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Items: 1 to 50 of 106

1.

Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements.

Deng L, Wu RA, Sonneville R, Kochenova OV, Labib K, Pellman D, Walter JC.

Mol Cell. 2019 Mar 7;73(5):915-929.e6. doi: 10.1016/j.molcel.2018.12.021.

PMID:
30849395
2.

Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.

Jiao AL, Perales R, Umbreit NT, Haswell JR, Piper ME, Adams BD, Pellman D, Kennedy S, Slack FJ.

RNA. 2019 Mar;25(3):352-363. doi: 10.1261/rna.069773.118. Epub 2018 Dec 11.

PMID:
30538148
3.

Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression.

Mowery CT, Reyes JM, Cabal-Hierro L, Higby KJ, Karlin KL, Wang JH, Kimmerling RJ, Cejas P, Lim K, Li H, Furusawa T, Long HW, Pellman D, Chapuy B, Bustin M, Manalis SR, Westbrook TF, Lin CY, Lane AA.

Cell Rep. 2018 Nov 13;25(7):1898-1911.e5. doi: 10.1016/j.celrep.2018.10.061.

4.

TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer.

Witwicki RM, Ekram MB, Qiu X, Janiszewska M, Shu S, Kwon M, Trinh A, Frias E, Ramadan N, Hoffman G, Yu K, Xie Y, McAllister G, McDonald R, Golji J, Schlabach M, deWeck A, Keen N, Chan HM, Ruddy D, Rejtar T, Sovath S, Silver S, Sellers WR, Jagani Z, Hogarty MD, Roberts C, Brown M, Stegmaier K, Long H, Shivdasani RA, Pellman D, Polyak K.

Cell Rep. 2018 Oct 30;25(5):1255-1267.e5. doi: 10.1016/j.celrep.2018.10.023.

5.

Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival.

Oser MG, Fonseca R, Chakraborty AA, Brough R, Spektor A, Jennings RB, Flaifel A, Novak JS, Gulati A, Buss E, Younger ST, McBrayer SK, Cowley GS, Bonal DM, Nguyen QD, Brulle-Soumare L, Taylor P, Cairo S, Ryan CJ, Pease EJ, Maratea K, Travers J, Root DE, Signoretti S, Pellman D, Ashton S, Lord CJ, Barry ST, Kaelin WG Jr.

Cancer Discov. 2019 Feb;9(2):230-247. doi: 10.1158/2159-8290.CD-18-0389. Epub 2018 Oct 29.

6.

Nuclear envelope assembly defects link mitotic errors to chromothripsis.

Liu S, Kwon M, Mannino M, Yang N, Renda F, Khodjakov A, Pellman D.

Nature. 2018 Sep;561(7724):551-555. doi: 10.1038/s41586-018-0534-z. Epub 2018 Sep 19.

7.

How the Genome Folds, Divides, Lives, and Dies.

Johnson WL, Xie KT, Kwon M, Liu S, Pellman D.

Cold Spring Harb Symp Quant Biol. 2017;82:349-360. doi: 10.1101/sqb.2017.82.035527. Epub 2018 May 25. No abstract available.

PMID:
29802151
8.

Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation.

Marteil G, Guerrero A, Vieira AF, de Almeida BP, Machado P, Mendonça S, Mesquita M, Villarreal B, Fonseca I, Francia ME, Dores K, Martins NP, Jana SC, Tranfield EM, Barbosa-Morais NL, Paredes J, Pellman D, Godinho SA, Bettencourt-Dias M.

Nat Commun. 2018 Mar 28;9(1):1258. doi: 10.1038/s41467-018-03641-x.

9.

Cell Biology: When Your Own Chromosomes Act like Foreign DNA.

Spektor A, Umbreit NT, Pellman D.

Curr Biol. 2017 Nov 20;27(22):R1228-R1231. doi: 10.1016/j.cub.2017.09.043.

10.

Cancer biology: Genome jail-break triggers lockdown.

Umbreit NT, Pellman D.

Nature. 2017 Oct 19;550(7676):340-341. doi: 10.1038/nature24146. Epub 2017 Oct 4. No abstract available.

PMID:
28976957
11.

A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity.

Arellano-Santoyo H, Geyer EA, Stokasimov E, Chen GY, Su X, Hancock W, Rice LM, Pellman D.

Dev Cell. 2017 Jul 10;42(1):37-51.e8. doi: 10.1016/j.devcel.2017.06.011.

12.

The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.

Li H, Mar BG, Zhang H, Puram RV, Vazquez F, Weir BA, Hahn WC, Ebert B, Pellman D.

Blood. 2017 Jan 26;129(4):497-508. doi: 10.1182/blood-2016-05-714493. Epub 2016 Oct 18.

13.

From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes.

Zhang CZ, Pellman D.

Cold Spring Harb Symp Quant Biol. 2015;80:117-37. doi: 10.1101/sqb.2015.80.027623. Epub 2016 Mar 11. Review.

PMID:
26968629
14.

Modeling the initiation of Ewing sarcoma tumorigenesis in differentiating human embryonic stem cells.

Gordon DJ, Motwani M, Pellman D.

Oncogene. 2016 Jun 16;35(24):3092-102. doi: 10.1038/onc.2015.368. Epub 2015 Oct 12.

15.

Chromothripsis: A New Mechanism for Rapid Karyotype Evolution.

Leibowitz ML, Zhang CZ, Pellman D.

Annu Rev Genet. 2015;49:183-211. doi: 10.1146/annurev-genet-120213-092228. Epub 2015 Oct 6. Review.

PMID:
26442848
16.

Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds.

Kwon M, Bagonis M, Danuser G, Pellman D.

Dev Cell. 2015 Aug 10;34(3):323-37. doi: 10.1016/j.devcel.2015.06.013. Epub 2015 Jul 30.

17.

Chromothripsis from DNA damage in micronuclei.

Zhang CZ, Spektor A, Cornils H, Francis JM, Jackson EK, Liu S, Meyerson M, Pellman D.

Nature. 2015 Jun 11;522(7555):179-84. doi: 10.1038/nature14493. Epub 2015 May 27.

18.

Polyploidy can drive rapid adaptation in yeast.

Selmecki AM, Maruvka YE, Richmond PA, Guillet M, Shoresh N, Sorenson AL, De S, Kishony R, Michor F, Dowell R, Pellman D.

Nature. 2015 Mar 19;519(7543):349-52. doi: 10.1038/nature14187. Epub 2015 Mar 2.

19.

Aurea mediocritas: the importance of a balanced genome.

Varetti G, Pellman D, Gordon DJ.

Cold Spring Harb Perspect Biol. 2014 Sep 18;6(11):a015842. doi: 10.1101/cshperspect.a015842. Review.

20.

Cytokinesis failure triggers hippo tumor suppressor pathway activation.

Ganem NJ, Cornils H, Chiu SY, O'Rourke KP, Arnaud J, Yimlamai D, Théry M, Camargo FD, Pellman D.

Cell. 2014 Aug 14;158(4):833-848. doi: 10.1016/j.cell.2014.06.029.

21.

Causes and consequences of centrosome abnormalities in cancer.

Godinho SA, Pellman D.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130467. doi: 10.1098/rstb.2013.0467. Review.

22.

Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.

Lane AA, Chapuy B, Lin CY, Tivey T, Li H, Townsend EC, van Bodegom D, Day TA, Wu SC, Liu H, Yoda A, Alexe G, Schinzel AC, Sullivan TJ, Malinge S, Taylor JE, Stegmaier K, Jaffe JD, Bustin M, te Kronnie G, Izraeli S, Harris MH, Stevenson KE, Neuberg D, Silverman LB, Sallan SE, Bradner JE, Hahn WC, Crispino JD, Pellman D, Weinstock DM.

Nat Genet. 2014 Jun;46(6):618-23. doi: 10.1038/ng.2949. Epub 2014 Apr 20.

23.

Oncogene-like induction of cellular invasion from centrosome amplification.

Godinho SA, Picone R, Burute M, Dagher R, Su Y, Leung CT, Polyak K, Brugge JS, Théry M, Pellman D.

Nature. 2014 Jun 5;510(7503):167-71. doi: 10.1038/nature13277. Epub 2014 Apr 13.

24.

Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks.

Lee DH, Acharya SS, Kwon M, Drane P, Guan Y, Adelmant G, Kalev P, Shah J, Pellman D, Marto JA, Chowdhury D.

Mol Cell. 2014 May 8;54(3):512-25. doi: 10.1016/j.molcel.2014.03.020. Epub 2014 Apr 3.

25.

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.

Cowley GS, Weir BA, Vazquez F, Tamayo P, Scott JA, Rusin S, East-Seletsky A, Ali LD, Gerath WF, Pantel SE, Lizotte PH, Jiang G, Hsiao J, Tsherniak A, Dwinell E, Aoyama S, Okamoto M, Harrington W, Gelfand E, Green TM, Tomko MJ, Gopal S, Wong TC, Li H, Howell S, Stransky N, Liefeld T, Jang D, Bistline J, Hill Meyers B, Armstrong SA, Anderson KC, Stegmaier K, Reich M, Pellman D, Boehm JS, Mesirov JP, Golub TR, Root DE, Hahn WC.

Sci Data. 2014 Sep 30;1:140035. doi: 10.1038/sdata.2014.35. eCollection 2014. Erratum in: Sci Data. 2014;1:140044. Wong, Terrence C [corrected to Wong, Terence C].

26.

Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements.

Zhang CZ, Leibowitz ML, Pellman D.

Genes Dev. 2013 Dec 1;27(23):2513-30. doi: 10.1101/gad.229559.113. Review.

27.

Inhibition of Cdc42 during mitotic exit is required for cytokinesis.

Atkins BD, Yoshida S, Saito K, Wu CF, Lew DJ, Pellman D.

J Cell Biol. 2013 Jul 22;202(2):231-40. doi: 10.1083/jcb.201301090.

28.

Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control.

Su X, Arellano-Santoyo H, Portran D, Gaillard J, Vantard M, Thery M, Pellman D.

Nat Cell Biol. 2013 Aug;15(8):948-57. doi: 10.1038/ncb2801. Epub 2013 Jul 14.

29.

Linking abnormal mitosis to the acquisition of DNA damage.

Ganem NJ, Pellman D.

J Cell Biol. 2012 Dec 10;199(6):871-81. doi: 10.1083/jcb.201210040. Review.

30.

Move in for the kill: motile microtubule regulators.

Su X, Ohi R, Pellman D.

Trends Cell Biol. 2012 Nov;22(11):567-75. doi: 10.1016/j.tcb.2012.08.003. Epub 2012 Sep 6. Review.

31.

Regulation of the formin Bnr1 by septins anda MARK/Par1-family septin-associated kinase.

Buttery SM, Kono K, Stokasimov E, Pellman D.

Mol Biol Cell. 2012 Oct;23(20):4041-53. doi: 10.1091/mbc.E12-05-0395. Epub 2012 Aug 23.

32.

Proteasomal degradation resolves competition between cell polarization and cellular wound healing.

Kono K, Saeki Y, Yoshida S, Tanaka K, Pellman D.

Cell. 2012 Jul 6;150(1):151-64. doi: 10.1016/j.cell.2012.05.030. Epub 2012 Jun 21.

33.

"Two" much of a good thing: telomere damage-induced genome doubling drives tumorigenesis.

Varetti G, Pellman D.

Cancer Cell. 2012 Jun 12;21(6):712-4. doi: 10.1016/j.ccr.2012.05.033.

34.

Absolute quantification of somatic DNA alterations in human cancer.

Carter SL, Cibulskis K, Helman E, McKenna A, Shen H, Zack T, Laird PW, Onofrio RC, Winckler W, Weir BA, Beroukhim R, Pellman D, Levine DA, Lander ES, Meyerson M, Getz G.

Nat Biotechnol. 2012 May;30(5):413-21. doi: 10.1038/nbt.2203.

35.

Causes and consequences of aneuploidy in cancer.

Gordon DJ, Resio B, Pellman D.

Nat Rev Genet. 2012 Jan 24;13(3):189-203. doi: 10.1038/nrg3123. Review.

PMID:
22269907
36.

DNA breaks and chromosome pulverization from errors in mitosis.

Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Pan Y, Nezi L, Protopopov A, Chowdhury D, Pellman D.

Nature. 2012 Jan 18;482(7383):53-8. doi: 10.1038/nature10802.

37.

Mechanisms underlying the dual-mode regulation of microtubule dynamics by Kip3/kinesin-8.

Su X, Qiu W, Gupta ML Jr, Pereira-Leal JB, Reck-Peterson SL, Pellman D.

Mol Cell. 2011 Sep 2;43(5):751-63. doi: 10.1016/j.molcel.2011.06.027.

38.

Centrosomes and cilia in human disease.

Bettencourt-Dias M, Hildebrandt F, Pellman D, Woods G, Godinho SA.

Trends Genet. 2011 Aug;27(8):307-15. doi: 10.1016/j.tig.2011.05.004. Epub 2011 Jun 15. Review.

39.

Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast.

Storchová Z, Becker JS, Talarek N, Kögelsberger S, Pellman D.

Mol Biol Cell. 2011 May;22(9):1473-85. doi: 10.1091/mbc.E10-08-0673. Epub 2011 Mar 9.

40.

Cancer genomes evolve by pulverizing single chromosomes.

Meyerson M, Pellman D.

Cell. 2011 Jan 7;144(1):9-10. doi: 10.1016/j.cell.2010.12.025.

41.

HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cells.

Breuer M, Kolano A, Kwon M, Li CC, Tsai TF, Pellman D, Brunet S, Verlhac MH.

J Cell Biol. 2010 Dec 27;191(7):1251-60. doi: 10.1083/jcb.201005065. Epub 2010 Dec 20.

42.

Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells.

Vinciguerra P, Godinho SA, Parmar K, Pellman D, D'Andrea AD.

J Clin Invest. 2010 Nov;120(11):3834-42. doi: 10.1172/JCI43391.

43.

David Pellman: Grasping the geometry of cancer. Interviewed by Caitlin Sedwick.

Pellman D.

J Cell Biol. 2010 Jul 12;190(1):4-5. doi: 10.1083/jcb.1901pi. No abstract available.

44.

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.

Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS.

Nat Chem Biol. 2010 May;6(5):359-68. doi: 10.1038/nchembio.345. Epub 2010 Apr 11.

45.

Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance.

Tischfield MA, Baris HN, Wu C, Rudolph G, Van Maldergem L, He W, Chan WM, Andrews C, Demer JL, Robertson RL, Mackey DA, Ruddle JB, Bird TD, Gottlob I, Pieh C, Traboulsi EI, Pomeroy SL, Hunter DG, Soul JS, Newlin A, Sabol LJ, Doherty EJ, de Uzcátegui CE, de Uzcátegui N, Collins ML, Sener EC, Wabbels B, Hellebrand H, Meitinger T, de Berardinis T, Magli A, Schiavi C, Pastore-Trossello M, Koc F, Wong AM, Levin AV, Geraghty MT, Descartes M, Flaherty M, Jamieson RV, Møller HU, Meuthen I, Callen DF, Kerwin J, Lindsay S, Meindl A, Gupta ML Jr, Pellman D, Engle EC.

Cell. 2010 Jan 8;140(1):74-87. doi: 10.1016/j.cell.2009.12.011.

46.

Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.

Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT.

Mol Cell Biol. 2009 Nov;29(21):5911-22. doi: 10.1128/MCB.00558-09. Epub 2009 Aug 24.

47.

A mechanism linking extra centrosomes to chromosomal instability.

Ganem NJ, Godinho SA, Pellman D.

Nature. 2009 Jul 9;460(7252):278-82. doi: 10.1038/nature08136. Epub 2009 Jun 7.

48.

Mechanisms for concentrating Rho1 during cytokinesis.

Yoshida S, Bartolini S, Pellman D.

Genes Dev. 2009 Apr 1;23(7):810-23. doi: 10.1101/gad.1785209.

49.

A little CIN may cost a lot: revisiting aneuploidy and cancer.

Chandhok NS, Pellman D.

Curr Opin Genet Dev. 2009 Feb;19(1):74-81. doi: 10.1016/j.gde.2008.12.004. Epub 2009 Feb 3. Review.

PMID:
19195877
50.

Centrosomes and cancer: how cancer cells divide with too many centrosomes.

Godinho SA, Kwon M, Pellman D.

Cancer Metastasis Rev. 2009 Jun;28(1-2):85-98. doi: 10.1007/s10555-008-9163-6. Review.

PMID:
19156503

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