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Items: 1 to 50 of 176

1.

Treatment of Streptococcus pneumoniae otitis media in a chinchilla model by transtympanic delivery of antibiotics.

Yang R, Sabharwal V, Shlykova N, Okonkwo OS, Pelton SI, Kohane DS.

JCI Insight. 2018 Oct 4;3(19). pii: 123415. doi: 10.1172/jci.insight.123415. [Epub ahead of print]

2.

Infants at risk for Invasive Pneumococcal Disease in the PCV13 Era.

Yildirim I, Pelton SI.

Clin Infect Dis. 2018 Oct 3. doi: 10.1093/cid/ciy848. [Epub ahead of print] No abstract available.

PMID:
30281070
3.

Decline in Pneumococcal Disease Attenuated in Older Adults and Those with Comorbidities Following Universal Childhood PCV13 Immunization.

Pelton SI, Bornheimer R, Doroff R, Shea KM, Sato R, Weycker D.

Clin Infect Dis. 2018 Sep 20. doi: 10.1093/cid/ciy800. [Epub ahead of print]

PMID:
30239637
4.

Effectiveness and impact of the 10-valent pneumococcal conjugate vaccine, PHiD-CV: review of clinical trials and post-marketing experience.

Mrkvan T, Pelton SI, Ruiz-Guiñazú J, Palmu AA, Borys D.

Expert Rev Vaccines. 2018 Sep;17(9):797-818. doi: 10.1080/14760584.2018.1516551.

PMID:
30185083
5.

The old man's friend.

Rijkers GT, Pelton SI.

Pneumonia (Nathan). 2018 Jul 25;10:8. doi: 10.1186/s41479-018-0052-7. eCollection 2018. No abstract available.

6.

The relative invasive disease potential of Streptococcus pneumoniae among children after PCV introduction: A systematic review and meta-analysis.

Balsells E, Dagan R, Yildirim I, Gounder PP, Steens A, Muñoz-Almagro C, Mameli C, Kandasamy R, Givon Lavi N, Daprai L, van der Ende A, Trzciński K, Nzenze SA, Meiring S, Foster D, Bulkow LR, Rudolph K, Valero-Rello A, Ducker S, Vestrheim DF, von Gottberg A, Pelton SI, Zuccotti G, Pollard AJ, Sanders EAM, Campbell H, Madhi SA, Nair H, Kyaw MH.

J Infect. 2018 Nov;77(5):368-378. doi: 10.1016/j.jinf.2018.06.004. Epub 2018 Jun 30.

PMID:
29964140
7.

Deconstructing Pneumococcal Progression from Colonization to Disease.

Pelton SI.

Infect Immun. 2018 May 22;86(6). pii: e00225-18. doi: 10.1128/IAI.00225-18. Print 2018 Jun.

PMID:
29610253
8.

Risk of exacerbation following pneumonia in adults with heart failure or chronic obstructive pulmonary disease.

Bornheimer R, Shea KM, Sato R, Weycker D, Pelton SI.

PLoS One. 2017 Oct 13;12(10):e0184877. doi: 10.1371/journal.pone.0184877. eCollection 2017.

9.

Disproportionate Exposure to Antibiotics in Children at Risk for Invasive Pneumococcal Disease: Potential for Emerging Resistance and Opportunity for Antibiotic Stewardship.

Barlam TF, Morgan JR, Kaplan WA, Outterson K, Pelton SI.

J Pediatric Infect Dis Soc. 2017 Sep 7. doi: 10.1093/jpids/pix070. [Epub ahead of print]

PMID:
28992176
10.

Surveillance of pneumococcal colonization and invasive pneumococcal disease reveals shift in prevalent carriage serotypes in Massachusetts' children to relatively low invasiveness.

Yildirim I, Little BA, Finkelstein J, Lee G, Hanage WP, Shea K, Pelton SI; T; he Massachusetts Dept. of Public Health.

Vaccine. 2017 Jul 13;35(32):4002-4009. doi: 10.1016/j.vaccine.2017.05.077. Epub 2017 Jun 20.

PMID:
28645717
11.

Panel 6: Vaccines.

Pettigrew MM, Alderson MR, Bakaletz LO, Barenkamp SJ, Hakansson AP, Mason KM, Nokso-Koivisto J, Patel J, Pelton SI, Murphy TF.

Otolaryngol Head Neck Surg. 2017 Apr;156(4_suppl):S76-S87. doi: 10.1177/0194599816632178. Review.

12.

Capacity of Pneumococci to Activate Macrophage Nuclear Factor κB: Influence on Necroptosis and Pneumonia Severity.

Coleman FT, Blahna MT, Kamata H, Yamamoto K, Zabinski MC, Kramnik I, Wilson AA, Kotton DN, Quinton LJ, Jones MR, Pelton SI, Mizgerd JP.

J Infect Dis. 2017 Aug 15;216(4):425-435. doi: 10.1093/infdis/jix159.

PMID:
28368460
13.

Treatment of otitis media by transtympanic delivery of antibiotics.

Yang R, Sabharwal V, Okonkwo OS, Shlykova N, Tong R, Lin LY, Wang W, Guo S, Rosowski JJ, Pelton SI, Kohane DS.

Sci Transl Med. 2016 Sep 14;8(356):356ra120. doi: 10.1126/scitranslmed.aaf4363.

14.

The Global Evolution of Meningococcal Epidemiology Following the Introduction of Meningococcal Vaccines.

Pelton SI.

J Adolesc Health. 2016 Aug;59(2 Suppl):S3-S11. doi: 10.1016/j.jadohealth.2016.04.012. Review.

15.

Efficacy of Solithromycin (CEM-101) for Experimental Otitis Media Caused by Nontypeable Haemophilus influenzae and Streptococcus pneumoniae.

Figueira M, Fernandes P, Pelton SI.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5533-8. doi: 10.1128/AAC.00863-16. Print 2016 Sep.

16.

Rates and costs of invasive pneumococcal disease and pneumonia in persons with underlying medical conditions.

Weycker D, Farkouh RA, Strutton DR, Edelsberg J, Shea KM, Pelton SI.

BMC Health Serv Res. 2016 May 13;16:182. doi: 10.1186/s12913-016-1432-4.

17.

Pneumococcal Disease in the Era of Pneumococcal Conjugate Vaccine.

Yildirim I, Shea KM, Pelton SI.

Infect Dis Clin North Am. 2015 Dec;29(4):679-97. doi: 10.1016/j.idc.2015.07.009. Review.

18.

Individual Benefit vs Societal Effect of Antibiotic Prescribing for Preschool Children With Recurrent Wheeze.

Cohen RT, Pelton SI.

JAMA. 2015 Nov 17;314(19):2027-9. doi: 10.1001/jama.2015.14953. No abstract available.

PMID:
26575058
19.

Population genomic datasets describing the post-vaccine evolutionary epidemiology of Streptococcus pneumoniae.

Croucher NJ, Finkelstein JA, Pelton SI, Parkhill J, Bentley SD, Lipsitch M, Hanage WP.

Sci Data. 2015 Oct 27;2:150058. doi: 10.1038/sdata.2015.58. eCollection 2015.

20.

Rates of pneumonia among children and adults with chronic medical conditions in Germany.

Pelton SI, Shea KM, Farkouh RA, Strutton DR, Braun S, Jacob C, Klok R, Gruen ES, Weycker D.

BMC Infect Dis. 2015 Oct 30;15:470. doi: 10.1186/s12879-015-1162-y.

21.

Rethinking risk for pneumococcal disease in adults: the role of risk stacking.

Pelton SI, Shea KM, Weycker D, Farkouh RA, Strutton DR, Edelsberg J.

Open Forum Infect Dis. 2015 Mar 20;2(1):ofv020. doi: 10.1093/ofid/ofv020. eCollection 2015 Jan.

22.

Stability of the pneumococcal population structure in Massachusetts as PCV13 was introduced.

Chang Q, Stevenson AE, Croucher NJ, Lee GM, Pelton SI, Lipsitch M, Finkelstein JA, Hanage WP.

BMC Infect Dis. 2015 Feb 18;15:68. doi: 10.1186/s12879-015-0797-z.

23.

Rates of pneumococcal disease in adults with chronic medical conditions.

Shea KM, Edelsberg J, Weycker D, Farkouh RA, Strutton DR, Pelton SI.

Open Forum Infect Dis. 2014 May 27;1(1):ofu024. doi: 10.1093/ofid/ofu024. eCollection 2014 Mar.

24.

Vaccination, underlying comorbidities, and risk of invasive pneumococcal disease.

Yildirim I, Shea KM, Little BA, Silverio AL, Pelton SI; Members of the Massachusetts Department of Public Health.

Pediatrics. 2015 Mar;135(3):495-503. doi: 10.1542/peds.2014-2426. Epub 2015 Feb 2.

25.

Seasonal variation in penicillin susceptibility and invasive pneumococcal disease.

Iroh Tam PY, Madoff LC, O'Connell M, Pelton SI.

Pediatr Infect Dis J. 2015 Apr;34(4):456-7. doi: 10.1097/INF.0000000000000620.

26.

Severity of invasive pneumococcal disease in children caused by susceptible and nonsusceptible isolates.

Iroh Tam PY, Coombes B, Madoff L, Pelton SI.

Pediatr Infect Dis J. 2014 Nov;33(11):1206-7. doi: 10.1097/INF.0000000000000415. No abstract available. Erratum in: Pediatr Infect Dis J. 2015 May;34(5):554.

27.

Invasive pneumococcal disease after implementation of 13-valent conjugate vaccine.

Iroh Tam PY, Madoff LC, Coombes B, Pelton SI.

Pediatrics. 2014 Aug;134(2):210-7. doi: 10.1542/peds.2014-0473. Epub 2014 Jul 7.

28.

Risk of pneumococcal disease in children with chronic medical conditions in the era of pneumococcal conjugate vaccine.

Pelton SI, Weycker D, Farkouh RA, Strutton DR, Shea KM, Edelsberg J.

Clin Infect Dis. 2014 Sep 1;59(5):615-23. doi: 10.1093/cid/ciu348. Epub 2014 May 13.

PMID:
24825867
29.

Direct and indirect effects of PCV13 on nasopharyngeal carriage of PCV13 unique pneumococcal serotypes in Massachusetts' children.

Loughlin AM, Hsu K, Silverio AL, Marchant CD, Pelton SI.

Pediatr Infect Dis J. 2014 May;33(5):504-10. doi: 10.1097/INF.0000000000000279.

PMID:
24670957
30.

Impact of 13-Valent Pneumococcal Conjugate Vaccination on Streptococcus pneumoniae Carriage in Young Children in Massachusetts.

Lee GM, Kleinman K, Pelton SI, Hanage W, Huang SS, Lakoma M, Dutta-Linn M, Croucher NJ, Stevenson A, Finkelstein JA.

J Pediatric Infect Dis Soc. 2014 Mar;3(1):23-32. doi: 10.1093/jpids/pit057. Epub 2013 Oct 3.

31.

Variation of pneumococcal Pilus-1 expression results in vaccine escape during Experimental Otitis Media [EOM].

Figueira M, Moschioni M, De Angelis G, Barocchi M, Sabharwal V, Masignani V, Pelton SI.

PLoS One. 2014 Jan 8;9(1):e83798. doi: 10.1371/journal.pone.0083798. eCollection 2014.

32.

Cost-effectiveness of Tdap vaccination of adults aged ≥65 years in the prevention of pertussis in the US: a dynamic model of disease transmission.

McGarry LJ, Krishnarajah G, Hill G, Masseria C, Skornicki M, Pruttivarasin N, Arondekar B, Roiz J, Pelton SI, Weinstein MC.

PLoS One. 2014 Jan 9;9(1):e72723. doi: 10.1371/journal.pone.0072723. eCollection 2014.

33.

Xylitol syrup for the prevention of acute otitis media.

Vernacchio L, Corwin MJ, Vezina RM, Pelton SI, Feldman HA, Coyne-Beasley T, Mitchell AA.

Pediatrics. 2014 Feb;133(2):289-95. doi: 10.1542/peds.2013-2373. Epub 2014 Jan 6.

34.

Capsular switching as a strategy to increase pneumococcal virulence in experimental otitis media model.

Sabharwal V, Stevenson A, Figueira M, Orthopoulos G, Trzciński K, Pelton SI.

Microbes Infect. 2014 Apr;16(4):292-9. doi: 10.1016/j.micinf.2013.12.002. Epub 2013 Dec 20.

PMID:
24361902
35.

The challenge of preventing invasive pneumococcal disease in children with comorbid illnesses.

Pelton SI.

Clin Infect Dis. 2014 Feb;58(4):526-7. doi: 10.1093/cid/cit792. Epub 2013 Dec 2. No abstract available.

PMID:
24300045
36.

Cost-effectiveness analysis of Tdap in the prevention of pertussis in the elderly.

McGarry LJ, Krishnarajah G, Hill G, Skornicki M, Pruttivarasin N, Masseria C, Arondekar B, Pelton SI, Weinstein MC.

PLoS One. 2013 Sep 3;8(9):e67260. doi: 10.1371/journal.pone.0067260. eCollection 2013.

37.

Using pneumococcal carriage data to monitor postvaccination changes in invasive disease.

Weinberger DM, Bruden DT, Grant LR, Lipsitch M, O'Brien KL, Pelton SI, Sanders EA, Feikin DR.

Am J Epidemiol. 2013 Nov 1;178(9):1488-95. doi: 10.1093/aje/kwt156. Epub 2013 Sep 7.

38.

Antibody persistence and immunologic memory after sequential pneumococcal conjugate and polysaccharide vaccination in HIV-infected children on highly active antiretroviral therapy.

Abzug MJ, Song LY, Levin MJ, Nachman SA, Borkowsky W, Pelton SI; International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1024 and P1061s Protocol Teams.

Vaccine. 2013 Oct 1;31(42):4782-90. doi: 10.1016/j.vaccine.2013.08.002. Epub 2013 Aug 14.

39.

Do community-level predictors of pneumococcal carriage continue to play a role in the conjugate vaccine era?

Hsu KK, Rifas-Shiman SL, Shea KM, Kleinman KP, Lee GM, Lakoma M, Pelton SI, Finkelstein JA, Huang SS.

Epidemiol Infect. 2014 Feb;142(2):379-87. doi: 10.1017/S0950268813000794. Epub 2013 Apr 26.

40.

Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens.

Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2209-18. doi: 10.1073/pnas.1303573110. Epub 2013 May 28.

41.

Population genomics of post-vaccine changes in pneumococcal epidemiology.

Croucher NJ, Finkelstein JA, Pelton SI, Mitchell PK, Lee GM, Parkhill J, Bentley SD, Hanage WP, Lipsitch M.

Nat Genet. 2013 Jun;45(6):656-63. doi: 10.1038/ng.2625. Epub 2013 May 5.

42.

Panel 6: Vaccines.

Pelton SI, Pettigrew MM, Barenkamp SJ, Godfroid F, Grijalva CG, Leach A, Patel J, Murphy TF, Selak S, Bakaletz LO.

Otolaryngol Head Neck Surg. 2013 Apr;148(4 Suppl):E90-101. doi: 10.1177/0194599812466535. Review.

43.

Increasing focus on local epidemiology demonstrates potential value of pneumococcal conjugate vaccines in Middle East and North Africa Region.

Pelton SI.

Vaccine. 2012 Dec 31;30 Suppl 6:G1. doi: 10.1016/j.vaccine.2012.07.019. No abstract available.

PMID:
23228351
44.

Formulations for trans-tympanic antibiotic delivery.

Khoo X, Simons EJ, Chiang HH, Hickey JM, Sabharwal V, Pelton SI, Rosowski JJ, Langer R, Kohane DS.

Biomaterials. 2013 Jan;34(4):1281-8. doi: 10.1016/j.biomaterials.2012.10.025. Epub 2012 Nov 9.

45.

Modeling the impact of the 13-valent pneumococcal conjugate vaccine serotype catch-up program using United States claims data.

Strutton DR, Farkouh RA, Rubin JL, McGarry LJ, Loiacono PM, Klugman KP, Pelton SI, Gilmore KE, Weinstein MC.

BMC Infect Dis. 2012 Aug 3;12:175. doi: 10.1186/1471-2334-12-175.

46.

Regulation of bacterial trafficking in the nasopharynx.

Pelton SI.

Paediatr Respir Rev. 2012 Sep;13(3):150-3. doi: 10.1016/j.prrv.2012.04.001. Epub 2012 May 2. Review.

47.

Immunogenicity, immunologic memory, and safety following measles revaccination in HIV-infected children receiving highly active antiretroviral therapy.

Abzug MJ, Qin M, Levin MJ, Fenton T, Beeler JA, Bellini WJ, Audet S, Sowers SB, Borkowsky W, Nachman SA, Pelton SI, Rosenblatt HM; International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1024 and P1061s Protocol Teams.

J Infect Dis. 2012 Aug 15;206(4):512-22. doi: 10.1093/infdis/jis386. Epub 2012 Jun 12.

48.

Evolving picture of invasive pneumococcal disease in massachusetts children: a comparison of disease in 2007-2009 with earlier periods.

Yildirim I, Stevenson A, Hsu KK, Pelton SI.

Pediatr Infect Dis J. 2012 Oct;31(10):1016-21. doi: 10.1097/INF.0b013e3182615615.

PMID:
22673142
49.

Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice.

Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP.

J Clin Invest. 2012 May;122(5):1758-63. doi: 10.1172/JCI59408. Epub 2012 Apr 2.

50.

Virulence of Streptococcus pneumoniae serotype 6C in experimental otitis media.

Sabharwal V, Figueira M, Pelton SI, Pettigrew MM.

Microbes Infect. 2012 Aug;14(9):712-8. doi: 10.1016/j.micinf.2012.02.008. Epub 2012 Mar 3.

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