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From radioactive ligands to biosensors: binding methods with olfactory proteins.

Pelosi P, Zhu J, Knoll W.

Appl Microbiol Biotechnol. 2018 Jul 27. doi: 10.1007/s00253-018-9253-5. [Epub ahead of print] Review.


Periodic Fluctuation of Tidal Volumes Further Improves Variable Ventilation in Experimental Acute Respiratory Distress Syndrome.

Güldner A, Huhle R, Beda A, Kiss T, Bluth T, Rentzsch I, Kerber S, Carvalho NC, Kasper M, Pelosi P, de Abreu MG.

Front Physiol. 2018 Jul 12;9:905. doi: 10.3389/fphys.2018.00905. eCollection 2018.


Between hypoxia or hyperoxia: not perfect but more physiologic.

Robba C, Ball L, Pelosi P.

J Thorac Dis. 2018 Jun;10(Suppl 17):S2052-S2054. doi: 10.21037/jtd.2018.05.129. No abstract available.


Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis.

Serpa Neto A, Bos LD, Campos PPZA, Hemmes SNT, Bluth T, Calfee CS, Ferner M, Güldner A, Hollmann MW, India I, Kiss T, Laufenberg-Feldmann R, Sprung J, Sulemanji D, Unzueta C, Vidal Melo MF, Weingarten TN, Tuip-de Boer AM, Pelosi P, Gama de Abreu M, Schultz MJ; PROVHILO* and the PROVE** investigators.

Eur J Anaesthesiol. 2018 Sep;35(9):702-709. doi: 10.1097/EJA.0000000000000846.


The LAS VEGAS risk score for prediction of postoperative pulmonary complications: An observational study.

Neto AS, da Costa LGV, Hemmes SNT, Canet J, Hedenstierna G, Jaber S, Hiesmayr M, Hollmann MW, Mills GH, Vidal Melo MF, Pearse R, Putensen C, Schmid W, Severgnini P, Wrigge H, Gama de Abreu M, Pelosi P, Schultz MJ; LAS VEGAS.

Eur J Anaesthesiol. 2018 Sep;35(9):691-701. doi: 10.1097/EJA.0000000000000845.


Balanced Crystalloids Versus Saline for Perioperative Intravenous Fluid Administration in Children Undergoing Neurosurgery: A Randomized Clinical Trial.

Lima MF, Neville IS, Cavalheiro S, Bourguignon DC, Pelosi P, Malbouisson LMS.

J Neurosurg Anesthesiol. 2018 Jun 15. doi: 10.1097/ANA.0000000000000515. [Epub ahead of print]


Performances of CPAP Devices With an Oronasal Mask.

Vargas M, Marra A, Vivona L, Ball L, Marinò V, Pelosi P, Servillo G.

Respir Care. 2018 Aug;63(8):1033-1039. doi: 10.4187/respcare.05930. Epub 2018 May 29.


Practice of mechanical ventilation in cardiac arrest patients and effects of targeted temperature management: A substudy of the targeted temperature management trial.

Harmon MBA, van Meenen DMP, van der Veen ALIP, Binnekade JM, Dankiewicz J, Ebner F, Nielsen N, Pelosi P, Schultz MJ, Horn J, Friberg H, Juffermans NP; TTM trial investigators.

Resuscitation. 2018 Aug;129:29-36. doi: 10.1016/j.resuscitation.2018.04.040. Epub 2018 May 12.


Individualized, perioperative, hemodynamic goal-directed therapy in major abdominal surgery (iPEGASUS trial): study protocol for a randomized controlled trial.

Funcke S, Saugel B, Koch C, Schulte D, Zajonz T, Sander M, Gratarola A, Ball L, Pelosi P, Spadaro S, Ragazzi R, Volta CA, Mencke T, Zitzmann A, Neukirch B, Azparren G, Giné M, Moral V, Pinnschmidt HO, Díaz-Cambronero O, Estelles MJA, Velez ME, Montañes MV, Belda J, Soro M, Puig J, Reuter DA, Haas SA.

Trials. 2018 May 9;19(1):273. doi: 10.1186/s13063-018-2620-9.


RELAx - REstricted versus Liberal positive end-expiratory pressure in patients without ARDS: protocol for a randomized controlled trial.

Algera AG, Pisani L, Bergmans DCJ, den Boer S, de Borgie CAJ, Bosch FH, Bruin K, Cherpanath TG, Determann RM, Dondorp AM, Dongelmans DA, Endeman H, Haringman JJ, Horn J, Juffermans NP, van Meenen DM, van der Meer NJ, Merkus MP, Moeniralam HS, Purmer I, Tuinman PR, Slabbekoorn M, Spronk PE, Vlaar APJ, Gama de Abreu M, Pelosi P, Serpa Neto A, Schultz MJ, Paulus F; RELAx Investigators and the PROVE Network Investigators.

Trials. 2018 May 9;19(1):272. doi: 10.1186/s13063-018-2640-5.


Tracheostomy in intensive care: Patients and families will never walk alone!

Pelosi P, Ball L, Brunetti I, Vargas M, Patroniti N.

Anaesth Crit Care Pain Med. 2018 Jun;37(3):197-199. doi: 10.1016/j.accpm.2018.04.001. No abstract available.


PRactice of VENTilation in Middle-Income Countries (PRoVENT-iMIC): rationale and protocol for a prospective international multicentre observational study in intensive care units in Asia.

Pisani L, Algera AG, Serpa Neto A, Ahsan A, Beane A, Chittawatanarat K, Faiz A, Haniffa R, Hashemian R, Hashmi M, Imad HA, Indraratna K, Iyer S, Kayastha G, Krishna B, Moosa H, Nadjm B, Pattnaik R, Sampath S, Thwaites L, Tun NN, Yunos NM, Grasso S, Paulus F, de Abreu MG, Pelosi P, Dondorp AM, Schultz MJ; PRoVENT–iMIC investigators, MORU and the PROVE network.

BMJ Open. 2018 Apr 28;8(4):e020841. doi: 10.1136/bmjopen-2017-020841.


Impact of Different Tidal Volume Levels at Low Mechanical Power on Ventilator-Induced Lung Injury in Rats.

Moraes L, Silva PL, Thompson A, Santos CL, Santos RS, Fernandes MVS, Morales MM, Martins V, Capelozzi VL, de Abreu MG, Pelosi P, Rocco PRM.

Front Physiol. 2018 Apr 4;9:318. doi: 10.3389/fphys.2018.00318. eCollection 2018.


The fragility of statistically significant findings in randomised controlled anaesthesiology trials: systematic review of the medical literature.

Mazzinari G, Ball L, Serpa Neto A, Errando CL, Dondorp AM, Bos LD, Gama de Abreu M, Pelosi P, Schultz MJ.

Br J Anaesth. 2018 May;120(5):935-941. doi: 10.1016/j.bja.2018.01.012. Epub 2018 Feb 13. Review.


A systematic review and consensus definitions for standardised end-points in perioperative medicine: pulmonary complications.

Abbott TEF, Fowler AJ, Pelosi P, Gama de Abreu M, Møller AM, Canet J, Creagh-Brown B, Mythen M, Gin T, Lalu MM, Futier E, Grocott MP, Schultz MJ, Pearse RM; StEP-COMPAC Group.

Br J Anaesth. 2018 May;120(5):1066-1079. doi: 10.1016/j.bja.2018.02.007. Epub 2018 Mar 27. Review.


Reply to: high versus low positive end-expiratory pressure for abdominal surgery.

Treschan TA, Gama de Abreu M, Pelosi P, Schultz MJ; PROVE Network Investigators.

Eur J Anaesthesiol. 2018 Jan;35(1):67-68. doi: 10.1097/EJA.0000000000000719. No abstract available.


Odorant-binding protein-based identification of natural spatial repellents for the African malaria mosquito Anopheles gambiae.

Kröber T, Koussis K, Bourquin M, Tsitoura P, Konstantopoulou M, Awolola TS, Dani FR, Qiao H, Pelosi P, Iatrou K, Guerin PM.

Insect Biochem Mol Biol. 2018 May;96:36-50. doi: 10.1016/j.ibmb.2018.03.008. Epub 2018 Apr 12.


Proteomic analysis of chemosensory organs in the honey bee parasite Varroa destructor: A comprehensive examination of the potential carriers for semiochemicals.

Iovinella I, McAfee A, Mastrobuoni G, Kempa S, Foster LJ, Pelosi P, Dani FR.

J Proteomics. 2018 Jun 15;181:131-141. doi: 10.1016/j.jprot.2018.04.009. Epub 2018 Apr 10.


A death pheromone, oleic acid, triggers hygienic behavior in honey bees (Apis mellifera L.).

McAfee A, Chapman A, Iovinella I, Gallagher-Kurtzke Y, Collins TF, Higo H, Madilao LL, Pelosi P, Foster LJ.

Sci Rep. 2018 Apr 9;8(1):5719. doi: 10.1038/s41598-018-24054-2.


Ventilator-induced lung injury during controlled ventilation in patients with acute respiratory distress syndrome: less is probably better.

Cruz FF, Ball L, Rocco PRM, Pelosi P.

Expert Rev Respir Med. 2018 May;12(5):403-414. doi: 10.1080/17476348.2018.1457954. Epub 2018 Mar 29.


Acute exacerbation of idiopathic pulmonary fibrosis: lessons learned from acute respiratory distress syndrome?

Marchioni A, Tonelli R, Ball L, Fantini R, Castaniere I, Cerri S, Luppi F, Malerba M, Pelosi P, Clini E.

Crit Care. 2018 Mar 23;22(1):80. doi: 10.1186/s13054-018-2002-4. Review.


Potentially modifiable respiratory variables contributing to outcome in ICU patients without ARDS: a secondary analysis of PRoVENT.

Simonis FD, Barbas CSV, Artigas-Raventós A, Canet J, Determann RM, Anstey J, Hedenstierna G, Hemmes SNT, Hermans G, Hiesmayr M, Hollmann MW, Jaber S, Martin-Loeches I, Mills GH, Pearse RM, Putensen C, Schmid W, Severgnini P, Smith R, Treschan TA, Tschernko EM, Vidal Melo MF, Wrigge H, de Abreu MG, Pelosi P, Schultz MJ, Neto AS; PRoVENT investigators; PROVE Network investigators.

Ann Intensive Care. 2018 Mar 21;8(1):39. doi: 10.1186/s13613-018-0385-7.


Close down the lungs and keep them resting to minimize ventilator-induced lung injury.

Pelosi P, Rocco PRM, Gama de Abreu M.

Crit Care. 2018 Mar 20;22(1):72. doi: 10.1186/s13054-018-1991-3. Review.


Biologic Impact of Mechanical Power at High and Low Tidal Volumes in Experimental Mild Acute Respiratory Distress Syndrome.

Santos RS, Maia LA, Oliveira MV, Santos CL, Moraes L, Pinto EF, Samary CDS, Machado JA, Carvalho AC, Fernandes MVS, Martins V, Capelozzi VL, Morales MM, Koch T, Gama de Abreu M, Pelosi P, Silva PL, Rocco PRM.

Anesthesiology. 2018 Jun;128(6):1193-1206. doi: 10.1097/ALN.0000000000002143.


Effect of On-Demand vs Routine Nebulization of Acetylcysteine With Salbutamol on Ventilator-Free Days in Intensive Care Unit Patients Receiving Invasive Ventilation: A Randomized Clinical Trial.

van Meenen DMP, van der Hoeven SM, Binnekade JM, de Borgie CAJM, Merkus MP, Bosch FH, Endeman H, Haringman JJ, van der Meer NJM, Moeniralam HS, Slabbekoorn M, Muller MCA, Stilma W, van Silfhout B, Neto AS, Ter Haar HFM, Van Vliet J, Wijnhoven JW, Horn J, Juffermans NP, Pelosi P, Gama de Abreu M, Schultz MJ, Paulus F.

JAMA. 2018 Mar 13;319(10):993-1001. doi: 10.1001/jama.2018.0949.


Niemann-Pick C2 Proteins: A New Function for an Old Family.

Zhu J, Guo M, Ban L, Song LM, Liu Y, Pelosi P, Wang G.

Front Physiol. 2018 Jan 31;9:52. doi: 10.3389/fphys.2018.00052. eCollection 2018.


Correction to: External confirmation and exploration of the Kigali modification for diagnosing moderate or severe ARDS.

Vercesi V, Pisani L, van Tongeren PSI, Lagrand WK, Leopold SJ, Huson MMA, Henwood PC, Walden A, Smit M, Riviello ED, Pelosi P, Dondorp AM, Schultz MJ; Lung Ultrasound Consortium.

Intensive Care Med. 2018 Mar;44(3):403-404. doi: 10.1007/s00134-018-5098-8.


Variable versus conventional lung protective mechanical ventilation during open abdominal surgery (PROVAR): a randomised controlled trial.

Spieth PM, Güldner A, Uhlig C, Bluth T, Kiss T, Conrad C, Bischlager K, Braune A, Huhle R, Insorsi A, Tarantino F, Ball L, Schultz MJ, Abolmaali N, Koch T, Pelosi P, Gama de Abreu M; PROtective Ventilation (PROVE) Network.

Br J Anaesth. 2018 Mar;120(3):581-591. doi: 10.1016/j.bja.2017.11.078. Epub 2017 Dec 1.


Effects of peep on lung injury, pulmonary function, systemic circulation and mortality in animals with uninjured lungs-a systematic review.

Algera AG, Pisani L, Chaves RCF, Amorim TC, Cherpanath T, Determann R, Dongelmans DA, Paulus F, Tuinman PR, Pelosi P, Gama de Abreu M, Schultz MJ, Serpa Neto A; PROVE Network Investigators.

Ann Transl Med. 2018 Jan;6(2):25. doi: 10.21037/atm.2017.12.05. Review.


Interaction between peri-operative blood transfusion, tidal volume, airway pressure and postoperative ARDS: an individual patient data meta-analysis.

Serpa Neto A, Juffermans NP, Hemmes SNT, Barbas CSV, Beiderlinden M, Biehl M, Fernandez-Bustamante A, Futier E, Gajic O, Jaber S, Kozian A, Licker M, Lin WQ, Memtsoudis SG, Miranda DR, Moine P, Paparella D, Ranieri M, Scavonetto F, Schilling T, Selmo G, Severgnini P, Sprung J, Sundar S, Talmor D, Treschan T, Unzueta C, Weingarten TN, Wolthuis EK, Wrigge H, de Abreu MG, Pelosi P, Schultz MJ; PROVE Network Investigators.

Ann Transl Med. 2018 Jan;6(2):23. doi: 10.21037/atm.2018.01.16.


Ultrasound-Guided Percutaneous Dilational Tracheostomy: A Systematic Review of Randomized Controlled Trials and Meta-Analysis.

Gobatto ALN, Besen BAMP, Cestari M, Pelosi P, Malbouisson LMS.

J Intensive Care Med. 2018 Jan 1:885066618755334. doi: 10.1177/0885066618755334. [Epub ahead of print]


Positive end-expiratory pressure and recruitment maneuvers in obese patients: should we chase oxygenation?

Ball L, Pelosi P.

Minerva Anestesiol. 2018 Apr;84(4):429-431. doi: 10.23736/S0375-9393.18.12608-3. Epub 2018 Jan 29. No abstract available.


Should the lungs be rested or open during anaesthesia to prevent postoperative complications?

Schultz MJ, Neto AS, Pelosi P, de Abreu MG.

Lancet Respir Med. 2018 Mar;6(3):163-165. doi: 10.1016/S2213-2600(18)30025-0. Epub 2018 Jan 19. No abstract available.


External confirmation and exploration of the Kigali modification for diagnosing moderate or severe ARDS.

Vercesi V, Pisani L, van Tongeren PSI, Lagrand WK, Leopold SJ, Huson MMA, Henwood PC, Walden A, Smit M, Riviello ED, Pelosi P, Dondorp AM, Schultz MJ; Lung Ultrasound Consortium.

Intensive Care Med. 2018 Apr;44(4):523-524. doi: 10.1007/s00134-018-5048-5. Epub 2018 Jan 24. No abstract available. Erratum in: Intensive Care Med. 2018 Feb 20;:.


Intensive Care Medicine: Different Recipes for Shared Goals.

Ball L, Riforgiato C, Pelosi P.

Turk J Anaesthesiol Reanim. 2017 Dec;45(6):327-328. doi: 10.5152/TJAR.2017.251101. Epub 2017 Dec 1. No abstract available.


Tracheal intubation in critically ill patients: a comprehensive systematic review of randomized trials.

Cabrini L, Landoni G, Baiardo Radaelli M, Saleh O, Votta CD, Fominskiy E, Putzu A, Snak de Souza CD, Antonelli M, Bellomo R, Pelosi P, Zangrillo A.

Crit Care. 2018 Jan 20;22(1):6. doi: 10.1186/s13054-017-1927-3.


Intratidal Analysis of Intraoperative Respiratory System Mechanics: Keep it Simple.

Huhle R, D'Antini D, Herrmann J, Raimondo P, Mirabella L, Hemmes SNT, Schultz MJ, Pelosi P, Kaczka DW, Cinnella G, Gama de Abreu M.

Anesth Analg. 2018 Feb;126(2):725-726. doi: 10.1213/ANE.0000000000002556. No abstract available.


The real role of the PEEP in operating room: pros & cons.

Pelosi P, Hedenstierna G, Ball L, Edmark L, Bignami E.

Minerva Anestesiol. 2018 Feb;84(2):229-235. doi: 10.23736/S0375-9393.18.12416-3. Epub 2018 Jan 17. No abstract available.


Mortality and long-term quality of life after percutaneous tracheotomy in Intensive Care Unit: a prospective observational study.

Vargas M, Sutherasan Y, Brunetti I, Micalizzi C, Insorsi A, Ball L, Folentino M, Sileo R, DE Lucia A, Cerana M, Accattatis A, DE Lisi D, Gratarola A, Mora F, Peretti G, Servillo G, Pelosi P.

Minerva Anestesiol. 2018 Jan 16. doi: 10.23736/S0375-9393.18.12133-X. [Epub ahead of print]


Variability in Tidal Volume Affects Lung and Cardiovascular Function Differentially in a Rat Model of Experimental Emphysema.

Wierzchon CGRS, Padilha G, Rocha NN, Huhle R, Coelho MS, Santos CL, Santos RS, Samary CS, Silvino FRG, Pelosi P, Gama de Abreu M, Rocco PRM, Silva PL.

Front Physiol. 2017 Dec 18;8:1071. doi: 10.3389/fphys.2017.01071. eCollection 2017.


Return to Work and Participation in Society After Out-of-Hospital Cardiac Arrest.

Lilja G, Nielsen N, Bro-Jeppesen J, Dunford H, Friberg H, Hofgren C, Horn J, Insorsi A, Kjaergaard J, Nilsson F, Pelosi P, Winters T, Wise MP, Cronberg T.

Circ Cardiovasc Qual Outcomes. 2018 Jan;11(1):e003566. doi: 10.1161/CIRCOUTCOMES.117.003566.


Effects of pressure support ventilation on ventilator-induced lung injury in mild acute respiratory distress syndrome depend on level of positive end-expiratory pressure: A randomised animal study.

Magalhães PAF, Padilha GA, Moraes L, Santos CL, Maia LA, Braga CL, Duarte MDCMB, Andrade LB, Schanaider A, Capellozzi VL, Huhle R, Gama de Abreu M, Pelosi P, Rocco PRM, Silva PL.

Eur J Anaesthesiol. 2018 Apr;35(4):298-306. doi: 10.1097/EJA.0000000000000763.


Mesenchymal Stem Cells From Bone Marrow, Adipose Tissue, and Lung Tissue Differentially Mitigate Lung and Distal Organ Damage in Experimental Acute Respiratory Distress Syndrome.

Silva JD, Lopes-Pacheco M, Paz AHR, Cruz FF, Melo EB, de Oliveira MV, Xisto DG, Capelozzi VL, Morales MM, Pelosi P, Cirne-Lima E, Rocco PRM.

Crit Care Med. 2018 Feb;46(2):e132-e140. doi: 10.1097/CCM.0000000000002833.


Role of the extracellular matrix in the genesis of ventilator-induced lung injury.

Cruz FF, Rocco PRM, Pelosi P.

Med Klin Intensivmed Notfmed. 2018 Feb;113(Suppl 1):2-6. doi: 10.1007/s00063-017-0376-8. Epub 2017 Nov 7. Review.


Educational and Training Programs in Intensive Care Medicine are the Right Way.

Ball L, Riforgiato C, Pelosi P.

Turk J Anaesthesiol Reanim. 2017 Oct;45(5):247-248. doi: 10.5152/TJAR.2017.200902. Epub 2017 Oct 1. No abstract available.


Reverse chemical ecology: Olfactory proteins from the giant panda and their interactions with putative pheromones and bamboo volatiles.

Zhu J, Arena S, Spinelli S, Liu D, Zhang G, Wei R, Cambillau C, Scaloni A, Wang G, Pelosi P.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9802-E9810. doi: 10.1073/pnas.1711437114. Epub 2017 Oct 23.


Erratum to: Immunomodulation after ischemic stroke: potential mechanisms and implications for therapy.

Samary CS, Pelosi P, Silva PL, Rocco PRM.

Crit Care. 2017 Oct 18;21(1):256. doi: 10.1186/s13054-017-1834-7. No abstract available.


Intraoperative fraction of inspired oxygen: bringing back the focus on patient outcome.

Ball L, Lumb AB, Pelosi P.

Br J Anaesth. 2017 Jul 1;119(1):16-18. doi: 10.1093/bja/aex176. No abstract available.


Bone Status in a Patient with Insulin-Like Growth Factor-1 Receptor Deletion Syndrome: Bone Quality and Structure Evaluation Using Dual-Energy X-Ray Absorptiometry, Peripheral Quantitative Computed Tomography, and Quantitative Ultrasonography.

Pelosi P, Lapi E, Cavalli L, Verrotti A, Pantaleo M, de Martino M, Stagi S.

Front Endocrinol (Lausanne). 2017 Sep 5;8:227. doi: 10.3389/fendo.2017.00227. eCollection 2017.


Diagnostic Value of Endotracheal Aspirates Sonication on Ventilator-Associated Pneumonia Microbiologic Diagnosis.

Fernández-Barat L, Motos A, Ranzani OT, Bassi GL, Aguilera Xiol E, Senussi T, Travierso C, Chiurazzi C, Idone F, Muñoz L, Vila J, Ferrer M, Pelosi P, Blasi F, Antonelli M, Torres A.

Microorganisms. 2017 Sep 20;5(3). pii: E62. doi: 10.3390/microorganisms5030062.

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