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Baseline Serum HE4 But Not Tissue HE4 Expression Predicts Response to the Levonorgestrel-Releasing Intrauterine System in Atypical Hyperplasia and Early Stage Endometrial Cancer.

Behrouzi R, Ryan NAJ, Barr CE, Derbyshire AE, Wan YL, Maskell Z, Stocking K, Pemberton PW, Bolton J, McVey RJ, Crosbie EJ.

Cancers (Basel). 2020 Jan 23;12(2). pii: E276. doi: 10.3390/cancers12020276.


Genetic interaction between placental growth factor and vascular endothelial growth factor A in psoriasis.

Young HS, Kamaly-Asl ID, Laws PM, Pemberton P, Griffiths CEM.

Clin Exp Dermatol. 2019 Sep 23. doi: 10.1111/ced.14102. [Epub ahead of print]


The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polycystic Ovary Syndrome.

Sathyapalan T, Hobkirk JP, Javed Z, Carroll S, Coady AM, Pemberton P, Smith A, Cianflone K, Atkin SL.

Front Endocrinol (Lausanne). 2019 Jun 25;10:394. doi: 10.3389/fendo.2019.00394. eCollection 2019.


Altered cognitive function in systemic lupus erythematosus and associations with inflammation and functional and structural brain changes.

Barraclough M, McKie S, Parker B, Jackson A, Pemberton P, Elliott R, Bruce IN.

Ann Rheum Dis. 2019 Jul;78(7):934-940. doi: 10.1136/annrheumdis-2018-214677. Epub 2019 Apr 12.


PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a Multi-Center, Randomized Double-Blind, Placebo-Controlled Phase III Trial.

Kitson SJ, Maskell Z, Sivalingam VN, Allen JL, Ali S, Burns S, Gilmour K, Latheef R, Slade RJ, Pemberton PW, Shaw J, Ryder WD, Kitchener HC, Crosbie EJ.

Clin Cancer Res. 2019 Apr 15;25(8):2424-2432. doi: 10.1158/1078-0432.CCR-18-3339. Epub 2018 Dec 18.


The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk.

MacKintosh ML, Derbyshire AE, McVey RJ, Bolton J, Nickkho-Amiry M, Higgins CL, Kamieniorz M, Pemberton PW, Kirmani BH, Ahmed B, Syed AA, Ammori BJ, Renehan AG, Kitchener HC, Crosbie EJ.

Int J Cancer. 2019 Feb 1;144(3):641-650. doi: 10.1002/ijc.31913. Epub 2018 Nov 20.


Links between a biomarker profile, cold ischaemic time and clinical outcome following simultaneous pancreas and kidney transplantation.

Khambalia HA, Alexander MY, Nirmalan M, Weston R, Pemberton P, Moinuddin Z, Summers A, van Dellen D, Augustine T.

Cytokine. 2018 May;105:8-16. doi: 10.1016/j.cyto.2018.01.006. Epub 2018 Feb 8.


Effect of Roux-en-Y Bariatric Surgery on Lipoproteins, Insulin Resistance, and Systemic and Vascular Inflammation in Obesity and Diabetes.

Yadav R, Hama S, Liu Y, Siahmansur T, Schofield J, Syed AA, France M, Pemberton P, Adam S, Ho JH, Aghamohammadzadeh R, Dhage S, Donn R, Malik RA, New JP, Jeziorska M, Durrington P, Ammori BA, Soran H.

Front Immunol. 2017 Nov 15;8:1512. doi: 10.3389/fimmu.2017.01512. eCollection 2017.


An Essential Role of Maspin in Embryogenesis and Tumor Suppression-Response.

Zhang M, Hendrix MJC, Pemberton PA, Sakr WA, Sheng S.

Cancer Res. 2017 Sep 15;77(18):5208-5210. doi: 10.1158/0008-5472.CAN-17-1254. Epub 2017 Sep 6. No abstract available.


Defining Disease, Diagnosis, and Translational Medicine within a Homeostatic Perturbation Paradigm: The National Institutes of Health Undiagnosed Diseases Program Experience.

Gall T, Valkanas E, Bello C, Markello T, Adams C, Bone WP, Brandt AJ, Brazill JM, Carmichael L, Davids M, Davis J, Diaz-Perez Z, Draper D, Elson J, Flynn ED, Godfrey R, Groden C, Hsieh CK, Fischer R, Golas GA, Guzman J, Huang Y, Kane MS, Lee E, Li C, Links AE, Maduro V, Malicdan MCV, Malik FS, Nehrebecky M, Park J, Pemberton P, Schaffer K, Simeonov D, Sincan M, Smedley D, Valivullah Z, Wahl C, Washington N, Wolfe LA, Xu K, Zhu Y, Gahl WA, Tifft CJ, Toro C, Adams DR, He M, Robinson PN, Haendel MA, Zhai RG, Boerkoel CF.

Front Med (Lausanne). 2017 May 26;4:62. doi: 10.3389/fmed.2017.00062. eCollection 2017.


Imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation.

Skeoch S, Cristinacce PLH, Williams H, Pemberton P, Xu D, Sun J, James J, Yuan C, Hatsukami T, Hockings PD, Alexander MY, Waterton JC, Bruce IN.

Sci Rep. 2017 Apr 11;7(1):827. doi: 10.1038/s41598-017-00989-w.


The Association Between Visiting Intensivists and ICU Outcomes.

Whitehouse T, Hodson J, Pemberton P, Veenith T, Snelson C, Bion J, Rubenfeld GD.

Crit Care Med. 2017 Jun;45(6):949-955. doi: 10.1097/CCM.0000000000002373.


Limonene in exhaled breath is elevated in hepatic encephalopathy.

O'Hara ME, Fernández Del Río R, Holt A, Pemberton P, Shah T, Whitehouse T, Mayhew CA.

J Breath Res. 2016 Nov 21;10(4):046010.


Elimination characteristics of post-operative isoflurane levels in alveolar exhaled breath via PTR-MS analysis.

Fernández Del Río R, O'Hara ME, Pemberton P, Whitehouse T, Mayhew CA.

J Breath Res. 2016 Oct 12;10(4):046006.


Association of a promoter polymorphism in FSHR with ovarian reserve and response to ovarian stimulation in women undergoing assisted reproductive treatment.

Tohlob D, Abo Hashem E, Ghareeb N, Ghanem M, Elfarahaty R, Byers H, Pemberton P, Roberts SA, Newman WG, Mohiyiddeen L.

Reprod Biomed Online. 2016 Sep;33(3):391-7. doi: 10.1016/j.rbmo.2016.06.001. Epub 2016 Jun 17.


Platelet-Rich Plasma in Grafted Maxillae: Growth Factor Quantification and Dynamic Histomorphometric Evaluation.

Badr M, Oliver R, Pemberton P, Coulthard P.

Implant Dent. 2016 Aug;25(4):492-8. doi: 10.1097/ID.0000000000000410.


Measuring the biological effect of presurgical metformin treatment in endometrial cancer.

Sivalingam VN, Kitson S, McVey R, Roberts C, Pemberton P, Gilmour K, Ali S, Renehan AG, Kitchener HC, Crosbie EJ.

Br J Cancer. 2016 Feb 2;114(3):281-9. doi: 10.1038/bjc.2015.453. Epub 2016 Jan 21.


Is It Time to Beta Block the Septic Patient?

Pemberton P, Veenith T, Snelson C, Whitehouse T.

Biomed Res Int. 2015;2015:424308. doi: 10.1155/2015/424308. Epub 2015 Oct 18. Review.


Twenty-four hour infusion of human recombinant activated protein C (Xigris) early in severe acute pancreatitis: The XIG-AP 1 trial.

Miranda CJ, Mason JM, Babu BI, Sheen AJ, Eddleston JM, Parker MJ, Pemberton P, Siriwardena AK.

Pancreatology. 2015 Nov-Dec;15(6):635-41. doi: 10.1016/j.pan.2015.10.001. Epub 2015 Oct 20.


Volatile Biomarkers in Breath Associated With Liver Cirrhosis - Comparisons of Pre- and Post-liver Transplant Breath Samples.

Fernández Del Río R, O'Hara ME, Holt A, Pemberton P, Shah T, Whitehouse T, Mayhew CA.

EBioMedicine. 2015 Jul 26;2(9):1243-50. doi: 10.1016/j.ebiom.2015.07.027. eCollection 2015 Sep.


Effect of Extended-Release Niacin on High-Density Lipoprotein (HDL) Functionality, Lipoprotein Metabolism, and Mediators of Vascular Inflammation in Statin-Treated Patients.

Yadav R, Liu Y, Kwok S, Hama S, France M, Eatough R, Pemberton P, Schofield J, Siahmansur TJ, Malik R, Ammori BA, Issa B, Younis N, Donn R, Stevens A, Durrington P, Soran H.

J Am Heart Assoc. 2015 Sep 15;4(9):e001508. doi: 10.1161/JAHA.114.001508.


Modification of the Beckman-Coulter second-generation enzyme-linked immunosorbent assay protocol improves the reliability of serum antimüllerian hormone measurement.

Craciunas L, Roberts SA, Yates AP, Smith A, Fitzgerald C, Pemberton PW.

Fertil Steril. 2015 Feb;103(2):554-59.e1. doi: 10.1016/j.fertnstert.2014.10.052. Epub 2014 Dec 6.


Internalization by multiple endocytic pathways and lysosomal processing impact maspin-based therapeutics.

Bodenstine TM, Seftor RE, Seftor EA, Khalkhali-Ellis Z, Samii NA, Monarrez JC, Chandler GS, Pemberton PA, Hendrix MJ.

Mol Cancer Res. 2014 Oct;12(10):1480-91. doi: 10.1158/1541-7786.MCR-14-0067. Epub 2014 Sep 25.


Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea.

Yadav R, France M, Aghamohammadzadeh R, Liu Y, Hama S, Kwok S, Schofield J, Turkington P, Syed AA, Malik R, Pemberton P, Greenstein A, Durrington P, Ammori B, Gibson M, Jeziorska M, Soran H.

J Clin Endocrinol Metab. 2014 Sep;99(9):3390-8. doi: 10.1210/jc.2013-3939. Epub 2014 May 13.


The Manchester Acute Coronary Syndromes (MACS) decision rule for suspected cardiac chest pain: derivation and external validation.

Body R, Carley S, McDowell G, Pemberton P, Burrows G, Cook G, Lewis PS, Smith A, Mackway-Jones K.

Heart. 2014 Sep 15;100(18):1462-8. doi: 10.1136/heartjnl-2014-305564. Epub 2014 Apr 29.


Cell adhesion molecules as potential biomarkers of nephritis, damage and accelerated atherosclerosis in patients with SLE.

Skeoch S, Haque S, Pemberton P, Bruce IN.

Lupus. 2014 Jul;23(8):819-24. doi: 10.1177/0961203314528061. Epub 2014 Mar 19.


The measurement of anti-Müllerian hormone: a critical appraisal.

Rustamov O, Smith A, Roberts SA, Yates AP, Fitzgerald C, Krishnan M, Nardo LG, Pemberton PW.

J Clin Endocrinol Metab. 2014 Mar;99(3):723-32. doi: 10.1210/jc.2013-3476. Epub 2013 Jan 1. Review.


The predictive ability of triglycerides and waist (hypertriglyceridemic waist) in assessing metabolic triad change in obese children and adolescents.

Hobkirk JP, King RF, Gately P, Pemberton P, Smith A, Barth JH, Harman N, Davies I, Carroll S.

Metab Syndr Relat Disord. 2013 Oct;11(5):336-42. doi: 10.1089/met.2012.0152. Epub 2013 Jun 12.


Effects of bariatric surgery on human small artery function: evidence for reduction in perivascular adipocyte inflammation, and the restoration of normal anticontractile activity despite persistent obesity.

Aghamohammadzadeh R, Greenstein AS, Yadav R, Jeziorska M, Hama S, Soltani F, Pemberton PW, Ammori B, Malik RA, Soran H, Heagerty AM.

J Am Coll Cardiol. 2013 Jul 9;62(2):128-135. doi: 10.1016/j.jacc.2013.04.027. Epub 2013 May 9.


Suppression of inflammation reduces endothelial microparticles in active systemic lupus erythematosus.

Parker B, Al-Husain A, Pemberton P, Yates AP, Ho P, Gorodkin R, Teh LS, Alexander MY, Bruce IN.

Ann Rheum Dis. 2014 Jun;73(6):1144-50. doi: 10.1136/annrheumdis-2012-203028. Epub 2013 May 5.


The metabolic inter-relationships between changes in waist circumference, triglycerides, insulin sensitivity and small, dense low-density lipoprotein particles with acute weight loss in clinically obese children and adolescents.

Hobkirk JP, King RF, Davies I, Harman N, Gately P, Pemberton P, Smith A, Barth JH, Carroll S.

Pediatr Obes. 2014 Jun;9(3):209-17. doi: 10.1111/j.2047-6310.2013.00165.x. Epub 2013 Apr 25.


Serum cystatin C is independently associated with renal impairment and high sensitivity C-reactive protein in systemic lupus erythematosus.

Chew C, Pemberton PW, Husain AA, Haque S, Bruce IN.

Clin Exp Rheumatol. 2013 Mar-Apr;31(2):251-5. Epub 2012 Dec 17.


Small dense LDL is more susceptible to glycation than more buoyant LDL in Type 2 diabetes.

Younis NN, Soran H, Pemberton P, Charlton-Menys V, Elseweidy MM, Durrington PN.

Clin Sci (Lond). 2013 Mar;124(5):343-9. doi: 10.1042/CS20120304.


High-density lipoprotein impedes glycation of low-density lipoprotein.

Younis NN, Soran H, Charlton-Menys V, Sharma R, Hama S, Pemberton P, Elseweidy MM, Durrington PN.

Diab Vasc Dis Res. 2013 Mar;10(2):152-60. doi: 10.1177/1479164112454309. Epub 2012 Aug 13.


Anti-Mullerian hormone: poor assay reproducibility in a large cohort of subjects suggests sample instability.

Rustamov O, Smith A, Roberts SA, Yates AP, Fitzgerald C, Krishnan M, Nardo LG, Pemberton PW.

Hum Reprod. 2012 Oct;27(10):3085-91. doi: 10.1093/humrep/des260. Epub 2012 Jul 9.


Maspin: molecular mechanisms and therapeutic implications.

Bodenstine TM, Seftor RE, Khalkhali-Ellis Z, Seftor EA, Pemberton PA, Hendrix MJ.

Cancer Metastasis Rev. 2012 Dec;31(3-4):529-51. doi: 10.1007/s10555-012-9361-0. Review.


PCOS and peripheral AMH levels in relation to FSH receptor gene single nucleotide polymorphisms.

Mohiyiddeen L, Salim S, Mulugeta B, McBurney H, Newman WG, Pemberton P, Nardo LG.

Gynecol Endocrinol. 2012 May;28(5):375-7. doi: 10.3109/09513590.2011.633649. Epub 2012 Mar 20.


25-Hydroxyvitamin D deficiency is associated with increased aortic stiffness in patients with systemic lupus erythematosus.

Reynolds JA, Haque S, Berry JL, Pemberton P, Teh LS, Ho P, Gorodkin R, Bruce IN.

Rheumatology (Oxford). 2012 Mar;51(3):544-51. doi: 10.1093/rheumatology/ker352. Epub 2011 Nov 24.


Longitudinal factor analysis reveals a distinct clustering of cardiometabolic improvements during intensive, short-term dietary and exercise intervention in obese children and adolescents.

Hobkirk JP, King RF, Gately P, Pemberton P, Smith A, Barth JH, Carroll S.

Metab Syndr Relat Disord. 2012 Feb;10(1):20-5. doi: 10.1089/met.2011.0050. Epub 2011 Sep 21.


Regional anaesthesia always works--provided you put the right dose of the right drug in the right place.

Rajendram R, Pemberton P, Hayward A.

Br J Anaesth. 2011 Jul;107(1):103; author reply 103-4. doi: 10.1093/bja/aer181. No abstract available.


Anti-Mullerian hormone-tailored stimulation protocols improve outcomes whilst reducing adverse effects and costs of IVF.

Yates AP, Rustamov O, Roberts SA, Lim HY, Pemberton PW, Smith A, Nardo LG.

Hum Reprod. 2011 Sep;26(9):2353-62. doi: 10.1093/humrep/der182. Epub 2011 Jun 13.


Adiponectin and lipid profiles compared with insulins in relation to early growth of British South Asian and European children: the Manchester children's growth and vascular health study.

Bansal N, Anderson SG, Vyas A, Gemmell I, Charlton-Menys V, Oldroyd J, Pemberton P, Durrington PN, Clayton PE, Cruickshank JK.

J Clin Endocrinol Metab. 2011 Aug;96(8):2567-74. doi: 10.1210/jc.2011-0046. Epub 2011 Jun 1.


Low soluble P-selectin may facilitate early exclusion of acute myocardial infarction.

Body R, Pemberton P, Ali F, McDowell G, Carley S, Smith A, Mackway-Jones K.

Clin Chim Acta. 2011 Mar 18;412(7-8):614-8. doi: 10.1016/j.cca.2010.12.016. Epub 2010 Dec 16.


The reproducibility of serum anti-Müllerian hormone in subfertile women: within and between patient variability.

Rustamov O, Pemberton PW, Roberts SA, Smith A, Yates AP, Patchava SD, Nardo LG.

Fertil Steril. 2011 Mar 1;95(3):1185-7. doi: 10.1016/j.fertnstert.2010.10.001. Epub 2010 Oct 30.


A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer.

Heath EI, Heilbrun LK, Li J, Vaishampayan U, Harper F, Pemberton P, Sarkar FH.

Am J Transl Res. 2010 Jul 23;2(4):402-11.


Explanations for the lower rates of diabetic neuropathy in Indian Asians versus Europeans.

Abbott CA, Chaturvedi N, Malik RA, Salgami E, Yates AP, Pemberton PW, Boulton AJ.

Diabetes Care. 2010 Jun;33(6):1325-30. doi: 10.2337/dc09-2067. Epub 2010 Mar 9.


The relationships between AMH, androgens, insulin resistance and basal ovarian follicular status in non-obese subfertile women with and without polycystic ovary syndrome.

Nardo LG, Yates AP, Roberts SA, Pemberton P, Laing I.

Hum Reprod. 2009 Nov;24(11):2917-23. doi: 10.1093/humrep/dep225. Epub 2009 Jul 18.


Biomarkers of oxidant stress, insulin sensitivity and endothelial activation in rheumatoid arthritis: a cross-sectional study of their association with accelerated atherosclerosis.

Pemberton PW, Ahmad Y, Bodill H, Lokko D, Hider SL, Yates AP, Walker MG, Laing I, Bruce IN.

BMC Res Notes. 2009 May 9;2:83. doi: 10.1186/1756-0500-2-83.


Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients.

Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, Jeziorska M, Laing I, Yates AP, Pemberton PW, Malik RA, Heagerty AM.

Circulation. 2009 Mar 31;119(12):1661-70. doi: 10.1161/CIRCULATIONAHA.108.821181. Epub 2009 Mar 16.


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