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Modeling Alzheimer's disease with iPSC-derived brain cells.

Penney J, Ralvenius WT, Tsai LH.

Mol Psychiatry. 2020 Jan;25(1):148-167. doi: 10.1038/s41380-019-0468-3. Epub 2019 Aug 7. Review.


Visualization and Quantification of the Oral Hygiene Effects of Brushing, Dentifrice Use, and Brush Wear Using a Tooth Brushing Simulator.

Ledder RG, Latimer J, Forbes S, Penney JL, Sreenivasan PK, McBain AJ.

Front Public Health. 2019 May 8;7:91. doi: 10.3389/fpubh.2019.00091. eCollection 2019.


Examining the Role of HDACs in DNA Double-Strand Break Repair in Neurons.

Pao PC, Penney J, Tsai LH.

Methods Mol Biol. 2019;1983:225-234. doi: 10.1007/978-1-4939-9434-2_13.


Protective Effects of Protegrin in Dextran Sodium Sulfate-Induced Murine Colitis.

Huynh E, Penney J, Caswell J, Li J.

Front Pharmacol. 2019 Feb 28;10:156. doi: 10.3389/fphar.2019.00156. eCollection 2019.


Elimination of senescent cells prevents neurodegeneration in mice.

Penney J, Tsai LH.

Nature. 2018 Oct;562(7728):503-504. doi: 10.1038/d41586-018-06677-7. No abstract available.


LUMAN/CREB3 Plays a Dual Role in Stress Responses as a Cofactor of the Glucocorticoid Receptor and a Regulator of Secretion.

Penney J, Taylor T, MacLusky N, Lu R.

Front Mol Neurosci. 2018 Sep 26;11:352. doi: 10.3389/fnmol.2018.00352. eCollection 2018.


Protegrin 1 Enhances Innate Cellular Defense via the Insulin-Like Growth Factor 1 Receptor Pathway.

Penney J, Li J.

Front Cell Infect Microbiol. 2018 Sep 28;8:331. doi: 10.3389/fcimb.2018.00331. eCollection 2018.


Epidemiology of adolescent substance use in Norfolk schools.

Roderick E, Penney J, Murrells T, Dargan PI, Norman IJ.

QJM. 2018 Oct 1;111(10):699-706. doi: 10.1093/qjmed/hcy153.


APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.

Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH.

Neuron. 2018 Jun 27;98(6):1294. doi: 10.1016/j.neuron.2018.06.011. No abstract available.


APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.

Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH.

Neuron. 2018 Jun 27;98(6):1141-1154.e7. doi: 10.1016/j.neuron.2018.05.008. Epub 2018 May 31. Erratum in: Neuron. 2018 Jun 27;98 (6):1294.


A Developmental Switch in Microglial HDAC Function.

Mathys H, Penney J, Tsai LH.

Immunity. 2018 Mar 20;48(3):476-478. doi: 10.1016/j.immuni.2018.03.010.


Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.

Rauch F, Geng Y, Lamplugh L, Hekmatnejad B, Gaumond MH, Penney J, Yamanaka Y, Moffatt P.

Bone. 2018 Feb;107:131-142. doi: 10.1016/j.bone.2017.11.013. Epub 2017 Nov 22.


Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia.

Seo J, Kritskiy O, Watson LA, Barker SJ, Dey D, Raja WK, Lin YT, Ko T, Cho S, Penney J, Silva MC, Sheridan SD, Lucente D, Gusella JF, Dickerson BC, Haggarty SJ, Tsai LH.

J Neurosci. 2017 Oct 11;37(41):9917-9924. doi: 10.1523/JNEUROSCI.0621-17.2017. Epub 2017 Sep 14.


Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects.

Penney J, Seo J, Kritskiy O, Elmsaouri S, Gao F, Pao PC, Su SC, Tsai LH.

J Neurosci. 2017 Sep 6;37(36):8655-8666. doi: 10.1523/JNEUROSCI.0591-17.2017. Epub 2017 Aug 3.


The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons.

Yamakawa H, Cheng J, Penney J, Gao F, Rueda R, Wang J, Yamakawa S, Kritskiy O, Gjoneska E, Tsai LH.

Cell Rep. 2017 Aug 8;20(6):1319-1334. doi: 10.1016/j.celrep.2017.07.044.


High burden of Schistosoma mansoni infection in school-aged children in Marolambo District, Madagascar.

Spencer SA, Penney JMSJ, Russell HJ, Howe AP, Linder C, Rakotomampianina ALD, Nandimbiniaina AM, Squire SB, Stothard JR, Bustinduy AL, Rahetilahy AM.

Parasit Vectors. 2017 Jun 24;10(1):307. doi: 10.1186/s13071-017-2249-7.


Characterization of nuclear foci-targeting of Luman/CREB3 recruitment factor (LRF/CREBRF) and its potential role in inhibition of herpes simplex virus-1 replication.

Audas TE, Hardy-Smith PW, Penney J, Taylor T, Lu R.

Eur J Cell Biol. 2016 Dec;95(12):611-622. doi: 10.1016/j.ejcb.2016.10.006. Epub 2016 Oct 26.


Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism.

Kauwe G, Tsurudome K, Penney J, Mori M, Gray L, Calderon MR, Elazouzzi F, Chicoine N, Sonenberg N, Haghighi AP.

Neuron. 2016 Dec 21;92(6):1204-1212. doi: 10.1016/j.neuron.2016.10.063. Epub 2016 Dec 1.


The road to restoring neural circuits for the treatment of Alzheimer's disease.

Canter RG, Penney J, Tsai LH.

Nature. 2016 Nov 10;539(7628):187-196. doi: 10.1038/nature20412. Review.


LUMAN/CREB3 is a key regulator of glucocorticoid-mediated stress responses.

Penney J, Mendell A, Zeng M, Tran K, Lymer J, Turner PV, Choleris E, MacLusky N, Lu R.

Mol Cell Endocrinol. 2017 Jan 5;439:95-104. doi: 10.1016/j.mce.2016.10.022. Epub 2016 Oct 24.


LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction.

Penney J, Tsurudome K, Liao EH, Kauwe G, Gray L, Yanagiya A, R Calderon M, Sonenberg N, Haghighi AP.

Nat Commun. 2016 Jul 19;7:12188. doi: 10.1038/ncomms12188.


JAKMIP1: Translating the Message for Social Behavior.

Penney J, Tsai LH.

Neuron. 2015 Dec 16;88(6):1070-1072. doi: 10.1016/j.neuron.2015.12.003.


Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials.

Huntington Study Group PHAROS Investigators, Biglan KM, Shoulson I, Kieburtz K, Oakes D, Kayson E, Shinaman MA, Zhao H, Romer M, Young A, Hersch S, Penney J, Marder K, Paulsen J, Quaid K, Siemers E, Tanner C, Mallonee W, Suter G, Dubinsky R, Gray C, Nance M, Bundlie S, Radtke D, Kostyk S, Baic C, Caress J, Walker F, Hunt V, O'Neill C, Chouinard S, Factor S, Greenamyre T, Wood-Siverio C, Corey-Bloom J, Song D, Peavy G, Moskowitz C, Wesson M, Samii A, Bird T, Lipe H, Blindauer K, Marshall F, Zimmerman C, Goldstein J, Rosas D, Novak P, Caviness J, Adler C, Duffy A, Wheelock V, Tempkin T, Richman D, Seeberger L, Albin R, Chou KL, Racette B, Perlmutter JS, Perlman S, Bordelon Y, Martin W, Wieler M, Leavitt B, Raymond L, Decolongon J, Clarke L, Jankovic J, Hunter C, Hauser RA, Sanchez-Ramos J, Furtado S, Suchowersky O, Klimek ML, Guttman M, Sethna R, Feigin A, Cox M, Shannon B, Percy A, Dure L, Harrison M, Johnson W, Higgins D, Molho E, Nickerson C, Evans S, Hobson D, Singer C, Galvez-Jimenez N, Shannon K, Comella C, Ross C, Saint-Hilaire MH, Testa C, Rosenblatt A, Hogarth P, Weiner W, Como P, Kumar R, Cotto C, Stout J, Brocht A, Watts A, Eberly S, Weaver C, Foroud T, Gusella J, MacDonald M, Myers R, Fahn S, Shults C.

JAMA Neurol. 2016 Jan;73(1):102-10. doi: 10.1001/jamaneurol.2015.2736.


Epidemiology of adolescent substance use in London schools.

Penney J, Dargan PI, Padmore J, Wood DM, Norman IJ.

QJM. 2016 Jun;109(6):405-9. doi: 10.1093/qjmed/hcv171. Epub 2015 Sep 26.


Histone deacetylases in memory and cognition.

Penney J, Tsai LH.

Sci Signal. 2014 Dec 9;7(355):re12. doi: 10.1126/scisignal.aaa0069. Review.


Chromatin regulation of DNA damage repair and genome integrity in the central nervous system.

Pan L, Penney J, Tsai LH.

J Mol Biol. 2014 Oct 9;426(20):3376-88. doi: 10.1016/j.jmb.2014.08.001. Epub 2014 Aug 14. Review.


Expression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos.

You L, Chen L, Penney J, Miao D, Yang XJ.

Epigenetics. 2014 Jun;9(6):860-72. doi: 10.4161/epi.28530. Epub 2014 Mar 19.


From framework to the frontline: designing a structure and process for drug supply shortage planning.

Singleton R, Chubbs K, Flynn J, Kaposy C, Peckham G, Penney J, Pullman D.

Healthc Manage Forum. 2013 Spring;26(1):41-5.


Atherosclerotic risk factors and their association with hospital mortality among patients with first myocardial infarction (from the National Registry of Myocardial Infarction).

Canto JG, Kiefe CI, Rogers WJ, Peterson ED, Frederick PD, French WJ, Gibson CM, Pollack CV Jr, Ornato JP, Zalenski RJ, Penney J, Tiefenbrunn AJ, Greenland P; NRMI Investigators.

Am J Cardiol. 2012 Nov 1;110(9):1256-61. doi: 10.1016/j.amjcard.2012.06.025. Epub 2012 Jul 27.


TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction.

Penney J, Tsurudome K, Liao EH, Elazzouzi F, Livingstone M, Gonzalez M, Sonenberg N, Haghighi AP.

Neuron. 2012 Apr 12;74(1):166-78. doi: 10.1016/j.neuron.2012.01.030.


Number of coronary heart disease risk factors and mortality in patients with first myocardial infarction.

Canto JG, Kiefe CI, Rogers WJ, Peterson ED, Frederick PD, French WJ, Gibson CM, Pollack CV Jr, Ornato JP, Zalenski RJ, Penney J, Tiefenbrunn AJ, Greenland P; NRMI Investigators.

JAMA. 2011 Nov 16;306(19):2120-7. doi: 10.1001/jama.2011.1654.


Transient sevoflurane output failure in a Datum vaporiser with concurrent foreign body.

Penney JA, Hocking G, Weightman WM.

Anaesth Intensive Care. 2011 Mar;39(2):313-4. No abstract available.


The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction.

Tsurudome K, Tsang K, Liao EH, Ball R, Penney J, Yang JS, Elazzouzi F, He T, Chishti A, Lnenicka G, Lai EC, Haghighi AP.

Neuron. 2010 Dec 9;68(5):879-93. doi: 10.1016/j.neuron.2010.11.016.


Nurses share their views on end-of-life issues.

McLennan S, Celi LA, Gillett G, Penney J, Foss M.

Nurs N Z. 2010 May;16(4):12-4. No abstract available.


Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila neuromuscular junction.

Merino C, Penney J, González M, Tsurudome K, Moujahidine M, O'Connor MB, Verheyen EM, Haghighi P.

J Cell Biol. 2009 May 18;185(4):713-25. doi: 10.1083/jcb.200809127.


Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications.

Brocklebank D, Gayán J, Andresen JM, Roberts SA, Young AB, Snodgrass SR, Penney JB, Ramos-Arroyo MA, Cha JJ, Rosas HD, Hersch SM, Feigin A, Cherny SS, Wexler NS, Housman DE, Cardon LR; International-Venezuela Collaborative Research Group.

Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5;150B(3):425-9. doi: 10.1002/ajmg.b.30826.


Professor Sir Raymond 'Bill' Hoffenberg: a celebration and thanksgiving.

Driver J, London D, Penney J.

Clin Med (Lond). 2008 Jun;8(3):340-5. No abstract available.


Expression pattern diversity and functional conservation between retroposed PRAT genes from Drosophila melanogaster and Drosophila virilis.

Penney J, Bossé J, Clark DV.

J Mol Evol. 2008 May;66(5):457-71. doi: 10.1007/s00239-008-9098-0. Epub 2008 Apr 8.


Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.

Julien SG, Dubé N, Read M, Penney J, Paquet M, Han Y, Kennedy BP, Muller WJ, Tremblay ML.

Nat Genet. 2007 Mar;39(3):338-46. Epub 2007 Jan 28.


Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study.

Li JL, Hayden MR, Warby SC, Durr A, Morrison PJ, Nance M, Ross CA, Margolis RL, Rosenblatt A, Squitieri F, Frati L, Gómez-Tortosa E, García CA, Suchowersky O, Klimek ML, Trent RJ, McCusker E, Novelletto A, Frontali M, Paulsen JS, Jones R, Ashizawa T, Lazzarini A, Wheeler VC, Prakash R, Xu G, Djoussé L, Mysore JS, Gillis T, Hakky M, Cupples LA, Saint-Hilaire MH, Cha JH, Hersch SM, Penney JB, Harrison MB, Perlman SL, Zanko A, Abramson RK, Lechich AJ, Duckett A, Marder K, Conneally PM, Gusella JF, MacDonald ME, Myers RH.

BMC Med Genet. 2006 Aug 17;7:71.


Differential loss of striatal projection systems in Huntington's disease: a quantitative immunohistochemical study.

Deng YP, Albin RL, Penney JB, Young AB, Anderson KD, Reiner A.

J Chem Neuroanat. 2004 Jun;27(3):143-64.


Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset.

Wexler NS, Lorimer J, Porter J, Gomez F, Moskowitz C, Shackell E, Marder K, Penchaszadeh G, Roberts SA, Gayán J, Brocklebank D, Cherny SS, Cardon LR, Gray J, Dlouhy SR, Wiktorski S, Hodes ME, Conneally PM, Penney JB, Gusella J, Cha JH, Irizarry M, Rosas D, Hersch S, Hollingsworth Z, MacDonald M, Young AB, Andresen JM, Housman DE, De Young MM, Bonilla E, Stillings T, Negrette A, Snodgrass SR, Martinez-Jaurrieta MD, Ramos-Arroyo MA, Bickham J, Ramos JS, Marshall F, Shoulson I, Rey GJ, Feigin A, Arnheim N, Acevedo-Cruz A, Acosta L, Alvir J, Fischbeck K, Thompson LM, Young A, Dure L, O'Brien CJ, Paulsen J, Brickman A, Krch D, Peery S, Hogarth P, Higgins DS Jr, Landwehrmeyer B; U.S.-Venezuela Collaborative Research Project.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3498-503. Epub 2004 Mar 1.


Novel objects in a holeboard probe the role of the locus coeruleus in curiosity: support for two modes of attention in the rat.

Mansour AA, Babstock DM, Penney JH, Martin GM, McLean JH, Harley CW.

Behav Neurosci. 2003 Jun;117(3):621-31.


A unique short-chain dehydrogenase/reductase in Arabidopsis glucose signaling and abscisic acid biosynthesis and functions.

Cheng WH, Endo A, Zhou L, Penney J, Chen HC, Arroyo A, Leon P, Nambara E, Asami T, Seo M, Koshiba T, Sheen J.

Plant Cell. 2002 Nov;14(11):2723-43.


Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington's disease.

Spektor BS, Miller DW, Hollingsworth ZR, Kaneko YA, Solano SM, Johnson JM, Penney JB Jr, Young AB, Luthi-Carter R.

Brain Res Mol Brain Res. 2002 Jun 15;102(1-2):118-28.


Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson's disease: a randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial.

Shoulson I, Oakes D, Fahn S, Lang A, Langston JW, LeWitt P, Olanow CW, Penney JB, Tanner C, Kieburtz K, Rudolph A; Parkinson Study Group.

Ann Neurol. 2002 May;51(5):604-12.


Correlative controls of senescence and plant death in Arabidopsis thaliana (Brassicaceae).

Noodén LD, Penney JP.

J Exp Bot. 2001 Nov;52(364):2151-9.


Novel mutation in the TOR1A (DYT1) gene in atypical early onset dystonia and polymorphisms in dystonia and early onset parkinsonism.

Leung JC, Klein C, Friedman J, Vieregge P, Jacobs H, Doheny D, Kamm C, DeLeon D, Pramstaller PP, Penney JB, Eisengart M, Jankovic J, Gasser T, Bressman SB, Corey DP, Kramer P, Brin MF, Ozelius LJ, Breakefield XO.

Neurogenetics. 2001 Jul;3(3):133-43.


Outcomes following staged bilateral pallidotomy in advanced Parkinson's disease.

Counihan TJ, Shinobu LA, Eskandar EN, Cosgrove GR, Penney JB Jr.

Neurology. 2001 Mar 27;56(6):799-802.


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