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Muscle ultrasound detects subclinical early reinnervation.

Pelosi L, Heiss-Dunlop W.

Clin Neurophysiol. 2020 Feb;131(2):594-595. doi: 10.1016/j.clinph.2019.11.031. Epub 2019 Dec 10. No abstract available.


Increased Circulating Levels of Interleukin-6 Affect the Redox Balance in Skeletal Muscle.

Forcina L, Miano C, Scicchitano BM, Rizzuto E, Berardinelli MG, De Benedetti F, Pelosi L, Musarò A.

Oxid Med Cell Longev. 2019 Nov 16;2019:3018584. doi: 10.1155/2019/3018584. eCollection 2019.


Muscle ultrasound in the assessment of oxaliplatin-induced neurotoxicity.

Pelosi L, Han CH, McKeage MJ.

Clin Neurophysiol. 2020 Jan;131(1):343-344. doi: 10.1016/j.clinph.2019.10.001. Epub 2019 Oct 24. No abstract available.


Vanillic Acid Restores Coenzyme Q Biosynthesis and ATP Production in Human Cells Lacking COQ6.

Acosta Lopez MJ, Trevisson E, Canton M, Vazquez-Fonseca L, Morbidoni V, Baschiera E, Frasson C, Pelosi L, Rascalou B, Desbats MA, Alcázar-Fabra M, Ríos JJ, Sánchez-García A, Basso G, Navas P, Pierrel F, Brea-Calvo G, Salviati L.

Oxid Med Cell Longev. 2019 Jul 10;2019:3904905. doi: 10.1155/2019/3904905. eCollection 2019.


Ubiquinone Biosynthesis over the Entire O2 Range: Characterization of a Conserved O2-Independent Pathway.

Pelosi L, Vo CD, Abby SS, Loiseau L, Rascalou B, Hajj Chehade M, Faivre B, Goussé M, Chenal C, Touati N, Binet L, Cornu D, Fyfe CD, Fontecave M, Barras F, Lombard M, Pierrel F.

mBio. 2019 Jul 9;10(4). pii: e01319-19. doi: 10.1128/mBio.01319-19.


Spinocerebellar ataxia type 2-neuronopathy or neuropathy?

Pelosi L, Iodice R, Antenora A, Kilfoyle D, Mulroy E, Rodrigues M, Roxburgh R, Iovino A, Filla A, Manganelli F, Santoro L.

Muscle Nerve. 2019 Sep;60(3):271-278. doi: 10.1002/mus.26613. Epub 2019 Jul 5.


Carpal tunnel syndrome in advanced age: A sonographic and electrodiagnostic study.

Mulroy E, Pelosi L.

Muscle Nerve. 2019 Sep;60(3):236-241. doi: 10.1002/mus.26496. Epub 2019 May 8.


An Overview about the Biology of Skeletal Muscle Satellite Cells.

Forcina L, Miano C, Pelosi L, Musarò A.

Curr Genomics. 2019 Jan;20(1):24-37. doi: 10.2174/1389202920666190116094736. Review.


Nerve ultrasound as a diagnostic tool for sensory neuronopathy in spinocerebellar ataxia syndrome.

Leadbetter R, Weatherall M, Pelosi L.

Clin Neurophysiol. 2019 Apr;130(4):568-572. doi: 10.1016/j.clinph.2018.12.010. Epub 2019 Jan 19.


A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone.

Hajj Chehade M, Pelosi L, Fyfe CD, Loiseau L, Rascalou B, Brugière S, Kazemzadeh K, Vo CD, Ciccone L, Aussel L, Couté Y, Fontecave M, Barras F, Lombard M, Pierrel F.

Cell Chem Biol. 2019 Apr 18;26(4):482-492.e7. doi: 10.1016/j.chembiol.2018.12.001. Epub 2019 Jan 24.


Diagnostic sensitivity of electrophysiology and ultrasonography in ulnar neuropathies of different severity.

Pelosi L, Mulroy E.

Clin Neurophysiol. 2019 Feb;130(2):297-302. doi: 10.1016/j.clinph.2018.11.018. Epub 2018 Dec 7.


Ulnar neuropathy with abnormal non-localizing electrophysiology: Clinical, electrophysiological and ultrasound findings.

Pelosi L, Tse DMY, Mulroy E, Chancellor AM, Boland MR.

Clin Neurophysiol. 2018 Oct;129(10):2155-2161. doi: 10.1016/j.clinph.2018.07.020. Epub 2018 Aug 12.


Peripheral nerves are pathologically small in cerebellar ataxia neuropathy vestibular areflexia syndrome: a controlled ultrasound study.

Pelosi L, Mulroy E, Leadbetter R, Kilfoyle D, Chancellor AM, Mossman S, Wing L, Wu TY, Roxburgh RH.

Eur J Neurol. 2018 Apr;25(4):659-665. doi: 10.1111/ene.13563. Epub 2018 Feb 26.


Peripheral nerve ultrasound findings in mucolipidosis type 3.

Mulroy E, Chancellor AM, Pelosi L.

Neuroradiology. 2018 Feb;60(2):207-209. doi: 10.1007/s00234-017-1953-5. Epub 2017 Dec 7.


Peripheral nerve ultrasound in Friedreich ataxia.

Mulroy E, Pelosi L, Leadbetter R, Joshi P, Rodrigues M, Mossman S, Kilfoyle D, Roxburgh R.

Muscle Nerve. 2018 May;57(5):852-856. doi: 10.1002/mus.26012. Epub 2017 Nov 27.


Neuronopathy and neuropathy in autosomal dominant spino-cerebellar ataxia (SCA): A preliminary peripheral nerve ultrasound study.

Pelosi L, Mulroy E, Rodrigues MJ, Roxburgh RH.

Clin Neurophysiol. 2017 Dec;128(12):2436-2437. doi: 10.1016/j.clinph.2017.09.114. Epub 2017 Oct 12. No abstract available.


The physiopathologic role of oxidative stress in skeletal muscle.

Scicchitano BM, Pelosi L, Sica G, Musarò A.

Mech Ageing Dev. 2018 Mar;170:37-44. doi: 10.1016/j.mad.2017.08.009. Epub 2017 Aug 26. Review.


Increased Circulating Levels of Interleukin-6 Induce Perturbation in Redox-Regulated Signaling Cascades in Muscle of Dystrophic Mice.

Pelosi L, Forcina L, Nicoletti C, Scicchitano BM, Musarò A.

Oxid Med Cell Longev. 2017;2017:1987218. doi: 10.1155/2017/1987218. Epub 2017 Aug 6.


The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ.

Loiseau L, Fyfe C, Aussel L, Hajj Chehade M, Hernández SB, Faivre B, Hamdane D, Mellot-Draznieks C, Rascalou B, Pelosi L, Velours C, Cornu D, Lombard M, Casadesús J, Pierrel F, Fontecave M, Barras F.

J Biol Chem. 2017 Jul 14;292(28):11937-11950. doi: 10.1074/jbc.M117.789164. Epub 2017 May 30.


Oxidative stress in Duchenne muscular dystrophy: focus on the NRF2 redox pathway.

Petrillo S, Pelosi L, Piemonte F, Travaglini L, Forcina L, Catteruccia M, Petrini S, Verardo M, D'Amico A, Musarò A, Bertini E.

Hum Mol Genet. 2017 Jul 15;26(14):2781-2790. doi: 10.1093/hmg/ddx173.


Peripheral nerve ultrasound in cerebellar ataxia neuropathy vestibular areflexia syndrome (CANVAS).

Pelosi L, Leadbetter R, Mulroy E, Chancellor AM, Mossman S, Roxburgh R.

Muscle Nerve. 2017 Jul;56(1):160-162. doi: 10.1002/mus.25476. Epub 2016 Nov 28.


Evolution of Ubiquinone Biosynthesis: Multiple Proteobacterial Enzymes with Various Regioselectivities To Catalyze Three Contiguous Aromatic Hydroxylation Reactions.

Pelosi L, Ducluzeau AL, Loiseau L, Barras F, Schneider D, Junier I, Pierrel F.

mSystems. 2016 Aug 30;1(4). pii: e00091-16. eCollection 2016 Jul-Aug.


Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast.

Payet LA, Leroux M, Willison JC, Kihara A, Pelosi L, Pierrel F.

Cell Chem Biol. 2016 Oct 20;23(10):1241-1250. doi: 10.1016/j.chembiol.2016.08.008. Epub 2016 Sep 29.


The importance of clinical monitoring for compliance with Continuous Positive Airway Pressure.

Pelosi LB, Silveira MLC, Eckeli AL, Chayamiti EMPC, Almeida LA, Sander HH, Küpper DS, Valera FCP.

Braz J Otorhinolaryngol. 2017 Jul - Aug;83(4):439-444. doi: 10.1016/j.bjorl.2016.05.013. Epub 2016 Jul 14.


SAM68 is a physiological regulator of SMN2 splicing in spinal muscular atrophy.

Pagliarini V, Pelosi L, Bustamante MB, Nobili A, Berardinelli MG, D'Amelio M, Musarò A, Sette C.

J Cell Biol. 2015 Oct 12;211(1):77-90. doi: 10.1083/jcb.201502059. Epub 2015 Oct 5.


Coq6 is responsible for the C4-deamination reaction in coenzyme Q biosynthesis in Saccharomyces cerevisiae.

Ozeir M, Pelosi L, Ismail A, Mellot-Draznieks C, Fontecave M, Pierrel F.

J Biol Chem. 2015 Oct 2;290(40):24140-51. doi: 10.1074/jbc.M115.675744. Epub 2015 Aug 10.


Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice.

Pelosi L, Berardinelli MG, Forcina L, Spelta E, Rizzuto E, Nicoletti C, Camilli C, Testa E, Catizone A, De Benedetti F, Musarò A.

Hum Mol Genet. 2015 Nov 1;24(21):6041-53. doi: 10.1093/hmg/ddv323. Epub 2015 Aug 6.


Functional and Morphological Improvement of Dystrophic Muscle by Interleukin 6 Receptor Blockade.

Pelosi L, Berardinelli MG, De Pasquale L, Nicoletti C, D'Amico A, Carvello F, Moneta GM, Catizone A, Bertini E, De Benedetti F, Musarò A.

EBioMedicine. 2015 Feb 26;2(4):285-93. doi: 10.1016/j.ebiom.2015.02.014. eCollection 2015 Apr.


Nicotine-induced cellular stresses and autophagy in human cancer colon cells: A supportive effect on cell homeostasis via up-regulation of Cox-2 and PGE(2) production.

Pelissier-Rota MA, Pelosi L, Meresse P, Jacquier-Sarlin MR.

Int J Biochem Cell Biol. 2015 Aug;65:239-56. doi: 10.1016/j.biocel.2015.06.013. Epub 2015 Jun 19.


MicroRNAs modulated by local mIGF-1 expression in mdx dystrophic mice.

Pelosi L, Coggi A, Forcina L, Musarò A.

Front Aging Neurosci. 2015 May 5;7:69. doi: 10.3389/fnagi.2015.00069. eCollection 2015.


Local overexpression of V1a-vasopressin receptor enhances regeneration in tumor necrosis factor-induced muscle atrophy.

Costa A, Toschi A, Murfuni I, Pelosi L, Sica G, Adamo S, Scicchitano BM.

Biomed Res Int. 2014;2014:235426. doi: 10.1155/2014/235426. Epub 2014 May 20.


Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.

Lemm JA, Liu M, Gentles RG, Ding M, Voss S, Pelosi LA, Wang YK, Rigat KL, Mosure KW, Bender JA, Knipe JO, Colonno R, Meanwell NA, Kadow JF, Santone KS, Roberts SB, Gao M.

Antimicrob Agents Chemother. 2014 Jun;58(6):3485-95. doi: 10.1128/AAC.02495-13. Epub 2014 Apr 14.


Three conserved histidine residues contribute to mitochondrial iron transport through mitoferrins.

Brazzolotto X, Pierrel F, Pelosi L.

Biochem J. 2014 May 15;460(1):79-89. doi: 10.1042/BJ20140107.


Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.

Gentles RG, Ding M, Bender JA, Bergstrom CP, Grant-Young K, Hewawasam P, Hudyma T, Martin S, Nickel A, Regueiro-Ren A, Tu Y, Yang Z, Yeung KS, Zheng X, Chao S, Sun JH, Beno BR, Camac DM, Chang CH, Gao M, Morin PE, Sheriff S, Tredup J, Wan J, Witmer MR, Xie D, Hanumegowda U, Knipe J, Mosure K, Santone KS, Parker DD, Zhuo X, Lemm J, Liu M, Pelosi L, Rigat K, Voss S, Wang Y, Wang YK, Colonno RJ, Gao M, Roberts SB, Gao Q, Ng A, Meanwell NA, Kadow JF.

J Med Chem. 2014 Mar 13;57(5):1855-79. doi: 10.1021/jm4016894. Epub 2014 Jan 7.


Exploring the conformational dynamics of the bovine ADP/ATP carrier in mitochondria.

Rey M, Forest E, Pelosi L.

Biochemistry. 2012 Dec 4;51(48):9727-35. doi: 10.1021/bi300759x. Epub 2012 Nov 19.


Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei.

Peña-Diaz P, Pelosi L, Ebikeme C, Colasante C, Gao F, Bringaud F, Voncken F.

J Biol Chem. 2012 Dec 7;287(50):41861-74. doi: 10.1074/jbc.M112.404699. Epub 2012 Oct 16.


Effect on hepatitis C virus replication of combinations of direct-acting antivirals, including NS5A inhibitor daclatasvir.

Pelosi LA, Voss S, Liu M, Gao M, Lemm JA.

Antimicrob Agents Chemother. 2012 Oct;56(10):5230-9. doi: 10.1128/AAC.01209-12. Epub 2012 Jul 30.


Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase.

Ding M, He F, Hudyma TW, Zheng X, Poss MA, Kadow JF, Beno BR, Rigat KL, Wang YK, Fridell RA, Lemm JA, Qiu D, Liu M, Voss S, Pelosi LA, Roberts SB, Gao M, Knipe J, Gentles RG.

Bioorg Med Chem Lett. 2012 Apr 15;22(8):2866-71. doi: 10.1016/j.bmcl.2012.02.063. Epub 2012 Mar 1.


The transmembrane prolines of the mitochondrial ADP/ATP carrier are involved in nucleotide binding and transport and its biogenesis.

Babot M, Blancard C, Pelosi L, Lauquin GJ, Trézéguet V.

J Biol Chem. 2012 Mar 23;287(13):10368-78. doi: 10.1074/jbc.M111.320697. Epub 2012 Feb 9.


Atrophy/hypertrophy cell signaling in muscles of young athletes trained with vibrational-proprioceptive stimulation.

Kern H, Pelosi L, Coletto L, Musarò A, Sandri M, Vogelauer M, Trimmel L, Cvecka J, Hamar D, Kovarik J, Löfler S, Sarabon N, Protasi F, Adami N, Biral D, Zampieri S, Carraro U.

Neurol Res. 2011 Dec;33(10):998-1009. doi: 10.1179/016164110X12767786356633.


Yeast ADP/ATP carrier isoform 2: conformational dynamics and role of the RRRMMM signature sequence methionines.

Clémençon B, Rey M, Trézéguet V, Forest E, Pelosi L.

J Biol Chem. 2011 Oct 14;286(41):36119-31. doi: 10.1074/jbc.M111.277376. Epub 2011 Aug 25.


A hybrid model to study pathological mutations of the human ADP/ATP carriers.

Thomas A, Rey M, Aubry L, Pelosi L.

Biochimie. 2011 Sep;93(9):1415-23. doi: 10.1016/j.biochi.2011.04.015. Epub 2011 Apr 28.


Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.

Zheng X, Hudyma TW, Martin SW, Bergstrom C, Ding M, He F, Romine J, Poss MA, Kadow JF, Chang CH, Wan J, Witmer MR, Morin P, Camac DM, Sheriff S, Beno BR, Rigat KL, Wang YK, Fridell R, Lemm J, Qiu D, Liu M, Voss S, Pelosi L, Roberts SB, Gao M, Knipe J, Gentles RG.

Bioorg Med Chem Lett. 2011 May 15;21(10):2925-9. doi: 10.1016/j.bmcl.2011.03.067. Epub 2011 Mar 23.


SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides: potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.

Gentles RG, Ding M, Zheng X, Chupak L, Poss MA, Beno BR, Pelosi L, Liu M, Lemm J, Wang YK, Roberts S, Gao M, Kadow J.

Bioorg Med Chem Lett. 2011 May 15;21(10):3142-7. doi: 10.1016/j.bmcl.2011.03.008. Epub 2011 Mar 6.


Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.

Gentles RG, Sheriff S, Beno BR, Wan C, Kish K, Ding M, Zheng X, Chupak L, Poss MA, Witmer MR, Morin P, Wang YK, Rigat K, Lemm J, Voss S, Liu M, Pelosi L, Roberts SB, Gao M, Kadow JF.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2212-5. doi: 10.1016/j.bmcl.2011.03.011. Epub 2011 Mar 6. Erratum in: Bioorg Med Chem Lett. 2011 Sep 15;21(18):5650-1.


Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform 1 revealed by hydrogen/deuterium exchange coupled to mass spectrometry.

Rey M, Man P, Clémençon B, Trézéguet V, Brandolin G, Forest E, Pelosi L.

J Biol Chem. 2010 Nov 5;285(45):34981-90. doi: 10.1074/jbc.M110.146209. Epub 2010 Aug 30.


Native membrane proteins vs. yeast recombinant: an example: the mitochondrial ADP/ATP carrier.

Arnou B, Dahout-Gonzalez C, Pelosi L, Lauquin GJ, Brandolin G, Trézéguet V.

Methods Mol Biol. 2010;654:19-28. doi: 10.1007/978-1-60761-762-4_2.


Effective removal of nonionic detergents in protein mass spectrometry, hydrogen/deuterium exchange, and proteomics.

Rey M, Mrázek H, Pompach P, Novák P, Pelosi L, Brandolin G, Forest E, Havlícek V, Man P.

Anal Chem. 2010 Jun 15;82(12):5107-16. doi: 10.1021/ac100171m.


Association of phosphatidic acid with the bovine mitochondrial ADP/ATP carrier.

Epand RM, Epand RF, Berno B, Pelosi L, Brandolin G.

Biochemistry. 2009 Dec 29;48(51):12358-64. doi: 10.1021/bi901769r.


Recombinant immobilized rhizopuspepsin as a new tool for protein digestion in hydrogen/deuterium exchange mass spectrometry.

Rey M, Man P, Brandolin G, Forest E, Pelosi L.

Rapid Commun Mass Spectrom. 2009 Nov;23(21):3431-8. doi: 10.1002/rcm.4260.


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