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Items: 11

1.

Beyond Traditional Structure-Based Drug Design: The Role of Iron Complexation, Strain, and Water in the Binding of Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylase 2.

Bembenek SD, Venkatesan H, Peltier HM, Rosen MD, Barrett TD, Kanelakis KC, Palomino HL, Brondstetter TI, Mirzadegan T, Rabinowitz MH.

ACS Omega. 2019 Apr 30;4(4):6703-6708. doi: 10.1021/acsomega.9b00199. Epub 2019 Apr 12.

2.

Emerging technologies for metabolite generation and structural diversification.

Cusack KP, Koolman HF, Lange UE, Peltier HM, Piel I, Vasudevan A.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5471-83. doi: 10.1016/j.bmcl.2013.08.003. Epub 2013 Aug 11.

3.

Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor.

Barrett TD, Palomino HL, Brondstetter TI, Kanelakis KC, Wu X, Haug PV, Yan W, Young A, Hua H, Hart JC, Tran DT, Venkatesan H, Rosen MD, Peltier HM, Sepassi K, Rizzolio MC, Bembenek SD, Mirzadegan T, Rabinowitz MH, Shankley NP.

Mol Pharmacol. 2011 Jun;79(6):910-20. doi: 10.1124/mol.110.070508. Epub 2011 Mar 3.

PMID:
21372172
4.

Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.

Rosen MD, Venkatesan H, Peltier HM, Bembenek SD, Kanelakis KC, Zhao LX, Leonard BE, Hocutt FM, Wu X, Palomino HL, Brondstetter TI, Haugh PV, Cagnon L, Yan W, Liotta LA, Young A, Mirzadegan T, Shankley NP, Barrett TD, Rabinowitz MH.

ACS Med Chem Lett. 2010 Oct 5;1(9):526-9. doi: 10.1021/ml100198y. eCollection 2010 Dec 9.

5.

Molecular and functional analysis of a novel MEK2 mutation in cardio-facio-cutaneous syndrome: transmission through four generations.

Rauen KA, Tidyman WE, Estep AL, Sampath S, Peltier HM, Bale SJ, Lacassie Y.

Am J Med Genet A. 2010 Apr;152A(4):807-14. doi: 10.1002/ajmg.a.33342.

6.

Expedient synthesis of N-methyl tubulysin analogues with high cytotoxicity.

Patterson AW, Peltier HM, Ellman JA.

J Org Chem. 2008 Jun 20;73(12):4362-9. doi: 10.1021/jo800384x. Epub 2008 May 15.

PMID:
18479168
7.

Design, synthesis, and biological properties of highly potent tubulysin D analogues.

Patterson AW, Peltier HM, Sasse F, Ellman JA.

Chemistry. 2007;13(34):9534-41.

PMID:
17828721
8.

One-pot asymmetric synthesis of either diastereomer of tert-butanesulfinyl-protected amines from ketones.

Tanuwidjaja J, Peltier HM, Ellman JA.

J Org Chem. 2007 Jan 19;72(2):626-9.

PMID:
17221983
9.

The total synthesis of tubulysin D.

Peltier HM, McMahon JP, Patterson AW, Ellman JA.

J Am Chem Soc. 2006 Dec 20;128(50):16018-9.

PMID:
17165738
10.

N-sulfinyl metalloenamine conjugate additions: asymmetric synthesis of piperidines.

Peltier HM, Ellman JA.

J Org Chem. 2005 Sep 2;70(18):7342-5.

PMID:
16122257
11.

Catalytic enantioselective sulfinyl transfer using cinchona alkaloid catalysts.

Peltier HM, Evans JW, Ellman JA.

Org Lett. 2005 Apr 28;7(9):1733-6.

PMID:
15844893

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