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Items: 24

1.

An analysis of the attrition of drug candidates from four major pharmaceutical companies.

Waring MJ, Arrowsmith J, Leach AR, Leeson PD, Mandrell S, Owen RM, Pairaudeau G, Pennie WD, Pickett SD, Wang J, Wallace O, Weir A.

Nat Rev Drug Discov. 2015 Jul;14(7):475-86. doi: 10.1038/nrd4609. Epub 2015 Jun 19. Review.

PMID:
26091267
2.

A high content screening assay for identifying lysosomotropic compounds.

Nadanaciva S, Lu S, Gebhard DF, Jessen BA, Pennie WD, Will Y.

Toxicol In Vitro. 2011 Apr;25(3):715-23. doi: 10.1016/j.tiv.2010.12.010. Epub 2010 Dec 22.

PMID:
21184822
3.

Custom cDNA microarrays; technologies and applications.

Pennie WD.

Toxicology. 2002 Dec 27;181-182:551-4. Review.

PMID:
12505365
4.

Use of genomics in toxicology and epidemiology: findings and recommendations of a workshop.

Henry CJ, Phillips R, Carpanini F, Corton JC, Craig K, Igarashi K, Leboeuf R, Marchant G, Osborn K, Pennie WD, Smith LL, Teta MJ, Vu V.

Environ Health Perspect. 2002 Oct;110(10):1047-50.

5.

Toxicogenomics; transcript profiling and potential application to chemical allergy.

Pennie WD, Kimber I.

Toxicol In Vitro. 2002 Jun;16(3):319-26. Review.

PMID:
12020605
6.

Application of genomics to the definition of the molecular basis for toxicity.

Pennie WD, Woodyatt NJ, Aldridge TC, Orphanides G.

Toxicol Lett. 2001 Mar 31;120(1-3):353-8.

PMID:
11323194
7.

Obstacles to the prediction of estrogenicity from chemical structure: assay-mediated metabolic transformation and the apparent promiscuous nature of the estrogen receptor.

Elsby R, Ashby J, Sumpter JP, Brooks AN, Pennie WD, Maggs JL, Lefevre PA, Odum J, Beresford N, Paton D, Park BK.

Biochem Pharmacol. 2000 Nov 15;60(10):1519-30.

PMID:
11020455
8.

Identification of a possible association between carbon tetrachloride-induced hepatotoxicity and interleukin-8 expression.

Holden PR, James NH, Brooks AN, Roberts RA, Kimber I, Pennie WD.

J Biochem Mol Toxicol. 2000;14(5):283-90.

PMID:
10970000
9.

The principles and practice of toxigenomics: applications and opportunities.

Pennie WD, Tugwood JD, Oliver GJ, Kimber I.

Toxicol Sci. 2000 Apr;54(2):277-83. Review. No abstract available.

PMID:
10774809
10.
11.

Oestradiol is a potent mitogen and modulator of GnRH signalling in alphaT3-1 cells: are these effects causally related?

Williams B, Brooks AN, Aldridge TC, Pennie WD, Stephenson R, McArdle CA.

J Endocrinol. 2000 Jan;164(1):31-43.

PMID:
10607935
12.
13.

Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation.

Watts RG, Huang C, Young MR, Li JJ, Dong Z, Pennie WD, Colburn NH.

Oncogene. 1998 Dec 31;17(26):3493-8.

14.

Differential activation by xenoestrogens of ER alpha and ER beta when linked to different response elements.

Pennie WD, Aldridge TC, Brooks AN.

J Endocrinol. 1998 Sep;158(3):R11-4.

PMID:
9846177
17.

Differential expression of TIMP-3 during neoplastic progression in the mouse JB6 model system.

Pennie WD, Sun Y, Kim H, Colburn NH.

Methods Mol Biol. 1997;85:249-61. No abstract available.

PMID:
9276329
19.

The 5' enhancer of the mouse mammary tumor virus long terminal repeat contains a functional AP-2 element.

Mellentin-Michelotti J, John S, Pennie WD, Williams T, Hager GL.

J Biol Chem. 1994 Dec 16;269(50):31983-90.

20.

Analysis of the transforming functions of bovine papillomavirus type 4.

Pennie WD, Grindlay GJ, Cairney M, Campo MS.

Virology. 1993 Apr;193(2):614-20.

PMID:
8384749
21.

BPV-4 induces amplification and activation of 'silent' BPV-1 in a sub-line of C127 cells.

Smith KT, Coggins LW, Doherty I, Pennie WD, Cairney M, Campo MS.

Oncogene. 1993 Jan;8(1):151-6.

PMID:
8380914
22.
23.

The B subgroup bovine papillomaviruses lack an identifiable E6 open reading frame.

Jackson ME, Pennie WD, McCaffery RE, Smith KT, Grindlay GJ, Campo MS.

Mol Carcinog. 1991;4(5):382-7.

PMID:
1654923
24.

Cooperation between bovine papillomavirus type 4 and ras in the morphological transformation of primary bovine fibroblasts.

Jaggar RT, Pennie WD, Smith KT, Jackson ME, Campo MS.

J Gen Virol. 1990 Dec;71 ( Pt 12):3041-6.

PMID:
2177095

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