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Items: 26

1.

Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells.

Reitman ZJ, Paolella BR, Bergthold G, Pelton K, Becker S, Jones R, Sinai CE, Malkin H, Huang Y, Grimmet L, Herbert ZT, Sun Y, Weatherbee JL, Alberta JA, Daley JF, Rozenblatt-Rosen O, Condurat AL, Qian K, Khadka P, Segal RA, Haas-Kogan D, Filbin MG, Suva ML, Regev A, Stiles CD, Kieran MW, Goumnerova L, Ligon KL, Shalek AK, Bandopadhayay P, Beroukhim R.

Nat Commun. 2019 Aug 19;10(1):3731. doi: 10.1038/s41467-019-11493-2.

PMID:
31427603
2.

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.

Neftel C, Laffy J, Filbin MG, Hara T, Shore ME, Rahme GJ, Richman AR, Silverbush D, Shaw ML, Hebert CM, Dewitt J, Gritsch S, Perez EM, Gonzalez Castro LN, Lan X, Druck N, Rodman C, Dionne D, Kaplan A, Bertalan MS, Small J, Pelton K, Becker S, Bonal D, Nguyen QD, Servis RL, Fung JM, Mylvaganam R, Mayr L, Gojo J, Haberler C, Geyeregger R, Czech T, Slavc I, Nahed BV, Curry WT, Carter BS, Wakimoto H, Brastianos PK, Batchelor TT, Stemmer-Rachamimov A, Martinez-Lage M, Frosch MP, Stamenkovic I, Riggi N, Rheinbay E, Monje M, Rozenblatt-Rosen O, Cahill DP, Patel AP, Hunter T, Verma IM, Ligon KL, Louis DN, Regev A, Bernstein BE, Tirosh I, Suvà ML.

Cell. 2019 Aug 8;178(4):835-849.e21. doi: 10.1016/j.cell.2019.06.024. Epub 2019 Jul 18.

PMID:
31327527
3.

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.

Wen PY, Touat M, Alexander BM, Mellinghoff IK, Ramkissoon S, McCluskey CS, Pelton K, Haidar S, Basu SS, Gaffey SC, Brown LE, Martinez-Ledesma JE, Wu S, Kim J, Wei W, Park MA, Huse JT, Kuhn JG, Rinne ML, Colman H, Agar NYR, Omuro AM, DeAngelis LM, Gilbert MR, de Groot JF, Cloughesy TF, Chi AS, Roberts TM, Zhao JJ, Lee EQ, Nayak L, Heath JR, Horky LL, Batchelor TT, Beroukhim R, Chang SM, Ligon AH, Dunn IF, Koul D, Young GS, Prados MD, Reardon DA, Yung WKA, Ligon KL.

J Clin Oncol. 2019 Mar 20;37(9):741-750. doi: 10.1200/JCO.18.01207. Epub 2019 Feb 4.

4.

Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial.

Keskin DB, Anandappa AJ, Sun J, Tirosh I, Mathewson ND, Li S, Oliveira G, Giobbie-Hurder A, Felt K, Gjini E, Shukla SA, Hu Z, Li L, Le PM, Allesøe RL, Richman AR, Kowalczyk MS, Abdelrahman S, Geduldig JE, Charbonneau S, Pelton K, Iorgulescu JB, Elagina L, Zhang W, Olive O, McCluskey C, Olsen LR, Stevens J, Lane WJ, Salazar AM, Daley H, Wen PY, Chiocca EA, Harden M, Lennon NJ, Gabriel S, Getz G, Lander ES, Regev A, Ritz J, Neuberg D, Rodig SJ, Ligon KL, Suvà ML, Wucherpfennig KW, Hacohen N, Fritsch EF, Livak KJ, Ott PA, Wu CJ, Reardon DA.

Nature. 2019 Jan;565(7738):234-239. doi: 10.1038/s41586-018-0792-9. Epub 2018 Dec 19.

5.

Linking single-cell measurements of mass, growth rate, and gene expression.

Kimmerling RJ, Prakadan SM, Gupta AJ, Calistri NL, Stevens MM, Olcum S, Cermak N, Drake RS, Pelton K, De Smet F, Ligon KL, Shalek AK, Manalis SR.

Genome Biol. 2018 Nov 27;19(1):207. doi: 10.1186/s13059-018-1576-0.

6.

Serum cholesterol levels and tumor growth in a PTEN-null transgenic mouse model of prostate cancer.

Allott EH, Masko EM, Freedland AR, Macias E, Pelton K, Solomon KR, Mostaghel EA, Thomas GV, Pizzo SV, Freeman MR, Freedland SJ.

Prostate Cancer Prostatic Dis. 2018 Jun;21(2):196-203. doi: 10.1038/s41391-018-0045-x. Epub 2018 May 23.

7.

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.

Filbin MG, Tirosh I, Hovestadt V, Shaw ML, Escalante LE, Mathewson ND, Neftel C, Frank N, Pelton K, Hebert CM, Haberler C, Yizhak K, Gojo J, Egervari K, Mount C, van Galen P, Bonal DM, Nguyen QD, Beck A, Sinai C, Czech T, Dorfer C, Goumnerova L, Lavarino C, Carcaboso AM, Mora J, Mylvaganam R, Luo CC, Peyrl A, Popović M, Azizi A, Batchelor TT, Frosch MP, Martinez-Lage M, Kieran MW, Bandopadhayay P, Beroukhim R, Fritsch G, Getz G, Rozenblatt-Rosen O, Wucherpfennig KW, Louis DN, Monje M, Slavc I, Ligon KL, Golub TR, Regev A, Bernstein BE, Suvà ML.

Science. 2018 Apr 20;360(6386):331-335. doi: 10.1126/science.aao4750.

8.

Leveraging molecular datasets for biomarker-based clinical trial design in glioblastoma.

Tanguturi SK, Trippa L, Ramkissoon SH, Pelton K, Knoff D, Sandak D, Lindeman NI, Ligon AH, Beroukhim R, Parmigiani G, Wen PY, Ligon KL, Alexander BM.

Neuro Oncol. 2017 Jul 1;19(7):908-917. doi: 10.1093/neuonc/now312.

9.

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.

Bandopadhayay P, Ramkissoon LA, Jain P, Bergthold G, Wala J, Zeid R, Schumacher SE, Urbanski L, O'Rourke R, Gibson WJ, Pelton K, Ramkissoon SH, Han HJ, Zhu Y, Choudhari N, Silva A, Boucher K, Henn RE, Kang YJ, Knoff D, Paolella BR, Gladden-Young A, Varlet P, Pages M, Horowitz PM, Federation A, Malkin H, Tracy AA, Seepo S, Ducar M, Van Hummelen P, Santi M, Buccoliero AM, Scagnet M, Bowers DC, Giannini C, Puget S, Hawkins C, Tabori U, Klekner A, Bognar L, Burger PC, Eberhart C, Rodriguez FJ, Hill DA, Mueller S, Haas-Kogan DA, Phillips JJ, Santagata S, Stiles CD, Bradner JE, Jabado N, Goren A, Grill J, Ligon AH, Goumnerova L, Waanders AJ, Storm PB, Kieran MW, Ligon KL, Beroukhim R, Resnick AC.

Nat Genet. 2016 Mar;48(3):273-82. doi: 10.1038/ng.3500. Epub 2016 Feb 1.

10.

Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas.

Verreault M, Schmitt C, Goldwirt L, Pelton K, Haidar S, Levasseur C, Guehennec J, Knoff D, Labussière M, Marie Y, Ligon AH, Mokhtari K, Hoang-Xuan K, Sanson M, Alexander BM, Wen PY, Delattre JY, Ligon KL, Idbaih A.

Clin Cancer Res. 2016 Mar 1;22(5):1185-96. doi: 10.1158/1078-0432.CCR-15-1015. Epub 2015 Oct 19. Erratum in: Clin Cancer Res. 2016 May 1;22(9):2313.

11.

Hypercholesterolemia induces angiogenesis and accelerates growth of breast tumors in vivo.

Pelton K, Coticchia CM, Curatolo AS, Schaffner CP, Zurakowski D, Solomon KR, Moses MA.

Am J Pathol. 2014 Jul;184(7):2099-110. doi: 10.1016/j.ajpath.2014.03.006.

12.

Cholesterol and prostate cancer.

Pelton K, Freeman MR, Solomon KR.

Curr Opin Pharmacol. 2012 Dec;12(6):751-9. doi: 10.1016/j.coph.2012.07.006. Epub 2012 Jul 21. Review.

13.

Hypercholesterolemia promotes an osteoporotic phenotype.

Pelton K, Krieder J, Joiner D, Freeman MR, Goldstein SA, Solomon KR.

Am J Pathol. 2012 Sep;181(3):928-36. doi: 10.1016/j.ajpath.2012.05.034. Epub 2012 Jul 4.

14.

The response of the prostate to circulating cholesterol: activating transcription factor 3 (ATF3) as a prominent node in a cholesterol-sensing network.

Kim J, Di Vizio D, Kim TK, Kim J, Kim M, Pelton K, Clinton SK, Hai T, Hwang D, Solomon KR, Freeman MR.

PLoS One. 2012;7(7):e39448. doi: 10.1371/journal.pone.0039448. Epub 2012 Jul 2. Erratum in: PLoS One. 2012;7(8). doi:10.1371/annotation/b77e9022-f87c-4f77-9f82-9072351e3360.

15.

Increased smooth muscle contractility in mice deficient for neuropilin 2.

Bielenberg DR, Seth A, Shimizu A, Pelton K, Cristofaro V, Ramachandran A, Zwaans BM, Chen C, Krishnan R, Seth M, Huang L, Takashima S, Klagsbrun M, Sullivan MP, Adam RM.

Am J Pathol. 2012 Aug;181(2):548-59. doi: 10.1016/j.ajpath.2012.04.013. Epub 2012 Jun 9.

16.

Impact of circulating cholesterol levels on growth and intratumoral androgen concentration of prostate tumors.

Mostaghel EA, Solomon KR, Pelton K, Freeman MR, Montgomery RB.

PLoS One. 2012;7(1):e30062. doi: 10.1371/journal.pone.0030062. Epub 2012 Jan 18.

17.

FosB regulates stretch-induced expression of extracellular matrix proteins in smooth muscle.

Ramachandran A, Gong EM, Pelton K, Ranpura SA, Mulone M, Seth A, Gomez P 3rd, Adam RM.

Am J Pathol. 2011 Dec;179(6):2977-89. doi: 10.1016/j.ajpath.2011.08.034. Epub 2011 Oct 11.

18.

Prohibitin is a cholesterol-sensitive regulator of cell cycle transit.

Dong P, Flores J, Pelton K, Solomon KR.

J Cell Biochem. 2010 Dec 1;111(5):1367-74. doi: 10.1002/jcb.22865.

PMID:
20830747
19.

Ezetimibe reduces enlarged prostate in an animal model of benign prostatic hyperplasia.

Pelton K, Di Vizio D, Insabato L, Schaffner CP, Freeman MR, Solomon KR.

J Urol. 2010 Oct;184(4):1555-9. doi: 10.1016/j.juro.2010.05.083. Epub 2010 Aug 21.

PMID:
20728125
20.

Open versus closed treatment of the fibula in Maissoneuve injuries.

Pelton K, Thordarson DB, Barnwell J.

Foot Ankle Int. 2010 Jul;31(7):604-8. doi: 10.3113/FAI.2010.0604.

PMID:
20663427
21.

Ezetimibe is an inhibitor of tumor angiogenesis.

Solomon KR, Pelton K, Boucher K, Joo J, Tully C, Zurakowski D, Schaffner CP, Kim J, Freeman MR.

Am J Pathol. 2009 Mar;174(3):1017-26. doi: 10.2353/ajpath.2009.080551. Epub 2009 Jan 29.

22.

Genome sequence and analysis of a Propionibacterium acnes bacteriophage.

Farrar MD, Howson KM, Bojar RA, West D, Towler JC, Parry J, Pelton K, Holland KT.

J Bacteriol. 2007 Jun;189(11):4161-7. Epub 2007 Mar 30.

23.

Tibiotalocalcaneal arthrodesis using a dynamically locked retrograde intramedullary nail.

Pelton K, Hofer JK, Thordarson DB.

Foot Ankle Int. 2006 Oct;27(10):759-63.

PMID:
17054874
24.

Atrial natriuretic factor receptors in cultured renomedullary interstitial cells.

Fontoura BM, Nussenzveig DR, Pelton KM, Maack T.

Am J Physiol. 1990 Apr;258(4 Pt 1):C692-9.

PMID:
2159215
25.

Primary amyloidosis A. Immunohistochemical and biochemical characterization.

Picken MM, Pelton K, Frangione B, Gallo G.

Am J Pathol. 1987 Dec;129(3):536-42.

26.

Oncocytic adenoma of the parotid gland with psammoma bodies.

Feiner HD, Goldstein S, Ittman M, Pelton K, Jacobs J.

Arch Pathol Lab Med. 1986 Jul;110(7):640-4.

PMID:
3755026

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