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Influence of Positive End-Expiratory Pressure Titration on the Effects of Pronation in Acute Respiratory Distress Syndrome: A Comprehensive Experimental Study.

Scaramuzzo G, Ball L, Pino F, Ricci L, Larsson A, Guérin C, Pelosi P, Perchiazzi G.

Front Physiol. 2020 Mar 12;11:179. doi: 10.3389/fphys.2020.00179. eCollection 2020.


Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017.

Vincent JL, Sakr Y, Singer M, Martin-Loeches I, Machado FR, Marshall JC, Finfer S, Pelosi P, Brazzi L, Aditianingsih D, Timsit JF, Du B, Wittebole X, Máca J, Kannan S, Gorordo-Delsol LA, De Waele JJ, Mehta Y, Bonten MJM, Khanna AK, Kollef M, Human M, Angus DC; EPIC III Investigators.

JAMA. 2020 Mar 24. doi: 10.1001/jama.2020.2717. [Epub ahead of print]


Protocol for outcome reporting and follow-up in the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest trial (TTM2).

Lilja G, Nielsen N, Ullén S, Nordstrom EB, Dankiewicz J, Friberg H, Heimburg K, Jakobsen JC, Levin H, Callaway C, Cariou A, Eastwood GM, Helbok R, Hovdenes J, Kirkegaard H, Leithner C, Morgan MPG, Nordberg P, Oddo M, Pelosi P, Rylander C, Saxena M, Taccone FS, Siranec M, Wise MP, Young PJ, Cronberg T.

Resuscitation. 2020 Mar 20. pii: S0300-9572(20)30113-1. doi: 10.1016/j.resuscitation.2020.03.004. [Epub ahead of print]


Isoleucine residues determine chiral discrimination of odorant-binding protein.

Zaremska V, Tan J, Lim S, Knoll W, Pelosi P.

Chemistry. 2020 Mar 13. doi: 10.1002/chem.202000872. [Epub ahead of print]


Noninvasive respiratory support in the hypoxaemic peri-operative/periprocedural patient: a joint ESA/ESICM guideline.

Leone M, Einav S, Chiumello D, Constantin JM, De Robertis E, De Abreu MG, Gregoretti C, Jaber S, Maggiore SM, Pelosi P, Sorbello M, Afshari A; Guideline contributors.

Intensive Care Med. 2020 Apr;46(4):697-713. doi: 10.1007/s00134-020-05948-0. Epub 2020 Mar 10.


Noninvasive respiratory support in the hypoxaemic peri-operative/periprocedural patient: A joint ESA/ESICM guideline.

Leone M, Einav S, Chiumello D, Constantin JM, De Robertis E, Abreu MG, Gregoretti C, Jaber S, Maggiore SM, Pelosi P, Sorbello M, Afshari A.

Eur J Anaesthesiol. 2020 Apr;37(4):265-279. doi: 10.1097/EJA.0000000000001166.


Understanding the Mysteries of Mechanical Power.

Silva PL, Pelosi P, Rocco PRM.

Anesthesiology. 2020 Mar 2. doi: 10.1097/ALN.0000000000003222. [Epub ahead of print] No abstract available.


The Major Cat Allergen Fel d 1 Binds Steroid and Fatty Acid Semiochemicals: A Combined In Silico and In Vitro Study.

Bienboire-Frosini C, Durairaj R, Pelosi P, Pageat P.

Int J Mol Sci. 2020 Feb 18;21(4). pii: E1365. doi: 10.3390/ijms21041365.


Myocardial Function during Low versus Intermediate Tidal Volume Ventilation in Patients without Acute Respiratory Distress Syndrome.

Cherpanath TGV, Simonis FD, Bouma BJ, de Bruin-Bon RH, Determann RM, Juffermans NP, Gama de Abreu M, Pelosi P, Serpa Neto A, Groeneveld JAB, Schultz MJ, Lagrand WK.

Anesthesiology. 2020 Feb 11. doi: 10.1097/ALN.0000000000003175. [Epub ahead of print]


Effects of variable versus nonvariable controlled mechanical ventilation on pulmonary inflammation in experimental acute respiratory distress syndrome in pigs.

Wittenstein J, Scharffenberg M, Braune A, Huhle R, Bluth T, Herzog M, Güldner A, Ball L, Simonassi F, Zeidler-Rentzsch I, Vidal Melo MF, Koch T, Rocco PRM, Pelosi P, Kotzerke J, Gama de Abreu M, Kiss T.

Br J Anaesth. 2020 Feb 4. pii: S0007-0912(20)30005-2. doi: 10.1016/j.bja.2019.12.040. [Epub ahead of print]


Associations between changes in oxygenation, dead space and driving pressure induced by the first prone position session and mortality in patients with acute respiratory distress syndrome.

van Meenen DM, Roozeman JP, Serpa Neto A, Pelosi P, Gama de Abreu M, Horn J, Cremer OL, Paulus F, Schultz MJ; MARS Consortium.

J Thorac Dis. 2019 Dec;11(12):5004-5013. doi: 10.21037/jtd.2019.12.38.


Ventilatory support and mechanical properties of the fibrotic lung acting as a "squishy ball".

Marchioni A, Tonelli R, Rossi G, Spagnolo P, Luppi F, Cerri S, Cocconcelli E, Pellegrino MR, Fantini R, Tabbì L, Castaniere I, Ball L, Malbrain MLNG, Pelosi P, Clini E.

Ann Intensive Care. 2020 Feb 4;10(1):13. doi: 10.1186/s13613-020-0632-6. Review.


Hemodynamic Monitoring in Patients With Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis.

Simonassi F, Ball L, Badenes R, Millone M, Citerio G, Zona G, Pelosi P, Robba C.

J Neurosurg Anesthesiol. 2020 Jan 31. doi: 10.1097/ANA.0000000000000679. [Epub ahead of print]


Intraabdominal Pressure Targeted Positive End-expiratory Pressure during Laparoscopic Surgery: An Open-label, Nonrandomized, Crossover, Clinical Trial.

Mazzinari G, Diaz-Cambronero O, Alonso-Iñigo JM, Garcia-Gregorio N, Ayas-Montero B, Ibañez JL, Serpa Neto A, Ball L, Gama de Abreu M, Pelosi P, Maupoey J, Argente Navarro MP, Schultz MJ.

Anesthesiology. 2020 Apr;132(4):667-677. doi: 10.1097/ALN.0000000000003146.


Extracranial complications after traumatic brain injury: targeting the brain and the body.

Robba C, Bonatti G, Pelosi P, Citerio G.

Curr Opin Crit Care. 2020 Apr;26(2):137-146. doi: 10.1097/MCC.0000000000000707.


Re-evaluation of the effects of high PEEP with recruitment manoeuvres versus low PEEP without recruitment manoeuvres during general anaesthesia for surgery -Protocol and statistical analysis plan for an individual patient data meta-analysis of PROVHILO, iPROVE and PROBESE.

Campos NS, Bluth T, Hemmes SNT, Librero J, Pozo N, Ferrando C, Ball L, Mazzinari G, Pelosi P, Gama de Abreu M, Schultz MJ, Neto AS; para el Comité de en Redacción nombre de The Reevaluation of PEEP in Anesthesia Meta-Analysis los investigadores en nombre red de PROVHILO, iPROVE y PROBESE Investigadores e Investigadores de la Red PROVE.

Rev Esp Anestesiol Reanim. 2020 Feb;67(2):76-89. doi: 10.1016/j.redar.2019.08.002. Epub 2020 Jan 16. English, Spanish. No abstract available.


A critical approach to personalised medicine in ARDS.

Ball L, Silva PL, Rocco PRM, Pelosi P.

Lancet Respir Med. 2020 Mar;8(3):218-219. doi: 10.1016/S2213-2600(19)30352-2. Epub 2020 Jan 13. No abstract available.


Static and Dynamic Transpulmonary Driving Pressures Affect Lung and Diaphragm Injury during Pressure-controlled versus Pressure-support Ventilation in Experimental Mild Lung Injury in Rats.

Pinto EF, Santos RS, Antunes MA, Maia LA, Padilha GA, de A Machado J, Carvalho ACF, Fernandes MVS, Capelozzi VL, de Abreu MG, Pelosi P, Rocco PRM, Silva PL.

Anesthesiology. 2020 Feb;132(2):307-320. doi: 10.1097/ALN.0000000000003060.


How to use cerebral ultrasound in the ICU.

Bertuetti R, Gritti P, Pelosi P, Robba C.

Minerva Anestesiol. 2020 Mar;86(3):327-340. doi: 10.23736/S0375-9393.19.13852-7. Epub 2020 Jan 8.


Effects of Protective Mechanical Ventilation With Different PEEP Levels on Alveolar Damage and Inflammation in a Model of Open Abdominal Surgery: A Randomized Study in Obese Versus Non-obese Rats.

Maia LA, Fernandes MVS, Santos RS, Agra LC, Carvalho AC, Rocha NN, Oliveira MV, Santos CL, Morales MM, Capelozzi VL, Souza SAL, Gutfilen B, Schultz MJ, Gama de Abreu M, Pelosi P, Silva PL, Rocco PRM.

Front Physiol. 2019 Dec 17;10:1513. doi: 10.3389/fphys.2019.01513. eCollection 2019.


Probe-dependence of competitive fluorescent ligand binding assays to odorant-binding proteins.

Tan J, Zaremska V, Lim S, Knoll W, Pelosi P.

Anal Bioanal Chem. 2020 Jan;412(3):547-554. doi: 10.1007/s00216-019-02309-9. Epub 2019 Dec 18.


Tracheal intubation in patients at risk for cervical spinal cord injury: A systematic review.

Cabrini L, Baiardo Redaelli M, Filippini M, Fominskiy E, Pasin L, Pintaudi M, Plumari VP, Putzu A, Votta CD, Pallanch O, Ball L, Landoni G, Pelosi P, Zangrillo A.

Acta Anaesthesiol Scand. 2020 Apr;64(4):443-454. doi: 10.1111/aas.13532. Epub 2019 Dec 27. Review.


Mechanical ventilation in patients with acute ischaemic stroke: from pathophysiology to clinical practice.

Robba C, Bonatti G, Battaglini D, Rocco PRM, Pelosi P.

Crit Care. 2019 Dec 2;23(1):388. doi: 10.1186/s13054-019-2662-8. Review.


Pulmonary levels of biomarkers for inflammation and lung injury in protective versus conventional one-lung ventilation for oesophagectomy: A randomised clinical trial.

van der Woude MC, Bormans L, van der Horst RP, Sosef MN, Belgers HJ, Hemmes SN, Tuip-de Boer A, Gama de Abreu M, Pelosi P, Spronk PE, Neto AS, Schultz MJ.

Eur J Anaesthesiol. 2019 Dec 4. doi: 10.1097/EJA.0000000000001126. [Epub ahead of print]


Personalized pharmacological therapy for ARDS: a light at the end of the tunnel.

Silva PL, Pelosi P, Rocco PRM.

Expert Opin Investig Drugs. 2020 Jan;29(1):49-61. doi: 10.1080/13543784.2020.1699531. Epub 2019 Dec 3. Review.


Static and Dynamic Transpulmonary Driving Pressures Affect Lung and Diaphragm Injury during Pressure-controlled versus Pressure-support Ventilation in Experimental Mild Lung Injury in Rats.

Pinto EF, Santos RS, Antunes MA, Maia LA, Padilha GA, de A Machado J, Carvalho ACF, Fernandes MVS, Capelozzi VL, de Abreu MG, Pelosi P, Rocco PRM, Silva PL.

Anesthesiology. 2019 Nov 20. doi: 10.1097/ALN.0000000000003060. [Epub ahead of print]


Intraoperative Ventilation Strategies to Reduce Pulmonary Complications in Obese Patients-Reply.

Gama de Abreu M, Schultz M, Pelosi P; Writing Committee for the PROBESE Collaborative Group.

JAMA. 2019 Nov 12;322(18):1829. doi: 10.1001/jama.2019.14400. No abstract available.


Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury.

Henzler D, Schmidt A, Xu Z, Ismaiel N, Zhang H, Slutsky AS, Pelosi P.

Intensive Care Med Exp. 2019 Nov 5;7(1):60. doi: 10.1186/s40635-019-0272-z.


Immunomodulatory effects of anesthetic agents in perioperative medicine.

Boavista Barros Heil L, Leme Silva P, Ferreira Cruz F, Pelosi P, Rieken Macedo Rocco P.

Minerva Anestesiol. 2020 Feb;86(2):181-195. doi: 10.23736/S0375-9393.19.13627-9. Epub 2019 Oct 28.


Correction to: Tracheal intubation in critically ill patients: a comprehensive systematic review of randomized trials.

Cabrini L, Landoni G, Baiardo Redaelli M, Saleh O, Votta CD, Fominskiy E, Putzu A, de Souza CDS, Antonelli M, Bellomo R, Pelosi P, Zangrillo A.

Crit Care. 2019 Oct 21;23(1):325. doi: 10.1186/s13054-019-2634-z.


Normalization of mechanical power to anthropometric indices: impact on its association with mortality in critically ill patients.

Serpa Neto A, Deliberato RO, Johnson AE, Pollard TJ, Celi LA, Pelosi P, Gama de Abreu M, Schultz MJ; PROVE Network Investigators.

Intensive Care Med. 2019 Dec;45(12):1835-1837. doi: 10.1007/s00134-019-05794-9. Epub 2019 Oct 8. No abstract available.


Lung-protective ventilation for the surgical patient: international expert panel-based consensus recommendations.

Young CC, Harris EM, Vacchiano C, Bodnar S, Bukowy B, Elliott RRD, Migliarese J, Ragains C, Trethewey B, Woodward A, Gama de Abreu M, Girard M, Futier E, Mulier JP, Pelosi P, Sprung J.

Br J Anaesth. 2019 Dec;123(6):898-913. doi: 10.1016/j.bja.2019.08.017. Epub 2019 Oct 3. Review.


Current understanding of the therapeutic benefits of mesenchymal stem cells in acute respiratory distress syndrome.

Lopes-Pacheco M, Robba C, Rocco PRM, Pelosi P.

Cell Biol Toxicol. 2020 Feb;36(1):83-102. doi: 10.1007/s10565-019-09493-5. Epub 2019 Sep 4.


Targeted hypothermia versus targeted Normothermia after out-of-hospital cardiac arrest (TTM2): A randomized clinical trial-Rationale and design.

Dankiewicz J, Cronberg T, Lilja G, Jakobsen JC, Bělohlávek J, Callaway C, Cariou A, Eastwood G, Erlinge D, Hovdenes J, Joannidis M, Kirkegaard H, Kuiper M, Levin H, Morgan MPG, Nichol AD, Nordberg P, Oddo M, Pelosi P, Rylander C, Saxena M, Storm C, Taccone F, Ullén S, Wise MP, Young P, Friberg H, Nielsen N.

Am Heart J. 2019 Nov;217:23-31. doi: 10.1016/j.ahj.2019.06.012. Epub 2019 Jun 26.


What's new in intensive care: tracheostomy-what is known and what remains to be determined.

Aquino Esperanza J, Pelosi P, Blanch L.

Intensive Care Med. 2019 Nov;45(11):1619-1621. doi: 10.1007/s00134-019-05758-z. Epub 2019 Aug 26. No abstract available.


High Flow Nasal Cannula Oxygen vs. Conventional Oxygen Therapy and Noninvasive Ventilation in Emergency Department Patients: A Systematic Review and Meta-Analysis.

Tinelli V, Cabrini L, Fominskiy E, Franchini S, Ferrante L, Ball L, Pelosi P, Landoni G, Zangrillo A, Secchi A.

J Emerg Med. 2019 Sep;57(3):322-328. doi: 10.1016/j.jemermed.2019.06.033. Epub 2019 Aug 14.


Perioperative anaesthetic management of patients with or at risk of acute distress respiratory syndrome undergoing emergency surgery.

Battaglini D, Robba C, Rocco PRM, De Abreu MG, Pelosi P, Ball L.

BMC Anesthesiol. 2019 Aug 14;19(1):153. doi: 10.1186/s12871-019-0804-9. Review.


Optic nerve sheath diameter: present and future perspectives for neurologists and critical care physicians.

Lochner P, Czosnyka M, Naldi A, Lyros E, Pelosi P, Mathur S, Fassbender K, Robba C.

Neurol Sci. 2019 Dec;40(12):2447-2457. doi: 10.1007/s10072-019-04015-x. Epub 2019 Jul 31.


The diagnostic accuracy for ARDS of global versus regional lung ultrasound scores - a post hoc analysis of an observational study in invasively ventilated ICU patients.

Pisani L, Vercesi V, van Tongeren PSI, Lagrand WK, Leopold SJ, Huson MAM, Henwood PC, Walden A, Smit MR, Riviello ED, Pelosi P, Dondorp AM, Schultz MJ; Lung Ultrasound Consortium.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):44. doi: 10.1186/s40635-019-0241-6.


Power to mechanical power to minimize ventilator-induced lung injury?

Silva PL, Ball L, Rocco PRM, Pelosi P.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):38. doi: 10.1186/s40635-019-0243-4. Review.


Development of a model for anemia of inflammation that is relevant to critical care.

Boshuizen M, van Bruggen R, Zaat SA, Schultz MJ, Aguilera E, Motos A, Senussi T, Idone FA, Pelosi P, Torres A, Bassi GL, Juffermans NP.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):47. doi: 10.1186/s40635-019-0261-2.


Effects of crystalloid, hyper-oncotic albumin, and iso-oncotic albumin on lung and kidney damage in experimental acute lung injury.

Mendes RS, Oliveira MV, Padilha GA, Rocha NN, Santos CL, Maia LA, Fernandes MVS, Cruz FF, Olsen PC, Capelozzi VL, de Abreu MG, Pelosi P, Rocco PRM, Silva PL.

Respir Res. 2019 Jul 16;20(1):155. doi: 10.1186/s12931-019-1115-x.


Effects of Obesity on Pulmonary Inflammation and Remodeling in Experimental Moderate Acute Lung Injury.

Maia LA, Cruz FF, de Oliveira MV, Samary CS, Fernandes MVS, Trivelin SAA, Rocha NN, Gama de Abreu M, Pelosi P, Silva PL, Rocco PRM.

Front Immunol. 2019 May 29;10:1215. doi: 10.3389/fimmu.2019.01215. eCollection 2019.


Systematic review and meta-analysis of single injection fascia iliaca blocks in the peri-operative management of patients with hip fractures.

Fadhlillah F, Chan D, Pelosi P, Rubulotta F.

Minerva Anestesiol. 2019 Nov;85(11):1211-1218. doi: 10.23736/S0375-9393.19.13535-3. Epub 2019 Jul 4.


Videolaryngoscopy in critically ill patients.

Jaber S, De Jong A, Pelosi P, Cabrini L, Reignier J, Lascarrou JB.

Crit Care. 2019 Jun 17;23(1):221. doi: 10.1186/s13054-019-2487-5.


Ultrasound non-invasive intracranial pressure assessment in paediatric neurocritical care: a pilot study.

Robba C, Cardim D, Czosnyka M, Abecasis F, Pezzato S, Buratti S, Moscatelli A, Sortica C, Racca F, Pelosi P, Rasulo F.

Childs Nerv Syst. 2020 Jan;36(1):117-124. doi: 10.1007/s00381-019-04235-8. Epub 2019 Jun 15.


Endotoxin-Induced Emphysema Exacerbation: A Novel Model of Chronic Obstructive Pulmonary Disease Exacerbations Causing Cardiopulmonary Impairment and Diaphragm Dysfunction.

de Oliveira MV, Rocha NN, Santos RS, Rocco MRM, de Magalhães RF, Silva JD, Souza SAL, Capelozzi VL, Pelosi P, Silva PL, Rocco PRM.

Front Physiol. 2019 May 28;10:664. doi: 10.3389/fphys.2019.00664. eCollection 2019.


Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial.

Writing Committee for the PROBESE Collaborative Group of the PROtective VEntilation Network (PROVEnet) for the Clinical Trial Network of the European Society of Anaesthesiology, Bluth T, Serpa Neto A, Schultz MJ, Pelosi P, Gama de Abreu M; PROBESE Collaborative Group, Bluth T, Bobek I, Canet JC, Cinnella G, de Baerdemaeker L, Gama de Abreu M, Gregoretti C, Hedenstierna G, Hemmes SNT, Hiesmayr M, Hollmann MW, Jaber S, Laffey J, Licker MJ, Markstaller K, Matot I, Mills GH, Mulier JP, Pelosi P, Putensen C, Rossaint R, Schmitt J, Schultz MJ, Senturk M, Serpa Neto A, Severgnini P, Sprung J, Vidal Melo MF, Wrigge H.

JAMA. 2019 Jun 18;321(23):2292-2305. doi: 10.1001/jama.2019.7505. Erratum in: JAMA. 2019 Nov 12;322(18):1829-1830.


Intraoperative immunomodulatory effects of sevoflurane versus total intravenous anesthesia with propofol in bariatric surgery (the OBESITA trial): study protocol for a randomized controlled pilot trial.

de Sousa GC, Cruz FF, Heil LB, Sobrinho CJS, Saddy F, Knibel FP, Pereira JB, Schultz MJ, Pelosi P, Gama de Abreu M, Silva PL, Rocco PRM.

Trials. 2019 May 28;20(1):300. doi: 10.1186/s13063-019-3399-z.


How I ventilate an obese patient.

Ball L, Pelosi P.

Crit Care. 2019 May 16;23(1):176. doi: 10.1186/s13054-019-2466-x. No abstract available.

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