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The Uptake of New Knee Replacement Implants in the UK: Analysis of the National Joint Registry for England and Wales.

Penfold CM, Blom AW, Wilkinson JM, Judge A, Whitehouse MR.

J Arthroplasty. 2019 Nov 9. pii: S0883-5403(19)31022-8. doi: 10.1016/j.arth.2019.10.045. [Epub ahead of print]


Understanding the uptake of new hip replacement implants in the UK: a cohort study using data from the National Joint Registry for England and Wales.

Penfold CM, Blom AW, Sayers A, Wilkinson JM, Hunt L, Judge A, Whitehouse MR.

BMJ Open. 2019 Nov 25;9(11):e029572. doi: 10.1136/bmjopen-2019-029572.


An overview of systematic reviews of complementary and alternative therapies for infantile colic.

Perry R, Leach V, Penfold C, Davies P.

Syst Rev. 2019 Nov 11;8(1):271. doi: 10.1186/s13643-019-1191-5.


Phase II randomised control feasibility trial of a nutrition and physical activity intervention after radical prostatectomy for prostate cancer.

Hackshaw-McGeagh LE, Penfold C, Shingler E, Robles LA, Perks CM, Holly JMP, Rowe E, Koupparis A, Bahl A, Persad R, Shiridzinomwa C, Johnson L, Biernacka KM, Frankow A, Woodside JV, Gilchrist S, Oxley J, Abrams P, Lane JA, Martin RM.

BMJ Open. 2019 Nov 6;9(11):e029480. doi: 10.1136/bmjopen-2019-029480.


Variability in long-term pain and function trajectories after total knee replacement: A cohort study.

Wylde V, Penfold C, Rose A, Blom AW.

Orthop Traumatol Surg Res. 2019 Nov;105(7):1345-1350. doi: 10.1016/j.otsr.2019.08.014. Epub 2019 Oct 5.


Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications.

Herbert G, Perry R, Andersen HK, Atkinson C, Penfold C, Lewis SJ, Ness AR, Thomas S.

Cochrane Database Syst Rev. 2019 Jul 22;7:CD004080. doi: 10.1002/14651858.CD004080.pub4.


'It was nothing that you would think was anything': Qualitative analysis of appraisal and help seeking preceding brain cancer diagnosis.

Scott SE, Penfold C, Saji S, Curtis S, Watts C, Hamilton W, Joannides AJ, Walter FM.

PLoS One. 2019 Mar 22;14(3):e0213599. doi: 10.1371/journal.pone.0213599. eCollection 2019.


Missed opportunities for diagnosing brain tumours in primary care: a qualitative study of patient experiences.

Walter FM, Penfold C, Joannides A, Saji S, Johnson M, Watts C, Brodbelt A, Jenkinson MD, Price SJ, Hamilton W, Scott SE.

Br J Gen Pract. 2019 Apr;69(681):e224-e235. doi: 10.3399/bjgp19X701861. Epub 2019 Mar 11.


Dietary behaviors and survival in people with head and neck cancer: Results from Head and Neck 5000.

Lang S, Schimansky S, Beynon R, Penfold C, Davies A, Waylen A, Thomas S, Pring M, Pawlita M, Waterboer T, Ness AR.

Head Neck. 2019 Jul;41(7):2074-2084. doi: 10.1002/hed.25660. Epub 2019 Jan 30.


Competition in Biofilms between Cystic Fibrosis Isolates of Pseudomonas aeruginosa Is Shaped by R-Pyocins.

Oluyombo O, Penfold CN, Diggle SP.

mBio. 2019 Jan 29;10(1). pii: e01828-18. doi: 10.1128/mBio.01828-18.


Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000.

Schimansky S, Lang S, Beynon R, Penfold C, Davies A, Waylen A, Thomas S, Pring M, Pawlita M, Waterboer T, Ness A.

Head Neck. 2019 Apr;41(4):1053-1062. doi: 10.1002/hed.25543. Epub 2018 Dec 14.


Inferring Gene Regulatory Networks from Multiple Datasets.

Penfold CA, Gherman I, Sybirna A, Wild DL.

Methods Mol Biol. 2019;1883:251-282. doi: 10.1007/978-1-4939-8882-2_11. Review.


Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function.

Buchan SL, Dou L, Remer M, Booth SG, Dunn SN, Lai C, Semmrich M, Teige I, Mårtensson L, Penfold CA, Chan HTC, Willoughby JE, Mockridge CI, Dahal LN, Cleary KLS, James S, Rogel A, Kannisto P, Jernetz M, Williams EL, Healy E, Verbeek JS, Johnson PWM, Frendéus B, Cragg MS, Glennie MJ, Gray JC, Al-Shamkhani A, Beers SA.

Immunity. 2018 Nov 20;49(5):958-970.e7. doi: 10.1016/j.immuni.2018.09.014. Epub 2018 Nov 13.


Branch-recombinant Gaussian processes for analysis of perturbations in biological time series.

Penfold CA, Sybirna A, Reid JE, Huang Y, Wernisch L, Ghahramani Z, Grant M, Surani MA.

Bioinformatics. 2018 Sep 1;34(17):i1005-i1013. doi: 10.1093/bioinformatics/bty603.


Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications.

Herbert G, Perry R, Andersen HK, Atkinson C, Penfold C, Lewis SJ, Ness AR, Thomas S.

Cochrane Database Syst Rev. 2018 Oct 24;10:CD004080. doi: 10.1002/14651858.CD004080.pub3. Update in: Cochrane Database Syst Rev. 2019 Jul 22;7:CD004080.


DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival.

Ambatipudi S, Langdon R, Richmond RC, Suderman M, Koestler DC, Kelsey KT, Kazmi N, Penfold C, Ho KM, McArdle W, Ring SM, Pring M, Waterboer T, Pawlita M, Gaunt TR, Davey Smith G, Thomas S, Ness AR, Relton CL.

Oral Oncol. 2018 Oct;85:87-94. doi: 10.1016/j.oraloncology.2018.08.021. Epub 2018 Sep 5.


Depressive symptoms in relation to overall survival in people with head and neck cancer: A longitudinal cohort study.

Jansen F, Verdonck-de Leeuw IM, Cuijpers P, Leemans CR, Waterboer T, Pawlita M, Penfold C, Thomas SJ, Waylen A, Ness AR.

Psychooncology. 2018 Sep;27(9):2245-2256. doi: 10.1002/pon.4816. Epub 2018 Jul 23.


The changing aetiology of head and neck squamous cell cancer: A tale of three cancers?

Thomas SJ, Penfold CM, Waylen A, Ness AR.

Clin Otolaryngol. 2018 May 16. doi: 10.1111/coa.13144. [Epub ahead of print] No abstract available.


Comparative transcriptome analysis in Arabidopsis ein2/ore3 and ahk3/ore12 mutants during dark-induced leaf senescence.

Kim J, Park SJ, Lee IH, Chu H, Penfold CA, Kim JH, Buchanan-Wollaston V, Nam HG, Woo HR, Lim PO.

J Exp Bot. 2018 May 25;69(12):3023-3036. doi: 10.1093/jxb/ery137.


Tobacco smoking and alcohol drinking at diagnosis of head and neck cancer and all-cause mortality: Results from head and neck 5000, a prospective observational cohort of people with head and neck cancer.

Beynon RA, Lang S, Schimansky S, Penfold CM, Waylen A, Thomas SJ, Pawlita M, Waterboer T, Martin RM, May M, Ness AR.

Int J Cancer. 2018 Sep 1;143(5):1114-1127. doi: 10.1002/ijc.31416. Epub 2018 Apr 23.


Systematic review evaluating randomized controlled trials of smoking and alcohol cessation interventions in people with head and neck cancer and oral dysplasia.

Shingler E, Robles LA, Perry R, Penfold C, Ness AR, Thomas S, Lane JA, Martin RM.

Head Neck. 2018 Aug;40(8):1845-1853. doi: 10.1002/hed.25138. Epub 2018 Mar 30.


Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.

Yu X, Chan HTC, Orr CM, Dadas O, Booth SG, Dahal LN, Penfold CA, O'Brien L, Mockridge CI, French RR, Duriez P, Douglas LR, Pearson AR, Cragg MS, Tews I, Glennie MJ, White AL.

Cancer Cell. 2018 Apr 9;33(4):664-675.e4. doi: 10.1016/j.ccell.2018.02.009. Epub 2018 Mar 22.


PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.

Buchan SL, Fallatah M, Thirdborough SM, Taraban VY, Rogel A, Thomas LJ, Penfold CA, He LZ, Curran MA, Keler T, Al-Shamkhani A.

Clin Cancer Res. 2018 May 15;24(10):2383-2394. doi: 10.1158/1078-0432.CCR-17-3057. Epub 2018 Mar 7.


Change in alcohol and tobacco consumption after a diagnosis of head and neck cancer: Findings from Head and Neck 5000.

Penfold CM, Thomas SJ, Waylen A, Ness AR.

Head Neck. 2018 Jul;40(7):1389-1399. doi: 10.1002/hed.25116. Epub 2018 Feb 27.


Can Quantab titrator sticks reliably predict urinary sodium?

Hamilton FW, Penfold CM, Ness AR, Stevenson KP, Atkinson C, Day AM, Sebepos-Rogers GM, Tyrrell-Price J.

Clin Nutr ESPEN. 2018 Feb;23:217-221. doi: 10.1016/j.clnesp.2017.09.011. Epub 2017 Oct 31.


Augmentation of CD134 (OX40)-dependent NK anti-tumour activity is dependent on antibody cross-linking.

Turaj AH, Cox KL, Penfold CA, French RR, Mockridge CI, Willoughby JE, Tutt AL, Griffiths J, Johnson PWM, Glennie MJ, Levy R, Cragg MS, Lim SH.

Sci Rep. 2018 Feb 2;8(1):2278. doi: 10.1038/s41598-018-20656-y.


Validation of the English Version of the 14-Item Mediterranean Diet Adherence Screener of the PREDIMED Study, in People at High Cardiovascular Risk in the UK.

Papadaki A, Johnson L, Toumpakari Z, England C, Rai M, Toms S, Penfold C, Zazpe I, Martínez-González MA, Feder G.

Nutrients. 2018 Jan 28;10(2). pii: E138. doi: 10.3390/nu10020138.


Finding a solution: Heparinised saline versus normal saline in the maintenance of invasive arterial lines in intensive care.

Everson M, Webber L, Penfold C, Shah S, Freshwater-Turner D.

J Intensive Care Soc. 2016 Nov;17(4):284-289. doi: 10.1177/1751143716653763. Epub 2016 Jun 21.


The Effectiveness of Green Tea or Green Tea Extract on Insulin Resistance and Glycemic Control in Type 2 Diabetes Mellitus: A Meta-Analysis.

Yu J, Song P, Perry R, Penfold C, Cooper AR.

Diabetes Metab J. 2017 Aug;41(4):251-262. doi: 10.4093/dmj.2017.41.4.251. Review.


Tobacco and alcohol cessation or reduction interventions in people with oral dysplasia and head and neck cancer: systematic review protocol.

Shingler E, Robles LA, Perry R, Penfold C, Ness A, Thomas S, Athene Lane J, Martin RM.

Syst Rev. 2017 Aug 10;6(1):161. doi: 10.1186/s13643-017-0555-y.


Diagnosing adult primary brain tumours: can we do better?

Penfold C, Joannides AJ, Bell J, Walter FM.

Br J Gen Pract. 2017 Jun;67(659):278-279. doi: 10.3399/bjgp17X691277. No abstract available.


Nursing work and sensory experiences of hospital design: A before and after qualitative study following a move to all-single room inpatient accommodation.

Donetto S, Penfold C, Anderson J, Robert G, Maben J.

Health Place. 2017 Jul;46:121-129. doi: 10.1016/j.healthplace.2017.05.001. Epub 2017 May 17.


An overview of systematic reviews of complementary and alternative therapies for fibromyalgia using both AMSTAR and ROBIS as quality assessment tools.

Perry R, Leach V, Davies P, Penfold C, Ness A, Churchill R.

Syst Rev. 2017 May 15;6(1):97. doi: 10.1186/s13643-017-0487-6. Review.


Recommendation to test limonene hydroperoxides 0·3% and linalool hydroperoxides 1·0% in the British baseline patch test series.

Wlodek C, Penfold CM, Bourke JF, Chowdhury MMU, Cooper SM, Ghaffar S, Green C, Holden CR, Johnston GA, Mughal AA, Reckling C, Sabroe RA, Stone NM, Thompson D, Wilkinson SM, Buckley DA.

Br J Dermatol. 2017 Dec;177(6):1708-1715. doi: 10.1111/bjd.15648. Epub 2017 Nov 16.


Six key topics informal carers of patients with breathlessness in advanced disease want to learn about and why: MRC phase I study to inform an educational intervention.

Farquhar M, Penfold C, Benson J, Lovick R, Mahadeva R, Howson S, Burkin J, Booth S, Gilligan D, Todd C, Ewing G.

PLoS One. 2017 May 5;12(5):e0177081. doi: 10.1371/journal.pone.0177081. eCollection 2017.


Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition.

Huang Y, Kim JK, Do DV, Lee C, Penfold CA, Zylicz JJ, Marioni JC, Hackett JA, Surani MA.

Elife. 2017 Mar 21;6. pii: e22345. doi: 10.7554/eLife.22345.


Clinicians' Views of Educational Interventions for Carers of Patients With Breathlessness Due to Advanced Disease: Findings From an Online Survey.

Ewing G, Penfold C, Benson JA, Mahadeva R, Howson S, Burkin J, Booth S, Lovick R, Gilligan D, Todd C, Farquhar M.

J Pain Symptom Manage. 2017 Feb;53(2):265-271. doi: 10.1016/j.jpainsymman.2016.08.015. Epub 2016 Oct 8.


What change in body mass index is needed to improve metabolic health status in childhood obesity: protocol for a systematic review.

Birch L, Perry R, Penfold C, Beynon R, Hamilton-Shield J.

Syst Rev. 2016 Jul 26;5(1):120. doi: 10.1186/s13643-016-0299-0.


Inferring the perturbation time from biological time course data.

Yang J, Penfold CA, Grant MR, Rattray M.

Bioinformatics. 2016 Oct 1;32(19):2956-64. doi: 10.1093/bioinformatics/btw329. Epub 2016 Jun 10.


Randomized clinical trial of postoperative chewing gum versus standard care after colorectal resection.

Atkinson C, Penfold CM, Ness AR, Longman RJ, Thomas SJ, Hollingworth W, Kandiyali R, Leary SD, Lewis SJ.

Br J Surg. 2016 Jul;103(8):962-70. doi: 10.1002/bjs.10194. Epub 2016 May 5.


What Are the Key Elements of Educational Interventions for Lay Carers of Patients With Advanced Disease? A Systematic Literature Search and Narrative Review of Structural Components, Processes and Modes of Delivery.

Farquhar M, Penfold C, Walter FM, Kuhn I, Benson J.

J Pain Symptom Manage. 2016 Jul;52(1):117-130.e27. doi: 10.1016/j.jpainsymman.2015.12.341. Epub 2016 Apr 23. Review.


Prostate cancer - evidence of exercise and nutrition trial (PrEvENT): study protocol for a randomised controlled feasibility trial.

Hackshaw-McGeagh L, Lane JA, Persad R, Gillatt D, Holly JM, Koupparis A, Rowe E, Johnston L, Cloete J, Shiridzinomwa C, Abrams P, Penfold CM, Bahl A, Oxley J, Perks CM, Martin R.

Trials. 2016 Mar 7;17(1):123. doi: 10.1186/s13063-016-1248-x.


Time-Series Transcriptomics Reveals That AGAMOUS-LIKE22 Affects Primary Metabolism and Developmental Processes in Drought-Stressed Arabidopsis.

Bechtold U, Penfold CA, Jenkins DJ, Legaie R, Moore JD, Lawson T, Matthews JS, Vialet-Chabrand SR, Baxter L, Subramaniam S, Hickman R, Florance H, Sambles C, Salmon DL, Feil R, Bowden L, Hill C, Baker NR, Lunn JE, Finkenstädt B, Mead A, Buchanan-Wollaston V, Beynon J, Rand DA, Wild DL, Denby KJ, Ott S, Smirnoff N, Mullineaux PM.

Plant Cell. 2016 Feb;28(2):345-66. doi: 10.1105/tpc.15.00910. Epub 2016 Feb 3.


Osteoarthritis prevalence and modifiable factors: a population study.

Plotnikoff R, Karunamuni N, Lytvyak E, Penfold C, Schopflocher D, Imayama I, Johnson ST, Raine K.

BMC Public Health. 2015 Nov 30;15:1195. doi: 10.1186/s12889-015-2529-0.


Transcriptional Dynamics Driving MAMP-Triggered Immunity and Pathogen Effector-Mediated Immunosuppression in Arabidopsis Leaves Following Infection with Pseudomonas syringae pv tomato DC3000.

Lewis LA, Polanski K, de Torres-Zabala M, Jayaraman S, Bowden L, Moore J, Penfold CA, Jenkins DJ, Hill C, Baxter L, Kulasekaran S, Truman W, Littlejohn G, Prusinska J, Mead A, Steinbrenner J, Hickman R, Rand D, Wild DL, Ott S, Buchanan-Wollaston V, Smirnoff N, Beynon J, Denby K, Grant M.

Plant Cell. 2015 Nov;27(11):3038-64. doi: 10.1105/tpc.15.00471. Epub 2015 Nov 13.


Development and Characterization of Monoclonal Antibodies Specific for Mouse and Human Fcγ Receptors.

Tutt AL, James S, Laversin SA, Tipton TR, Ashton-Key M, French RR, Hussain K, Vaughan AT, Dou L, Earley A, Dahal LN, Lu C, Dunscombe M, Chan HT, Penfold CA, Kim JH, Potter EA, Mockridge CI, Roghanian A, Oldham RJ, Cox KL, Lim SH, Teige I, Frendéus B, Glennie MJ, Beers SA, Cragg MS.

J Immunol. 2015 Dec 1;195(11):5503-16. doi: 10.4049/jimmunol.1402988. Epub 2015 Oct 28.


Recruitment, response rates and characteristics of 5511 people enrolled in a prospective clinical cohort study: head and neck 5000.

Ness AR, Waylen A, Hurley K, Jeffreys M, Penfold C, Pring M, Leary SD, Allmark C, Toms S, Ring S, Peters TJ, Hollingworth W, Worthington H, Nutting C, Fisher S, Rogers SN, Thomas SJ; Head and Neck 5000 Study Team.

Clin Otolaryngol. 2016 Dec;41(6):804-809. doi: 10.1111/coa.12548. Epub 2016 Feb 8. No abstract available.


One size fits all? Mixed methods evaluation of the impact of 100% single-room accommodation on staff and patient experience, safety and costs.

Maben J, Griffiths P, Penfold C, Simon M, Anderson JE, Robert G, Pizzo E, Hughes J, Murrells T, Barlow J.

BMJ Qual Saf. 2016 Apr;25(4):241-56. doi: 10.1136/bmjqs-2015-004265. Epub 2015 Sep 25.


Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies.

Rogers PJ, Hogenkamp PS, de Graaf C, Higgs S, Lluch A, Ness AR, Penfold C, Perry R, Putz P, Yeomans MR, Mela DJ.

Int J Obes (Lond). 2016 Mar;40(3):381-94. doi: 10.1038/ijo.2015.177. Epub 2015 Sep 14. Review.


Inferring orthologous gene regulatory networks using interspecies data fusion.

Penfold CA, Millar JB, Wild DL.

Bioinformatics. 2015 Jun 15;31(12):i97-105. doi: 10.1093/bioinformatics/btv267.

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