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Six-Month Outcomes After High Hyperopia Correction Using Laser-Assisted In Situ Keratomileusis With a Large Ablation Zone.

Gauthier-Fournet L, Penin F, Arba Mosquera S.

Cornea. 2019 Sep;38(9):1147-1153. doi: 10.1097/ICO.0000000000002011.


NS2 proteases from hepatitis C virus and related hepaciviruses share composite active sites and previously unrecognized intrinsic proteolytic activities.

Boukadida C, Fritz M, Blumen B, Fogeron ML, Penin F, Martin A.

PLoS Pathog. 2018 Feb 7;14(2):e1006863. doi: 10.1371/journal.ppat.1006863. eCollection 2018 Feb.


The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particle types.

Denolly S, Mialon C, Bourlet T, Amirache F, Penin F, Lindenbach B, Boson B, Cosset FL.

PLoS Pathog. 2017 Dec 18;13(12):e1006774. doi: 10.1371/journal.ppat.1006774. eCollection 2017 Dec.


Wheat Germ Cell-Free Overexpression for the Production of Membrane Proteins.

Fogeron ML, Badillo A, Penin F, Böckmann A.

Methods Mol Biol. 2017;1635:91-108. doi: 10.1007/978-1-4939-7151-0_5.


Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A.

Badillo A, Receveur-Brechot V, Sarrazin S, Cantrelle FX, Delolme F, Fogeron ML, Molle J, Montserret R, Bockmann A, Bartenschlager R, Lohmann V, Lippens G, Ricard-Blum S, Hanoulle X, Penin F.

Biochemistry. 2017 Jun 20;56(24):3029-3048. doi: 10.1021/acs.biochem.7b00212. Epub 2017 Jun 7.


Assessing the physiological relevance of alternate architectures of the p7 protein of hepatitis C virus in different environments.

Holzmann N, Chipot C, Penin F, Dehez F.

Bioorg Med Chem. 2016 Oct 15;24(20):4920-4927. doi: 10.1016/j.bmc.2016.07.063. Epub 2016 Jul 29.


Cell-free expression, purification, and membrane reconstitution for NMR studies of the nonstructural protein 4B from hepatitis C virus.

Fogeron ML, Jirasko V, Penzel S, Paul D, Montserret R, Danis C, Lacabanne D, Badillo A, Gouttenoire J, Moradpour D, Bartenschlager R, Penin F, Meier BH, Böckmann A.

J Biomol NMR. 2016 Jun;65(2):87-98. doi: 10.1007/s10858-016-0040-2. Epub 2016 May 27.


Coevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins.

Champeimont R, Laine E, Hu SW, Penin F, Carbone A.

Sci Rep. 2016 May 20;6:26401. doi: 10.1038/srep26401.


Ion Channel Function and Cross-Species Determinants in Viral Assembly of Nonprimate Hepacivirus p7.

Walter S, Bollenbach A, Doerrbecker J, Pfaender S, Brown RJP, Vieyres G, Scott C, Foster R, Kumar A, Zitzmann N, Griffin S, Penin F, Pietschmann T, Steinmann E.

J Virol. 2016 Apr 29;90(10):5075-5089. doi: 10.1128/JVI.00132-16. Print 2016 May 15.


The N-terminal Helical Region of the Hepatitis C Virus p7 Ion Channel Protein Is Critical for Infectious Virus Production.

Scull MA, Schneider WM, Flatley BR, Hayden R, Fung C, Jones CT, van de Belt M, Penin F, Rice CM.

PLoS Pathog. 2015 Nov 20;11(11):e1005297. doi: 10.1371/journal.ppat.1005297. eCollection 2015 Nov.


Functional expression, purification, characterization, and membrane reconstitution of non-structural protein 2 from hepatitis C virus.

Fogeron ML, Paul D, Jirasko V, Montserret R, Lacabanne D, Molle J, Badillo A, Boukadida C, Georgeault S, Roingeard P, Martin A, Bartenschlager R, Penin F, Böckmann A.

Protein Expr Purif. 2015 Dec;116:1-6. doi: 10.1016/j.pep.2015.08.027. Epub 2015 Aug 29.


Hepatitis C Virus Envelope Glycoprotein E1 Forms Trimers at the Surface of the Virion.

Falson P, Bartosch B, Alsaleh K, Tews BA, Loquet A, Ciczora Y, Riva L, Montigny C, Montpellier C, Duverlie G, Pécheur EI, le Maire M, Cosset FL, Dubuisson J, Penin F.

J Virol. 2015 Oct;89(20):10333-46. doi: 10.1128/JVI.00991-15. Epub 2015 Aug 5.


Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses.

Hueging K, Weller R, Doepke M, Vieyres G, Todt D, Wölk B, Vondran FW, Geffers R, Lauber C, Kaderali L, Penin F, Pietschmann T.

PLoS One. 2015 Jul 30;10(7):e0134529. doi: 10.1371/journal.pone.0134529. eCollection 2015.


A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication.

Dujardin M, Madan V, Montserret R, Ahuja P, Huvent I, Launay H, Leroy A, Bartenschlager R, Penin F, Lippens G, Hanoulle X.

J Biol Chem. 2015 Jul 31;290(31):19104-20. doi: 10.1074/jbc.M115.644419. Epub 2015 Jun 17.


Aminoterminal amphipathic α-helix AH1 of hepatitis C virus nonstructural protein 4B possesses a dual role in RNA replication and virus production.

Gouttenoire J, Montserret R, Paul D, Castillo R, Meister S, Bartenschlager R, Penin F, Moradpour D.

PLoS Pathog. 2014 Nov 13;10(10):e1004501. doi: 10.1371/journal.ppat.1004501. eCollection 2014 Oct.


Wheat germ cell-free expression: Two detergents with a low critical micelle concentration allow for production of soluble HCV membrane proteins.

Fogeron ML, Badillo A, Jirasko V, Gouttenoire J, Paul D, Lancien L, Moradpour D, Bartenschlager R, Meier BH, Penin F, Böckmann A.

Protein Expr Purif. 2015 Jan;105:39-46. doi: 10.1016/j.pep.2014.10.003. Epub 2014 Oct 12.


Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication.

Berger C, Romero-Brey I, Radujkovic D, Terreux R, Zayas M, Paul D, Harak C, Hoppe S, Gao M, Penin F, Lohmann V, Bartenschlager R.

Gastroenterology. 2014 Nov;147(5):1094-105.e25. doi: 10.1053/j.gastro.2014.07.019. Epub 2014 Jul 18.


Identification of conserved residues in hepatitis C virus envelope glycoprotein E2 that modulate virus dependence on CD81 and SRB1 entry factors.

Lavie M, Sarrazin S, Montserret R, Descamps V, Baumert TF, Duverlie G, Séron K, Penin F, Dubuisson J.

J Virol. 2014 Sep;88(18):10584-97. doi: 10.1128/JVI.01402-14. Epub 2014 Jul 2.


NS2 proteins of GB virus B and hepatitis C virus share common protease activities and membrane topologies.

Boukadida C, Marnata C, Montserret R, Cohen L, Blumen B, Gouttenoire J, Moradpour D, Penin F, Martin A.

J Virol. 2014 Jul;88(13):7426-44. doi: 10.1128/JVI.00656-14. Epub 2014 Apr 16.


Determinants for membrane association of the hepatitis C virus NS2 protease domain.

Lange CM, Bellecave P, Dao Thi VL, Tran HT, Penin F, Moradpour D, Gouttenoire J.

J Virol. 2014 Jun;88(11):6519-23. doi: 10.1128/JVI.00224-14. Epub 2014 Mar 19.


Efficient and stable reconstitution of the ABC transporter BmrA for solid-state NMR studies.

Kunert B, Gardiennet C, Lacabanne D, Calles-Garcia D, Falson P, Jault JM, Meier BH, Penin F, Böckmann A.

Front Mol Biosci. 2014 Jun 12;1:5. doi: 10.3389/fmolb.2014.00005. eCollection 2014.


Reply: To PMID 23317648.

Baudu P, Penin F, Arba Mosquera S.

Am J Ophthalmol. 2013 Oct;156(4):848-9. doi: 10.1016/j.ajo.2013.07.004. No abstract available.


Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease.

Morikawa K, Gouttenoire J, Hernandez C, Dao Thi VL, Tran HT, Lange CM, Dill MT, Heim MH, Donzé O, Penin F, Quadroni M, Moradpour D.

Hepatology. 2014 Feb;59(2):423-33. doi: 10.1002/hep.26671. Epub 2013 Dec 18.


Additional glycosylation within a specific hypervariable region of subtype 3a of hepatitis C virus protects against virus neutralization.

Anjum S, Wahid A, Afzal MS, Albecka A, Alsaleh K, Ahmad T, Baumert TF, Wychowski C, Qadri I, Penin F, Dubuisson J.

J Infect Dis. 2013 Dec 1;208(11):1888-97. doi: 10.1093/infdis/jit376. Epub 2013 Aug 1.


The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection.

Bartenschlager R, Lohmann V, Penin F.

Nat Rev Microbiol. 2013 Jul;11(7):482-96. doi: 10.1038/nrmicro3046. Epub 2013 Jun 10. Review.


Hepatitis C virus proteins: from structure to function.

Moradpour D, Penin F.

Curr Top Microbiol Immunol. 2013;369:113-42. doi: 10.1007/978-3-642-27340-7_5. Review.


Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B.

Esser-Nobis K, Romero-Brey I, Ganten TM, Gouttenoire J, Harak C, Klein R, Schemmer P, Binder M, Schnitzler P, Moradpour D, Bartenschlager R, Polyak SJ, Stremmel W, Penin F, Eisenbach C, Lohmann V.

Hepatology. 2013 Mar;57(3):953-63. doi: 10.1002/hep.26260. Epub 2013 Feb 7.


Uncorrected binocular performance after biaspheric ablation profile for presbyopic corneal treatment using AMARIS with the PresbyMAX module.

Baudu P, Penin F, Arba Mosquera S.

Am J Ophthalmol. 2013 Apr;155(4):636-647, 647.e1. doi: 10.1016/j.ajo.2012.10.023. Epub 2013 Jan 11.


Disulfide bonds in hepatitis C virus glycoprotein E1 control the assembly and entry functions of E2 glycoprotein.

Wahid A, Helle F, Descamps V, Duverlie G, Penin F, Dubuisson J.

J Virol. 2013 Feb;87(3):1605-17. doi: 10.1128/JVI.02659-12. Epub 2012 Nov 21.


Solid-state NMR sequential assignments of the C-terminal oligomerization domain of human C4b-binding protein.

Luckgei N, Habenstein B, Ravotti F, Megy S, Penin F, Marchand JB, Hill F, Böckmann A, Meier BH.

Biomol NMR Assign. 2014 Apr;8(1):1-6. doi: 10.1007/s12104-012-9440-8. Epub 2012 Nov 9.


The p7 protein of hepatitis C virus forms structurally plastic, minimalist ion channels.

Chandler DE, Penin F, Schulten K, Chipot C.

PLoS Comput Biol. 2012;8(9):e1002702. doi: 10.1371/journal.pcbi.1002702. Epub 2012 Sep 20.


Characterization of hepatitis C virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps.

Dao Thi VL, Granier C, Zeisel MB, Guérin M, Mancip J, Granio O, Penin F, Lavillette D, Bartenschlager R, Baumert TF, Cosset FL, Dreux M.

J Biol Chem. 2012 Sep 7;287(37):31242-57. doi: 10.1074/jbc.M112.365924. Epub 2012 Jul 5.


[Detecting and preventing the mistreatment of elderly people].

Penin F.

Soins Gerontol. 2012 May-Jun;(95):14-5. French.


Structural analysis of hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal peptide peptidase.

Oehler V, Filipe A, Montserret R, da Costa D, Brown G, Penin F, McLauchlan J.

J Virol. 2012 Aug;86(15):7818-28. doi: 10.1128/JVI.00457-12. Epub 2012 May 16.


Sublimable C5A delivery provides sustained and prolonged anti-HIV microbicidal activities.

Maskiewicz R, Bobardt M, Chatterji U, Gunaseelan S, Dezzutti CS, Penin F, Gallay PA.

Antimicrob Agents Chemother. 2012 Jun;56(6):3336-43. doi: 10.1128/AAC.00186-12. Epub 2012 Mar 19.


Analysis of the RNA chaperoning activity of the hepatitis C virus core protein on the conserved 3'X region of the viral genome.

Sharma KK, de Rocquigny H, Darlix JL, Lavergne JP, Pénin F, Lessinger JM, Mély Y.

Nucleic Acids Res. 2012 Mar;40(6):2540-53. doi: 10.1093/nar/gkr1140. Epub 2011 Nov 29.


Conserved glycine 33 residue in flexible domain I of hepatitis C virus core protein is critical for virus infectivity.

Angus AG, Loquet A, Stack SJ, Dalrymple D, Gatherer D, Penin F, Patel AH.

J Virol. 2012 Jan;86(2):679-90. doi: 10.1128/JVI.05452-11. Epub 2011 Nov 9.


Characterization of unique signature sequences in the divergent maternal protein Bcl2l10.

Guillemin Y, Cornut-Thibaut A, Gillet G, Penin F, Aouacheria A.

Mol Biol Evol. 2011 Dec;28(12):3271-83. doi: 10.1093/molbev/msr152. Epub 2011 Jun 24.


Effects of hepatitis C virus on suppressor of cytokine signaling mRNA levels: comparison between different genotypes and core protein sequence analysis.

Pascarella S, Clément S, Guilloux K, Conzelmann S, Penin F, Negro F.

J Med Virol. 2011 Jun;83(6):1005-15. doi: 10.1002/jmv.22072.


Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A.

Verdegem D, Badillo A, Wieruszeski JM, Landrieu I, Leroy A, Bartenschlager R, Penin F, Lippens G, Hanoulle X.

J Biol Chem. 2011 Jun 10;286(23):20441-54. doi: 10.1074/jbc.M110.182436. Epub 2011 Apr 13.


Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus.

Morikawa K, Lange CM, Gouttenoire J, Meylan E, Brass V, Penin F, Moradpour D.

J Viral Hepat. 2011 May;18(5):305-15. doi: 10.1111/j.1365-2893.2011.01451.x. Epub 2011 Mar 23. Review.


NS2 protein of hepatitis C virus interacts with structural and non-structural proteins towards virus assembly.

Popescu CI, Callens N, Trinel D, Roingeard P, Moradpour D, Descamps V, Duverlie G, Penin F, Héliot L, Rouillé Y, Dubuisson J.

PLoS Pathog. 2011 Feb 10;7(2):e1001278. doi: 10.1371/journal.ppat.1001278.


Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidol.

Teissier E, Zandomeneghi G, Loquet A, Lavillette D, Lavergne JP, Montserret R, Cosset FL, Böckmann A, Meier BH, Penin F, Pécheur EI.

PLoS One. 2011 Jan 25;6(1):e15874. doi: 10.1371/journal.pone.0015874.


Targeting cell entry of enveloped viruses as an antiviral strategy.

Teissier E, Penin F, Pécheur EI.

Molecules. 2010 Dec 30;16(1):221-50. doi: 10.3390/molecules16010221. Review.


Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly.

Jirasko V, Montserret R, Lee JY, Gouttenoire J, Moradpour D, Penin F, Bartenschlager R.

PLoS Pathog. 2010 Dec 16;6(12):e1001233. doi: 10.1371/journal.ppat.1001233.


Identification of new functional regions in hepatitis C virus envelope glycoprotein E2.

Albecka A, Montserret R, Krey T, Tarr AW, Diesis E, Ball JK, Descamps V, Duverlie G, Rey F, Penin F, Dubuisson J.

J Virol. 2011 Feb;85(4):1777-92. doi: 10.1128/JVI.02170-10. Epub 2010 Dec 8.


Assembly of infectious hepatitis C virus particles.

Bartenschlager R, Penin F, Lohmann V, André P.

Trends Microbiol. 2011 Feb;19(2):95-103. doi: 10.1016/j.tim.2010.11.005. Epub 2010 Dec 14. Review.


Amphipathic alpha-helix AH2 is a major determinant for the oligomerization of hepatitis C virus nonstructural protein 4B.

Gouttenoire J, Roingeard P, Penin F, Moradpour D.

J Virol. 2010 Dec;84(24):12529-37. doi: 10.1128/JVI.01798-10. Epub 2010 Oct 6.


Hepatitis C virus RNA replication requires a conserved structural motif within the transmembrane domain of the NS5B RNA-dependent RNA polymerase.

Brass V, Gouttenoire J, Wahl A, Pal Z, Blum HE, Penin F, Moradpour D.

J Virol. 2010 Nov;84(21):11580-4. doi: 10.1128/JVI.01519-10. Epub 2010 Aug 25.


NMR structure and ion channel activity of the p7 protein from hepatitis C virus.

Montserret R, Saint N, Vanbelle C, Salvay AG, Simorre JP, Ebel C, Sapay N, Renisio JG, Böckmann A, Steinmann E, Pietschmann T, Dubuisson J, Chipot C, Penin F.

J Biol Chem. 2010 Oct 8;285(41):31446-61. doi: 10.1074/jbc.M110.122895. Epub 2010 Jul 28.

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