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Items: 47


Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity.

Risom T, Wang X, Liang J, Zhang X, Pelz C, Campbell LG, Eng J, Chin K, Farrington C, Narla G, Langer EM, Sun XX, Su Y, Daniel CJ, Dai MS, Löhr CV, Sears RC.

J Clin Invest. 2020 Jan 2;130(1):231-246. doi: 10.1172/JCI126390.


Integrated Metabolomics-DNA Methylation Analysis Reveals Significant Long-Term Tissue-Dependent Directional Alterations in Aminoacyl-tRNA Biosynthesis in the Left Ventricle of the Heart and Hippocampus Following Proton Irradiation.

Torres ERS, Hall R, Bobe G, Choi J, Impey S, Pelz C, Lindner JR, Stevens JF, Raber J.

Front Mol Biosci. 2019 Sep 10;6:77. doi: 10.3389/fmolb.2019.00077. eCollection 2019.


Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals.

Su Y, Pelz C, Huang T, Torkenczy K, Wang X, Cherry A, Daniel CJ, Liang J, Nan X, Dai MS, Adey A, Impey S, Sears RC.

Genes Dev. 2018 Nov 1;32(21-22):1398-1419. doi: 10.1101/gad.314377.118. Epub 2018 Oct 26.


Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer.

Risom T, Langer EM, Chapman MP, Rantala J, Fields AJ, Boniface C, Alvarez MJ, Kendsersky ND, Pelz CR, Johnson-Camacho K, Dobrolecki LE, Chin K, Aswani AJ, Wang NJ, Califano A, Lewis MT, Tomlin CJ, Spellman PT, Adey A, Gray JW, Sears RC.

Nat Commun. 2018 Sep 19;9(1):3815. doi: 10.1038/s41467-018-05729-w.


Inositol-C2-PAF acts as a biological response modifier and antagonizes cancer-relevant processes in mammary carcinoma cells.

Pelz C, Häckel S, Semini G, Schrötter S, Bintig W, Stricker S, Mrawietz G, Klein A, Lucka L, Shmanai V, Eickholt B, Hildmann A, Danker K.

Cell Oncol (Dordr). 2018 Oct;41(5):505-516. doi: 10.1007/s13402-018-0387-3. Epub 2018 Jul 25.


MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.

Farrell AS, Joly MM, Allen-Petersen BL, Worth PJ, Lanciault C, Sauer D, Link J, Pelz C, Heiser LM, Morton JP, Muthalagu N, Hoffman MT, Manning SL, Pratt ED, Kendsersky ND, Egbukichi N, Amery TS, Thoma MC, Jenny ZP, Rhim AD, Murphy DJ, Sansom OJ, Crawford HC, Sheppard BC, Sears RC.

Nat Commun. 2017 Nov 23;8(1):1728. doi: 10.1038/s41467-017-01967-6.


ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells.

Langer EM, Kendsersky ND, Daniel CJ, Kuziel GM, Pelz C, Murphy KM, Capecchi MR, Sears RC.

Oncogene. 2018 Feb 22;37(8):1005-1019. doi: 10.1038/onc.2017.356. Epub 2017 Oct 30.


Bi-directional and shared epigenomic signatures following proton and 56Fe irradiation.

Impey S, Jopson T, Pelz C, Tafessu A, Fareh F, Zuloaga D, Marzulla T, Riparip LK, Stewart B, Rosi S, Turker MS, Raber J.

Sci Rep. 2017 Aug 31;7(1):10227. doi: 10.1038/s41598-017-09191-4.


Reprogramming human gallbladder cells into insulin-producing β-like cells.

Galivo F, Benedetti E, Wang Y, Pelz C, Schug J, Kaestner KH, Grompe M.

PLoS One. 2017 Aug 16;12(8):e0181812. doi: 10.1371/journal.pone.0181812. eCollection 2017.


Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes.

Li B, Dorrell C, Canaday PS, Pelz C, Haft A, Finegold M, Grompe M.

Stem Cell Reports. 2017 Aug 8;9(2):478-489. doi: 10.1016/j.stemcr.2017.06.003. Epub 2017 Jul 6.


Efficient generation of pancreatic β-like cells from the mouse gallbladder.

Wang Y, Galivo F, Pelz C, Haft A, Lee J, Kim SK, Grompe M.

Stem Cell Res. 2016 Nov;17(3):587-596. doi: 10.1016/j.scr.2016.10.009. Epub 2016 Oct 27.


Short- and long-term effects of 56Fe irradiation on cognition and hippocampal DNA methylation and gene expression.

Impey S, Jopson T, Pelz C, Tafessu A, Fareh F, Zuloaga D, Marzulla T, Riparip LK, Stewart B, Rosi S, Turker MS, Raber J.

BMC Genomics. 2016 Oct 24;17(1):825.


Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus.

Impey S, Pelz C, Tafessu A, Marzulla T, Turker MS, Raber J.

BMC Genomics. 2016 Mar 31;17:273. doi: 10.1186/s12864-016-2581-x.


RNA sequencing distinguishes benign from malignant pancreatic lesions sampled by EUS-guided FNA.

Rodriguez SA, Impey SD, Pelz C, Enestvedt B, Bakis G, Owens M, Morgan TK.

Gastrointest Endosc. 2016 Aug;84(2):252-8. doi: 10.1016/j.gie.2016.01.042. Epub 2016 Jan 22.


Targeted deletion of miR-132/-212 impairs memory and alters the hippocampal transcriptome.

Hansen KF, Sakamoto K, Aten S, Snider KH, Loeser J, Hesse AM, Page CE, Pelz C, Arthur JS, Impey S, Obrietan K.

Learn Mem. 2016 Jan 15;23(2):61-71. doi: 10.1101/lm.039578.115. Print 2016 Feb.


The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.

Zhang QS, Deater M, Schubert K, Marquez-Loza L, Pelz C, Sinclair DA, Grompe M.

Stem Cell Res. 2015 Jul;15(1):130-40. doi: 10.1016/j.scr.2015.05.007. Epub 2015 May 22.


Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers.

Naugler WE, Tarlow BD, Fedorov LM, Taylor M, Pelz C, Li B, Darnell J, Grompe M.

Gastroenterology. 2015 Sep;149(3):728-40.e15. doi: 10.1053/j.gastro.2015.05.043. Epub 2015 May 29.


Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling.

Zhang QS, Benedetti E, Deater M, Schubert K, Major A, Pelz C, Impey S, Marquez-Loza L, Rathbun RK, Kato S, Bagby GC, Grompe M.

Stem Cell Reports. 2015 Jan 13;4(1):90-102. doi: 10.1016/j.stemcr.2014.10.014. Epub 2014 Nov 26.


Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing.

Hansen KF, Sakamoto K, Pelz C, Impey S, Obrietan K.

Sci Rep. 2014 Nov 6;4:6930. doi: 10.1038/srep06930.


Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes.

Tarlow BD, Pelz C, Naugler WE, Wakefield L, Wilson EM, Finegold MJ, Grompe M.

Cell Stem Cell. 2014 Nov 6;15(5):605-18. doi: 10.1016/j.stem.2014.09.008. Epub 2014 Oct 9.


Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer.

Janghorban M, Farrell AS, Allen-Petersen BL, Pelz C, Daniel CJ, Oddo J, Langer EM, Christensen DJ, Sears RC.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9157-62. doi: 10.1073/pnas.1317630111. Epub 2014 Jun 9.


A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis.

Lesiak A, Pelz C, Ando H, Zhu M, Davare M, Lambert TJ, Hansen KF, Obrietan K, Appleyard SM, Impey S, Wayman GA.

PLoS One. 2013 Jun 6;8(6):e64658. doi: 10.1371/journal.pone.0064658. Print 2013.


Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis.

Farrell AS, Pelz C, Wang X, Daniel CJ, Wang Z, Su Y, Janghorban M, Zhang X, Morgan C, Impey S, Sears RC.

Mol Cell Biol. 2013 Aug;33(15):2930-49. doi: 10.1128/MCB.01455-12. Epub 2013 May 28.


In vivo selection of transplanted hepatocytes by pharmacological inhibition of fumarylacetoacetate hydrolase in wild-type mice.

Paulk NK, Wursthorn K, Haft A, Pelz C, Clarke G, Newell AH, Olson SB, Harding CO, Finegold MJ, Bateman RL, Witte JF, McClard R, Grompe M.

Mol Ther. 2012 Oct;20(10):1981-7. doi: 10.1038/mt.2012.154. Epub 2012 Aug 7.


Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.

Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A.

Hum Mol Genet. 2011 Oct 1;20(19):3852-66. doi: 10.1093/hmg/ddr306. Epub 2011 Jul 13.


Purpose of recently detected inhibitory domain of the Helicobacter pylori protein CagA.

Steininger S, Pelz C, Vogelmann R.

Gut Microbes. 2011 May-Jun;2(3):167-72. Epub 2011 May 1.


KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription.

Xie L, Pelz C, Wang W, Bashar A, Varlamova O, Shadle S, Impey S.

EMBO J. 2011 Apr 20;30(8):1473-84. doi: 10.1038/emboj.2011.91. Epub 2011 Mar 29.


Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming.

Powell AE, Anderson EC, Davies PS, Silk AD, Pelz C, Impey S, Wong MH.

Cancer Res. 2011 Feb 15;71(4):1497-505. doi: 10.1158/0008-5472.CAN-10-3223. Epub 2011 Feb 8.


A novel inhibitory domain of Helicobacter pylori protein CagA reduces CagA effects on host cell biology.

Pelz C, Steininger S, Weiss C, Coscia F, Vogelmann R.

J Biol Chem. 2011 Mar 18;286(11):8999-9008. doi: 10.1074/jbc.M110.166504. Epub 2011 Jan 6.


Global rank-invariant set normalization (GRSN) to reduce systematic distortions in microarray data.

Pelz CR, Kulesz-Martin M, Bagby G, Sears RC.

BMC Bioinformatics. 2008 Dec 4;9:520. doi: 10.1186/1471-2105-9-520.


Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles.

Kulesz-Martin M, Lagowski J, Fei S, Pelz C, Sears R, Powell MB, Halaban R, Johnson J.

J Investig Dermatol Symp Proc. 2005 Nov;10(2):142-52. Review.


Modeling random effects for censored data by a multivariate normal regression model.

Klein JP, Pelz C, Zhang MJ.

Biometrics. 1999 Jun;55(2):497-506.


Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program.

Filipovich AH, Stone JV, Tomany SC, Ireland M, Kollman C, Pelz CJ, Casper JT, Cowan MJ, Edwards JR, Fasth A, Gale RP, Junker A, Kamani NR, Loechelt BJ, Pietryga DW, Ringdén O, Vowels M, Hegland J, Williams AV, Klein JP, Sobocinski KA, Rowlings PA, Horowitz MM.

Blood. 2001 Mar 15;97(6):1598-603.


T-cell depletion of bone marrow transplants for leukemia from donors other than HLA-identical siblings: advantage of T-cell antibodies with narrow specificities.

Champlin RE, Passweg JR, Zhang MJ, Rowlings PA, Pelz CJ, Atkinson KA, Barrett AJ, Cahn JY, Drobyski WR, Gale RP, Goldman JM, Gratwohl A, Gordon-Smith EC, Henslee-Downey PJ, Herzig RH, Klein JP, Marmont AM, O'Reilly RJ, Ringdén O, Slavin S, Sobocinski KA, Speck B, Weiner RS, Horowitz MM.

Blood. 2000 Jun 15;95(12):3996-4003.


Factors correlated with progression-free survival after high-dose chemotherapy and hematopoietic stem cell transplantation for metastatic breast cancer.

Rowlings PA, Williams SF, Antman KH, Fields KK, Fay JW, Reed E, Pelz CJ, Klein JP, Sobocinski KA, Kennedy MJ, Freytes CO, McCarthy PL Jr, Herzig RH, Stadtmauer EA, Lazarus HM, Pecora AL, Bitran JD, Wolff SN, Gale RP, Armitage JO, Vaughan WP, Spitzer G, Horowitz MM.

JAMA. 1999 Oct 13;282(14):1335-43.


Recurrent and de novo glomerular disease after renal transplantation: a report from Renal Allograft Disease Registry (RADR).

Hariharan S, Adams MB, Brennan DC, Davis CL, First MR, Johnson CP, Ouseph R, Peddi VR, Pelz CJ, Roza AM, Vincenti F, George V.

Transplantation. 1999 Sep 15;68(5):635-41.


IA in Kenyon cells of the mushroom body of honeybees resembles shaker currents: kinetics, modulation by K+, and simulation.

Pelz C, Jander J, Rosenboom H, Hammer M, Menzel R.

J Neurophysiol. 1999 Apr;81(4):1749-59.


Recurrent and de novo glomerular disease after renal transplantation: a report from renal allograft disease registry.

Hariharan S, Adams MB, Brennan DC, Davis CL, First MR, Johnson CP, Ouseph R, Peddi VR, Pelz C, Roza AM, Vincenti F, George V.

Transplant Proc. 1999 Feb-Mar;31(1-2):223-4. No abstract available.


Prognostic value of intraoperative blood flow measurements in vascular access surgery.

Johnson CP, Zhu YR, Matt C, Pelz C, Roza AM, Adams MB.

Surgery. 1998 Oct;124(4):729-37; discussion 737-8.


Successful unrelated marrow transplantation for patients over the age of 40 with chronic myelogenous leukemia.

Drobyski WR, Pelz C, Kabler-Babbitt C, Hessner M, Baxter-Lowe LA, Keever-Taylor CA.

Biol Blood Marrow Transplant. 1998;4(1):3-12.


Neonatal cord blood leptin: its relationship to birth weight, body mass index, maternal diabetes, and steroids.

Shekhawat PS, Garland JS, Shivpuri C, Mick GJ, Sasidharan P, Pelz CJ, McCormick KL.

Pediatr Res. 1998 Mar;43(3):338-43.


High-dose chemotherapy with autologous hematopoietic stem-cell support for breast cancer in North America.

Antman KH, Rowlings PA, Vaughan WP, Pelz CJ, Fay JW, Fields KK, Freytes CO, Gale RP, Hillner BE, Holland HK, Kennedy MJ, Klein JP, Lazarus HM, McCarthy PL Jr, Saez R, Spitzer G, Stadtmauer EA, Williams SF, Wolff S, Sobocinski KA, Armitage JO, Horowitz MM.

J Clin Oncol. 1997 May;15(5):1870-9.


Report from the International Bone Marrow Transplant Registry and Autologous Blood and Marrow Transplant Registry - North America.

Passweg JR, Rowlings PA, Armitage JO, Gale RP, Pelz CJ, Sobocinski KA, Klein JP, Zhang MJ, Horowitz MM.

Clin Transpl. 1995:117-27.


Characterization of the membrane-associated GTPase activity: effects of chemotactic factors and toxins.

Pelz C, Matsumoto T, Molski TF, Becker EL, Sha'afi RI.

J Cell Biochem. 1989 Feb;39(2):197-206.


Treatment of rabbit neutrophils with phorbol esters results in increased ADP-ribosylation catalyzed by pertussis toxin and inhibition of the GTPase stimulated by fMet-Leu-Phe.

Matsumoto T, Molski TF, Volpi M, Pelz C, Kanaho Y, Becker EL, Feinstein MB, Naccache PH, Sha'afi RI.

FEBS Lett. 1986 Mar 31;198(2):295-300.


[Transanal endoscopic surgery of the rectum - testing a new method in animal experiments].

Buess G, Theiss R, Hutterer F, Pichlmaier H, Pelz C, Holfeld T, Said S, Isselhard W.

Leber Magen Darm. 1983 Mar;13(2):73-7. German.


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