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The Effect of Rifampin on the Pharmacokinetics and Safety of Lorlatinib: Results of a Phase One, Open-Label, Crossover Study in Healthy Participants.

Chen J, Xu H, Pawlak S, James LP, Peltz G, Lee K, Ginman K, Bergeron M, Pithavala YK.

Adv Ther. 2019 Dec 20. doi: 10.1007/s12325-019-01198-9. [Epub ahead of print]


The Phosphatidylethanolamine Biosynthesis Pathway Provides a New Target for Cancer Chemotherapy.

Guan Y, Chen X, Wu M, Zhu W, Arslan A, Takeda S, Nguyen MH, Majeti R, Thomas D, Zheng M, Peltz G.

J Hepatol. 2019 Nov 21. pii: S0168-8278(19)30676-2. doi: 10.1016/j.jhep.2019.11.007. [Epub ahead of print]


Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 1-2 trial.

Shaw AT, Solomon BJ, Chiari R, Riely GJ, Besse B, Soo RA, Kao S, Lin CC, Bauer TM, Clancy JS, Thurm H, Martini JF, Peltz G, Abbattista A, Li S, Ou SI.

Lancet Oncol. 2019 Dec;20(12):1691-1701. doi: 10.1016/S1470-2045(19)30655-2. Epub 2019 Oct 25.


Clinical Management of Adverse Events Associated with Lorlatinib.

Bauer TM, Felip E, Solomon BJ, Thurm H, Peltz G, Chioda MD, Shaw AT.

Oncologist. 2019 Aug;24(8):1103-1110. doi: 10.1634/theoncologist.2018-0380. Epub 2019 Mar 19.


Lorlatinib in patients with ALK-positive non-small-cell lung cancer: results from a global phase 2 study.

Solomon BJ, Besse B, Bauer TM, Felip E, Soo RA, Camidge DR, Chiari R, Bearz A, Lin CC, Gadgeel SM, Riely GJ, Tan EH, Seto T, James LP, Clancy JS, Abbattista A, Martini JF, Chen J, Peltz G, Thurm H, Ou SI, Shaw AT.

Lancet Oncol. 2018 Dec;19(12):1654-1667. doi: 10.1016/S1470-2045(18)30649-1. Epub 2018 Nov 6. Erratum in: Lancet Oncol. 2019 Jan;20(1):e10.


Laminin α1 is a genetic modifier of TGF-β1-stimulated pulmonary fibrosis.

Lee CM, Cho SJ, Cho WK, Park JW, Lee JH, Choi AM, Rosas IO, Zheng M, Peltz G, Lee CG, Elias JA.

JCI Insight. 2018 Sep 20;3(18). pii: 99574. doi: 10.1172/jci.insight.99574. eCollection 2018 Sep 20.


A Flawed Design Produces Flawed Results.

Peltz G.

J Addict Med. 2018 May/Jun;12(3):252. doi: 10.1097/ADM.0000000000000394. No abstract available.


The Neurobiology of Opioid Addiction and the Potential for Prevention Strategies.

Peltz G, Südhof TC.

JAMA. 2018 May 22;319(20):2071-2072. doi: 10.1001/jama.2018.3394. No abstract available.


Dynamic landscape and regulation of RNA editing in mammals.

Tan MH, Li Q, Shanmugam R, Piskol R, Kohler J, Young AN, Liu KI, Zhang R, Ramaswami G, Ariyoshi K, Gupte A, Keegan LP, George CX, Ramu A, Huang N, Pollina EA, Leeman DS, Rustighi A, Goh YPS; GTEx Consortium; Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group; Statistical Methods groups—Analysis Working Group; Enhancing GTEx (eGTEx) groups; NIH Common Fund; NIH/NCI; NIH/NHGRI; NIH/NIMH; NIH/NIDA; Biospecimen Collection Source Site—NDRI; Biospecimen Collection Source Site—RPCI; Biospecimen Core Resource—VARI; Brain Bank Repository—University of Miami Brain Endowment Bank; Leidos Biomedical—Project Management; ELSI Study; Genome Browser Data Integration &Visualization—EBI; Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz, Chawla A, Del Sal G, Peltz G, Brunet A, Conrad DF, Samuel CE, O'Connell MA, Walkley CR, Nishikura K, Li JB.

Nature. 2017 Oct 11;550(7675):249-254. doi: 10.1038/nature24041.


Human hepatic organoids for the analysis of human genetic diseases.

Guan Y, Xu D, Garfin PM, Ehmer U, Hurwitz M, Enns G, Michie S, Wu M, Zheng M, Nishimura T, Sage J, Peltz G.

JCI Insight. 2017 Sep 7;2(17). pii: 94954. doi: 10.1172/jci.insight.94954. eCollection 2017 Sep 7.


Profiling of ARDS pulmonary edema fluid identifies a metabolically distinct subset.

Rogers AJ, Contrepois K, Wu M, Zheng M, Peltz G, Ware LB, Matthay MA.

Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L703-L709. doi: 10.1152/ajplung.00438.2016. Epub 2017 Mar 3.


Palonosetron and hydroxyzine pre-treatment reduces the objective signs of experimentally-induced acute opioid withdrawal in humans: a double-blinded, randomized, placebo-controlled crossover study.

Erlendson MJ, D'Arcy N, Encisco EM, Yu JJ, Rincon-Cruz L, Peltz G, Clark JD, Chu LF.

Am J Drug Alcohol Abuse. 2017 Jan;43(1):78-86. doi: 10.1080/00952990.2016.1210614. Epub 2016 Aug 11.


Treating Liver Fibrosis: (Re)Programmed to Succeed.

Guan Y, Xu D, Peltz G.

Cell Stem Cell. 2016 Jun 2;18(6):683-4. doi: 10.1016/j.stem.2016.05.007.


The multiple PDZ domain protein Mpdz/MUPP1 regulates opioid tolerance and opioid-induced hyperalgesia.

Donaldson R, Sun Y, Liang DY, Zheng M, Sahbaie P, Dill DL, Peltz G, Buck KJ, Clark JD.

BMC Genomics. 2016 Apr 29;17:313. doi: 10.1186/s12864-016-2634-1.


A Pharmacogenetic Discovery: Cystamine Protects Against Haloperidol-Induced Toxicity and Ischemic Brain Injury.

Zhang H, Zheng M, Wu M, Xu D, Nishimura T, Nishimura Y, Giffard R, Xiong X, Xu LJ, Clark JD, Sahbaie P, Dill DL, Peltz G.

Genetics. 2016 May;203(1):599-609. doi: 10.1534/genetics.115.184648. Epub 2016 Mar 18.


Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design.

Smith JD, Suresh S, Schlecht U, Wu M, Wagih O, Peltz G, Davis RW, Steinmetz LM, Parts L, St Onge RP.

Genome Biol. 2016 Mar 8;17:45. doi: 10.1186/s13059-016-0900-9.


Analysis of the psychological impact of cancer-related symptoms on patients with non-small cell lung cancer.

Walker MS, Pohl GM, Houts AC, Peltz G, Miller PJE, Schwartzberg LS, Stepanski EJ, Marciniak M.

Psychooncology. 2017 Jun;26(6):755-762. doi: 10.1002/pon.4071. Epub 2016 Jan 20.


Can Humanized Mice Predict Drug "Behavior" in Humans?

Xu D, Peltz G.

Annu Rev Pharmacol Toxicol. 2016;56:323-38. doi: 10.1146/annurev-pharmtox-010715-103644. Epub 2015 Oct 22. Review.


Long-Acting Opioids for Treating Neonatal Abstinence Syndrome: A High Price for a Short Stay?

Peltz G, Anand KJ.

JAMA. 2015 Nov 17;314(19):2023-4. doi: 10.1001/jama.2015.13537. No abstract available.


Humanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: a case study with furosemide.

Xu D, Michie SA, Zheng M, Takeda S, Wu M, Peltz G.

J Pharmacol Exp Ther. 2015 Jul;354(1):73-8. doi: 10.1124/jpet.115.224493. Epub 2015 May 11.


Ondansetron pharmacokinetics in pregnant women and neonates: towards a new treatment for neonatal abstinence syndrome.

Elkomy MH, Sultan P, Carvalho B, Peltz G, Wu M, Clavijo C, Galinkin JL, Drover DR.

Clin Pharmacol Ther. 2015 Feb;97(2):167-76. doi: 10.1002/cpt.5. Epub 2014 Dec 4.


The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans.

Zheng M, Zhang H, Dill DL, Clark JD, Tu S, Yablonovitch AL, Tan MH, Zhang R, Rujescu D, Wu M, Tessarollo L, Vieira W, Gottesman MM, Deng S, Eberlin LS, Zare RN, Billard JM, Gillet JP, Li JB, Peltz G.

PLoS Med. 2015 Feb 3;12(2):e1001782. doi: 10.1371/journal.pmed.1001782. eCollection 2015 Feb.


Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicity.

Xu D, Wu M, Nishimura S, Nishimura T, Michie SA, Zheng M, Yang Z, Yates AJ, Day JS, Hillgren KM, Takeda ST, Guan Y, Guo Y, Peltz G.

J Pharmacol Exp Ther. 2015 Feb;352(2):274-80. doi: 10.1124/jpet.114.220798. Epub 2014 Nov 25.


The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration.

Liang DY, Zheng M, Sun Y, Sahbaie P, Low SA, Peltz G, Scherrer G, Flores C, Clark JD.

BMC Genomics. 2014 May 8;15:345. doi: 10.1186/1471-2164-15-345.


Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing.

Xu D, Nishimura T, Nishimura S, Zhang H, Zheng M, Guo YY, Masek M, Michie SA, Glenn J, Peltz G.

PLoS Med. 2014 Apr 15;11(4):e1001628. doi: 10.1371/journal.pmed.1001628. eCollection 2014 Apr.


Enabling autologous human liver regeneration with differentiated adipocyte stem cells.

Xu D, Nishimura T, Zheng M, Wu M, Su H, Sato N, Lee G, Michie S, Glenn J, Peltz G.

Cell Transplant. 2014;23(12):1573-84. doi: 10.3727/096368913X673432. Epub 2013 Oct 21.


Liquid chromatography/mass spectrometry methods for measuring dipeptide abundance in non-small-cell lung cancer.

Wu M, Xu Y, Fitch WL, Zheng M, Merritt RE, Shrager JB, Zhang W, Dill DL, Peltz G, Hoang CD.

Rapid Commun Mass Spectrom. 2013 Sep 30;27(18):2091-2098. doi: 10.1002/rcm.6656.


Acute and chronic phases of complex regional pain syndrome in mice are accompanied by distinct transcriptional changes in the spinal cord.

Gallagher JJ, Tajerian M, Guo T, Shi X, Li W, Zheng M, Peltz G, Kingery WS, Clark JD.

Mol Pain. 2013 Aug 8;9:40. doi: 10.1186/1744-8069-9-40.


Prospective observational comparison of clinical outcomes between african-american and caucasian patients receiving second-line treatment with pemetrexed for advanced non-small-cell lung cancer.

Pennella E, Obasaju CK, Pohl G, Peltz G, Girvan AC, Winfree KB, Martinez B, Marciniak M, Walker MS, Stepanski E, Schwartzberg LS, Adjei A.

Clin Lung Cancer. 2013 Nov;14(6):726-35. doi: 10.1016/j.cllc.2013.06.011. Epub 2013 Jul 31.


Perinatal factors and breast cancer risk among Hispanics.

Sanderson M, Pérez A, Weriwoh ML, Alexander LR, Peltz G, Agboto V, O'Hara H, Khoder W.

J Epidemiol Glob Health. 2013 Jun;3(2):89-94. doi: 10.1016/j.jegh.2013.02.004. Epub 2013 Mar 13.


Reply to bissig and grompe.

Peltz G.

Trends Pharmacol Sci. 2013 Aug;34(8):426. doi: 10.1016/ Epub 2013 Jul 11. No abstract available.


Can 'humanized' mice improve drug development in the 21st century?

Peltz G.

Trends Pharmacol Sci. 2013 May;34(5):255-60. doi: 10.1016/ Epub 2013 Apr 19.


Metabolomic-derived novel cyst fluid biomarkers for pancreatic cysts: glucose and kynurenine.

Park WG, Wu M, Bowen R, Zheng M, Fitch WL, Pai RK, Wodziak D, Visser BC, Poultsides GA, Norton JA, Banerjee S, Chen AM, Friedland S, Scott BA, Pasricha PJ, Lowe AW, Peltz G.

Gastrointest Endosc. 2013 Aug;78(2):295-302.e2. doi: 10.1016/j.gie.2013.02.037. Epub 2013 Apr 6.


Human pharmacogenetic analysis in chimeric mice with 'humanized livers'.

Hu Y, Wu M, Nishimura T, Zheng M, Peltz G.

Pharmacogenet Genomics. 2013 Feb;23(2):78-83. doi: 10.1097/FPC.0b013e32835cb2c7.


Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction.

Nishimura T, Hu Y, Wu M, Pham E, Suemizu H, Elazar M, Liu M, Idilman R, Yurdaydin C, Angus P, Stedman C, Murphy B, Glenn J, Nakamura M, Nomura T, Chen Y, Zheng M, Fitch WL, Peltz G.

J Pharmacol Exp Ther. 2013 Feb;344(2):388-96. doi: 10.1124/jpet.112.198697. Epub 2012 Nov 8. Erratum in: J Pharmacol Exp Ther. 2013 May;345(2):327. Nishimura, Toshiko [corrected to Nishimura, Toshihiko].


Opiate-induced changes in brain adenosine levels and narcotic drug responses.

Wu M, Sahbaie P, Zheng M, Lobato R, Boison D, Clark JD, Peltz G.

Neuroscience. 2013 Jan 3;228:235-42. doi: 10.1016/j.neuroscience.2012.10.031. Epub 2012 Oct 22.


Identification of drug targets by chemogenomic and metabolomic profiling in yeast.

Wu M, Zheng M, Zhang W, Suresh S, Schlecht U, Fitch WL, Aronova S, Baumann S, Davis R, St Onge R, Dill DL, Peltz G.

Pharmacogenet Genomics. 2012 Dec;22(12):877-86. doi: 10.1097/FPC.0b013e32835aa888.


Computational genetic discoveries that could improve perioperative medicine.

Zheng M, Dill D, Clark JD, Peltz G.

Curr Opin Anaesthesiol. 2012 Aug;25(4):428-33. doi: 10.1097/ACO.0b013e32835561f9. Review.


Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.

Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, Costigan M, Herbert TA, Yarkoni-Abitbul M, Tichauer D, Livneh J, Gershon E, Zheng M, Tan K, John SL, Slade GD, Jordan J, Woolf CJ, Peltz G, Maixner W, Diatchenko L, Seltzer Z, Salter MW, Mogil JS.

Nat Med. 2012 Mar 25;18(4):595-9. doi: 10.1038/nm.2710.


Cd14 SNPs regulate the innate immune response.

Liu HH, Hu Y, Zheng M, Suhoski MM, Engleman EG, Dill DL, Hudnall M, Wang J, Spolski R, Leonard WJ, Peltz G.

Mol Immunol. 2012 Jun;51(2):112-27. doi: 10.1016/j.molimm.2012.02.112. Epub 2012 Mar 23.


A better prognosis for genetic association studies in mice.

Zheng M, Dill D, Peltz G.

Trends Genet. 2012 Feb;28(2):62-9. doi: 10.1016/j.tig.2011.10.006. Epub 2011 Nov 24.


H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load.

Boon AC, Finkelstein D, Zheng M, Liao G, Allard J, Klumpp K, Webster R, Peltz G, Webby RJ.

mBio. 2011 Sep 6;2(5). pii: e00171-11. doi: 10.1128/mBio.00171-11. Print 2011.


Next-generation computational genetic analysis: multiple complement alleles control survival after Candida albicans infection.

Peltz G, Zaas AK, Zheng M, Solis NV, Zhang MX, Liu HH, Hu Y, Boxx GM, Phan QT, Dill D, Filler SG.

Infect Immun. 2011 Nov;79(11):4472-9. doi: 10.1128/IAI.05666-11. Epub 2011 Aug 29.


Immunomodulation in perioperative medicine.

Peltz G.

Pain Manag. 2011 Mar;1(2):103-6. doi: 10.2217/pmt.11.5. No abstract available.


The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.

Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M, Ito M, Suematsu M, Peltz G, Nakamura M, Suemizu H.

Biochem Biophys Res Commun. 2011 Feb 18;405(3):405-10. doi: 10.1016/j.bbrc.2011.01.042. Epub 2011 Jan 14.


Genetic discovery: the prescription for chronic pain.

Zheng M, Peltz G.

Genome Med. 2010 Nov 15;2(11):82. doi: 10.1186/gm203.


A review and characterization of the various perceptions of quality cancer care.

Colosia AD, Peltz G, Pohl G, Liu E, Copley-Merriman K, Khan S, Kaye JA.

Cancer. 2011 Mar 1;117(5):884-96. doi: 10.1002/cncr.25644. Epub 2010 Oct 11. Review.


Genetic susceptibility to the delayed sequelae of neonatal respiratory syncytial virus infection is MHC dependent.

Tregoning JS, Yamaguchi Y, Wang B, Mihm D, Harker JA, Bushell ES, Zheng M, Liao G, Peltz G, Openshaw PJ.

J Immunol. 2010 Nov 1;185(9):5384-91. doi: 10.4049/jimmunol.1001594. Epub 2010 Oct 4.


The role of interleukin-1 in wound biology. Part II: In vivo and human translational studies.

Hu Y, Liang D, Li X, Liu HH, Zhang X, Zheng M, Dill D, Shi X, Qiao Y, Yeomans D, Carvalho B, Angst MS, Clark JD, Peltz G.

Anesth Analg. 2010 Dec;111(6):1534-42. doi: 10.1213/ANE.0b013e3181f691eb. Epub 2010 Oct 1.


The role of interleukin-1 in wound biology. Part I: Murine in silico and in vitro experimental analysis.

Hu Y, Liang D, Li X, Liu HH, Zhang X, Zheng M, Dill D, Shi X, Qiao Y, Yeomans D, Carvalho B, Angst MS, Clark JD, Peltz G.

Anesth Analg. 2010 Dec;111(6):1525-33. doi: 10.1213/ANE.0b013e3181f5ef5a. Epub 2010 Oct 1.


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