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Items: 32


TLR4 signaling improves PD-1 blockade therapy during chronic viral infection.

Wang Y, Chung YR, Eitzinger S, Palacio N, Gregory S, Bhattacharyya M, Penaloza-MacMaster P.

PLoS Pathog. 2019 Feb 6;15(2):e1007583. doi: 10.1371/journal.ppat.1007583. eCollection 2019 Feb.


Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy.

Badamchi-Zadeh A, Moynihan KD, Larocca RA, Aid M, Provine NM, Iampietro MJ, Kinnear E, Penaloza-MacMaster P, Abbink P, Blass E, Tregoning JS, Irvine DJ, Barouch DH.

J Immunol. 2018 Nov 1;201(9):2744-2752. doi: 10.4049/jimmunol.1800885. Epub 2018 Sep 24.


T-cell subset differentiation and antibody responses following antiretroviral therapy during simian immunodeficiency virus infection.

Bhattacharyya M, Whitney JB, Seaman M, Barouch DH, Penaloza-MacMaster P.

Immunology. 2018 Dec;155(4):458-466. doi: 10.1111/imm.12985. Epub 2018 Aug 14.


Dynamics of Lymphocyte Reconstitution After Hematopoietic Transplantation During Chronic Lymphocytic Choriomeningitis Virus Infection.

Bhattacharyya M, Penaloza-MacMaster P.

AIDS Res Hum Retroviruses. 2018 May;34(5):430-438. doi: 10.1089/AID.2017.0251. Epub 2018 Apr 18.


Adenovirus Vector Vaccination Impacts NK Cell Rheostat Function following Lymphocytic Choriomeningitis Virus Infection.

Blass E, Aid M, Martinot AJ, Larocca RA, Kang ZH, Badamchi-Zadeh A, Penaloza-MacMaster P, Reeves RK, Barouch DH.

J Virol. 2018 May 14;92(11). pii: e02103-17. doi: 10.1128/JVI.02103-17. Print 2018 Jun 1.


Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy.

Xu D, Robinson AP, Ishii T, Duncan DS, Alden TD, Goings GE, Ifergan I, Podojil JR, Penaloza-MacMaster P, Kearney JA, Swanson GT, Miller SD, Koh S.

J Exp Med. 2018 Apr 2;215(4):1169-1186. doi: 10.1084/jem.20171285. Epub 2018 Feb 27.


Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells.

Nakashima H, Alayo QA, Penaloza-MacMaster P, Freeman GJ, Kuchroo VK, Reardon DA, Fernandez S, Caligiuri M, Chiocca EA.

Sci Rep. 2018 Jan 9;8(1):208. doi: 10.1038/s41598-017-18540-2.


Novel Concepts for HIV Vaccine Vector Design.

Alayo QA, Provine NM, Penaloza-MacMaster P.

mSphere. 2017 Dec 6;2(6). pii: e00415-17. doi: 10.1128/mSphere.00415-17. eCollection 2017 Nov-Dec. Review.


Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection.

Bhattacharyya M, Madden P, Henning N, Gregory S, Aid M, Martinot AJ, Barouch DH, Penaloza-MacMaster P.

Immunology. 2017 Oct;152(2):328-343. doi: 10.1111/imm.12771. Epub 2017 Jul 14.


CD8 T-cell regulation by T regulatory cells and the programmed cell death protein 1 pathway.

Penaloza-MacMaster P.

Immunology. 2017 Jun;151(2):146-153. doi: 10.1111/imm.12739. Epub 2017 Apr 25. Review.


T regulatory cells are critical for the maintenance, anamnestic expansion and protection elicited by vaccine-induced CD8 T cells.

Bhattacharyya M, Penaloza-MacMaster P.

Immunology. 2017 Jul;151(3):340-348. doi: 10.1111/imm.12734. Epub 2017 Apr 18.


Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function.

Larocca RA, Provine NM, Aid M, Iampietro MJ, Borducchi EN, Badamchi-Zadeh A, Abbink P, Ng'ang'a D, Bricault CA, Blass E, Penaloza-MacMaster P, Stephenson KE, Barouch DH.

Sci Immunol. 2016 Nov;1(5). pii: eaaf7643. doi: 10.1126/sciimmunol.aaf7643. Epub 2016 Nov 4.


Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens.

Penaloza MacMaster P, Shields JL, Alayo QA, Cabral C, Jimenez J, Mondesir J, Chandrashekar A, Cabral JM, Lim M, Iampietro MJ, Provine NM, Bricault CA, Seaman M, Orlinger K, Aspoeck A, Fuhrmann G, Lilja AE, Monath T, Mangeat B, Pinschewer DD, Barouch DH.

Vaccine. 2017 Jan 3;35(1):1-9. doi: 10.1016/j.vaccine.2016.11.063. Epub 2016 Nov 26.


Inhibitory receptor expression on memory CD8 T cells following Ad vector immunization.

Penaloza-MacMaster P, Alayo QA, Ra J, Provine NM, Larocca R, Lee B, Barouch DH.

Vaccine. 2016 Sep 22;34(41):4955-4963. doi: 10.1016/j.vaccine.2016.08.048. Epub 2016 Aug 24.


Immediate Dysfunction of Vaccine-Elicited CD8+ T Cells Primed in the Absence of CD4+ T Cells.

Provine NM, Larocca RA, Aid M, Penaloza-MacMaster P, Badamchi-Zadeh A, Borducchi EN, Yates KB, Abbink P, Kirilova M, Ng'ang'a D, Bramson J, Haining WN, Barouch DH.

J Immunol. 2016 Sep 1;197(5):1809-22. doi: 10.4049/jimmunol.1600591. Epub 2016 Jul 22.


Transient CD4+ T Cell Depletion Results in Delayed Development of Functional Vaccine-Elicited Antibody Responses.

Provine NM, Badamchi-Zadeh A, Bricault CA, Penaloza-MacMaster P, Larocca RA, Borducchi EN, Seaman MS, Barouch DH.

J Virol. 2016 Apr 14;90(9):4278-4288. doi: 10.1128/JVI.00039-16. Print 2016 May.


CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells.

Penaloza-MacMaster P, Provine NM, Blass E, Barouch DH.

J Immunol. 2015 Aug 1;195(3):1054-63. doi: 10.4049/jimmunol.1403237. Epub 2015 Jun 26.


Programmed cell death 1 and Helios distinguish TCR-αβ+ double-negative (CD4-CD8-) T cells that derive from self-reactive CD8 T cells.

Rodríguez-Rodríguez N, Apostolidis SA, Penaloza-MacMaster P, Martín Villa JM, Barouch DH, Tsokos GC, Crispín JC.

J Immunol. 2015 May 1;194(9):4207-14. doi: 10.4049/jimmunol.1402775. Epub 2015 Mar 30.


Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection.

Penaloza-MacMaster P, Barber DL, Wherry EJ, Provine NM, Teigler JE, Parenteau L, Blackmore S, Borducchi EN, Larocca RA, Yates KB, Shen H, Haining WN, Sommerstein R, Pinschewer DD, Ahmed R, Barouch DH.

Science. 2015 Jan 16;347(6219):278-82. doi: 10.1126/science.aaa2148.


Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.

Penaloza-MacMaster P, Kamphorst AO, Wieland A, Araki K, Iyer SS, West EE, O'Mara L, Yang S, Konieczny BT, Sharpe AH, Freeman GJ, Rudensky AY, Ahmed R.

J Exp Med. 2014 Aug 25;211(9):1905-18. doi: 10.1084/jem.20132577. Epub 2014 Aug 11.


Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys.

Whitney JB, Hill AL, Sanisetty S, Penaloza-MacMaster P, Liu J, Shetty M, Parenteau L, Cabral C, Shields J, Blackmore S, Smith JY, Brinkman AL, Peter LE, Mathew SI, Smith KM, Borducchi EN, Rosenbloom DI, Lewis MG, Hattersley J, Li B, Hesselgesser J, Geleziunas R, Robb ML, Kim JH, Michael NL, Barouch DH.

Nature. 2014 Aug 7;512(7512):74-7. doi: 10.1038/nature13594. Epub 2014 Jul 20.


Hexon hypervariable region-modified adenovirus type 5 (Ad5) vectors display reduced hepatotoxicity but induce T lymphocyte phenotypes similar to Ad5 vectors.

Teigler JE, Penaloza-MacMaster P, Obeng R, Provine NM, Larocca RA, Borducchi EN, Barouch DH.

Clin Vaccine Immunol. 2014 Aug;21(8):1137-44. doi: 10.1128/CVI.00207-14. Epub 2014 Jun 18.


Longitudinal requirement for CD4+ T cell help for adenovirus vector-elicited CD8+ T cell responses.

Provine NM, Larocca RA, Penaloza-MacMaster P, Borducchi EN, McNally A, Parenteau LR, Kaufman DR, Barouch DH.

J Immunol. 2014 Jun 1;192(11):5214-25. doi: 10.4049/jimmunol.1302806. Epub 2014 Apr 28.


Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens.

Penaloza-MacMaster P, Teigler JE, Obeng RC, Kang ZH, Provine NM, Parenteau L, Blackmore S, Ra J, Borducchi EN, Barouch DH.

J Virol. 2014 Jun;88(11):6243-54. doi: 10.1128/JVI.00406-14. Epub 2014 Mar 19.


Identification of novel markers for mouse CD4(+) T follicular helper cells.

Iyer SS, Latner DR, Zilliox MJ, McCausland M, Akondy RS, Penaloza-Macmaster P, Hale JS, Ye L, Mohammed AU, Yamaguchi T, Sakaguchi S, Amara RR, Ahmed R.

Eur J Immunol. 2013 Dec;43(12):3219-32. doi: 10.1002/eji.201343469. Epub 2013 Oct 14. Erratum in: Eur J Immunol. 2014 Jul;44(7):2197.


PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells.

West EE, Jin HT, Rasheed AU, Penaloza-Macmaster P, Ha SJ, Tan WG, Youngblood B, Freeman GJ, Smith KA, Ahmed R.

J Clin Invest. 2013 Jun;123(6):2604-15. doi: 10.1172/JCI67008. Epub 2013 May 15.


Comparative analysis of simian immunodeficiency virus gag-specific effector and memory CD8+ T cells induced by different adenovirus vectors.

Tan WG, Jin HT, West EE, Penaloza-MacMaster P, Wieland A, Zilliox MJ, McElrath MJ, Barouch DH, Ahmed R.

J Virol. 2013 Feb;87(3):1359-72. doi: 10.1128/JVI.02055-12. Epub 2012 Nov 21.


Alternative serotype adenovirus vaccine vectors elicit memory T cells with enhanced anamnestic capacity compared to Ad5 vectors.

Penaloza-MacMaster P, Provine NM, Ra J, Borducchi EN, McNally A, Simmons NL, Iampietro MJ, Barouch DH.

J Virol. 2013 Feb;87(3):1373-84. doi: 10.1128/JVI.02058-12. Epub 2012 Nov 14.


4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection.

Vezys V, Penaloza-MacMaster P, Barber DL, Ha SJ, Konieczny B, Freeman GJ, Mittler RS, Ahmed R.

J Immunol. 2011 Aug 15;187(4):1634-42. doi: 10.4049/jimmunol.1100077. Epub 2011 Jul 8.


Different patterns of expansion, contraction and memory differentiation of HIV-1 Gag-specific CD8 T cells elicited by adenovirus type 5 and modified vaccinia Ankara vaccines.

Pillai VK, Kannanganat S, Penaloza-Macmaster P, Chennareddi L, Robinson HL, Blackwell J, Amara RR.

Vaccine. 2011 Jul 26;29(33):5399-406. doi: 10.1016/j.vaccine.2011.05.083. Epub 2011 Jun 7.


Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice.

Penaloza-MacMaster P, Ur Rasheed A, Iyer SS, Yagita H, Blazar BR, Ahmed R.

J Virol. 2011 Jul;85(13):6168-74. doi: 10.1128/JVI.02205-10. Epub 2011 Apr 20.


T-cell reconstitution without T-cell immunopathology in two models of T-cell-mediated tissue destruction.

Penaloza-MacMaster P, Masopust D, Ahmed R.

Immunology. 2009 Oct;128(2):164-71. doi: 10.1111/j.1365-2567.2009.03080.x.

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