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Correction: ABL kinase inhibition sensitizes primary lung adenocarcinomas to chemotherapy by promoting tumor cell differentiation.

Khatri A, Gu JJ, McKernan CM, Xu X, Pendergast AM.

Oncotarget. 2019 Oct 15;10(57):6045-6046. doi: 10.18632/oncotarget.27258. eCollection 2019 Oct 15.


The Evolving Modern Management of Brain Metastasis.

Fecci PE, Champion CD, Hoj J, McKernan CM, Goodwin CR, Kirkpatrick JP, Anders CK, Pendergast AM, Sampson JH.

Clin Cancer Res. 2019 Nov 15;25(22):6570-6580. doi: 10.1158/1078-0432.CCR-18-1624. Epub 2019 Jun 18. Review.


ABL kinase inhibition sensitizes primary lung adenocarcinomas to chemotherapy by promoting tumor cell differentiation.

Khatri A, Gu JJ, McKernan CM, Xu X, Pendergast AM.

Oncotarget. 2019 Mar 8;10(20):1874-1886. doi: 10.18632/oncotarget.26740. eCollection 2019 Mar 8. Erratum in: Oncotarget. 2019 Oct 15;10(57):6045-6046.


ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia.

Khatri A, Kraft BD, Tata PR, Randell SH, Piantadosi CA, Pendergast AM.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1603-1612. doi: 10.1073/pnas.1816030116. Epub 2019 Jan 17.


Inactivation of ABL kinases suppresses non-small cell lung cancer metastasis.

Gu JJ, Rouse C, Xu X, Wang J, Onaitis MW, Pendergast AM.

JCI Insight. 2016 Dec 22;1(21):e89647. doi: 10.1172/jci.insight.89647.


Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.

Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, Moran MF, Grynpas MD, Wrana JL, Superti-Furga G, Koleske AJ, Pendergast AM, Rottapel R.

J Clin Invest. 2016 Dec 1;126(12):4482-4496. doi: 10.1172/JCI87802. Epub 2016 Oct 31.


ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling.

Wang J, Rouse C, Jasper JS, Pendergast AM.

Sci Signal. 2016 Feb 2;9(413):ra12. doi: 10.1126/scisignal.aad3210.


Multifunctional Abl kinases in health and disease.

Khatri A, Wang J, Pendergast AM.

J Cell Sci. 2016 Jan 1;129(1):9-16. doi: 10.1242/jcs.175521. Review.


The Emerging Role of ABL Kinases in Solid Tumors.

Wang J, Pendergast AM.

Trends Cancer. 2015 Oct 1;1(2):110-123.


Abl Kinases Regulate HGF/Met Signaling Required for Epithelial Cell Scattering, Tubulogenesis and Motility.

Li R, Knight JF, Park M, Pendergast AM.

PLoS One. 2015 May 6;10(5):e0124960. doi: 10.1371/journal.pone.0124960. eCollection 2015.


ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.

Trampont PC, Zhang L, Giles AJ, Walk SF, Gu JJ, Pendergast AM, Ravichandran KS.

Mol Cell Biol. 2015 Apr;35(8):1462-76. doi: 10.1128/MCB.01084-14. Epub 2015 Feb 17.


Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.

Sourbier C, Ricketts CJ, Matsumoto S, Crooks DR, Liao PJ, Mannes PZ, Yang Y, Wei MH, Srivastava G, Ghosh S, Chen V, Vocke CD, Merino M, Srinivasan R, Krishna MC, Mitchell JB, Pendergast AM, Rouault TA, Neckers L, Linehan WM.

Cancer Cell. 2014 Dec 8;26(6):840-850. doi: 10.1016/j.ccell.2014.10.005.


Abl family kinases regulate endothelial barrier function in vitro and in mice.

Chislock EM, Pendergast AM.

PLoS One. 2013 Dec 19;8(12):e85231. doi: 10.1371/journal.pone.0085231. eCollection 2013.


Tie2 (to) Abl: Signaling to endothelial cell survival.

Chislock EM, Pendergast AM.

Cell Cycle. 2013 Dec 15;12(24):3709-10. doi: 10.4161/cc.26877. Epub 2013 Oct 21. No abstract available.


Role of ABL family kinases in cancer: from leukaemia to solid tumours.

Greuber EK, Smith-Pearson P, Wang J, Pendergast AM.

Nat Rev Cancer. 2013 Aug;13(8):559-71. doi: 10.1038/nrc3563. Epub 2013 Jul 11. Review.


Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival.

Chislock EM, Ring C, Pendergast AM.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12432-7. doi: 10.1073/pnas.1304188110. Epub 2013 Jul 9.


Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.

Greuber EK, Pendergast AM.

J Immunol. 2012 Dec 1;189(11):5382-92. doi: 10.4049/jimmunol.1200974. Epub 2012 Oct 24.


Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1.

Gu JJ, Lavau CP, Pugacheva E, Soderblom EJ, Moseley MA, Pendergast AM.

Sci Signal. 2012 Jul 17;5(233):ra51. doi: 10.1126/scisignal.2002632.


Arg kinase regulates epithelial cell polarity by targeting β1-integrin and small GTPase pathways.

Li R, Pendergast AM.

Curr Biol. 2011 Sep 27;21(18):1534-42. doi: 10.1016/j.cub.2011.08.023. Epub 2011 Sep 8.


Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.

Ring C, Ginsberg MH, Haling J, Pendergast AM.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):149-54. doi: 10.1073/pnas.1012316108. Epub 2010 Dec 20.


Abl kinases are required for invadopodia formation and chemokine-induced invasion.

Smith-Pearson PS, Greuber EK, Yogalingam G, Pendergast AM.

J Biol Chem. 2010 Dec 17;285(51):40201-11. doi: 10.1074/jbc.M110.147330. Epub 2010 Oct 11.


Abl tyrosine kinases in T-cell signaling.

Gu JJ, Ryu JR, Pendergast AM.

Immunol Rev. 2009 Mar;228(1):170-83. doi: 10.1111/j.1600-065X.2008.00751.x. Review.


Regulation of cell-cell adhesion by Abi/Diaphanous complexes.

Ryu JR, Echarri A, Li R, Pendergast AM.

Mol Cell Biol. 2009 Apr;29(7):1735-48. doi: 10.1128/MCB.01483-08. Epub 2009 Jan 21.


Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.

Yogalingam G, Pendergast AM.

J Biol Chem. 2008 Dec 19;283(51):35941-53. doi: 10.1074/jbc.M804543200. Epub 2008 Oct 21.


Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment.

Augustine CK, Yoshimoto Y, Gupta M, Zipfel PA, Selim MA, Febbo P, Pendergast AM, Peters WP, Tyler DS.

Cancer Res. 2008 May 15;68(10):3777-84. doi: 10.1158/0008-5472.CAN-07-5949.


Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases.

Zandy NL, Pendergast AM.

Cell Cycle. 2008 Feb 15;7(4):444-8. Epub 2007 Dec 12. Review.


Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK.

Jung JH, Pendergast AM, Zipfel PA, Traugh JA.

Biochemistry. 2008 Jan 22;47(3):1094-104. Epub 2007 Dec 28.


Defective T cell development and function in the absence of Abelson kinases.

Gu JJ, Zhang N, He YW, Koleske AJ, Pendergast AM.

J Immunol. 2007 Dec 1;179(11):7334-43.


Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases.

Zandy NL, Playford M, Pendergast AM.

Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17686-91. Epub 2007 Oct 26.


Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis.

Tanos BE, Pendergast AM.

Cell Signal. 2007 Jul;19(7):1602-9. Epub 2007 Feb 22.


Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.

Tanos B, Pendergast AM.

J Biol Chem. 2006 Oct 27;281(43):32714-23. Epub 2006 Aug 29.


The Caenorhabditis elegans ABL-1 tyrosine kinase is required for Shigella flexneri pathogenesis.

Burton EA, Pendergast AM, Aballay A.

Appl Environ Microbiol. 2006 Jul;72(7):5043-51.


Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling.

Zipfel PA, Bunnell SC, Witherow DS, Gu JJ, Chislock EM, Ring C, Pendergast AM.

Curr Biol. 2006 Jan 10;16(1):35-46.


Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway.

Burton EA, Oliver TN, Pendergast AM.

Mol Cell Biol. 2005 Oct;25(20):8834-43.


Lower capillarization, VEGF protein, and VEGF mRNA response to acute exercise in the vastus lateralis muscle of aged vs. young women.

Croley AN, Zwetsloot KA, Westerkamp LM, Ryan NA, Pendergast AM, Hickner RC, Pofahl WE, Gavin TP.

J Appl Physiol (1985). 2005 Nov;99(5):1872-9. Epub 2005 Jul 14.


Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis.

Pendergast AM.

Nat Cell Biol. 2005 Mar;7(3):213-4. No abstract available.


ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory.

Grove M, Demyanenko G, Echarri A, Zipfel PA, Quiroz ME, Rodriguiz RM, Playford M, Martensen SA, Robinson MR, Wetsel WC, Maness PF, Pendergast AM.

Mol Cell Biol. 2004 Dec;24(24):10905-22.


Requirement for Abl kinases in T cell receptor signaling.

Zipfel PA, Zhang W, Quiroz M, Pendergast AM.

Curr Biol. 2004 Jul 27;14(14):1222-31.


Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.

Plattner R, Koleske AJ, Kazlauskas A, Pendergast AM.

Mol Cell Biol. 2004 Mar;24(6):2573-83.


Abl tyrosine kinases are required for infection by Shigella flexneri.

Burton EA, Plattner R, Pendergast AM.

EMBO J. 2003 Oct 15;22(20):5471-9. Erratum in: EMBO J. 2003 Nov 3;22(21):5962.


Activation and signaling of the Abl tyrosine kinase: bidirectional link with phosphoinositide signaling.

Plattner R, Pendergast AM.

Cell Cycle. 2003 Jul-Aug;2(4):273-4. Review. No abstract available.


Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction.

Finn AJ, Feng G, Pendergast AM.

Nat Neurosci. 2003 Jul;6(7):717-23.


A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.

Plattner R, Irvin BJ, Guo S, Blackburn K, Kazlauskas A, Abraham RT, York JD, Pendergast AM.

Nat Cell Biol. 2003 Apr;5(4):309-19. Erratum in: Nat Cell Biol. 2003 May;5(5):488.


The Abl family kinases: mechanisms of regulation and signaling.

Pendergast AM.

Adv Cancer Res. 2002;85:51-100. Review. No abstract available.


Bcr-Abl variants: biological and clinical aspects.

Advani AS, Pendergast AM.

Leuk Res. 2002 Aug;26(8):713-20. Review.


Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway.

Echarri A, Pendergast AM.

Curr Biol. 2001 Nov 13;11(22):1759-65.


The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.

Stradal T, Courtney KD, Rottner K, Hahne P, Small JV, Pendergast AM.

Curr Biol. 2001 Jun 5;11(11):891-5.


Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK.

Roig J, Tuazon PT, Zipfel PA, Pendergast AM, Traugh JA.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14346-51.

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