 2016 Apr 27;6:25064. doi: 10.1038/srep25064.


Absence of Prenatal Forebrain Defects in the Dp(16)1Yey/+ Mouse Model of Down Syndrome.

Goodliffe JW, Olmos-Serrano JL, Aziz NM, Pennings JL, Guedj F, Bianchi DW, Haydar TF.

J Neurosci. 2016 Mar 9;36(10):2926-44. doi: 10.1523/JNEUROSCI.2513-15.2016.


Males are from Mars, and females are from Venus: sex-specific fetal brain gene expression signatures in a mouse model of maternal diet-induced obesity.

Edlow AG, Guedj F, Pennings JL, Sverdlov D, Neri C, Bianchi DW.

Am J Obstet Gynecol. 2016 May;214(5):623.e1-623.e10. doi: 10.1016/j.ajog.2016.02.054. Epub 2016 Mar 3.


Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.

Vatakuti S, Pennings JL, Gore E, Olinga P, Groothuis GM.

Chem Res Toxicol. 2016 Mar 21;29(3):342-51. doi: 10.1021/acs.chemrestox.5b00491. Epub 2016 Mar 9.


Zebrafish embryos as a screen for DNA methylation modifications after compound exposure.

Bouwmeester MC, Ruiter S, Lommelaars T, Sippel J, Hodemaekers HM, van den Brandhof EJ, Pennings JL, Kamstra JH, Jelinek J, Issa JP, Legler J, van der Ven LT.

Toxicol Appl Pharmacol. 2016 Jan 15;291:84-96. doi: 10.1016/j.taap.2015.12.012. Epub 2015 Dec 19.


Development of an in vitro test to identify respiratory sensitizers in bronchial epithelial cells using gene expression profiling.

Dik S, Pennings JL, van Loveren H, Ezendam J.

Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):274-80. doi: 10.1016/j.tiv.2015.10.010. Epub 2015 Oct 28.


Diurnal Variation of Hormonal and Lipid Biomarkers in a Molecular Epidemiology-Like Setting.

van Kerkhof LW, Van Dycke KC, Jansen EH, Beekhof PK, van Oostrom CT, Ruskovska T, Velickova N, Kamcev N, Pennings JL, van Steeg H, Rodenburg W.

PLoS One. 2015 Aug 18;10(8):e0135652. doi: 10.1371/journal.pone.0135652. eCollection 2015.


Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice.

Van Dycke KC, Rodenburg W, van Oostrom CT, van Kerkhof LW, Pennings JL, Roenneberg T, van Steeg H, van der Horst GT.

Curr Biol. 2015 Jul 20;25(14):1932-7. doi: 10.1016/j.cub.2015.06.012.


First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach.

Koster MP, Vreeken RJ, Harms AC, Dane AD, Kuc S, Schielen PC, Hankemeier T, Berger R, Visser GH, Pennings JL.

Dis Markers. 2015;2015:857108. doi: 10.1155/2015/857108. Epub 2015 Jun 4.


Comparison of gene expression regulation in mouse- and human embryonic stem cell assays during neural differentiation and in response to valproic acid exposure.

Schulpen SH, Theunissen PT, Pennings JL, Piersma AH.

Reprod Toxicol. 2015 Aug 15;56:77-86. doi: 10.1016/j.reprotox.2015.06.043. Epub 2015 Jun 11.


Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity.

Raeven RH, van der Maas L, Tilstra W, Uittenbogaard JP, Bindels TH, Kuipers B, van der Ark A, Pennings JL, van Riet E, Jiskoot W, Kersten GF, Metz B.

J Proteome Res. 2015 Jul 2;14(7):2929-42. doi: 10.1021/acs.jproteome.5b00258. Epub 2015 Jun 2.


Biomarkers for circadian rhythm disruption independent of time of day.

Van Dycke KC, Pennings JL, van Oostrom CT, van Kerkhof LW, van Steeg H, van der Horst GT, Rodenburg W.

PLoS One. 2015 May 18;10(5):e0127075. doi: 10.1371/journal.pone.0127075. eCollection 2015.


Predictive performance of a seven-plex antibody array in prenatal screening for Down Syndrome.

Pennings JL, Imholz S, Zutt I, Koster MP, Siljee JE, de Vries A, Schielen PC, Rodenburg W.

Dis Markers. 2015;2015:519851. doi: 10.1155/2015/519851. Epub 2015 Apr 23.


Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay.

Schulpen SH, Pennings JL, Piersma AH.

Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.


The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome.

Guedj F, Pennings JL, Ferres MA, Graham LC, Wick HC, Miczek KA, Slonim DK, Bianchi DW.

Am J Med Genet A. 2015 Sep;167A(9):1993-2008. doi: 10.1002/ajmg.a.37156. Epub 2015 May 14.


Dysregulation of serum gamma interferon levels in vascular chronic Q Fever patients provides insights into disease pathogenesis.

Pennings JL, Kremers MN, Hodemaekers HM, Hagenaars JC, Koning OH, Renders NH, Hermans MH, de Klerk A, Notermans DW, Wever PC, Janssen R.

Clin Vaccine Immunol. 2015 Jun;22(6):664-71. doi: 10.1128/CVI.00078-15. Epub 2015 Apr 29.


Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood.

Pennings JL, Jennen DG, Nygaard UC, Namork E, Haug LS, van Loveren H, Granum B.

J Immunotoxicol. 2016;13(2):173-80. doi: 10.3109/1547691X.2015.1029147. Epub 2015 Mar 27.


Dried blood spot measurement of pregnancy-associated plasma protein A (PAPP-A) and free β-subunit of human chorionic gonadotropin (β-hCG) from a low-resource setting.

Browne JL, Schielen PC, Belmouden I, Pennings JL, Klipstein-Grobusch K.

Prenat Diagn. 2015 Jun;35(6):592-7. doi: 10.1002/pd.4578. Epub 2015 Apr 1.


An adverse outcome pathway framework for neural tube and axial defects mediated by modulation of retinoic acid homeostasis.

Tonk EC, Pennings JL, Piersma AH.

Reprod Toxicol. 2015 Aug 1;55:104-13. doi: 10.1016/j.reprotox.2014.10.008. Epub 2014 Oct 16. Review.


Liver DNA methylation analysis in adult female C57BL/6JxFVB mice following perinatal exposure to bisphenol A.

van Esterik JC, Vitins AP, Hodemaekers HM, Kamstra JH, Legler J, Pennings JL, Steegenga WT, Lute C, Jelinek J, Issa JP, Dollé ME, van der Ven LT.

Toxicol Lett. 2015 Jan 5;232(1):293-300. doi: 10.1016/j.toxlet.2014.10.021. Epub 2014 Oct 17.


A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen.

Driessen M, Vitins AP, Pennings JL, Kienhuis AS, Water Bv, van der Ven LT.

Toxicol Lett. 2015 Jan 22;232(2):403-12. doi: 10.1016/j.toxlet.2014.11.020. Epub 2014 Nov 24.


Comparison of the molecular topologies of stress-activated transcription factors HSF1, AP-1, NRF2, and NF-κB in their induction kinetics of HMOX1.

Pronk TE, van der Veen JW, Vandebriel RJ, van Loveren H, de Vink EP, Pennings JL.

Biosystems. 2014 Oct;124:75-85. doi: 10.1016/j.biosystems.2014.09.005. Epub 2014 Sep 6.


Molecular signatures of the evolving immune response in mice following a Bordetella pertussis infection.

Raeven RH, Brummelman J, Pennings JL, Nijst OE, Kuipers B, Blok LE, Helm K, van Riet E, Jiskoot W, van Els CA, Han WG, Kersten GF, Metz B.

PLoS One. 2014 Aug 19;9(8):e104548. doi: 10.1371/journal.pone.0104548. eCollection 2014.


Comparison of different blood collection, sample matrix, and immunoassay methods in a prenatal screening setting.

Pennings JL, Siljee JE, Imholz S, Kuc S, de Vries A, Schielen PC, Rodenburg W.

Dis Markers. 2014;2014:509821. doi: 10.1155/2014/509821. Epub 2014 Jul 15.


Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans.

Driessen M, Kienhuis AS, Vitins AP, Pennings JL, Pronk TE, van den Brandhof EJ, Roodbergen M, van de Water B, van der Ven LT.

Toxicol Lett. 2014 Oct 1;230(1):48-56. doi: 10.1016/j.toxlet.2014.06.844. Epub 2014 Jul 24.


Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice.

Jongbloed F, de Bruin RW, Pennings JL, Payán-Gómez C, van den Engel S, van Oostrom CT, de Bruin A, Hoeijmakers JH, van Steeg H, IJzermans JN, Dollé ME.

PLoS One. 2014 Jun 24;9(6):e100853. doi: 10.1371/journal.pone.0100853. eCollection 2014.

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