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Unanswered questions on the safety of MDT-U - Reply.

Penna GO, Gonçalves HS, Pontes MAA.

An Bras Dermatol. 2019 Oct 17;94(4):500. doi: 10.1590/abd1806-4841.201985641. eCollection 2019. No abstract available.


Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development.

Mouries J, Brescia P, Silvestri A, Spadoni I, Sorribas M, Wiest R, Mileti E, Galbiati M, Invernizzi P, Adorini L, Penna G, Rescigno M.

J Hepatol. 2019 Dec;71(6):1216-1228. doi: 10.1016/j.jhep.2019.08.005. Epub 2019 Aug 13.


Off-label prescription of SGLT-2 inhibitors to patients with type 1 diabetes: an online survey of diabetes specialists in Italy.

Scavini M, Bertuzzi F, Girelli A, Celleno R, Molinari C, Tripodi FP, Zanon MS, Di Bartolo P, La Penna G; Italian Association of Clinical Diabetologists.

Acta Diabetol. 2019 Nov;56(11):1235-1238. doi: 10.1007/s00592-019-01386-7. Epub 2019 Jul 29. No abstract available.


Socioeconomic determinants of leprosy new case detection in the 100 Million Brazilian Cohort: a population-based linkage study.

Nery JS, Ramond A, Pescarini JM, Alves A, Strina A, Ichihara MY, Fernandes Penna ML, Smeeth L, Rodrigues LC, Barreto ML, Brickley EB, Penna GO.

Lancet Glob Health. 2019 Sep;7(9):e1226-e1236. doi: 10.1016/S2214-109X(19)30260-8. Epub 2019 Jul 19.


30 years of the Unified Health System in the Federal District of Brasília.

Penna GO, Soranz D, Silva JAAD, Pinto LF.

Cien Saude Colet. 2019 Jun 27;24(6):1978. doi: 10.1590/1413-81232018246.09322019. Portuguese, English. No abstract available.


Dealing with Cu reduction in X-ray absorption spectroscopy experiments.

Stellato F, Chiaraluce R, Consalvi V, De Santis E, La Penna G, Proux O, Rossi G, Morante S.

Metallomics. 2019 Aug 1;11(8):1401-1410. doi: 10.1039/c9mt00110g. Epub 2019 Jul 3.


Computational models explain how copper binding to amyloid-β peptide oligomers enhances oxidative pathways.

La Penna G, Li MS.

Phys Chem Chem Phys. 2019 Apr 24;21(17):8774-8784. doi: 10.1039/c9cp00293f.


Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil.

Stefani MMA, Rosa PS, Costa MB, Schetinni APM, Manhães I, Pontes MAA, Costa P, Fachin LRV, Batista IMFD, Virmond M, Pereira E, Penna MLF, Penna GO.

PLoS One. 2019 Jan 10;14(1):e0209491. doi: 10.1371/journal.pone.0209491. eCollection 2019.


Understanding the Exceptional Properties of Nitroacetamides in Water: A Computational Model Including the Solvent.

La Penna G, Machetti F.

Molecules. 2018 Dec 13;23(12). pii: E3308. doi: 10.3390/molecules23123308.


Levodopa/Carbidopa Intestinal Gel Infusion Therapy: Focus on Gait and Balance.

Rispoli V, Golfrè Andreasi N, Penna G, Preda F, Contini E, Sensi M.

Mov Disord Clin Pract. 2018 Oct 25;5(5):542-545. doi: 10.1002/mdc3.12640. eCollection 2018 Sep-Oct.


Profile of dermatological consultations in Brazil (2018).

Sociedade Brasileira de Dermatologia, Miot HA, Penna GO, Ramos AMC, Penna MLF, Schmidt SM, Luz FB, Sousa MAJ, Palma SLL, Sanches Junior JA.

An Bras Dermatol. 2018 Nov/Dec;93(6):916-928. doi: 10.1590/abd1806-4841.20188802.


Multi-scale theoretical approach to X-ray absorption spectra in disordered systems: an application to the study of Zn(ii) in water.

Stellato F, Calandra M, D'Acapito F, De Santis E, La Penna G, Rossi G, Morante S.

Phys Chem Chem Phys. 2018 Oct 3;20(38):24775-24782. doi: 10.1039/c8cp04355h.


Reply of the authors of the Continuing Medical Education article to Dr. Jaison Barreto and Dr. Laila Laguiche.

Cruz RC, Bührer-Sékula S, Penna MLF, Penna GO, Talhari S.

An Bras Dermatol. 2018 Jul-Aug;93(4):625-626. doi: 10.1590/abd1806-4841.201893404. No abstract available.


Socioeconomic risk markers of leprosy in high-burden countries: A systematic review and meta-analysis.

Pescarini JM, Strina A, Nery JS, Skalinski LM, Andrade KVF, Penna MLF, Brickley EB, Rodrigues LC, Barreto ML, Penna GO.

PLoS Negl Trop Dis. 2018 Jul 9;12(7):e0006622. doi: 10.1371/journal.pntd.0006622. eCollection 2018 Jul. Review.


The achievements of the SUS in tackling the communicable diseases.

Teixeira MG, Costa MDCN, Paixão ESD, Carmo EH, Barreto FR, Penna GO.

Cien Saude Colet. 2018 Jun;23(6):1819-1828. doi: 10.1590/1413-81232018236.08402018. Portuguese, English.


Health surveillance at the SUS: development, effects and perspectives.

Teixeira MG, Costa MDCN, Carmo EH, Oliveira WK, Penna GO.

Cien Saude Colet. 2018 Jun;23(6):1811-1818. doi: 10.1590/1413-81232018236.09032018. Portuguese, English.


Unified Health System: 30 years of struggle!

Paim JS, Temporão JG, Penna GO, Santos NRD, Pinto LF.

Cien Saude Colet. 2018 Jun;23(6):1704. doi: 10.1590/1413-81232018236.06612018. English, Portuguese. No abstract available.


Copper Binding Induces Polymorphism in Amyloid-β Peptide: Results of Computational Models.

Pham DQH, Li MS, La Penna G.

J Phys Chem B. 2018 Jul 26;122(29):7243-7252. doi: 10.1021/acs.jpcb.8b03983. Epub 2018 Jul 17.


TERTp mutation is associated with a shorter progression free survival in patients with aggressive histology subtypes of follicular-cell derived thyroid carcinoma.

Penna GC, Pestana A, Cameselle JM, Momesso D, de Andrade FA, Vidal APA, Araujo Junior ML, Melo M, Fernandes PV, Corbo R, Vaisman M, Sobrinho-Simões M, Soares P, Vaisman F.

Endocrine. 2018 Sep;61(3):489-498. doi: 10.1007/s12020-018-1642-0. Epub 2018 Jun 15.


Clinical trial for uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): adverse effects approach.

Cruz RCDS, Bührer-Sékula S, Penna GO, Moraes MEA, Gonçalves HS, Stefani MMA, Penna MLF, Pontes MAA, Talhari S.

An Bras Dermatol. 2018 Jun;93(3):377-384. doi: 10.1590/abd1806-4841.20186709.


Single-dose rifampicin chemoprophylaxis protects those who need it least and is not a cost-effective intervention.

Lockwood DNJ, Krishnamurthy P, Kumar B, Penna G.

PLoS Negl Trop Dis. 2018 Jun 7;12(6):e0006403. doi: 10.1371/journal.pntd.0006403. eCollection 2018 Jun. No abstract available.


Mycobacterium leprae-Specific Antibodies in Multibacillary Leprosy Patients Decrease During and After Treatment With Either the Regular 12 Doses Multidrug Therapy (MDT) or the Uniform 6 Doses MDT.

Hungria EM, Bührer-Sékula S, Oliveira RM, Aderaldo LC, Pontes MAA, Cruz R, de Gonçalves HS, Penna MLF, Penna GO, Stefani MMA.

Front Immunol. 2018 May 14;9:915. doi: 10.3389/fimmu.2018.00915. eCollection 2018.


Structural Insights into the Osteopontin-Aptamer Complex by Molecular Dynamics Simulations.

La Penna G, Chelli R.

Front Chem. 2018 Jan 30;6:2. doi: 10.3389/fchem.2018.00002. eCollection 2018.


Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae.

Benjak A, Avanzi C, Singh P, Loiseau C, Girma S, Busso P, Fontes ANB, Miyamoto Y, Namisato M, Bobosha K, Salgado CG, da Silva MB, Bouth RC, Frade MAC, Filho FB, Barreto JG, Nery JAC, Bührer-Sékula S, Lupien A, Al-Samie AR, Al-Qubati Y, Alkubati AS, Bretzel G, Vera-Cabrera L, Sakho F, Johnson CR, Kodio M, Fomba A, Sow SO, Gado M, Konaté O, Stefani MMA, Penna GO, Suffys PN, Sarno EN, Moraes MO, Rosa PS, Baptista IMFD, Spencer JS, Aseffa A, Matsuoka M, Kai M, Cole ST.

Nat Commun. 2018 Jan 24;9(1):352. doi: 10.1038/s41467-017-02576-z.


Leprosy: current situation, clinical and laboratory aspects, treatment history and perspective of the uniform multidrug therapy for all patients.

Cruz RCDS, Bührer-Sékula S, Penna MLF, Penna GO, Talhari S.

An Bras Dermatol. 2017 Nov-Dec;92(6):761-773. doi: 10.1590/abd1806-4841.20176724. Review.


Towards High-Throughput Modelling of Copper Reactivity Induced by Structural Disorder in Amyloid Peptides.

La Penna G, Li MS.

Chemistry. 2018 Apr 6;24(20):5259-5270. doi: 10.1002/chem.201704654. Epub 2018 Feb 8.


Immediate postoperative of bariatric surgery in the intensive care unit versus an inpatient unit. A retrospective study with 828 patients.

Penna GLA, Vaz IP, Fonseca EC, Kalichsztein M, Nobre GF.

Rev Bras Ter Intensiva. 2017 Jul-Sep;29(3):325-330. doi: 10.5935/0103-507X.20170050. Portuguese, English.


Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients.

Penna GO, Bührer-Sékula S, Kerr LRS, Stefani MMA, Rodrigues LC, de Araújo MG, Ramos AMC, de Andrade ARC, Costa MB, Rosa PS, Gonçalves HS, Cruz R, Barreto ML, Pontes MAA, Penna MLF.

PLoS Negl Trop Dis. 2017 Jul 13;11(7):e0005725. doi: 10.1371/journal.pntd.0005725. eCollection 2017 Jul.


The Genetics of Papillary Microcarcinomas of the Thyroid: Diagnostic and Prognostic Implications.

Rodrigues AC, Penna G, Rodrigues E, Castro P, Sobrinho-Simões M, Soares P.

Curr Genomics. 2017 Jun;18(3):244-254. doi: 10.2174/1389202918666170105094459. Review.


Effect of Brazil's conditional cash transfer programme on tuberculosis incidence.

Nery JS, Rodrigues LC, Rasella D, Aquino R, Barreira D, Torrens AW, Boccia D, Penna GO, Penna MLF, Barreto ML, Pereira SM.

Int J Tuberc Lung Dis. 2017 Jul 1;21(7):790-796. doi: 10.5588/ijtld.16.0599.


Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases.

Stefani MMA, Avanzi C, Bührer-Sékula S, Benjak A, Loiseau C, Singh P, Pontes MAA, Gonçalves HS, Hungria EM, Busso P, Piton J, Silveira MIS, Cruz R, Schetinni A, Costa MB, Virmond MCL, Diorio SM, Dias-Baptista IMF, Rosa PS, Matsuoka M, Penna MLF, Cole ST, Penna GO.

PLoS Negl Trop Dis. 2017 Jun 15;11(6):e0005598. doi: 10.1371/journal.pntd.0005598. eCollection 2017 Jun.


Genomic diversity and immunomodulatory activity of Lactobacillus plantarum isolated from dairy products.

Zago M, Scaltriti E, Bonvini B, Fornasari ME, Penna G, Massimiliano L, Carminati D, Rescigno M, Giraffa G.

Benef Microbes. 2017 Aug 24;8(4):597-604. doi: 10.3920/BM2016.0223. Epub 2017 May 30.


Simultaneous Papillary Carcinoma in Thyroglossal Duct Cyst and Thyroid.

Penna GC, Mendes HG, Kraft AO, Berenstein CK, Fonseca B, Martorina WJ, de Souza AL, Meyer de Moraes G, Rajão KM, Sousa BÉ.

Case Rep Endocrinol. 2017;2017:8541078. doi: 10.1155/2017/8541078. Epub 2017 Feb 8.


Molecular Markers Involved in Tumorigenesis of Thyroid Carcinoma: Focus on Aggressive Histotypes.

Penna GC, Vaisman F, Vaisman M, Sobrinho-Simões M, Soares P.

Cytogenet Genome Res. 2016;150(3-4):194-207. doi: 10.1159/000456576. Epub 2017 Feb 24. Review.


Leprosy reactions: The predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR).

Hungria EM, Bührer-Sékula S, de Oliveira RM, Aderaldo LC, Pontes AA, Cruz R, Gonçalves HS, Penna ML, Penna GO, Stefani MM.

PLoS Negl Trop Dis. 2017 Feb 21;11(2):e0005396. doi: 10.1371/journal.pntd.0005396. eCollection 2017 Feb.


Telomerase and telomere biology in hematological diseases: A new therapeutic target.

Allegra A, Innao V, Penna G, Gerace D, Allegra AG, Musolino C.

Leuk Res. 2017 May;56:60-74. doi: 10.1016/j.leukres.2017.02.002. Epub 2017 Feb 7. Review.


Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil.

Hungria EM, Oliveira RM, Penna GO, Aderaldo LC, Pontes MA, Cruz R, Gonçalves HS, Penna ML, Kerr LR, Stefani MM, Bührer-Sékula S.

Infect Dis Poverty. 2016 Dec 6;5(1):110.


Impact of Cu(II) Binding on Structures and Dynamics of Aβ42 Monomer and Dimer: Molecular Dynamics Study.

Huy PD, Vuong QV, La Penna G, Faller P, Li MS.

ACS Chem Neurosci. 2016 Oct 19;7(10):1348-1363. Epub 2016 Aug 16.


Modeling (15)N NMR chemical shift changes in protein backbone with pressure.

La Penna G, Mori Y, Kitahara R, Akasaka K, Okamoto Y.

J Chem Phys. 2016 Aug 28;145(8):085104. doi: 10.1063/1.4961507.


Leprosy in children and adolescents under 15 years old in an urban centre in Brazil.

Santos SD, Penna GO, Costa Mda C, Natividade MS, Teixeira MG.

Mem Inst Oswaldo Cruz. 2016 May 24;111(6):359-64. doi: 10.1590/0074-02760160002.


Anti-PGL-1 Positivity as a Risk Marker for the Development of Leprosy among Contacts of Leprosy Cases: Systematic Review and Meta-analysis.

Penna ML, Penna GO, Iglesias PC, Natal S, Rodrigues LC.

PLoS Negl Trop Dis. 2016 May 18;10(5):e0004703. doi: 10.1371/journal.pntd.0004703. eCollection 2016 May. Review.


Themes and Reform of Primary Health Care (RCAPS) in the city of Rio de Janeiro, Brazil.

Soranz D, Pinto LF, Penna GO.

Cien Saude Colet. 2016 May;21(5):1327-38. doi: 10.1590/1413-81232015215.01022016. English, Portuguese.


The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.

Pozzi C, Cuomo A, Spadoni I, Magni E, Silvola A, Conte A, Sigismund S, Ravenda PS, Bonaldi T, Zampino MG, Cancelliere C, Di Fiore PP, Bardelli A, Penna G, Rescigno M.

Nat Med. 2016 Jun;22(6):624-31. doi: 10.1038/nm.4078. Epub 2016 May 2.


Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis.

Guglietta S, Chiavelli A, Zagato E, Krieg C, Gandini S, Ravenda PS, Bazolli B, Lu B, Penna G, Rescigno M.

Nat Commun. 2016 Mar 21;7:11037. doi: 10.1038/ncomms11037.


Assessing the relevance of indicators in tracking social determinants and progress toward equitable population health in Brazil.

Rasella D, Machado DB, Castellanos ME, Paim J, Szwarcwald CL, Lima D, Magno L, Pedrana L, Medina MG, Penna GO, Barreto ML.

Glob Health Action. 2016 Feb 5;9:29042. doi: 10.3402/gha.v9.29042. eCollection 2016.


Free Superoxide is an Intermediate in the Production of H2O2 by Copper(I)-Aβ Peptide and O2.

Reybier K, Ayala S, Alies B, Rodrigues JV, Bustos Rodriguez S, La Penna G, Collin F, Gomes CM, Hureau C, Faller P.

Angew Chem Int Ed Engl. 2016 Jan 18;55(3):1085-9. doi: 10.1002/anie.201508597. Epub 2015 Dec 2.


A gut-vascular barrier controls the systemic dissemination of bacteria.

Spadoni I, Zagato E, Bertocchi A, Paolinelli R, Hot E, Di Sabatino A, Caprioli F, Bottiglieri L, Oldani A, Viale G, Penna G, Dejana E, Rescigno M.

Science. 2015 Nov 13;350(6262):830-4. doi: 10.1126/science.aad0135.


A first-principle calculation of the XANES spectrum of Cu(2+) in water.

La Penna G, Minicozzi V, Morante S, Rossi GC, Stellato F.

J Chem Phys. 2015 Sep 28;143(12):124508. doi: 10.1063/1.4931808.


Dioxygen activation in the Cu-amyloid β complex.

Mirats A, Alí-Torres J, Rodríguez-Santiago L, Sodupe M, La Penna G.

Phys Chem Chem Phys. 2015 Nov 7;17(41):27270-4. doi: 10.1039/c5cp04025f.


BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity.

Fransen F, Zagato E, Mazzini E, Fosso B, Manzari C, El Aidy S, Chiavelli A, D'Erchia AM, Sethi MK, Pabst O, Marzano M, Moretti S, Romani L, Penna G, Pesole G, Rescigno M.

Immunity. 2015 Sep 15;43(3):527-40. doi: 10.1016/j.immuni.2015.08.011. Epub 2015 Sep 8.

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