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Items: 46


Theranostics and metabolotheranostics for precision medicine in oncology.

Bhujwalla ZM, Kakkad S, Chen Z, Jin J, Hapuarachchige S, Artemov D, Penet MF.

J Magn Reson. 2018 Jun;291:141-151. doi: 10.1016/j.jmr.2018.03.004. Epub 2018 Apr 26.


Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft.

Bharti SK, Mironchik Y, Wildes F, Penet MF, Goggins E, Krishnamachary B, Bhujwalla ZM.

Oncotarget. 2018 Feb 24;9(20):15326-15339. doi: 10.18632/oncotarget.24569. eCollection 2018 Mar 16.


A novel multiple biomarker panel for the early detection of high-grade serous ovarian carcinoma.

Han C, Bellone S, Siegel ER, Altwerger G, Menderes G, Bonazzoli E, Egawa-Takata T, Pettinella F, Bianchi A, Riccio F, Zammataro L, Yadav G, Marto JA, Penet MF, Levine DA, Drapkin R, Patel A, Litkouhi B, Ratner E, Silasi DA, Huang GS, Azodi M, Schwartz PE, Santin AD.

Gynecol Oncol. 2018 Jun;149(3):585-591. doi: 10.1016/j.ygyno.2018.03.050. Epub 2018 Mar 21.


Metabolomic characterization of experimental ovarian cancer ascitic fluid.

Bharti SK, Wildes F, Hung CF, Wu TC, Bhujwalla ZM, Penet MF.

Metabolomics. 2017 Oct;13. pii: 113. doi: 10.1007/s11306-017-1254-3. Epub 2017 Aug 24.


Acid-degradable Dextran as an Image Guided siRNA Carrier for COX-2 Downregulation.

Chen Z, Krishnamachary B, Penet MF, Bhujwalla ZM.

Theranostics. 2018 Jan 1;8(1):1-12. doi: 10.7150/thno.21052. eCollection 2018.


Manual Closed-Loop Insulin Delivery Using a Saddle Point Model Predictive Control Algorithm: Results of a Crossover Randomized Overnight Study.

Guilhem I, Penet M, Paillard A, Carpentier M, Esvant A, Lefebvre MA, Poirier JY.

J Diabetes Sci Technol. 2017 Sep;11(5):1007-1014. doi: 10.1177/1932296817717503. Epub 2017 Jul 5.


Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts.

Krishnamachary B, Stasinopoulos I, Kakkad S, Penet MF, Jacob D, Wildes F, Mironchik Y, Pathak AP, Solaiyappan M, Bhujwalla ZM.

Oncotarget. 2017 Mar 14;8(11):17981-17994. doi: 10.18632/oncotarget.14912.


Microglia activation in a pediatric rabbit model of tuberculous meningitis.

Tucker EW, Pokkali S, Zhang Z, DeMarco VP, Klunk M, Smith ES, Ordonez AA, Penet MF, Bhujwalla Z, Jain SK, Kannan S.

Dis Model Mech. 2016 Dec 1;9(12):1497-1506.


Effect of Pantethine on Ovarian Tumor Progression and Choline Metabolism.

Penet MF, Krishnamachary B, Wildes F, Mironchik Y, Mezzanzanica D, Podo F, de Reggi M, Gharib B, Bhujwalla ZM.

Front Oncol. 2016 Nov 16;6:244. eCollection 2016.


Structure and Function of a Prostate Cancer Dissemination-Permissive Extracellular Matrix.

Penet MF, Kakkad S, Pathak AP, Krishnamachary B, Mironchik Y, Raman V, Solaiyappan M, Bhujwalla ZM.

Clin Cancer Res. 2017 May 1;23(9):2245-2254. doi: 10.1158/1078-0432.CCR-16-1516. Epub 2016 Oct 31.


Magnetic Resonance Imaging and Spectroscopy in Cancer Theranostic Imaging.

Penet MF, Jin J, Chen Z, Bhujwalla ZM.

Top Magn Reson Imaging. 2016 Oct;25(5):215-221. Review.


Detection of Pancreatic Cancer-Induced Cachexia Using a Fluorescent Myoblast Reporter System and Analysis of Metabolite Abundance.

Winnard PT Jr, Bharti SK, Penet MF, Marik R, Mironchik Y, Wildes F, Maitra A, Bhujwalla ZM.

Cancer Res. 2016 Mar 15;76(6):1441-50. doi: 10.1158/0008-5472.CAN-15-1740. Epub 2015 Dec 30.


PSMA-specific theranostic nanoplex for combination of TRAIL gene and 5-FC prodrug therapy of prostate cancer.

Chen Z, Penet MF, Krishnamachary B, Banerjee SR, Pomper MG, Bhujwalla ZM.

Biomaterials. 2016 Feb;80:57-67. doi: 10.1016/j.biomaterials.2015.11.048. Epub 2015 Dec 2.


Magnetic Resonance Spectroscopy of siRNA-Based Cancer Therapy.

Penet MF, Chen Z, Mori N, Krishnamachary B, Bhujwalla ZM.

Methods Mol Biol. 2016;1372:37-47. doi: 10.1007/978-1-4939-3148-4_3.


Choline metabolism-based molecular diagnosis of cancer: an update.

Glunde K, Penet MF, Jiang L, Jacobs MA, Bhujwalla ZM.

Expert Rev Mol Diagn. 2015 Jun;15(6):735-47. doi: 10.1586/14737159.2015.1039515. Epub 2015 Apr 28. Review.


Cancer cachexia, recent advances, and future directions.

Penet MF, Bhujwalla ZM.

Cancer J. 2015 Mar-Apr;21(2):117-22. doi: 10.1097/PPO.0000000000000100. Review.


A biomimetic collagen derived peptide exhibits anti-angiogenic activity in triple negative breast cancer.

Rosca EV, Penet MF, Mori N, Koskimaki JE, Lee E, Pandey NB, Bhujwalla ZM, Popel AS.

PLoS One. 2014 Nov 10;9(11):e111901. doi: 10.1371/journal.pone.0111901. eCollection 2014.


Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism.

Penet MF, Shah T, Bharti S, Krishnamachary B, Artemov D, Mironchik Y, Wildes F, Maitra A, Bhujwalla ZM.

Clin Cancer Res. 2015 Jan 15;21(2):386-95. doi: 10.1158/1078-0432.CCR-14-0964. Epub 2014 Nov 4.


Molecular imaging of the tumor microenvironment for precision medicine and theranostics.

Penet MF, Krishnamachary B, Chen Z, Jin J, Bhujwalla ZM.

Adv Cancer Res. 2014;124:235-56. doi: 10.1016/B978-0-12-411638-2.00007-0. Review.


Hypoxic tumor environments exhibit disrupted collagen I fibers and low macromolecular transport.

Kakkad SM, Penet MF, Akhbardeh A, Pathak AP, Solaiyappan M, Raman V, Leibfritz D, Glunde K, Bhujwalla ZM.

PLoS One. 2013 Dec 12;8(12):e81869. doi: 10.1371/journal.pone.0081869. eCollection 2013.


MR - eyes for cancer: looking within an impenetrable disease.

Penet MF, Artemov D, Farahani K, Bhujwalla ZM.

NMR Biomed. 2013 Jul;26(7):745-55. doi: 10.1002/nbm.2980. Review.


Theranostic imaging of cancer.

Penet MF, Chen Z, Kakkad S, Pomper MG, Bhujwalla ZM.

Eur J Radiol. 2012 Sep;81 Suppl 1:S124-6. doi: 10.1016/S0720-048X(12)70051-7. No abstract available.


COX-2 in cancer: Gordian knot or Achilles heel?

Stasinopoulos I, Shah T, Penet MF, Krishnamachary B, Bhujwalla ZM.

Front Pharmacol. 2013 Mar 28;4:34. doi: 10.3389/fphar.2013.00034. eCollection 2013.


Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer.

Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM.

PLoS One. 2012;7(8):e44078. doi: 10.1371/journal.pone.0044078. Epub 2012 Aug 28.


PSMA-targeted theranostic nanoplex for prostate cancer therapy.

Chen Z, Penet MF, Nimmagadda S, Li C, Banerjee SR, Winnard PT Jr, Artemov D, Glunde K, Pomper MG, Bhujwalla ZM.

ACS Nano. 2012 Sep 25;6(9):7752-7762. doi: 10.1021/nn301725w. Epub 2012 Aug 9.


Prodrug enzymes and their applications in image-guided therapy of cancer: tracking prodrug enzymes to minimize collateral damage.

Penet MF, Chen Z, Li C, Winnard PT Jr, Bhujwalla ZM.

Drug Deliv Transl Res. 2012 Feb 1;2(1):22-30. doi: 10.1007/s13346-011-0052-0.


MRI of metastasis-permissive microenvironments.

Penet MF, Chen Z, Bhujwalla ZM.

Future Oncol. 2011 Nov;7(11):1269-84. doi: 10.2217/fon.11.114. Review.


Understanding cancer-induced cachexia: imaging the flame and its fuel.

Penet MF, Winnard PT Jr, Jacobs MA, Bhujwalla ZM.

Curr Opin Support Palliat Care. 2011 Dec;5(4):327-33. doi: 10.1097/SPC.0b013e32834c49ba. Review.


Metabolic signatures imaged in cancer-induced cachexia.

Penet MF, Gadiya MM, Krishnamachary B, Nimmagadda S, Pomper MG, Artemov D, Bhujwalla ZM.

Cancer Res. 2011 Nov 15;71(22):6948-56. doi: 10.1158/0008-5472.CAN-11-1095. Epub 2011 Sep 26.


Exploiting the tumor microenvironment for theranostic imaging.

Stasinopoulos I, Penet MF, Chen Z, Kakkad S, Glunde K, Bhujwalla ZM.

NMR Biomed. 2011 Jul;24(6):636-47. doi: 10.1002/nbm.1664. Epub 2011 Jan 28. Review.


The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway.

Jin K, Kong X, Shah T, Penet MF, Wildes F, Sgroi DC, Ma XJ, Huang Y, Kallioniemi A, Landberg G, Bieche I, Wu X, Lobie PE, Davidson NE, Bhujwalla ZM, Zhu T, Sukumar S.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2736-41. doi: 10.1073/pnas.1018859108. Epub 2011 Jun 20.


Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy.

Li C, Penet MF, Wildes F, Takagi T, Chen Z, Winnard PT, Artemov D, Bhujwalla ZM.

ACS Nano. 2010 Nov 23;4(11):6707-16. doi: 10.1021/nn102187v. Epub 2010 Oct 19.


MR molecular imaging of tumor vasculature and vascular targets.

Pathak AP, Penet MF, Bhujwalla ZM.

Adv Genet. 2010;69:1-30. doi: 10.1016/S0065-2660(10)69010-4. Review.


Applications of molecular MRI and optical imaging in cancer.

Penet MF, Mikhaylova M, Li C, Krishnamachary B, Glunde K, Pathak AP, Bhujwalla ZM.

Future Med Chem. 2010 Jun;2(6):975-88. Review.


Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells.

Shah T, Wildes F, Penet MF, Winnard PT Jr, Glunde K, Artemov D, Ackerstaff E, Gimi B, Kakkad S, Raman V, Bhujwalla ZM.

NMR Biomed. 2010 Jul;23(6):633-42. doi: 10.1002/nbm.1510.


Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer.

Glunde K, Artemov D, Penet MF, Jacobs MA, Bhujwalla ZM.

Chem Rev. 2010 May 12;110(5):3043-59. doi: 10.1021/cr9004007. Review. No abstract available.


Molecular and functional imaging of invasion and metastasis: windows into the metastatic cascade.

Stasinopoulos I, Penet MF, Krishnamachary B, Bhujwalla ZM.

Cancer Biomark. 2010;7(4):173-88. doi: 10.3233/CBM-2010-0188.


Noninvasive multiparametric imaging of metastasis-permissive microenvironments in a human prostate cancer xenograft.

Penet MF, Pathak AP, Raman V, Ballesteros P, Artemov D, Bhujwalla ZM.

Cancer Res. 2009 Nov 15;69(22):8822-9. doi: 10.1158/0008-5472.CAN-09-1782. Epub 2009 Oct 27.


Conjugation of poly-L-lysine to bacterial cytosine deaminase improves the efficacy of enzyme/prodrug cancer therapy.

Li C, Wildes F, Winnard P Jr, Artemov D, Penet MF, Bhujwalla ZM.

J Med Chem. 2008 Jun 26;51(12):3572-82. doi: 10.1021/jm800288h. Epub 2008 Jun 3.


Molecular and functional MRI of the tumor microenvironment.

Penet MF, Glunde K, Jacobs MA, Pathak AP, Bhujwalla ZM.

J Nucl Med. 2008 May;49(5):687-90. doi: 10.2967/jnumed.107.043349. Epub 2008 Apr 15. Review. No abstract available.


Image-guided enzyme/prodrug cancer therapy.

Li C, Penet MF, Winnard P Jr, Artemov D, Bhujwalla ZM.

Clin Cancer Res. 2008 Jan 15;14(2):515-22. doi: 10.1158/1078-0432.CCR-07-1837.


Protection against cerebral malaria by the low-molecular-weight thiol pantethine.

Penet MF, Abou-Hamdan M, Coltel N, Cornille E, Grau GE, de Reggi M, Gharib B.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1321-6. doi: 10.1073/pnas.0706867105. Epub 2008 Jan 14.


Magnetic resonance spectroscopy reveals an impaired brain metabolic profile in mice resistant to cerebral malaria infected with Plasmodium berghei ANKA.

Penet MF, Kober F, Confort-Gouny S, Le Fur Y, Dalmasso C, Coltel N, Liprandi A, Gulian JM, Grau GE, Cozzone PJ, Viola A.

J Biol Chem. 2007 May 11;282(19):14505-14. Epub 2007 Mar 15.


In vivo characterization of brain morphometric and metabolic endophenotypes in three inbred strains of mice using magnetic resonance techniques.

Penet MF, Laigle C, Fur YL, Confort-Gouny S, Heurteaux C, Cozzone PJ, Viola A.

Behav Genet. 2006 Sep;36(5):732-44.


Imaging experimental cerebral malaria in vivo: significant role of ischemic brain edema.

Penet MF, Viola A, Confort-Gouny S, Le Fur Y, Duhamel G, Kober F, Ibarrola D, Izquierdo M, Coltel N, Gharib B, Grau GE, Cozzone PJ.

J Neurosci. 2005 Aug 10;25(32):7352-8.


Vanin-1(-/-) mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher glutathione stores.

Martin F, Penet MF, Malergue F, Lepidi H, Dessein A, Galland F, de Reggi M, Naquet P, Gharib B.

J Clin Invest. 2004 Feb;113(4):591-7.

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